Development and Psychopathology最新文献

Research has robustly demonstrated that children exposed to early ecological adversity are at risk for developing antisocial, externalizing behavior problems (rule breaking, aggression, disregard for others). Yet, studies have also demonstrated multifinality in developmental pathways unfolding in adversity's aftermath, with many children showing remarkable resilience. Understanding sources of such resilience is critical, especially across different populations (Luthar et al., 2006, 2015). In Family Study (FS, 102 low-risk mothers, fathers, and infants) and Play Study (PS, 186 high-risk mother-toddler dyads), we test a model of parent-child attachment security, observed at 15 months in FS and 2.5 years in PS, as a moderator of effects of early family ecological adversity, assessed as a cumulative score of sociodemographic risks (graded for severity) at 7 months in FS and 2.5 years in PS, on children's antisocial, externalizing problems, observed and parent-reported at 5.5 years in FS and 7 years in PS. We supported moderation for mother-child relationships in both studies: Higher early family adversity was associated with more antisocial outcomes five years later, but only for children with less secure attachments. We highlight the key role of early security as a protective factor and a source of resilience for children in families experiencing adversity.

Delayed reward discounting (DRD), the tendency to prefer smaller rewards available immediately relative to larger rewards available after a delay, is associated with numerous health outcomes across the lifespan. Emerging literature points to the central role of early environments, specifically factors reflecting harshness (including lack of resources) and unpredictability (exposure to instability and stressful events) in the development of DRD. Yet, existing research uses disparate indicators of environmental risk and often draws on small samples resulting in conflicting findings, making comparisons across studies challenging. The current systematic review examined environmental factors that may place youth at greatest risk for heightened DRD and subsequent negative health outcomes. Search results identified 28 articles reflecting 20 unique samples. Additionally, meta-analyses were conducted to examine overall effects for the two most commonly examined environmental predictors (family income and family history of substance use disorder). Results suggest small-to-medium associations of environmental risk with DRD, with smaller associations observed for more distal predictors of harshness (e.g., family income) and larger associations among more proximal indicators of environmental instability (e.g., harsh parenting and parental pathology). Findings highlight the role of environmental factors on DRD development and may inform future interventions.

This study examined whether childhood adversity, specifically threat-related adversity, was associated with within-person changes in the cortisol awakening response (CAR) and diurnal cortisol slope (DCS), and whether these changes predicted increased depressive symptoms during adolescence. We also explored sex differences. In total, 283 first-year secondary school students in Belgium (M = 12.48 years; SD = 0.39; 42.8% female) participated in six assessments over 2.5 years. Childhood adversity (psychological, physical, and sexual victimization) reported at the first three waves was averaged. CAR and DCS latent residual change scores were derived from salivary cortisol samples collected during waves 1 and 3. Depressive symptom changes were assessed in linear growth curve models using self-reports from waves 3 to 6. The childhood adversity × sex interaction significantly predicted CAR and DCS changes, indicating a blunted CAR across waves for victimized boys, and a blunted DCS for victimized girls. Childhood adversity predicted the depressive symptoms intercept. No other predictors were associated with the depressive symptoms intercept, and none were linked to the depressive symptoms slope. Thus, childhood adversity may be linked to changes in diurnal cortisol patterns that differ by sex. Evidence for diurnal cortisol changes as a pathway to increased depressive symptoms remains inconclusive.

Early identification of risk for attention-deficit hyperactivity disorder (ADHD) symptoms can enable more timely interventions and improve long-term outcomes. While previous research has linked various maternal and perinatal factors to ADHD, few studies have examined these predictors collectively in a single comprehensive analysis. This study aimed to assess whether later ADHD symptoms can be predicted from information available at birth, specifically ethnicity, maternal metabolic markers, mental health, and socioeconomic status. It additionally aimed to identify the most influential predictors. Using data from the Born in Bradford (BiB) study, we applied multiple linear regression (LR) and machine learning techniques to predict ADHD symptoms as measured by the Hyperactivity/Inattention subscale of the Strengths and Difficulties Questionnaire (SDQ). A 10-fold cross-validated LR model explained 6.97% of the variance in SDQ scores. In the random forest model, infant male sex and maternal smoking during pregnancy emerged as the top predictors. These findings provide proof of principle for early identification of children at risk of ADHD. Future models may benefit from incorporating additional perinatal data to improve predictive accuracy.

Parental mentalizing, or the parent's capacity to think about the child as having an inner psychological world, has been shown to play an important role in sensitive parenting and child socioemotional development. Studies suggest that high levels of stress impair (parental) mentalizing, yet surprisingly few studies have experimentally investigated this. The present study aimed to address this gap by investigating the impact of child-focused stress on parental mentalizing measured using a newly developed self-report questionnaire, following an experimental design with a computer-controlled baby simulator in a sample of 29 community mothers. Both subjective arousal, measured by a self-report item, and biological arousal, assessed through galvanic skin response, were measured throughout the experiment. Attachment dimensions, childhood trauma, and borderline personality disorder (BPD) features were assessed at baseline. Results demonstrated that the induction of child-focused stress was associated with an increase in parental mentalizing difficulties. Increases in mentalizing difficulties were, in turn, associated with increases in subjective and biological arousal following the simulator task. Finally, attachment anxiety and childhood trauma were positively correlated with both arousal and parental mentalizing difficulties in the simulator task, whereas attachment avoidance and BPD features were not. The implications of these findings for early intervention are discussed.

Methylation alterations of the glucocorticoid receptor gene (NR3C1) may help explain why not all individuals experiencing insensitive parenting develop behavior problems, yet evidence from human cohorts remains limited. This longitudinal study examined associations among NR3C1 methylation, caregiver parenting, and child internalizing and externalizing behaviors. A total of 224 Han Chinese preschoolers (M_age = 47.33 ± 9.60 months; 42.5% girls) were recruited from Jinan, China, in 2021 (T1). Parenting quality and child behavior problems were reported by both parents, and NR3C1 methylation across 46 cytosine-phosphate-guanine sites in the exon 1F promoter region was sequenced from buccal cells. Follow-up assessments were conducted 1.5 years later among 113 children who stayed in the same kindergarten (M_age = 63.60 ± 7.68 months; 45.7% girls). NR3C1 methylation at baseline moderated the association between parenting and baseline, but not follow-up, behavior problems, consistent with differential susceptibility. Children with lower methylation exhibited more behavior problems under low-quality parenting but fewer under high-quality parenting. This interaction did not vary between parental and child sex, or NR3C1 BclI (rs41423247) and Tth111I (rs10052957) polymorphisms. Findings highlight the dynamic nature of Epigenome × Environment interactions and suggest that lower NR3C1 methylation may act as a plasticity factor in preschool children.

Economic hardship is known to shape children's self-regulation, yet little is understood about how fluctuations in hardship unfold over time and whether different patterns of unpredictability carry unique developmental consequences. Using a socioeconomically diverse sample, we tracked families' subjective economic hardship across 15-36 monthly assessments and applied an environmental statistics framework to quantify four indices of unpredictability: changepoints in mean, changepoints in variance, coefficient of variation, and noise. PCA identified two distinct forms of economic unpredictability: one marked by frequent, unpredictable hardship, and another by infrequent but abrupt hardship. Economic unpredictability was disproportionately experienced by racially minoritized and lower-income families in our sample, reinforcing structural inequities in economic resources. Relations between these indices and caregiver-reported measures of family routines and day-to-day unpredictability were weak, suggesting wide heterogeneity in the ways families adapt to economic unpredictability. Leveraging propensity score methods, we isolated the effects of unpredictability from hardship severity, finding that both were associated with greater self-regulation challenges in early childhood, with the strongest effects for hardship severity. These findings underscore the importance of capturing economic hardship as a dynamic and multidimensional experience, with implications for policy efforts aimed at promoting stability in families' access to resources over time.

Supportive parenting experiences link to secure attachment development, and secure attachment in turn links to children's emotional well-being. However, little is known whether child-factors, like their environmental sensitivity, moderate these associations for better or for worse. We used longitudinal data (three data waves spanning two years) from 614 children (Wave 1: M_age = 10.28; SD_age = 0.58; 44% boys). At all waves, attachment was operationalized as children's knowledge of the Secure Base Script with a coded narrative task. Children filled out questionnaires on supportive parenting, their environmental sensitivity and their depressive symptoms. Parents filled out questionnaires on children's internalizing problems. Results: environmental sensitivity moderated the link between supportive parenting and attachment. More sensitive children that perceived their parents as less supportive less likely developed SBS knowledge. Further, environmental sensitivity moderated the link between SBS knowledge and the development of internalizing problems. More sensitive children with less SBS knowledge developed more internalizing problems. The findings support the importance of accounting for environmental sensitivity in attachment research.

Early deprivation holds far-reaching implications for academic performance in adolescence. Yet, the implicated cascading mechanisms remain under-delineated, and little is known about why children may display diverse patterns of cognitive development. To address such gaps, we leveraged long-term longitudinal data derived from the Future of Families and Child Wellbeing Study (n = 2,085). Results indicated that early deprivation (age 3, caregivers' reports and observers' ratings; controlling for early threat and unpredictability) was negatively associated with adolescent academic performance (age 15, adolescents' reports) indirectly through a negative association with cognitive ability in middle childhood (age 9, standardized tests). Furthermore, such an indirect effect was less pronounced among children with higher (versus lower) negative emotionality (age 1, mothers' ratings), given that the negative link between early deprivation and subsequent cognitive ability was weaker among children with higher (versus lower) negative emotionality. Breaking down cognitive ability into sub-components (i.e., working memory, language ability, reading comprehension, and problem-solving), both language ability and applied problem-solving were involved in the deprivation-emotionality interaction. These findings highlight the critical role of cognitive ability in accounting for the long-term academic consequences of early deprivation and the key role of negative emotionality in shaping heterogeneity in such pathways.