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Google Search Data Reveals Gaps in Information Transparency and Patient Counseling for Mohs Micrographic Surgery. 谷歌搜索数据揭示了莫氏显微手术信息透明度和患者咨询方面的差距。
IF 2.5 3区 医学 Q2 DERMATOLOGY
Dermatologic Surgery
Pub Date : 2024-11-01 Epub Date: 2024-06-06 DOI: 10.1097/DSS.0000000000004277
Neil K Jairath, Sumanth Chennareddy, Sophia Manduca, Adriana Lopez, Jesse M Lewin
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引用次数: 0
Reconstructing a Defect Involving the Medial Cheek and Upper Lip. 修复面颊内侧和上唇的缺损
IF 2.5 3区 医学 Q2 DERMATOLOGY
Dermatologic Surgery
Pub Date : 2024-11-01 Epub Date: 2024-02-23 DOI: 10.1097/DSS.0000000000004131
Lindsey M Voller, Sumaira Z Aasi
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引用次数: 0
Pinch Grafts Versus Second Intention Wound Healing for Mohs Micrographic Surgery Defects Below the Knee: A Prospective Randomized Trial. 膝下莫氏显微手术缺损的捏合移植与第二意向伤口愈合：一项前瞻性随机试验。
IF 2.5 3区 医学 Q2 DERMATOLOGY
Dermatologic Surgery
Pub Date : 2024-11-01 Epub Date: 2024-08-01 DOI: 10.1097/DSS.0000000000004272
Tyler J Willenbrink, David G Brodland

Background: The surgical management of leg wounds following skin cancer extirpation is challenging. Pinch grafting (PG) is a technique that has been rarely described in the reconstruction of acute surgical wounds.

Objective: The purpose of this study was to evaluate whether PG resulted in faster healing times for below the knee wounds following Mohs micrographic surgery (MMS) when compared with second intention healing (SIH).

Materials and methods: This was a prospective randomized trial of patients with post-Mohs micrographic surgical wounds of the lower extremity who were randomized either to receive pinch grafts or to heal by second intention. Patients were followed through a combination of in-person and virtual visits until their wounds were completely reepithelialized.

Results: Median time to wound healing was 36 days in the PG group versus 56 days for the SIH group, representing a 56% improvement in healing time. There were no differences in complications between the 2 groups with trends toward decreased rates of pain and infection in the PG group.

Conclusion: PG is an effective simple method to hasten the healing of lower extremity wounds following MMS.

背景：皮肤癌切除术后腿部伤口的手术治疗具有挑战性。捏合移植术（PG）是一种在重建急性手术伤口方面鲜有描述的技术：本研究的目的是评估莫氏显微外科手术（MMS）后膝下伤口的愈合时间，与第二意向愈合（SIH）相比，PG 是否更快：这是一项前瞻性随机试验，对象是莫氏显微手术后下肢伤口的患者，他们被随机分配接受夹植或第二意向愈合。患者将通过亲临现场和虚拟访问相结合的方式接受随访，直至伤口完全再上皮化：PG组伤口愈合的中位时间为36天，而SIH组为56天，伤口愈合时间缩短了56%。两组的并发症没有差异，PG 组的疼痛和感染率呈下降趋势：结论：PG 是一种有效的简单方法，可加速 MMS 术后下肢伤口的愈合。
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引用次数: 0
Polynucleotides in Skin Regeneration: Targeting the Adenosine A2A Receptor and Salvage Pathway. 皮肤再生中的多核苷酸：以腺苷 A2A 受体和挽救途径为目标。
IF 2.5 3区 医学 Q2 DERMATOLOGY
Dermatologic Surgery
Pub Date : 2024-11-01 Epub Date: 2024-10-09 DOI: 10.1097/DSS.0000000000004438
Luiza Helena Urso Pitassi, Keenan Pearson, Luís Antônio de Assis, Brian Biesman, Mariana Calomeni, Shino Bay-Aguilera, Saranya P Wyles
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引用次数: 0
Introduction. 介绍。
IF 2.5 3区 医学 Q2 DERMATOLOGY
Dermatologic Surgery
Pub Date : 2024-11-01 DOI: 10.1097/DSS.0000000000004445
Saranya P Wyles, Magnus D Lynch
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引用次数: 0
Regenerative Medicine: On the Vanguard of Dermatology. 再生医学：皮肤病学的前沿。
IF 2.5 3区 医学 Q2 DERMATOLOGY
Dermatologic Surgery
Pub Date : 2024-11-01 Epub Date: 2024-09-04 DOI: 10.1097/DSS.0000000000004388
Magnus D Lynch, Saranya P Wyles
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引用次数: 0
Regenerative Skincare Technologies Derived From Human Fibroblasts: Growth Factors and Exosomes for Transformative Outcomes. 源自人类成纤维细胞的再生护肤技术：生长因子和外泌体的变革性成果。
IF 2.5 3区 医学 Q2 DERMATOLOGY
Dermatologic Surgery
Pub Date : 2024-11-01 DOI: 10.1097/DSS.0000000000004436
Tsing Cheng, Gail K Naughton, Elizabeth T Makino, Kuniko Kadoya, Prithwiraj Maitra

Background: Since the early 2000s, human fibroblast conditioned media (HFCM) has been used in topical growth factor skincare to support skin regeneration and skin rejuvenation. Human fibroblast conditioned media contains the fibroblast secretome including growth factors as well as exosomes. The potential benefits of topically applied exosomes are gaining interest in the medical aesthetic field.

Objective: This article aims to summarize the preclinical and clinical data available on regenerative HFCM-based topical skincare with a focus on studies investigating products applied to improve overall facial skin rejuvenation and/or after in-office cosmetic procedures. In addition, available data on fibroblast-derived exosomes will be covered.

Methods: A focused literature review was conducted to provide an overview of evidence on HFCM-based topical skincare.

Results: Human fibroblast conditioned media-based skincare significantly reduces signs of skin aging including photodamage, coarse lines and wrinkles, and sagging. After in-office cosmetic procedures, HFCM-based skincare can stimulate skin recovery and reduce downtime as well as provide skin quality benefits to enhance overall treatment outcomes. Application of purified exosomes from HFCM also demonstrated significant improvements in multiple skin aging parameters.

Conclusion: Human fibroblast conditioned media combines naturally secreted fibroblast-derived growth factors and exosomes that stimulate skin regeneration and rejuvenation as evidenced by a variety of assays and assessments including in vitro preclinical studies, clinical investigator grading, instrumentation measurements, biopsy analyses, and patient-reported outcomes.

背景：自 2000 年代初以来，人成纤维细胞条件培养基（HFCM）一直被用于局部生长因子护肤，以支持皮肤再生和皮肤年轻化。人成纤维细胞条件培养基含有成纤维细胞分泌组，包括生长因子和外泌体。医学美容领域对外泌体的潜在益处越来越感兴趣：本文旨在总结基于再生高频外泌体的局部护肤品的临床前和临床数据，重点研究用于改善整体面部皮肤年轻化和/或诊所美容手术后的产品。此外，还将涵盖有关成纤维细胞外泌体的现有数据：方法：进行重点文献综述，概述基于 HFCM 的局部护肤品的证据：结果：基于人成纤维细胞条件培养基的护肤品能明显减少皮肤老化迹象，包括光损伤、粗纹、皱纹和松弛。在诊室进行美容手术后，基于 HFCM 的护肤品可刺激皮肤恢复，减少停工期，并为皮肤质量带来益处，从而提高整体治疗效果。应用纯化的 HFCM 外泌体还能显著改善多种皮肤老化参数：结论：人成纤维细胞条件培养基结合了天然分泌的成纤维细胞生长因子和外泌体，可刺激皮肤再生和年轻化，体外临床前研究、临床研究人员分级、仪器测量、活检分析和患者报告结果等各种检测和评估都证明了这一点。
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引用次数: 0
Transient Epigenetic Reprogramming: The Future of Skin Rejuvenation. 瞬时表观遗传重编程：皮肤年轻化的未来。
IF 2.5 3区 医学 Q2 DERMATOLOGY
Dermatologic Surgery
Pub Date : 2024-11-01 DOI: 10.1097/DSS.0000000000004433
Siddharth Menon, Christine Monteleon, Augustine S J Rhodes, Vittorio Sebastiano, Edward Hsia
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引用次数: 0
Variations of the Island Pedicle Flap for Reconstruction of Nasal Defects. 用于鼻部缺损重建的岛状椎弓根皮瓣变异。
IF 2.5 3区 医学 Q2 DERMATOLOGY
Dermatologic Surgery
Pub Date : 2024-11-01 Epub Date: 2024-05-29 DOI: 10.1097/DSS.0000000000004246
Caroline Morris, Stanislav N Tolkachjov, W Joseph Overman, Vitaly Terushkin, Anna A Bar
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引用次数: 0
Examining Differences by Sex in Dermatofibrosarcoma Protuberans Patients: An Analysis of 7,839 Cases From the 2000 to 2020 Surveillance, Epidemiology, and End Results Database. 研究皮纤维肉瘤患者的性别差异：对 2000 年至 2020 年监测、流行病学和最终结果数据库中 7839 个病例的分析。
IF 2.5 3区 医学 Q2 DERMATOLOGY
Dermatologic Surgery
Pub Date : 2024-11-01 Epub Date: 2024-06-06 DOI: 10.1097/DSS.0000000000004254
Mitchell A Taylor, Bianca E Ituarte, Sierra I Thomas, Jennifer M Fernandez, Scott R Lauer, Ashley Wysong
{"title":"Examining Differences by Sex in Dermatofibrosarcoma Protuberans Patients: An Analysis of 7,839 Cases From the 2000 to 2020 Surveillance, Epidemiology, and End Results Database.","authors":"Mitchell A Taylor, Bianca E Ituarte, Sierra I Thomas, Jennifer M Fernandez, Scott R Lauer, Ashley Wysong","doi":"10.1097/DSS.0000000000004254","DOIUrl":"10.1097/DSS.0000000000004254","url":null,"abstract":"","PeriodicalId":11289,"journal":{"name":"Dermatologic Surgery","volume":" ","pages":"1071-1073"},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141283198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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