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A Prospective Self-controlled Clinical Trial of Nonactivated Low Leukocyte PRP in Female Pattern Hair Loss Patients of Childbearing Age. 非活性低白细胞 PRP 用于育龄期女性脱发患者的前瞻性自控临床试验。
IF 2.5 3区 医学 Q2 DERMATOLOGY Pub Date : 2024-10-01 Epub Date: 2024-05-14 DOI: 10.1097/DSS.0000000000004234
Xie-Ling Peng, Shao-Wen Li, Xue-Qing Zhou, Ke-Xin Zhu, Xiang-Rong Ni, Xiang-Dong Qi

Background: Alopecia significantly affects the mental health and social relationship of women since childbearing age, highlighting the need for a safe, effective, and convenient treatment.

Methods: The authors have conducted a prospective self-controlled trial involving 15 female patients at childbearing age with alopecia. These patients received a subcutaneous scalp injection of platelet-rich plasma once every 4 weeks for 3 treatments in total. Outcome measurements were included below: changes in hair density (hair/cm 2 ), hair follicle density (hair follicle/cm 2 ), and overall photographic assessment (improved or not) at 4, 12, and 24 weeks right after the first treatment.

Results: Comparing the photographs taken before and after the intervention, 67% of patients' hair density increased from 151 ± 39.82 hairs/cm 2 (preintervention) to 170.96 ± 37.14 hairs/cm 2 (at 24-week follow-up), representing an approximate increase of 19 hairs/cm 2 . Meanwhile, hair follicle density increased by approximately 15 follicles/cm 2 after 24 weeks since the first treatment, rising from 151.04 ± 41.99 follicles/cm 2 to 166.72 ± 37.13 follicles/cm 2 . The primary adverse reactions observed were local swelling and pain due to injections.

Conclusion: Local injection of nonactivated platelet-rich plasma with low leukocytes concentration could be an effective strategy to alleviate alopecia symptoms in female patients.

背景:脱发严重影响育龄妇女的心理健康和社会关系:脱发严重影响育龄妇女的心理健康和社会关系,因此需要一种安全、有效、方便的治疗方法:作者进行了一项前瞻性自我对照试验,涉及 15 名育龄期脱发女性患者。这些患者接受了富血小板血浆头皮皮下注射,每 4 周一次,共 3 个疗程。研究结果如下毛发密度(毛发/平方厘米)、毛囊密度(毛囊/平方厘米)的变化,以及首次治疗后 4、12 和 24 周的整体照片评估(是否有改善):对比干预前后的照片,67%的患者的毛发密度从干预前的 151 ± 39.82 根/平方厘米增加到 24 周随访时的 170.96 ± 37.14 根/平方厘米,大约增加了 19 根/平方厘米。同时,毛囊密度在首次治疗 24 周后增加了约 15 个毛囊/平方厘米,从 151.04 ± 41.99 个毛囊/平方厘米增至 166.72 ± 37.13 个毛囊/平方厘米。观察到的主要不良反应是注射引起的局部肿胀和疼痛:结论:局部注射白细胞浓度较低的非活性富血小板血浆可有效缓解女性患者的脱发症状。
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引用次数: 0
Comparing Energy-Based Devices for Striae Improvement: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. 比较改善纹路的能量型设备:随机对照试验的系统综述和网络元分析》。
IF 2.5 3区 医学 Q2 DERMATOLOGY Pub Date : 2024-10-01 Epub Date: 2024-05-31 DOI: 10.1097/DSS.0000000000004252
Ting-Ju Wu, Ya-Li Huang, Yi-No Kang, Kee-Hsin Chen, Chiehfeng Chen

Background: Striae distensae (SD) are cutaneous lesions that are caused by hormones or mechanical stress leading to rapid expansion of skin. Therefore, SD are now a cosmetic concern. However, improving SD is notoriously difficult. Among different treatments, energy-based devices (EBDs) are much more effective and controllable.

Objective: The aim of this review was to determine the most effective type of EBD for improving the appearance of striae.

Materials and methods: The study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The population comprised patients suffering from striae. Different types of EBDs used to improve striae were compared. The primary outcome of the reduction in the width of striae was evaluated. A random-effects model was performed. The means and standard deviations were extracted.

Results: Eighteen randomized controlled trials were included. The network meta-analysis revealed that after a comparison among the 4 types of EBDs, no significant differences were observed in the reduction of striae width.

Conclusion: Radiofrequency, ablative lasers, nonablative lasers, and intense pulsed light are all effective treatments for reducing the striae width. None of them was superior to the others. However, radiofrequency and ablative lasers may have the highest chance of improving the appearance of striae.

背景:条纹扩张(SD)是一种皮肤病变,由激素或机械压力导致皮肤快速扩张引起。因此,SD 现在已成为一种美容问题。然而,改善条纹是众所周知的难题。在各种治疗方法中,以能量为基础的设备(EBD)更为有效和可控:本综述旨在确定改善条纹外观最有效的 EBD 类型:本研究根据《系统综述和元分析首选报告项目》指南进行。研究对象包括条纹患者。对用于改善条纹的不同类型的 EBD 进行了比较。评估的主要结果是条纹宽度的减少。采用随机效应模型。结果:结果:共纳入 18 项随机对照试验。网络荟萃分析表明,在对 4 种 EBD 进行比较后,在减少条纹宽度方面未观察到显著差异:结论:射频、烧蚀激光、非烧蚀激光和强脉冲光都是减少条纹宽度的有效治疗方法。结论:射频、烧蚀激光、非烧蚀激光和强脉冲光都能有效减少条纹宽度,但没有一种方法优于其他方法。不过,射频和烧蚀激光可能最有可能改善条纹的外观。
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引用次数: 0
High-Intensity, High-Frequency, Parallel Ultrasound Beams for Cellulite of the Buttocks and Thighs. 高强度、高频率、平行超声波束治疗臀部和大腿的脂肪团。
IF 2.5 3区 医学 Q2 DERMATOLOGY Pub Date : 2024-10-01 Epub Date: 2024-05-16 DOI: 10.1097/DSS.0000000000004240
Jordan V Wang, Nkem Ugonabo, Shirin Bajaj, Neil Jairath, Girish Munavalli, Anne Chapas, Roy G Geronemus, Suzanne Kilmer

Background: Ultrasound energy can successfully treat fine lines and wrinkles, as well as lift the eyebrow and submentum. Ultrasound waves of high intensity induce thermal injury in the dermis with subsequent tissue remodeling.

Objective: To examine the utility of a novel ultrasound device that utilizes high-intensity, high-frequency, parallel ultrasound beams to improve the clinical appearance of cellulite on the thighs and buttocks.

Materials and methods: A prospective, multicenter, clinical study investigated this novel ultrasound device using 2 treatments.

Results: Sixty-five subjects completed both treatments. The mean age was 46 years, and 100% were women. Fitzpatrick skin types I to VI were represented. Assessments compared 3-month follow-up with baseline. Two blinded reviewers agreed in identifying pretreatment and post-treatment photographs for 89.2%. For Cellulite Severity Scale rating, there was significant improvement of 1.61 units ( p < .001). For cellulite Global Aesthetic Improvement Scale (GAIS), 89.2% had improvement, with a mean of 0.87 units ( p < .001). For Laxity Scale rating, there was significant improvement of 0.70 units ( p < .001). For skin laxity GAIS, 89.2% had improvement, with a mean of 0.76 units ( p < .001). No device-related adverse events occurred.

Conclusion: A novel ultrasound device that utilizes high-intensity, high-frequency, parallel ultrasound beams can safely and effectively improve the clinical appearance of cellulite on the thighs and buttocks.

背景介绍超声波能量可成功治疗细纹和皱纹,并可提升眉毛和下额。高强度的超声波会对真皮层造成热损伤,进而导致组织重塑:研究利用高强度、高频率、平行超声波束来改善大腿和臀部橘皮组织临床外观的新型超声波设备的效用:一项前瞻性、多中心临床研究使用两种治疗方法对这种新型超声设备进行了调查:结果:65 名受试者完成了两次治疗。平均年龄为 46 岁,100% 为女性。菲茨帕特里克皮肤类型为 I 型至 VI 型。随访 3 个月的评估结果与基线进行了比较。两名盲人评审员对 89.2% 的治疗前和治疗后照片的识别结果一致。橘皮组织严重程度量表评分显著改善了 1.61 个单位(p < .001)。在橘皮组织全球美学改善量表(GAIS)方面,89.2%的人有改善,平均改善了0.87个单位(p < .001)。在皮肤松弛量表评分方面,有 0.70 个单位的显著改善(p < .001)。在皮肤松弛GAIS方面,89.2%的人有所改善,平均改善0.76个单位(p < .001)。没有发生与设备相关的不良事件:结论:利用高强度、高频率、平行超声束的新型超声设备可以安全有效地改善大腿和臀部橘皮组织的临床外观。
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引用次数: 0
Repair of a Large Multi-Subunit Nasal Defect. 修复鼻腔大面积多单位缺损
IF 2.5 3区 医学 Q2 DERMATOLOGY Pub Date : 2024-10-01 Epub Date: 2024-03-15 DOI: 10.1097/DSS.0000000000004145
Adrian Jonathan Seine, Paul J M Salmon, Neil J Mortimer
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引用次数: 0
Reconstruction of a Multisubunit Defect of the Lateral Upper Lip. 上唇外侧多单位缺损再造术
IF 2.5 3区 医学 Q2 DERMATOLOGY Pub Date : 2024-10-01 Epub Date: 2024-02-23 DOI: 10.1097/DSS.0000000000004129
Kyle C Lauck, Jace Rickstrew, Stanislav N Tolkachjov
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引用次数: 0
Quality of Photographs of Lesions Referred for Dermatologic Surgery at an Academic Medical Center. 学术医学中心皮肤外科转诊病例的照片质量。
IF 2.5 3区 医学 Q2 DERMATOLOGY Pub Date : 2024-10-01 Epub Date: 2024-05-01 DOI: 10.1097/DSS.0000000000004226
Jonathan D Greenzaid, Matthew L Hrin, Wasim Haidari, Christine S Ahn, Laura Doerfler, Steven R Feldman
{"title":"Quality of Photographs of Lesions Referred for Dermatologic Surgery at an Academic Medical Center.","authors":"Jonathan D Greenzaid, Matthew L Hrin, Wasim Haidari, Christine S Ahn, Laura Doerfler, Steven R Feldman","doi":"10.1097/DSS.0000000000004226","DOIUrl":"10.1097/DSS.0000000000004226","url":null,"abstract":"","PeriodicalId":11289,"journal":{"name":"Dermatologic Surgery","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and Histological Effects of Calcium Hydroxyapatite Filler in the Orofacial Region: A Study in Rats. 羟磷灰石钙填充剂对口腔面部的临床和组织学影响:大鼠研究。
IF 2.5 3区 医学 Q2 DERMATOLOGY Pub Date : 2024-10-01 Epub Date: 2024-06-05 DOI: 10.1097/DSS.0000000000004260
Marianna Ávila Thums, Márcia Rodrigues Payeras, Karen Cherubini, Valesca Sander Koth, Fernanda Gonçalves Salum

Background: Calcium hydroxyapatite (CaHA) dermal filler has been increasingly used in facial aesthetic procedures.

Objective: To investigate clinical and histological changes associated with calcium hydroxyapatite (CaHA) dermal filler in the orofacial region.

Materials and methods: Forty-eight female Wistar rats were divided into CaHA and control groups. The material was applied in the ventral tongue and the submandibular region; the animals were euthanized after 7, 30, and 90 days.

Results: After 7 days, yellowish nodules with a firm consistency were observed on the tongue. In 2 animals, the material migrated to the base of the tongue. Histopathological examination revealed CaHA spheres surrounded by an infiltrate, predominantly composed of macrophages. In the CaHA group, the percentage of collagen in the tongue and dermis was higher compared with the control group ( p < .05) at both 30 and 90 days. The thickness of the epidermis/dermis was also higher in the CaHA group ( p < .05). In 5 submandibular glands containing material, areas of edema and hyperemia were observed, along with infiltrates of neutrophils, lymphocytes, and plasma cells. Changes in the morphology of ducts and acini in adjacent regions were evident.

Conclusion: CaHA exhibits satisfactory properties for filling and collagen biostimulation in the tested regions. Further studies are required to explore the potential for migration and the glandular alterations.

背景:羟基磷灰石钙(CaHA)皮肤填充剂越来越多地用于面部美容手术:羟基磷灰石钙(CaHA)皮肤填充剂越来越多地用于面部美容手术:材料与方法:将 48 只雌性 Wistar 大鼠分为 CaHA 组和对照组:将 48 只雌性 Wistar 大鼠分为 CaHA 组和对照组。材料:48 只雌性 Wistar 大鼠分为 CaHA 组和对照组,将材料涂抹在舌腹部和颌下区,分别在 7 天、30 天和 90 天后安乐死:结果:7 天后,动物的舌头上出现了黄色结节,质地坚硬。有两只动物的结节移至舌根部。组织病理学检查显示,CaHA球体周围有浸润,主要由巨噬细胞组成。与对照组相比,CaHA 组在 30 天和 90 天时舌头和真皮中胶原蛋白的百分比都更高(p < .05)。CaHA 组的表皮/真皮厚度也更高(p < .05)。在含有材料的 5 个颌下腺中,观察到水肿和充血区域,以及中性粒细胞、淋巴细胞和浆细胞的浸润。相邻区域的导管和腺尖的形态也发生了明显变化:结论:CaHA 在测试区域的填充和胶原生物刺激方面表现出令人满意的特性。结论:CaHA 在测试区域的填充和胶原生物刺激方面表现出令人满意的特性,但还需要进一步的研究来探索其迁移潜力和腺体改变。
{"title":"Clinical and Histological Effects of Calcium Hydroxyapatite Filler in the Orofacial Region: A Study in Rats.","authors":"Marianna Ávila Thums, Márcia Rodrigues Payeras, Karen Cherubini, Valesca Sander Koth, Fernanda Gonçalves Salum","doi":"10.1097/DSS.0000000000004260","DOIUrl":"10.1097/DSS.0000000000004260","url":null,"abstract":"<p><strong>Background: </strong>Calcium hydroxyapatite (CaHA) dermal filler has been increasingly used in facial aesthetic procedures.</p><p><strong>Objective: </strong>To investigate clinical and histological changes associated with calcium hydroxyapatite (CaHA) dermal filler in the orofacial region.</p><p><strong>Materials and methods: </strong>Forty-eight female Wistar rats were divided into CaHA and control groups. The material was applied in the ventral tongue and the submandibular region; the animals were euthanized after 7, 30, and 90 days.</p><p><strong>Results: </strong>After 7 days, yellowish nodules with a firm consistency were observed on the tongue. In 2 animals, the material migrated to the base of the tongue. Histopathological examination revealed CaHA spheres surrounded by an infiltrate, predominantly composed of macrophages. In the CaHA group, the percentage of collagen in the tongue and dermis was higher compared with the control group ( p < .05) at both 30 and 90 days. The thickness of the epidermis/dermis was also higher in the CaHA group ( p < .05). In 5 submandibular glands containing material, areas of edema and hyperemia were observed, along with infiltrates of neutrophils, lymphocytes, and plasma cells. Changes in the morphology of ducts and acini in adjacent regions were evident.</p><p><strong>Conclusion: </strong>CaHA exhibits satisfactory properties for filling and collagen biostimulation in the tested regions. Further studies are required to explore the potential for migration and the glandular alterations.</p>","PeriodicalId":11289,"journal":{"name":"Dermatologic Surgery","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple Moat Modification of Mohs Micrographic Surgery for the Treatment of Anogenital Extramammary Paget Disease: Challenges and Considerations. 莫氏显微摄影手术治疗肛门外乳腺胬肉病的多堑改造:挑战与考虑。
IF 2.5 3区 医学 Q2 DERMATOLOGY Pub Date : 2024-10-01 DOI: 10.1097/DSS.0000000000004415
Nahid Y Vidal, Jorge A Rios-Duarte, Mary E Lohman
{"title":"Multiple Moat Modification of Mohs Micrographic Surgery for the Treatment of Anogenital Extramammary Paget Disease: Challenges and Considerations.","authors":"Nahid Y Vidal, Jorge A Rios-Duarte, Mary E Lohman","doi":"10.1097/DSS.0000000000004415","DOIUrl":"https://doi.org/10.1097/DSS.0000000000004415","url":null,"abstract":"","PeriodicalId":11289,"journal":{"name":"Dermatologic Surgery","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nevus Psiloliparus Successfully Treated With Hair Transplantation. 毛发移植成功治疗了秃头痣。
IF 2.5 3区 医学 Q2 DERMATOLOGY Pub Date : 2024-10-01 Epub Date: 2024-04-30 DOI: 10.1097/DSS.0000000000004218
Cristina Romera de Blas, David Vega Díez, José María Ricart Vayá, Alba Gómez Zubiaur
{"title":"Nevus Psiloliparus Successfully Treated With Hair Transplantation.","authors":"Cristina Romera de Blas, David Vega Díez, José María Ricart Vayá, Alba Gómez Zubiaur","doi":"10.1097/DSS.0000000000004218","DOIUrl":"10.1097/DSS.0000000000004218","url":null,"abstract":"","PeriodicalId":11289,"journal":{"name":"Dermatologic Surgery","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recovery of Facial Nerve Function After Vismodegib Treatment of Advanced Basal Cell Carcinoma. Vismodegib 治疗晚期基底细胞癌后面部神经功能的恢复
IF 2.5 3区 医学 Q2 DERMATOLOGY Pub Date : 2024-10-01 Epub Date: 2024-05-21 DOI: 10.1097/DSS.0000000000004243
Chandler Jansen, Alison M Bailey, Ling-Lun Bob Hsia
{"title":"Recovery of Facial Nerve Function After Vismodegib Treatment of Advanced Basal Cell Carcinoma.","authors":"Chandler Jansen, Alison M Bailey, Ling-Lun Bob Hsia","doi":"10.1097/DSS.0000000000004243","DOIUrl":"10.1097/DSS.0000000000004243","url":null,"abstract":"","PeriodicalId":11289,"journal":{"name":"Dermatologic Surgery","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Dermatologic Surgery
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