Drug and alcohol review最新文献

Client Experiences of a Telephone-Delivered Intervention for Methamphetamine Use Disorder 电话介入治疗甲基苯丙胺使用障碍的个案经验。

IF 2.6 3区医学 Q2 SUBSTANCE ABUSE

Drug and alcohol review

Pub Date : 2026-02-06 DOI: 10.1111/dar.70108

Rachel L. Petukhova, Annette Peart, Robyn Gerhard, Peta Stragalinos, Victoria Manning, Shalini Arunogiri, Dan I. Lubman, Jasmin Grigg

Introduction

Despite the significant harms associated with methamphetamine use both in Australia and globally, treatment uptake remains low. Telephone-delivered interventions have potential to overcome many barriers to help-seeking; however, their utility for treatment of methamphetamine use disorder is not well understood. This study explored the experiences and perceived impacts of a standalone, telephone-delivered cognitive and behavioural intervention, Ready2Change, for individuals with methamphetamine use disorder.

Methods

In-depth semi-structured telephone interviews were conducted and analysed using Framework Analysis.

Results

Twenty-seven participants (mean age = 42.0 years, standard deviation = 10.7, range 27–63) completed an interview. Four major themes arose: (i) Therapeutic connection experienced via telephone; (ii) Telephone format promoting comfort; (iii) Accessing treatment anywhere, anytime; and (iv) Treatment gains via telephone.

Discussion and Conclusions

Evidence of therapeutic relationships was found in participant accounts of experiencing non-judgemental support from counsellors. However, some participants reported in-person treatment would create a stronger therapeutic relationship. Many participants described a sense of comfort the telephone format afforded them, permitting anonymity and facilitating openness. Participants reported the telephone modality to be highly accessible and convenient, particularly for those with multiple commitments. Participants reported various benefits, including greater insight regarding their methamphetamine use and reduced methamphetamine use. Contrastingly, some participants felt their use was too severe and complex to be treated via telephone. Telephone-delivered interventions represent a potentially valuable initial step in the treatment trajectory for people with methamphetamine use disorder.

导言：尽管在澳大利亚和全球使用甲基苯丙胺都有重大危害，但治疗吸收率仍然很低。电话提供的干预措施有可能克服寻求帮助的许多障碍；然而，它们在治疗甲基苯丙胺使用障碍方面的效用尚不清楚。本研究探讨了一个独立的，电话传递的认知和行为干预，Ready2Change，对甲基苯丙胺使用障碍个体的体验和感知影响。方法：进行深度半结构化电话访谈，采用框架分析法进行分析。结果：27名参与者（平均年龄= 42.0岁，标准差= 10.7，范围27-63）完成了访谈。出现了四个主要主题：(i)通过电话进行治疗联系；促进舒适的电话格式；随时随地获得治疗；（iv）通过电话获得的治疗收益。讨论和结论：治疗关系的证据在参与者经历咨询师非评判性支持的叙述中被发现。然而，一些参与者报告说，面对面的治疗可以建立更强的治疗关系。许多参与者描述了电话形式给他们带来的舒适感，允许匿名和促进开放。与会者报告说，电话方式非常方便，特别是对那些有多项承诺的人来说。参与者报告了各种好处，包括更深入地了解他们的甲基苯丙胺使用情况和减少甲基苯丙胺使用情况。相比之下，一些参与者认为他们的使用过于严重和复杂，无法通过电话治疗。电话提供的干预措施代表了甲基苯丙胺使用障碍患者治疗轨迹中潜在的有价值的第一步。

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引用次数: 0

Correction to ‘Factors Associated With Preferences for Opioid Agonist Therapies Among People Dependent on Opioids’ 修正“阿片类药物依赖者对阿片类药物激动剂治疗偏好的相关因素”。

IF 2.6 3区医学 Q2 SUBSTANCE ABUSE

Drug and alcohol review

Pub Date : 2026-02-05 DOI: 10.1111/dar.70114

M. J. Stowe, A. Conway, F. L. Altice, et al., “ Factors Associated With Preferences for Opioid Agonist Therapies Among People Dependent on Opioids,” Drug and Alcohol Review 45, no. 1 (2026): e70079, https://doi.org/10.1111/dar.70079.

In the author listing section, the last name for ‘Samantha College-Frisby’ was incorrect. It should read as ‘Samantha Colledge-Frisby’.

The online article has been corrected.

We apologise for this error.

M. J. Stowe， A. Conway， F. L. Altice，等，“阿片类药物依赖者对阿片类药物激动剂治疗偏好的相关因素”，《药物与酒精评论》，第45期。1 (2026): e70079, https://doi.org/10.1111/dar.70079。在作者列表部分，“Samantha College-Frisby”的姓不正确。应该读作“萨曼莎学院-弗里斯比”。网上的文章已被更正。我们为这个错误道歉。

引用次数: 0

Choosing and Managing Non-Abstinent Recovery: Experiences of Adults in Untreated Recovery From Alcohol Use Disorder 选择和管理非戒断性康复：未经治疗的成人酒精使用障碍康复经验。

IF 2.6 3区医学 Q2 SUBSTANCE ABUSE

Drug and alcohol review

Pub Date : 2026-02-04 DOI: 10.1111/dar.70103

Paul A. Gilbert, Loulwa Soweid, Gaurab Maharjan, Nina Mulia

Introduction

We sought to characterise non-abstinent recovery from alcohol use disorder (AUD), particularly to understand why some people choose non-abstinence instead of abstinence and to illuminate how they may continue drinking in a way consistent with recovery.

Methods

We conducted semi-structured interviews with 65 adults with resolved AUD and no history of treatment who were enrolled in a national United States study of recovery definitions and strategies. Using inductive and deductive coding, we identified and elaborated themes.

Results

Non-abstinent participants reported infrequent and low-level drinking, citing helpful internal resources, such as strong self-awareness of their limits and confidence in their ability to control their drinking. By contrast, individuals who chose abstinence were often not confident in their ability to stop drinking, and some recounted instances when they learned that, after years of abstinence, they could not safely control their drinking. In addition, individuals who chose moderated drinking appeared to have clear, self-imposed rules about when and how much they could drink. Close and supportive social relationships, as well as aging and changes of life circumstances and contexts, also helped curb excessive drinking and maintain non-abstinent recovery. Many participants described changing their recovery goal, sometimes multiple times, reflecting a dynamic process of recovery.

Discussion and Conclusions

Beyond documenting the existence of non-abstinent recovery, our study identified why and how moderated drinking might be part of successful recovery for some people. Strict or enduring abstinence may not be necessary for all individuals seeking to recover from alcohol use disorder.

引言：我们试图描述从酒精使用障碍（AUD）中非戒断性恢复的特征，特别是理解为什么有些人选择非戒断而不是戒酒，并阐明他们如何以与康复一致的方式继续饮酒。方法：我们对65名患有AUD且无治疗史的成年人进行了半结构化访谈，这些成年人参加了美国一项关于康复定义和策略的全国性研究。使用归纳和演绎编码，我们确定并阐述了主题。结果：不戒酒的参与者报告了很少和低水平饮酒，并引用了有益的内部资源，如对自己饮酒极限的强烈自我意识和对自己控制饮酒能力的信心。相比之下，选择戒酒的人往往对自己戒酒的能力没有信心，有些人讲述了他们在多年戒酒后得知自己无法安全地控制饮酒的情况。此外，选择适度饮酒的人似乎对何时饮酒和饮酒多少有明确的自我规定。亲密和支持性的社会关系，以及年龄和生活环境和背景的变化，也有助于抑制过度饮酒和保持不戒酒的恢复。许多参与者描述了改变他们的恢复目标，有时多次，反映了一个动态的恢复过程。讨论和结论：除了记录非戒酒康复的存在，我们的研究确定了为什么以及如何适度饮酒可能是一些人成功康复的一部分。严格或持久的戒酒可能不是所有寻求从酒精使用障碍中恢复的人所必需的。

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引用次数: 0

A Systematic Review Investigating the Psychosocial Factors Influencing Initiation, Use and Subjective Experience of Performance and Image-Enhancing Drugs in Women Who Weight-Train. 影响女性举重训练中成绩和形象增强药物的启动、使用和主观体验的社会心理因素的系统综述。

IF 2.6 3区医学 Q2 SUBSTANCE ABUSE

Drug and alcohol review

Pub Date : 2026-02-01 DOI: 10.1111/dar.70112

Hannah C Schuurs, Zoe Walter, Leanne Hides, Mair Underwood

Issue: Performance and image-enhancing drug (PIED) use among women is a growing phenomenon, particularly within weight-training populations. Despite increasing prevalence, research on the psychosocial factors involved in women's PIED use remains emergent and fragmented.

Approach: This systematic review of mixed methods studies uses an integrative approach to explore perspectives, motivations and psycho-social factors associated with women's use of PIEDs within weight-training populations. The review also investigates gendered experiences that may exist among women who use PIEDs.

Key findings: Following screening, 22 articles were included in the review and five key themes emerged from the analysis. Women's experiences with PIEDs were found to be significantly shaped by pressures to conform to societal beauty standards and gendered expectations. Unlike men, who often receive guidance from peer-driven "bro-science", women navigate PIED use largely in isolation, which increases potential risks. The stigma surrounding PIED use in women, particularly related to side-effects such as virilisation, further deters open discussions and engagement with healthcare services.

Implications: These findings highlight the importance of developing gender-specific educational materials and harm-reduction initiatives to address the unique challenges faced by women using PIEDs. Additionally, health services should be equipped to engage with this population in a non-judgmental manner and offer tailored support.

Conclusions: There is a clear need for further research into women's experiences with PIEDs. Gender-sensitive approaches to education, prevention, and healthcare are essential to mitigating the risks associated with PIED use among women in weight-training communities.

问题：在女性中使用性能和形象增强药物（PIED）是一种日益增长的现象，特别是在举重训练人群中。尽管越来越普遍，但对妇女使用PIED的社会心理因素的研究仍然是新兴的和分散的。方法：本研究系统回顾了混合方法的研究，采用综合方法来探索与举重训练人群中女性使用ped相关的观点、动机和心理社会因素。该综述还调查了可能存在于使用避孕药具的妇女中的性别体验。主要发现：经过筛选，22篇文章被纳入审查，分析中出现了五个关键主题。研究发现，女性患产后抑郁症的经历在很大程度上受到符合社会审美标准和性别期望的压力的影响。与男性不同的是，男性经常从同行驱动的“兄弟科学”中获得指导，女性在很大程度上是孤立地使用PIED的，这增加了潜在的风险。妇女使用PIED的耻辱，特别是与男性化等副作用有关，进一步阻碍了公开讨论和参与医疗服务。含义：这些发现强调了开发针对性别的教育材料和减少伤害倡议的重要性，以解决使用教育、传播和传播工具的妇女所面临的独特挑战。此外，卫生服务机构应具备以不加评判的方式与这一人群接触的能力，并提供量身定制的支持。结论：显然有必要进一步研究女性患PIEDs的经历。对性别敏感的教育、预防和保健方法对于减轻举重训练社区妇女使用PIED相关的风险至关重要。

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引用次数: 0

Interrupted Time Series Analysis of Alcohol Use Disorder Treatment Utilisation During the Coronavirus Pandemic in Hamburg, Germany 德国汉堡冠状病毒大流行期间酒精使用障碍治疗利用的中断时间序列分析

IF 2.6 3区医学 Q2 SUBSTANCE ABUSE

Drug and alcohol review

Pub Date : 2026-01-27 DOI: 10.1111/dar.70107

Jakob Manthey, Carolin Kilian, Ludwig Kraus, Anna Schranz, Bernd Schulte

Introduction

Alcohol use and treatment for alcohol use disorder (AUD) changed during the pandemic. Alcohol consumption increased among high-risk groups, while treatment utilisation declined, raising concerns about an expanding treatment gap. This study analyses inpatient and outpatient AUD treatment trends during the pandemic.

Methods

We analysed electronic health records from 5671 patients residing in Hamburg, Germany, who utilised at least one alcohol-related treatment between January 2016 and December 2021. Data from two statutory health insurance providers and two pension funds provided weekly numbers of patients receiving AUD treatment, including outpatient (psychiatric consultations, psychotherapy, pharmacotherapy), inpatient standard and intensive treatment, and outpatient and inpatient rehabilitation programs. Using a segmented regression approach, we examined changes over time for: (i) any treatment; (ii) outpatient treatment; and (iii) inpatient treatment across five periods of the pandemic: pre-pandemic, first lockdown, between lockdowns, second lockdown and post-second lockdown.

Results

During the first lockdown in spring 2020, AUD treatment utilisation declined by 27% before briefly returning to near pre-pandemic levels. A gradual decline was observed in later pandemic periods, even after containment measures were lifted. The decline was more pronounced in inpatient settings than in outpatient settings, at −45% and −15%, respectively, during the first lockdown.

Discussion and Conclusions

The utilisation of AUD treatment services dropped substantially during the pandemic, particularly in inpatient settings. This reduction may have contributed to the rise in alcohol-related deaths during this period. This study is the first to assess long-term inpatient and outpatient treatment trends across multiple pandemic phases.

在大流行期间，酒精使用和酒精使用障碍（AUD）的治疗发生了变化。高风险群体的酒精消费量增加，而治疗利用率下降，这引起了人们对治疗差距扩大的担忧。本研究分析了流感大流行期间住院和门诊AUD治疗趋势。方法：我们分析了居住在德国汉堡的5671名患者的电子健康记录，这些患者在2016年1月至2021年12月期间至少接受过一次酒精相关治疗。来自两家法定医疗保险提供商和两家养老基金的数据提供了每周接受AUD治疗的患者人数，包括门诊（精神病学咨询、心理治疗、药物治疗）、住院标准和强化治疗、门诊和住院康复方案。使用分段回归方法，我们检查了随时间的变化：(i)任何治疗；（ii）门诊治疗；（三）大流行期间的住院治疗：大流行前、第一次封锁、封锁之间、第二次封锁和第二次封锁后。结果：在2020年春季的第一次封锁期间，澳元治疗的使用率下降了27%，然后短暂恢复到接近大流行前的水平。在大流行后期，即使在取消了控制措施之后，也观察到死亡率逐渐下降。在第一次封锁期间，住院病房的下降幅度比门诊病房更明显，分别为-45%和-15%。讨论和结论：在大流行期间，AUD治疗服务的使用率大幅下降，特别是在住院环境中。这一减少可能导致了这一时期酒精相关死亡人数的上升。这项研究首次评估了多个大流行阶段的长期住院和门诊治疗趋势。

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引用次数: 0

Cannabis Marketing Restrictions and Exposure to Cannabis Marketing in Legal US Cannabis Markets: Findings From the International Cannabis Policy Study 美国合法大麻市场的大麻销售限制和大麻销售暴露：来自国际大麻政策研究的结果。

IF 2.6 3区医学 Q2 SUBSTANCE ABUSE

Drug and alcohol review

Pub Date : 2026-01-27 DOI: 10.1111/dar.70106

Lauren Winfield-Ward, Elle Wadsworth, Pete Driezen, David Hammond

Introduction

A growing number of US states have legalised adult ‘recreational’ cannabis. Restrictions on advertising and promotions are a key component of cannabis regulations in legal markets; however, there is little evidence on the impact of restrictions. This study examines differences in cannabis marketing exposure by the strength of marketing restrictions among US states with legal recreational sales.

Methods

Data are from the International Cannabis Policy Study: repeated cross-sectional surveys conducted annually (2018–2023) with 99,132 respondents aged 16–65. The ‘strength’ of marketing restrictions was measured using regulatory documents in 20 states with legal recreational cannabis sales. Adjusted mixed effects logistic regression models were fitted to analyse differences in past-12 month noticing of cannabis marketing by the strength of marketing restrictions overall and within specific marketing channels.

Results

People in states with low and moderate strength marketing restrictions reported similar exposure to cannabis marketing (61.4% and 61.8%, respectively). Compared to those with moderate strength restrictions, people in states with the highest strength restrictions reported the lowest exposure (53.4%: p = 0.037), with no significant differences for states with low strength restrictions (p = 0.067). Comprehensive restrictions on marketing via billboards and posters, and at sports events were associated with reductions in reported exposure to these channels. Cannabis marketing exposure was highest among people below the minimum legal age (16–20 years old; 63.0%: p < 0.001).

Discussion and Conclusions

Stronger regulations may reduce exposure to marketing in states with recreational cannabis markets; however, existing regulations appear to be inadequate to prevent advertising and promotions from reaching young people.

越来越多的美国州已经将成人“娱乐”大麻合法化。限制广告和促销是合法市场大麻条例的一个关键组成部分；然而，几乎没有证据表明限制措施的影响。本研究通过美国各州合法娱乐销售的营销限制力度来调查大麻营销暴露的差异。方法：数据来自国际大麻政策研究：每年（2018-2023年）对99,132名年龄在16-65岁之间的受访者进行重复横断面调查。市场限制的“力度”是通过20个州的监管文件来衡量的，这些州的娱乐性大麻销售是合法的。调整后的混合效应逻辑回归模型拟合，以分析过去12个月注意到的大麻营销总体上和特定营销渠道内的营销限制的强度的差异。结果：在低强度和中等强度营销限制的州，人们报告了类似的大麻营销暴露（分别为61.4%和61.8%）。与具有中等强度限制的人相比，具有最高强度限制的州的人报告的暴露最低（53.4%:p = 0.037），而具有低强度限制的州没有显著差异（p = 0.067）。全面限制通过广告牌和海报进行营销，以及在体育赛事中进行营销，与报告的这些渠道的接触减少有关。在最低法定年龄（16-20岁）以下的人群中，大麻营销接触最多；63.0%:p讨论和结论：在拥有休闲大麻市场的州，加强监管可能会减少对营销的接触；然而，现有监管似乎不足以防止广告和促销活动接触到年轻人。

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引用次数: 0

Emerging Risks of Nitazene-Adulterated Vapes in Australia: Balancing Regulation, Access and Harm Reduction 澳大利亚nitazene掺杂电子烟的新风险：平衡监管，获取和减少危害。

IF 2.6 3区医学 Q2 SUBSTANCE ABUSE

Drug and alcohol review

Pub Date : 2026-01-25 DOI: 10.1111/dar.70081

James Martin, Jennifer L. Schumann

引用次数: 0

Traces of Use: Uncovering Drug Use Insights From Paraphernalia Analysis 使用的痕迹：从随身物品分析中揭示药物使用的见解。

IF 2.6 3区医学 Q2 SUBSTANCE ABUSE

Drug and alcohol review

Pub Date : 2026-01-23 DOI: 10.1111/dar.70105

Emma L. Keller, Brock Peake, Bradley S. Simpson, Marie Longo, Jason M. White, Cobus Gerber

Introduction

The residue analysis of disposed paraphernalia from people who inject drugs is a novel way to discern drug taking behaviours. This study aimed to investigate the presence of conventional and novel psychoactive substances (NPS) in drug paraphernalia in South Australia.

Methods

Drug paraphernalia were collected in November and December 2024 from sharps disposal bins at three needle and syringe program locations. A total of 300 items of paraphernalia were taken from bins, including syringes, bags, drug storage vials/containers and filters. The items were rinsed with methanol, the solvent filtered and prepared for analysis using a Sciex 6500 + QTrap liquid chromatography tandem mass spectrometry (LC–MS/MS) and detections confirmed using authentic reference materials.

Results

A high proportion of paraphernalia contained methamphetamine (61%) and/or heroin (38%). A majority (57%) of the items analysed contained 2 or more drugs. In total, 14 different NPS were detected across 46 items of paraphernalia.

Discussion and Conclusions

The large number of paraphernalia items that had multiple drugs detected was likely an indication of polysubstance use. Residue analysis of drug paraphernalia is an objective approach to complement those currently used to ascertain drug trends, which strengthens harm reduction and public health responses to drug use. This study shows that drug residue analysis is feasible, non-invasive and effective, providing a near-real time approach to monitor the appearance of high potency NPS and other drugs being consumed, and determining trends in conventional substance use by people who inject drugs.

对注射吸毒者丢弃后的随身物品进行残留分析是一种识别吸毒行为的新方法。本研究旨在调查在南澳大利亚的毒品用具中传统和新型精神活性物质（NPS）的存在。方法：于2024年11月和12月在三个针头和注射器项目地点的锐器处理箱中收集药物用具。海关人员从垃圾桶中取出共300件随身物品，包括注射器、袋、储药瓶/容器和过滤器。样品用甲醇冲洗，溶剂过滤，用Sciex 6500 + QTrap液相色谱串联质谱仪（LC-MS/MS）进行分析，并使用真实的标准物质进行检测。结果：携带物品中含有甲基苯丙胺（61%）和/或海洛因（38%）的比例较高。大多数（57%）的分析项目含有2种或更多的药物。总共在46件随身物品中检测到14种不同的NPS。讨论和结论：大量的随身用品中检测到多种药物可能是使用多种药物的迹象。对吸毒用具进行残留分析是一种客观的方法，可以补充目前用于确定吸毒趋势的方法，从而加强减少危害和对吸毒作出公共卫生反应。这项研究表明，药物残留分析是可行的、非侵入性的和有效的，提供了一种近乎实时的方法来监测高效NPS和其他正在消耗的药物的外观，并确定注射吸毒者使用常规药物的趋势。

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引用次数: 0

Management of Opioid Withdrawal Syndrome and Commencement of Opioid Dependence Treatment Following Chronic Use of a Vaping Product Containing Protonitazene: Case Report 阿片类戒断综合征的管理和阿片类药物依赖治疗开始后，长期使用含有原硝唑的电子烟产品：病例报告。

IF 2.6 3区医学 Q2 SUBSTANCE ABUSE

Drug and alcohol review

Pub Date : 2026-01-23 DOI: 10.1111/dar.70104

Daniel Dutkiewicz, Hester Wilson, Thanjira Jiranantakan, Peter Chisholm, Kaniz Fatema, Mark Hardy

Introduction

Nitazenes, benzimidazole synthetic potent opioid μ-receptor agonists, have been implicated in increased risk for opioid toxicity. Subtypes of nitazenes, including protonitazene, have been recently detected in multiple overdose cases in Australia. We describe a case report of protonitazene dependence, inpatient withdrawal management and induction onto opioid dependence treatment.

Case Presentation

A 22-year-old man with no significant medical history presented to a metropolitan emergency department in opioid withdrawal after regular vaping of a product sold as cannabinoids. He required higher than expected buprenorphine doses and other standard treatment including diazepam and olanzapine to manage opioid withdrawal. Blood and urine samples taken in the emergency department later tested positive for protonitazene. Analysis of the vaping liquid was only positive for protonitazene. He was discharged for outpatient follow-up to later receive a 300 mg subcutaneous buprenorphine monthly injection.

Discussion and Conclusions

This case describes the clinical presentation of dependence, withdrawal and buprenorphine induction for opioid dependence due to chronic protonitazene vaping. Future research may help guide optimal doses of buprenorphine to manage nitazene withdrawal. Vaping devices have increased in popularity, especially amongst youth, which poses public health risks to the community if adulterated with other substances. Detection of nitazenes currently requires specialised laboratories. Protonitazene withdrawal management was complex in this case report. Youth are at risk of harms in vaping products adulterated with other substances, including nitazenes. State-wide toxicosurveillance programs, such as the NSW PRISE program, are essential for coordinating detection, clinical management and community awareness of nitazenes.

nitazene是一种苯并咪唑合成的强效阿片μ受体激动剂，与阿片毒性风险增加有关。最近在澳大利亚的多起过量用药病例中发现了包括原硝唑在内的硝唑类亚型。我们描述了一个病例报告，原他嗪依赖，住院患者戒断管理和诱导阿片类药物依赖治疗。病例介绍：一名22岁的男性，没有明显的病史，在定期吸食作为大麻素出售的产品后，因阿片类药物戒断而到大都会急诊室就诊。他需要高于预期的丁丙诺啡剂量和其他标准治疗，包括地西泮和奥氮平来控制阿片类药物戒断。在急诊室采集的血液和尿液样本后来检测出原硝唑呈阳性。汽化液分析仅对原硝泽烯呈阳性。他出院接受门诊随访，随后接受每月300毫克皮下丁丙诺啡注射。讨论与结论：本病例描述了慢性原他嗪雾化导致阿片类药物依赖的依赖、戒断和丁丙诺啡诱导的临床表现。未来的研究可能有助于指导丁丙诺啡的最佳剂量，以控制nitazene戒断。电子烟越来越受欢迎，尤其是在年轻人中，如果掺杂了其他物质，就会给社区带来公共健康风险。目前，nitazene的检测需要专门的实验室。本病例报告中原硝唑的停药管理较为复杂。青少年在电子烟产品中掺入了其他物质，包括nitazene，有受到伤害的风险。全州范围内的毒物监测计划，如NSW PRISE计划，对于协调检测、临床管理和社区对nitazene的认识至关重要。

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引用次数: 0

Alcohol Consumption and Atrial Fibrillation Risk: An Overview of Systematic Reviews and Network Meta-Analysis 饮酒与房颤风险：系统评价和网络荟萃分析综述

IF 2.6 3区医学 Q2 SUBSTANCE ABUSE

Drug and alcohol review

Pub Date : 2026-01-19 DOI: 10.1111/dar.70089

MohammadHossein Hadi, Sanjib Saha, Dennis Petrie, Maame Esi Woode, Ulf-Göran Gerdtham

Issues

Although alcohol consumption is linked to atrial fibrillation (AF), the relationship across different intake levels and between sexes remains unclear. This study presents the first network meta-analysis of prospective cohort studies bringing greater precision to these associations.

Approach

A systematic review identified five meta-analyses on alcohol and AF risk. From these, 13 cohort studies totalling over 80 million person-years were included in a random-effects network meta-analysis, including sex-stratified analyses.

Key Findings

Compared to low-level consumption (< 12 g/day), moderate intake (12–< 24 g/day) slightly increased AF risk (hazard ratio [HR] = 1.07; 95% confidence interval [CI] 1.04–1.10), similar at 24–< 36 g/day (HR = 1.09; 95% CI 1.00–1.20). No significant risk increase was observed for 36–< 60 g/day. Heavy consumption (≥ 60 g/day) showed the highest risk (HR = 2.84; 95% CI 1.57–5.14). Non-drinkers (‘Former’, ‘Never’ or ‘Occasional’) had HRs near 1, except ‘None’, which showed a slight increase (HR = 1.08; 95% CI 1.04–1.11).

Implications

In males, moderate consumption increased AF risk slightly, while heavy intake had a more pronounced effect (HR = 1.49; 95% CI 1.22–1.81). In females, moderate intake had no significant effect, but heavy intake significantly increased risk (HR = 2.53; 95% CI 1.05–6.08).

Conclusion

This network meta-analysis shows a nonlinear relationship between alcohol consumption and AF risk. Low-level or occasional intake poses the lowest risk. In males, moderate consumption slightly increases AF risk, while in females, risk rises substantially only with heavy intake. These findings support limiting alcohol consumption to reduce AF risk and highlight the need for further sex-stratified studies and consideration of sex-specific recommendations.

Registration

This network meta-analysis is a split review of an overview of reviews examining alcohol-attributable health and social harms, registered under PROSPERO ID442338.

问题：虽然饮酒与房颤（AF）有关，但不同摄入量和性别之间的关系尚不清楚。本研究首次提出了前瞻性队列研究的网络荟萃分析，使这些关联更加精确。方法：一项系统综述确定了5项关于酒精和房颤风险的荟萃分析。从这些研究中，13项队列研究总计超过8000万人年被纳入随机效应网络荟萃分析，包括性别分层分析。主要发现：与低水平摄入相比(提示：在男性中，适度摄入会略微增加房颤风险，而大量摄入则有更明显的影响（HR = 1.49; 95% CI 1.22-1.81）。在女性中，适度摄入无显著影响，但大量摄入显著增加风险（HR = 2.53; 95% CI 1.05-6.08）。结论：该网络荟萃分析显示饮酒与房颤风险之间存在非线性关系。少量或偶尔摄入的风险最低。在男性中，适量摄入会轻微增加房颤风险，而在女性中，只有大量摄入才会显著增加房颤风险。这些发现支持限制饮酒以降低房颤风险，并强调需要进一步的性别分层研究和考虑性别特异性建议。注册：该网络荟萃分析是一项针对酒精导致的健康和社会危害的综述的拆分性综述，注册号为PROSPERO ID442338。

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