Pub Date : 2025-02-08DOI: 10.1016/j.critrevonc.2025.104652
Dr. Shalini Gupta, Dr. Arushi Tomar, Dr. Lakshmi Manohar, Dr. Payal Panwar
The detection and treatment of cancer could be completely transformed by the application of nanotechnology. New nanoscale targeting methods have emerged as a result of advancements in materials science and protein engineering, giving cancer patients new hope. Only a small number of nanocarriers have been approved for clinical usage in targeting cancer cells, despite the fact that many have been licensed for human studies. We examine a few of the approved formulations in this study and talk about the difficulties in transferring laboratory results to clinical settings. This review emphasises the inherent challenges in cancer therapy as well as the different nanocarriers and chemicals that can be used for specific tumour targeting. Future advancements in cancer detection and therapy could be facilitated by nanotechnology, but still the area remains vast and more clinical as well as laboratory trails are the need of the hour to overcome the present barriers and align the discovery of the potential application of nanobots from a mere lab work to a full-fledged clinical and translational work.
{"title":"Nanobots: The current scenario","authors":"Dr. Shalini Gupta, Dr. Arushi Tomar, Dr. Lakshmi Manohar, Dr. Payal Panwar","doi":"10.1016/j.critrevonc.2025.104652","DOIUrl":"10.1016/j.critrevonc.2025.104652","url":null,"abstract":"<div><div>The detection and treatment of cancer could be completely transformed by the application of nanotechnology. New nanoscale targeting methods have emerged as a result of advancements in materials science and protein engineering, giving cancer patients new hope. Only a small number of nanocarriers have been approved for clinical usage in targeting cancer cells, despite the fact that many have been licensed for human studies. We examine a few of the approved formulations in this study and talk about the difficulties in transferring laboratory results to clinical settings. This review emphasises the inherent challenges in cancer therapy as well as the different nanocarriers and chemicals that can be used for specific tumour targeting. Future advancements in cancer detection and therapy could be facilitated by nanotechnology, but still the area remains vast and more clinical as well as laboratory trails are the need of the hour to overcome the present barriers and align the discovery of the potential application of nanobots from a mere lab work to a full-fledged clinical and translational work.</div></div>","PeriodicalId":11358,"journal":{"name":"Critical reviews in oncology/hematology","volume":"208 ","pages":"Article 104652"},"PeriodicalIF":5.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-07DOI: 10.1016/j.critrevonc.2025.104653
Maryam Shirzad , Afsaneh Salahvarzi , Sobia Razzaq , Mohammad Javad Javid-Naderi , Abbas Rahdar , Sonia Fathi-karkan , Azam Ghadami , Zelal Kharaba , Luiz Fernando Romanholo Ferreira
Prostate cancer is one of the major health challenges in the world and needs novel therapeutic approaches to overcome the limitations of conventional treatment. This review delineates the transformative potential of artificial intelligence (AL) in enhancing nanocarrier-based drug delivery systems for prostate cancer therapy. With its ability to optimize nanocarrier design and predict drug delivery kinetics, AI has revolutionized personalized treatment planning in oncology. We discuss how AI can be integrated with nanotechnology to address challenges related to tumor heterogeneity, drug resistance, and systemic toxicity. Emphasis is placed on strong AI-driven advancements in the design of nanocarriers, structural optimization, targeting of ligands, and pharmacokinetics. We also give an overview of how AI can better predict toxicity, reduce costs, and enable personalized medicine. While challenges persist in the way of data accessibility, regulatory hurdles, and interactions with the immune system, future directions based on explainable AI (XAI) models, integration of multimodal data, and green nanocarrier designs promise to move the field forward. Convergence between AI and nanotechnology has been one key step toward safer, more effective, and patient-tailored cancer therapy.
{"title":"Revolutionizing prostate cancer therapy: Artificial intelligence – Based nanocarriers for precision diagnosis and treatment","authors":"Maryam Shirzad , Afsaneh Salahvarzi , Sobia Razzaq , Mohammad Javad Javid-Naderi , Abbas Rahdar , Sonia Fathi-karkan , Azam Ghadami , Zelal Kharaba , Luiz Fernando Romanholo Ferreira","doi":"10.1016/j.critrevonc.2025.104653","DOIUrl":"10.1016/j.critrevonc.2025.104653","url":null,"abstract":"<div><div>Prostate cancer is one of the major health challenges in the world and needs novel therapeutic approaches to overcome the limitations of conventional treatment. This review delineates the transformative potential of artificial intelligence (AL) in enhancing nanocarrier-based drug delivery systems for prostate cancer therapy. With its ability to optimize nanocarrier design and predict drug delivery kinetics, AI has revolutionized personalized treatment planning in oncology. We discuss how AI can be integrated with nanotechnology to address challenges related to tumor heterogeneity, drug resistance, and systemic toxicity. Emphasis is placed on strong AI-driven advancements in the design of nanocarriers, structural optimization, targeting of ligands, and pharmacokinetics. We also give an overview of how AI can better predict toxicity, reduce costs, and enable personalized medicine. While challenges persist in the way of data accessibility, regulatory hurdles, and interactions with the immune system, future directions based on explainable AI (XAI) models, integration of multimodal data, and green nanocarrier designs promise to move the field forward. Convergence between AI and nanotechnology has been one key step toward safer, more effective, and patient-tailored cancer therapy.</div></div>","PeriodicalId":11358,"journal":{"name":"Critical reviews in oncology/hematology","volume":"208 ","pages":"Article 104653"},"PeriodicalIF":5.5,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-07DOI: 10.1016/j.critrevonc.2025.104655
Charalampos Theocharopoulos , Ioannis A. Ziogas , Benedetto Mungo , Helen Gogas , Dimitrios C. Ziogas , Elissaios Kontis
Biliary tract cancers (BTCs) constitute a heterogeneous group of malignancies with rising incidence and limited therapeutic options in advanced stages, leading to increased overall mortality. Extensive genomic profiling has identified key oncogenic drivers in BTCs that represent promising therapeutic targets and could change the treatment paradigm. Evidence suggests improved survival outcomes for patients with actionable molecular alterations who received matched targeted therapies. Human epidermal growth factor receptor 2 (HER2) is a receptor tyrosine kinase and proto-oncogene that has been extensively studied as a prognostic biomarker and a therapeutic target in multiple solid organ malignancies. Recent clinical trials on the combination of trastuzumab with tucatinib, FOLFOX, or pertuzumab for previously treated, HER2-positive, advanced BTCs have shown improved outcomes compared to current second-line therapies. Early evidence from observational studies on trastuzumab-containing regimens as first-line suggests promising efficacy. Furthermore, the recent tumor-agnostic approval of trastuzumab deruxtecan for HER2-positive solid tumors has formally introduced HER2-directed agents in the BTC therapeutic arsenal. This review aims to summarize the rapidly evolving landscape of HER2-directed agents for BTCs, highlighting current evidence of survival benefit. Beginning with a concise presentation of the structural and functional aspects of HER2, we detail the frequency and prognostic significance of HER2 alterations in BTCs and discuss all available preclinical and clinical data on anti-HER2 agents tested for BTCs.
{"title":"HER2-targeted therapies: Unraveling their role in biliary tract cancers","authors":"Charalampos Theocharopoulos , Ioannis A. Ziogas , Benedetto Mungo , Helen Gogas , Dimitrios C. Ziogas , Elissaios Kontis","doi":"10.1016/j.critrevonc.2025.104655","DOIUrl":"10.1016/j.critrevonc.2025.104655","url":null,"abstract":"<div><div>Biliary tract cancers (BTCs) constitute a heterogeneous group of malignancies with rising incidence and limited therapeutic options in advanced stages, leading to increased overall mortality. Extensive genomic profiling has identified key oncogenic drivers in BTCs that represent promising therapeutic targets and could change the treatment paradigm. Evidence suggests improved survival outcomes for patients with actionable molecular alterations who received matched targeted therapies. Human epidermal growth factor receptor 2 (HER2) is a receptor tyrosine kinase and proto-oncogene that has been extensively studied as a prognostic biomarker and a therapeutic target in multiple solid organ malignancies. Recent clinical trials on the combination of trastuzumab with tucatinib, FOLFOX, or pertuzumab for previously treated, HER2-positive, advanced BTCs have shown improved outcomes compared to current second-line therapies. Early evidence from observational studies on trastuzumab-containing regimens as first-line suggests promising efficacy. Furthermore, the recent tumor-agnostic approval of trastuzumab deruxtecan for HER2-positive solid tumors has formally introduced HER2-directed agents in the BTC therapeutic arsenal. This review aims to summarize the rapidly evolving landscape of HER2-directed agents for BTCs, highlighting current evidence of survival benefit. Beginning with a concise presentation of the structural and functional aspects of HER2, we detail the frequency and prognostic significance of HER2 alterations in BTCs and discuss all available preclinical and clinical data on anti-HER2 agents tested for BTCs.</div></div>","PeriodicalId":11358,"journal":{"name":"Critical reviews in oncology/hematology","volume":"208 ","pages":"Article 104655"},"PeriodicalIF":5.5,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-07DOI: 10.1016/j.critrevonc.2025.104656
Francesco Giulio Sullo , Simon Garinet , Hélène Blons , Julien Taieb , Pierre Laurent-Puig , Claire Gallois
Colorectal cancer (CRC) is the third leading cause of cancer death and accounts for 10 % of cancer diagnoses worldwide. Despite the advancements achieved over the latest decades, CRC treatments are still based on conventional chemotherapy whose efficacy is limited by acquired resistance and unfavorable toxicity profile, making the search for novel actionable targets a priority. In this context, gene fusions are emerging as promising -albeit very rare - new markers because of their recurrence across different tumor types and their potential actionability. The aim of this review is to investigate the role of gene fusions in CRC by focusing on pathogenesis, screening strategies as well as their clinical implications.
{"title":"Molecular features and clinical actionability of gene fusions in colorectal cancer","authors":"Francesco Giulio Sullo , Simon Garinet , Hélène Blons , Julien Taieb , Pierre Laurent-Puig , Claire Gallois","doi":"10.1016/j.critrevonc.2025.104656","DOIUrl":"10.1016/j.critrevonc.2025.104656","url":null,"abstract":"<div><div>Colorectal cancer (CRC) is the third leading cause of cancer death and accounts for 10 % of cancer diagnoses worldwide. Despite the advancements achieved over the latest decades, CRC treatments are still based on conventional chemotherapy whose efficacy is limited by acquired resistance and unfavorable toxicity profile, making the search for novel actionable targets a priority. In this context, gene fusions are emerging as promising -albeit very rare - new markers because of their recurrence across different tumor types and their potential actionability. The aim of this review is to investigate the role of gene fusions in CRC by focusing on pathogenesis, screening strategies as well as their clinical implications.</div></div>","PeriodicalId":11358,"journal":{"name":"Critical reviews in oncology/hematology","volume":"208 ","pages":"Article 104656"},"PeriodicalIF":5.5,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-06DOI: 10.1016/j.critrevonc.2025.104649
Yuan Gao , Mengxia Zhang , Guihua Wang , Weiwei Lai , Shuxian Liao , Yao Chen , Qian Ning , Shengsong Tang
Glioblastoma (GBM), a highly malignant “cold” tumor of the central nervous system, is characterized by its ability to remodel the GBM immune microenvironment (GME), leading to significant resistance to immunotherapy. GBM-associated microglia/macrophages (GAMs) are essential components of the GME. Targeting GAMs has emerged as a promising strategy against GBM. However, their highly immunosuppressive nature contributes to GBM progression and drug resistance, significantly impeding anti-GBM immunotherapy. Accumulating evidence suggests that metabolic reprogramming accompanies GBM progression and GAM polarization, which are in turn driven by specific metabolic abnormalities and altered cellular signaling pathways. Importantly, metabolic crosstalk between GBM and GAMs further promotes tumor progression. Clarifying and disrupting this metabolic crosstalk is expected to enhance the antitumor phenotype of GAMs and inhibit GBM malignant progression. This review explores metabolism-based interregulation between GBM and GAMs and summarizes recent therapeutic strategies targeting this crosstalk, offering new insights into GBM immunotherapy.
{"title":"Metabolic cross-talk between glioblastoma and glioblastoma-associated microglia/macrophages: From basic insights to therapeutic strategies","authors":"Yuan Gao , Mengxia Zhang , Guihua Wang , Weiwei Lai , Shuxian Liao , Yao Chen , Qian Ning , Shengsong Tang","doi":"10.1016/j.critrevonc.2025.104649","DOIUrl":"10.1016/j.critrevonc.2025.104649","url":null,"abstract":"<div><div>Glioblastoma (GBM), a highly malignant “cold” tumor of the central nervous system, is characterized by its ability to remodel the GBM immune microenvironment (GME), leading to significant resistance to immunotherapy. GBM-associated microglia/macrophages (GAMs) are essential components of the GME. Targeting GAMs has emerged as a promising strategy against GBM. However, their highly immunosuppressive nature contributes to GBM progression and drug resistance, significantly impeding anti-GBM immunotherapy. Accumulating evidence suggests that metabolic reprogramming accompanies GBM progression and GAM polarization, which are in turn driven by specific metabolic abnormalities and altered cellular signaling pathways. Importantly, metabolic crosstalk between GBM and GAMs further promotes tumor progression. Clarifying and disrupting this metabolic crosstalk is expected to enhance the antitumor phenotype of GAMs and inhibit GBM malignant progression. This review explores metabolism-based interregulation between GBM and GAMs and summarizes recent therapeutic strategies targeting this crosstalk, offering new insights into GBM immunotherapy.</div></div>","PeriodicalId":11358,"journal":{"name":"Critical reviews in oncology/hematology","volume":"208 ","pages":"Article 104649"},"PeriodicalIF":5.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-06DOI: 10.1016/j.critrevonc.2025.104627
Carla Colombo , Simone De Leo , Ilaria Campisi , Erica Palesandro , Fabio Turco , Consuelo Buttigliero , Laura Fugazzola , Marcello Tucci
Nowadays immune-based combinations are the standard first-line treatment for metastatic renal cell carcinoma and involve the use of either two immunotherapy agents or an immunotherapeutic drug associated with a tyrosine kinase inhibitor. Treatment-related toxicity is the primary cause of drug discontinuation or dose reduction. A thorough understanding of the prevention and management of adverse events of the immune-based combinations is critical to ensure the success of treatment. Endocrinological toxicities during treatment with immune-based combinations are frequent and often manageable. However, in some cases, diagnosis can be complex, and the treatment requires multidisciplinary discussion. In addition, it is often challenging to determine which agent in the combination is responsible for a specific toxicity. In this review, we analyze the evidence regarding treatment-related endocrinopathies in renal cell carcinoma first-line therapy. We also discuss monitoring strategies to diagnose endocrinological adverse events and provide some practical tools for their daily management.
{"title":"Endocrinological toxicities related to immunotherapy combinations for advanced renal cell carcinoma: Practical expert-based management recommendations","authors":"Carla Colombo , Simone De Leo , Ilaria Campisi , Erica Palesandro , Fabio Turco , Consuelo Buttigliero , Laura Fugazzola , Marcello Tucci","doi":"10.1016/j.critrevonc.2025.104627","DOIUrl":"10.1016/j.critrevonc.2025.104627","url":null,"abstract":"<div><div>Nowadays immune-based combinations are the standard first-line treatment for metastatic renal cell carcinoma and involve the use of either two immunotherapy agents or an immunotherapeutic drug associated with a tyrosine kinase inhibitor. Treatment-related toxicity is the primary cause of drug discontinuation or dose reduction. A thorough understanding of the prevention and management of adverse events of the immune-based combinations is critical to ensure the success of treatment. Endocrinological toxicities during treatment with immune-based combinations are frequent and often manageable. However, in some cases, diagnosis can be complex, and the treatment requires multidisciplinary discussion. In addition, it is often challenging to determine which agent in the combination is responsible for a specific toxicity. In this review, we analyze the evidence regarding treatment-related endocrinopathies in renal cell carcinoma first-line therapy. We also discuss monitoring strategies to diagnose endocrinological adverse events and provide some practical tools for their daily management.</div></div>","PeriodicalId":11358,"journal":{"name":"Critical reviews in oncology/hematology","volume":"209 ","pages":"Article 104627"},"PeriodicalIF":5.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Central nervous system (CNS) tumors represent the most frequent solid tumors among adolescents and children, and the leading cause of cancer-related death in men < 40 and women < 20 years of age. Brain tumors are challenging to diagnose, monitor, and treat. The current diagnostic approach involves magnetic resonance imaging (MRI), tumor histology, molecular characterization and cytologic analysis of cerebrospinal fluid (CSF). However, surgical procedures pose potential risks to the patient's health, not achieving good accuracy. For these reasons, it is crucial to identify new non-invasive disease biomarkers to improve patients’ stratification at diagnosis and during follow-up and prognosis. MicroRNAs (miRNAs) are a class of short RNA molecules that have been demonstrated in numerous studies to be dysregulated in brain tumor patients. As a result, they may be used as biomarkers of brain tumors. Additionally, miRNAs can be analyzed in liquid biopsy samples, such as blood and CSF, providing a non-invasive source of biomolecular data on patients' disease status. This review aims to highlight the role of miRNAs in liquid biopsy, also known as circulating miRNAs, as potential non-invasive cancer biomarkers in both adult and pediatric populations and to suggest their potential impact on clinical trials.
{"title":"Circulating microRNAs: A remarkable opportunity as non-invasive biomarkers from adult to pediatric brain tumor patients","authors":"Federica D’Antonio , Zaira Spinello , Lavinia Bargiacchi , Elena Splendiani , Sabrina Rossi , Laura Masuelli , Angela Mastronuzzi , Franco Locatelli , Elisabetta Ferretti , Giuseppina Catanzaro","doi":"10.1016/j.critrevonc.2025.104650","DOIUrl":"10.1016/j.critrevonc.2025.104650","url":null,"abstract":"<div><div>Central nervous system (CNS) tumors represent the most frequent solid tumors among adolescents and children, and the leading cause of cancer-related death in men < 40 and women < 20 years of age. Brain tumors are challenging to diagnose, monitor, and treat. The current diagnostic approach involves magnetic resonance imaging (MRI), tumor histology, molecular characterization and cytologic analysis of cerebrospinal fluid (CSF). However, surgical procedures pose potential risks to the patient's health, not achieving good accuracy. For these reasons, it is crucial to identify new non-invasive disease biomarkers to improve patients’ stratification at diagnosis and during follow-up and prognosis. MicroRNAs (miRNAs) are a class of short RNA molecules that have been demonstrated in numerous studies to be dysregulated in brain tumor patients. As a result, they may be used as biomarkers of brain tumors. Additionally, miRNAs can be analyzed in liquid biopsy samples, such as blood and CSF, providing a non-invasive source of biomolecular data on patients' disease status. This review aims to highlight the role of miRNAs in liquid biopsy, also known as circulating miRNAs, as potential non-invasive cancer biomarkers in both adult and pediatric populations and to suggest their potential impact on clinical trials.</div></div>","PeriodicalId":11358,"journal":{"name":"Critical reviews in oncology/hematology","volume":"208 ","pages":"Article 104650"},"PeriodicalIF":5.5,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143348336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Colorectal cancer (CRC) is the third most prevalent malignant tumor globally and is associated with high morbidity and mortality rates. The advancement of novel nanocarrier-based drug delivery systems has revolutionized therapeutic strategies for colonic drug delivery and cancer treatment. This review provides updated insights into various nanocarrier technologies, including quantum dots (QDs), polymeric nanoparticles (PNPs), magnetic and metallic nanoparticles, solid lipid nanoparticles (SLNs), and self-microemulsifying and self-nanoemulsifying drug delivery systems (SMEDDS/SNEDDS). These nanocarriers offer enhanced drug stability, controlled release, and targeted delivery, particularly for CRC treatment, resulting in up to 70 % improved therapeutic efficacy and a significant reduction in systemic toxicity as reported in preclinical studies. The review comprehensively discusses the structural composition, mechanisms of action, therapeutic potential, and imaging capabilities of these systems, with a focus on their applications in theranostics and targeted CRC therapy. For instance, polymeric nanoparticles have demonstrated a 50 % increase in bioavailability compared to conventional formulations, while QDs have enabled real-time imaging with high precision for tumor localization. Additionally, the toxicity profiles and challenges associated with these nanocarriers are critically evaluated. Despite significant progress in preclinical and clinical studies, the review highlights the need for optimizing biocompatibility, scalability, and regulatory standards to facilitate the clinical translation of these promising technologies. Emerging formulations such as graphene quantum dots and PEGylated nanoparticles have shown potential for achieving dual therapeutic and diagnostic applications with fewer adverse effects. Overall, nanocarrier-based systems hold great potential for personalized and more effective treatments in colon-targeted therapies.
{"title":"Recent insights and applications of nanocarriers-based drug delivery systems for colonic drug delivery and cancer therapy: An updated review","authors":"Sobia Noreen , Irsah Maqbool , Anum Saleem , Hassan Mahmood , Nadia Rai","doi":"10.1016/j.critrevonc.2025.104646","DOIUrl":"10.1016/j.critrevonc.2025.104646","url":null,"abstract":"<div><div>Colorectal cancer (CRC) is the third most prevalent malignant tumor globally and is associated with high morbidity and mortality rates. The advancement of novel nanocarrier-based drug delivery systems has revolutionized therapeutic strategies for colonic drug delivery and cancer treatment. This review provides updated insights into various nanocarrier technologies, including quantum dots (QDs), polymeric nanoparticles (PNPs), magnetic and metallic nanoparticles, solid lipid nanoparticles (SLNs), and self-microemulsifying and self-nanoemulsifying drug delivery systems (SMEDDS/SNEDDS). These nanocarriers offer enhanced drug stability, controlled release, and targeted delivery, particularly for CRC treatment, resulting in up to 70 % improved therapeutic efficacy and a significant reduction in systemic toxicity as reported in preclinical studies. The review comprehensively discusses the structural composition, mechanisms of action, therapeutic potential, and imaging capabilities of these systems, with a focus on their applications in theranostics and targeted CRC therapy. For instance, polymeric nanoparticles have demonstrated a 50 % increase in bioavailability compared to conventional formulations, while QDs have enabled real-time imaging with high precision for tumor localization. Additionally, the toxicity profiles and challenges associated with these nanocarriers are critically evaluated. Despite significant progress in preclinical and clinical studies, the review highlights the need for optimizing biocompatibility, scalability, and regulatory standards to facilitate the clinical translation of these promising technologies. Emerging formulations such as graphene quantum dots and PEGylated nanoparticles have shown potential for achieving dual therapeutic and diagnostic applications with fewer adverse effects. Overall, nanocarrier-based systems hold great potential for personalized and more effective treatments in colon-targeted therapies.</div></div>","PeriodicalId":11358,"journal":{"name":"Critical reviews in oncology/hematology","volume":"208 ","pages":"Article 104646"},"PeriodicalIF":5.5,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-03DOI: 10.1016/j.critrevonc.2025.104651
Dingyi Fu , Haoquan Miao , Zhonglin Wang , Chuang Yang
Gynecomastia is the most common breast condition in men, while male breast cancer remains relatively rare. This review explores the potential relationship between gynecomastia and male breast cancer, with a focus on the roles of hormonal imbalances, genetic factors, and molecular mechanisms in the progression of these conditions. While it remains controversial whether gynecomastia is a precancerous lesion for male breast cancer, this review summarizes the roles of estrogen and androgen receptors, the regulation of aromatase expression, and mutations in key genes such as BRCA1/2. These insights point to possible pathways by which gynecomastia could transition into male breast cancer. Additionally, hormones such as prolactin, insulin-like growth factor-1, and leptin may play significant roles in this progression. We provide an overview of the current understanding and identify key areas for further research, emphasizing the need for large-scale prospective studies to determine the causal relationship between gynecomastia and male breast cancer.
{"title":"Gynecomastia and its potential progression to male breast cancer: Mechanisms, genetic factors, and hormonal interactions","authors":"Dingyi Fu , Haoquan Miao , Zhonglin Wang , Chuang Yang","doi":"10.1016/j.critrevonc.2025.104651","DOIUrl":"10.1016/j.critrevonc.2025.104651","url":null,"abstract":"<div><div>Gynecomastia is the most common breast condition in men, while male breast cancer remains relatively rare. This review explores the potential relationship between gynecomastia and male breast cancer, with a focus on the roles of hormonal imbalances, genetic factors, and molecular mechanisms in the progression of these conditions. While it remains controversial whether gynecomastia is a precancerous lesion for male breast cancer, this review summarizes the roles of estrogen and androgen receptors, the regulation of aromatase expression, and mutations in key genes such as BRCA1/2. These insights point to possible pathways by which gynecomastia could transition into male breast cancer. Additionally, hormones such as prolactin, insulin-like growth factor-1, and leptin may play significant roles in this progression. We provide an overview of the current understanding and identify key areas for further research, emphasizing the need for large-scale prospective studies to determine the causal relationship between gynecomastia and male breast cancer.</div></div>","PeriodicalId":11358,"journal":{"name":"Critical reviews in oncology/hematology","volume":"208 ","pages":"Article 104651"},"PeriodicalIF":5.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143221209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.critrevonc.2024.104579
Alexey S. Rzhevskiy , Guzel R. Sagitova , Tamilla A. Karashaeva , Andrey O. Morozov , Anastasia S. Fatyanova , Vlada V. Kazantseva , Simon A. Joosse , Andrei V. Zvyagin , Majid Ebrahimi Warkini
The application of circulating tumor cells (CTCs) as diagnostic and prognostic markers in oncology is gaining increasing importance in clinical practice. Currently, various methods exist for detecting CTCs in patients' biological fluids. This systematic review aimed to compare the efficacy of different techniques for isolating and detecting CTCs from blood, against the FDA-cleared CellSearch® technology, in breast cancer patients. We performed a systematic literature search using two databases (PubMed and the Cochrane Library) with the following terms: ("Circulating tumor cells" OR CTC) AND "breast cancer", covering the period from 2004 to April 2023. The primary outcome measured was the sensitivity, specificity, and overall accuracy of various CTC enrichment methods in comparison with the CellSearch® System. Secondary outcomes included the prognostic value of CTCs in evaluating response to treatment based on survival rates. Generally, a high level of agreement between CellSearch and other methods was observed in isolating CTCs from patients' blood with both metastatic and early-stage disease. Studies asserting the superiority of new methods over CellSearch frequently used clinically unvalidated cut-off thresholds for their patient cohorts. Additionally, these studies sometimes included different nonoverlapping patient cohorts and lacked a standardized chemotherapy treatment protocol, which could affect the quantitative changes in CTC. It is evident that methods simultaneously composed of physical and immunomagnetic approaches for CTC isolation significantly surpass CellSearch, which relies solely on the expression of specific markers on the CTCs’ surface. The count of CTCs has been established as a predictive marker in terms of clinically important parameters namely progression-free survival (PFS) and overall survival (OS). The CTC-count value was significantly correlated with PFS and OS rates.
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