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A Case-Control Study of Behavioural and Social Predictors of Severe Leptospirosis in a Tertiary Care Centre, Central Kerala 喀拉拉邦中部三级保健中心严重钩端螺旋体病行为和社会预测因素的病例对照研究
Pub Date : 2023-09-08 DOI: 10.24018/ejmed.2023.5.5.1783
Anjely Sukumaran, A. Biju
Leptospirosis is a globally important zoonotic disease. The disease is caused by pathogenic Leptospira species. Infections result from direct or indirect exposure to infected reservoir animals that carry the pathogen in their renal tubules and shed pathogenic leptospirosis in the urine. This study was conducted to assess the social and behavioural predictors of severe Leptospirosis and to study the clinical profile and outcome of patients with severe leptospirosis .148 patients with leptospirosis were divided into severe and non-severe groups. The majority of our study population had risk factors like contact with soil or water through barefoot, farming, swimming, cattle rearing, contact with sewage and stagnant rainwater. Conditions such as inadequate access to safe drinking water and sanitation services, poor personal hygiene practices, low levels of literacy, and lack of access to health services, contribute to increased vulnerability to infection and work against prevention efforts. Severity predictor factors are Cut or injury prior to symptoms, NSAID intake for fever and Myalgia from the periphery, late referral and late initiation of antibiotics, acute kidney injury, pancreatitis, myocarditis, thrombocytopenia, ARDS, acute liver injury, platelet less than 50,000 and prolonged INR. Knowledge about risk factors for severe leptospirosis can improve prevention and control measures to mitigate the incidence of severe cases.
钩端螺旋体病是一种重要的全球性人畜共患疾病。该病是由致病性钩端螺旋体引起的。感染源于直接或间接接触受感染的宿主动物,这些宿主动物在其肾小管中携带病原体,并通过尿液排出致病性钩端螺旋体病。本研究旨在评估严重钩端螺旋体病的社会和行为预测因素,并研究严重钩端螺旋体病患者的临床特征和转归。148例钩端螺旋体病患者被分为严重组和非严重组。我们的大多数研究人群都有风险因素,如通过赤脚、耕作、游泳、养牛、接触污水和停滞的雨水接触土壤或水。诸如无法充分获得安全饮用水和环境卫生服务、个人卫生习惯不良、识字率低以及无法获得保健服务等条件,都加剧了感染的脆弱性,并阻碍了预防工作。严重程度的预测因素是在出现症状之前割伤或损伤、因发热和周围肌痛而服用非甾体抗炎药、转诊晚和开始使用抗生素、急性肾损伤、胰腺炎、心肌炎、血小板减少症、急性肝损伤、血小板少于50,000和INR延长。了解严重钩端螺旋体病的危险因素可以改善预防和控制措施,以减轻严重病例的发生率。
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引用次数: 0
Impacts of Extra Virgin Olive Oil Consumption on Glycemic Control in Patients with Metabolic Syndrome 特级初榨橄榄油对代谢综合征患者血糖控制的影响
Pub Date : 2023-09-06 DOI: 10.34104/ejmhs.023.01010107
The purpose of this study was to observe the impacts of extra virgin olive oil on glycemic control in patients with metabolic syndrome (MetS). A total number of 70 patients of both genders with MetS were selected with the age varying from 35 to 55 years. Among them, 35 patients who had consumed 25 ml of extra virgin olive oil daily for 12 weeks were included in the study group (Group B). Another 35 patients who did not consume extra virgin olive oil, were enrolled as the control group (Group A) for comparison. Levels of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) were measured in both the control and study groups at baseline and after 12 weeks. EVOO consumption group showed a statistically significant decrease in fasting blood glucose (p =.003) and glycosylated hemoglobin (p <0.001) in comparison to a control group who did not consume extra virgin olive oil. Regular consumption of extra virgin olive oil improves glycemic status in patients with metabolic syndrome.
本研究的目的是观察特级初榨橄榄油对代谢综合征(MetS)患者血糖控制的影响。共选取年龄在35 ~ 55岁之间的70例met患者,男女皆有。其中,35例连续12周每天食用25毫升特级初榨橄榄油的患者被纳入研究组(B组)。另外35例不食用特级初榨橄榄油的患者被纳入对照组(A组)进行比较。对照组和研究组在基线和12周后分别测量空腹血糖(FBG)和糖化血红蛋白(HbA1c)水平。与不食用特级初榨橄榄油的对照组相比,食用橄榄油组的空腹血糖(p = 0.003)和糖化血红蛋白(p <0.001)有统计学意义的降低。经常食用特级初榨橄榄油可以改善代谢综合征患者的血糖状况。
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引用次数: 1
Asymptomatic Candiduria in Kidney Transplant Recipients 肾移植受者的无症状念珠菌
Pub Date : 2023-08-31 DOI: 10.24018/ejmed.2023.5.4.1736
Youssef Hssaine, Adil Jahdaoui, Awatif El Hakkouni, M. Chettati, W. Fadili, I. Laouad
Infections remain a major cause of morbidity and mortality in kidney transplant patients and can be prevented by regular screening after transplantation.Candidiasis is common after renal transplantation and candida albicans is the most isolated species. The clinical presentation isn’t specific and sometimes asymptomatic.The etiological investigation is guided by epidemiological data specific to this population and by an analysis of individual risk factors as well as a mycological study which constitutes the key examination for positive diagnosis and resistance to antifungal agents.In this study, we report the results of a screening program for asymptomatic candiduria in renal transplant patients at the Mohammed VI University Hospital of Marrakech (Morocco).
感染仍然是肾移植患者发病和死亡的主要原因,可以通过移植后定期筛查来预防。念珠菌病常见于肾移植后,白色念珠菌是最孤立的一种。临床表现不明确,有时无症状。病因学调查的指导是针对这一人群的流行病学数据、对个体危险因素的分析以及真菌学研究,真菌学研究是诊断阳性和抗真菌药物耐药性的关键检查。在这项研究中,我们报告了马拉喀什穆罕默德六世大学医院(摩洛哥)肾移植患者无症状念珠菌筛查计划的结果。
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引用次数: 0
Correlation between the Volume of MRI Brain Infarct and Inflammatory Markers among Acute Ischemic Stroke Patients 急性缺血性脑卒中患者MRI脑梗死体积与炎症标志物的相关性研究
Pub Date : 2023-08-31 DOI: 10.24018/ejmed.2023.5.4.1845
Suraini Mohamad, Muhammad Syakir Saini, Anna Azmi, Maisarah Mohamad, G. AriffTharani, Baramesvaran Sabariah, Noor, S. M. Saini, M. S. Azmi, A.M.M. Ariff, T. G. Baramesvaran, S. M. Noor
Stroke is one of the top five leading causes of death in Malaysia and increases in the mortality rate between 2016 and 2019. There is growing evidence that inflammation plays an important role in acute ischemic stroke. Studies showed that the level of inflammatory markers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are strongly correlated with the volume of brain infarct detected using Magnetic Resonance Imaging (MRI). This cross-sectional study conducted in Hospital Pengajar Universiti Putra Malaysia (HPUPM) aims to determine the correlation between the volume of MRI brain infarct with inflammatory markers among patients with acute ischemic stroke in HPUPM. Patients’ sociodemographic information and level of inflammatory markers were extracted from the Hospital Information System (eHIS), the MRI images were accessed through the Picture Archiving and Communication System (PACS) whereas the MRI reports for each sample were searched from the Reporting Information System (RIS). In addition, the MRI sequences DWI/ADC and FLAIR axial were selected. The findings of the site and size of brain ischemia were studied. This study was based on 60 data sets of patients diagnosed with acute ischemic stroke in HPUPM. The majority of the patients were male (68.3%), Malay (51.7%) and ranging from age group 61-75 years old. The mean volume of MRI brain infarction was 27.3268±55.6957cm3. A statistically significant association was found between CRP and volume of brain infarction (r=0.297, p<0.05) whereas no association was found between ESR and volume of brain infarction (r=0.192, p>0.05). A significant association was found between CRP and volume of brain infarction. No association was found between ESR and volume of brain infarction.
中风是马来西亚五大死亡原因之一,2016年至2019年期间死亡率有所上升。越来越多的证据表明,炎症在急性缺血性中风中起着重要作用。研究表明,炎症标志物如c反应蛋白(CRP)和红细胞沉降率(ESR)的水平与磁共振成像(MRI)检测到的脑梗死体积密切相关。这项横断面研究在马来西亚蓬加大学医院(HPUPM)进行,旨在确定HPUPM急性缺血性脑卒中患者MRI脑梗死体积与炎症标志物之间的相关性。从医院信息系统(eHIS)中提取患者的社会人口学信息和炎症标志物水平,通过图片存档和通信系统(PACS)访问MRI图像,同时从报告信息系统(RIS)中检索每个样本的MRI报告。同时选取MRI序列DWI/ADC和FLAIR轴位。观察大鼠脑缺血的部位和大小。本研究基于60组HPUPM诊断为急性缺血性脑卒中的患者数据集。大多数患者为男性(68.3%),马来人(51.7%),年龄在61-75岁之间。MRI脑梗死平均体积为27.3268±55.6957cm3。CRP与脑梗死体积有统计学意义(r=0.297, p0.05)。发现CRP与脑梗死体积有显著相关性。没有发现ESR与脑梗死体积之间的关联。
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引用次数: 0
Isolation, Characterization and Antimicrobial Susceptibility Pattern of Pseudomonas aeruginosa from Tsetse Flies Captured in Yankari Game Reserve, Nigeria 尼日利亚Yankari禁猎区采采蝇中铜绿假单胞菌的分离、鉴定及药敏分析
Pub Date : 2023-08-31 DOI: 10.24018/ejmed.2023.5.4.1796
Youssouf M. Mouliom, D. Achukwi, Mohammed Mamman, E. O. Balogun, M. N. Shuaibu, Junaidu Kabir
microbiota is involved in their vector competence and may help in developing novel disease control tools. Pseudomonas aeruginosa is reported to be ubiquitous in the natural environment, humans, and animals. It has been used for biocontrol in plants.Methods: Twenty-five live tsetse flies, collected from Yankari Game Reserve, Nigeria, were dissected under sterile conditions. The midgut was incubated successively in standard culture media. Suspected isolates were then subjected to biochemical tests. The 16S rRNA gene sequence was used to confirm the genotype. The positive isolate was also tested for susceptibility to 17 antimicrobials.Results: Eight (32%) of the 25 flies tested were positive for P. aeruginosa. They were positive for oxidase, catalase, citrate, and motility tests and negative for urease, indole, Methyl Red tests. Analysis of 16S rRNA gene confirmed the identity of the isolate, and the phylogenetic relationship with other strains was established. The isolate was sensitive to fluoroquinolones and intermediate to chloramphenicol. Drug resistance was observed against aminoglycosides, penicillin, erythromycin, clindamycin and imipenemConclusion: The presence of P. aeruginosa in tsetse gut contributes to the repertoire of cultivable tsetse gut bacteria. It is crucial to investigate whether it could play a role in modulating the fly vector’s competence.
微生物群参与其媒介能力,可能有助于开发新的疾病控制工具。据报道,铜绿假单胞菌普遍存在于自然环境、人类和动物中。它已被用于植物的生物防治。方法:采集自尼日利亚Yankari野生动物保护区的采采蝇25只,在无菌条件下解剖。在标准培养基中连续培养中肠。然后对疑似分离物进行生化测试。采用16S rRNA基因序列进行基因型鉴定。阳性分离物还进行了对17种抗菌素的敏感性试验。结果:25只蝇中8只(32%)铜绿假单胞菌阳性。他们的氧化酶、过氧化氢酶、柠檬酸盐和运动试验呈阳性,脲酶、吲哚、甲基红试验呈阴性。16S rRNA基因分析证实了分离株的身份,并与其他菌株建立了系统发育关系。该菌株对氟喹诺酮类药物敏感,对氯霉素敏感。对氨基糖苷类、青霉素、红霉素、克林霉素和亚胺培耐药。结论:P. aeruginosa在采采蝇肠道中存在,是采采蝇可培养肠道菌群的重要组成部分。研究它是否能在调节蝇媒介的能力中发挥作用是至关重要的。
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引用次数: 0
Chordoma of the Sellar Region Mimicking Meningioma: A Literature Review and Illustrative Case 鞍区似脑膜瘤脊索瘤:一个文献回顾和说明性病例
Pub Date : 2023-08-31 DOI: 10.24018/ejmed.2023.5.4.1785
K. Guettabi, Jihad Echnin, Abdelkoudouss Laaidi, S. Hilmani, K. Ibahioin, Abdessamad Naja, A. Lakhdar
Background: Chordoma is a rare malignant tumor that accounts for 1-4% of primary malignant bone tumors arising primarily in the axial skeleton and primarily affects adults. It seems to have difficulty with diagnosis and treatment.Case description: A 63-year-old man with a history of diabetes treated with oral antidiabetic medication and hypertension. Presented with two years of bilateral decrease in visual acuity. Neurological examination revealed left ptosis, divergent strabismus, and higher cerebral function disorders. Brain MRI revealed a sellar and suprasellar lesion evokes a sellar meningioma, macro adenoma. Hormonal laboratory tests revealed that the prolactin level was elevated to 140ng/ml without any other hormonal disorder. The patient underwent partial surgical resection of the lesion through endoscopic endonasal. Histopathological examination revealed a chondroid chordoma.Postoperatively the patient had no endocrinological or neurological complications, but he kept the starbism and the ptosis in the left eye.Conclusion: In the context of progressive ophthalmological signs by a sellar and suprasellar lesion, the differential diagnosis should include chordoma along with meningioma, macro adenoma and metastasis.Complete and early surgical removal is the first line treatment.
背景:脊索瘤是一种罕见的恶性肿瘤,占原发性恶性骨肿瘤的1-4%,主要发生在中轴骨骼,主要影响成年人。它似乎很难诊断和治疗。病例描述:63岁男性,有糖尿病病史,口服降糖药治疗并伴有高血压。表现为两年的双侧视力下降。神经学检查显示左上睑下垂、发散性斜视及高级脑功能障碍。脑MRI显示鞍区及鞍上病变提示鞍区脑膜瘤,大腺瘤。激素实验室检查显示催乳素水平升高至140ng/ml,无其他激素紊乱。患者经鼻内窥镜行部分病变手术切除。组织病理学检查显示为软骨样脊索瘤。术后患者无内分泌及神经系统并发症,但左眼仍有斜视及上睑下垂。结论:在鞍区及鞍上病变的进展性眼科征象中,脊索瘤合并脑膜瘤、大腺瘤及转移应予以鉴别诊断。完全和早期的手术切除是第一线的治疗。
{"title":"Chordoma of the Sellar Region Mimicking Meningioma: A Literature Review and Illustrative Case","authors":"K. Guettabi, Jihad Echnin, Abdelkoudouss Laaidi, S. Hilmani, K. Ibahioin, Abdessamad Naja, A. Lakhdar","doi":"10.24018/ejmed.2023.5.4.1785","DOIUrl":"https://doi.org/10.24018/ejmed.2023.5.4.1785","url":null,"abstract":"Background: Chordoma is a rare malignant tumor that accounts for 1-4% of primary malignant bone tumors arising primarily in the axial skeleton and primarily affects adults. It seems to have difficulty with diagnosis and treatment.\u0000Case description: A 63-year-old man with a history of diabetes treated with oral antidiabetic medication and hypertension. Presented with two years of bilateral decrease in visual acuity. Neurological examination revealed left ptosis, divergent strabismus, and higher cerebral function disorders. Brain MRI revealed a sellar and suprasellar lesion evokes a sellar meningioma, macro adenoma. Hormonal laboratory tests revealed that the prolactin level was elevated to 140ng/ml without any other hormonal disorder. The patient underwent partial surgical resection of the lesion through endoscopic endonasal. Histopathological examination revealed a chondroid chordoma.\u0000Postoperatively the patient had no endocrinological or neurological complications, but he kept the starbism and the ptosis in the left eye.\u0000Conclusion: In the context of progressive ophthalmological signs by a sellar and suprasellar lesion, the differential diagnosis should include chordoma along with meningioma, macro adenoma and metastasis.\u0000Complete and early surgical removal is the first line treatment.","PeriodicalId":113708,"journal":{"name":"European Journal of Medical and Health Sciences","volume":"200 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121843274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Analysis of Optic Nerve Diameter Using Ultrasonography Between Normotensives and Preeclamptic Patients at University of Medical Sciences Teaching Hospital, Ondo, Nigeria 尼日利亚Ondo医科大学教学医院正常血压患者与子痫前期患者视神经直径超声对比分析
Pub Date : 2023-08-30 DOI: 10.24018/ejmed.2023.5.4.1829
Adebimpe Olamide Bello, A. Ogunsemoyin, Joseph Irewole Fatukasi, Lawal Olawale Oyeneyin, Babatola Bakare, S. Osho, Samuel Olayode Oyamakinde, Matthew Adeniran Adeyemo
Background: It is an established fact that obstetric patients withpreeclampsia do have increased optic nerve diameter compared with normotensive patients. Ultrasonography is increasingly advocated as a valuable screening tool for evaluating the optic nerve diameter as a surrogate marker for raised intracranial pressure due to its noninvasive nature, low cost, portability, dynamic real-time assessment and rapid performance. Thisstudy aims to compare the ultrasonographic measurement of optic nerve diameter between two groups of preeclamptic and normotensive pregnant women.Methodology: This cross-sectional descriptive study was carried out at the Department of Radiology, University of Medical Sciences Teaching Hospital Complex, (UNIMEDTHC), Ondo State, Nigeria. It consisted of 90 preeclamptic (study) and 90 normotensives (control) aged-matched pregnant women. The optic nerve diameters were measured by the radiologistusing a high frequency linear ultrasound probe (7.5–12 MHz).Results: The optic nerve diameter as measured by ocular ultrasound scan was statistically significantly higher (p-value of <0.05) in preeclamptic patients compared to normotensives with a mean of 6.22 ± 0.83 mm versus 4.50 ± 0.69 mm, respectively.Conclusion: Ocular ultrasound scan for measurement of optic nerve diameter is a reliable screening tool for assessing raised intracranial pressure in preeclamptic patients when compared to normotensive ones. Therefore, it is recommended that performing non-invasive ocular ultrasound scans be advocated for all pregnant women with or at risk of preeclampsia.
背景:与血压正常的患者相比,产科先兆子痫患者的视神经直径确实增加,这是一个既定的事实。超声检查因其无创、低成本、便携、动态实时、快速等优点,越来越被推崇为评价视神经直径作为颅内压升高的替代标志物的有价值的筛查工具。本研究旨在比较两组子痫前期和血压正常孕妇视神经直径的超声测量结果。方法:这项横断面描述性研究是在尼日利亚翁多州医科大学教学医院(UNIMEDTHC)放射学系进行的。它包括90名先兆子痫(研究)和90名血压正常(对照组)的年龄匹配的孕妇。放射科医师使用高频线性超声探头(7.5-12 MHz)测量视神经直径。结果:子痫前期患者的视神经直径(平均为6.22±0.83 mm)明显高于血压正常者(平均为4.50±0.69 mm), p值均<0.05。结论:与血压正常的患者相比,眼超声扫描测量视神经直径是评估子痫前期患者颅内压升高的可靠筛查工具。因此,建议对所有患有或有子痫前期风险的孕妇进行非侵入性眼部超声扫描。
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引用次数: 0
Vaginal Transection Versus Vaginal Entry Cuff Closure Technique Following Elective Abdominal Hysterectomy for Benign Lesions - A Prospective Comparative Study 阴道横断与阴道进入袖带闭合技术在选择性腹部子宫切除术后治疗良性病变-一项前瞻性比较研究
Pub Date : 2023-08-22 DOI: 10.24018/ejmed.2023.5.4.1870
Mamta Singh
Background: Total abdominal hysterectomy is most common performed gynaecological operation. There is no standard recommendation or guidelines regarding management of vaginal cuff. This study aimed to determine the advantages and disadvantages of vaginal transection versus vaginal entry technique following elective abdominal hysterectomies for benign lesions.Methodology: This is a comparative study involving 180 women undergoing elective hysterectomy in Sparsh hospital, from 10 Jan 2015 to 10 Jan 2020. Patient was randomized to either transactional vaginal or vagina entry technique of cuff closure. In this, we compare Operating time, length of hospital stays, estimated blood loss, post operative discharge. Vaginal length, vaginal cuff infection and granulation after 6 weeks follow up time. A prospective study on all hysterectomies performed by the single senior surgeon at Sparsh hospital in order to eliminate possible differences in surgical techniques and abilities.Result: We found in this study that operating time, blood loss, post operative discharge from vault is less in transection technique of vaginal cuff closure in comparison to vaginal entry technique. Febrile complain is more in vaginal entry cuff group patients. Hospital stay is long in vaginal entry technique patients. There is no difference in post operative vaginal length in both the techniques. Transection technique is easy to perform. Conclusion: Transection cuff closure technique is better than vaginal entry technique.
背景:腹式全子宫切除术是最常见的妇科手术。目前还没有关于阴道袖带治疗的标准建议或指南。本研究旨在确定选择性腹部子宫切除术后阴道横断术与阴道入路术的优缺点。方法:这是一项比较研究,涉及2015年1月10日至2020年1月10日在Sparsh医院接受选择性子宫切除术的180名妇女。患者随机分为阴道交易术和阴道袖带闭合术两组。在此,我们比较手术时间,住院时间,估计失血量,术后出院。阴道长度、阴道袖口感染及肉芽肿后6周随访时间。为了消除手术技术和能力可能存在的差异,对Sparsh医院一位资深外科医生进行的所有子宫切除术进行了前瞻性研究。结果:本研究发现阴道袖带闭合横断技术与阴道进入技术相比,手术时间、出血量、术后拱顶排出量少。阴道入口套组患者发热主诉较多。阴道入路术患者住院时间长。两种方法术后阴道长度无差异。横断技术很容易操作。结论:横断袖带闭合技术优于阴道进入技术。
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引用次数: 0
The Relationship Between Contextual Factors and the Mobility Ability 语境因素与流动能力的关系
Pub Date : 2023-08-22 DOI: 10.24018/ejmed.2023.5.4.1867
A. P. Fontes
Objective: To examine how the relationship between Mobility limitation is influenced by Contextual Factors in community-dwelling older adults.Design: This is a cross-sectional study.Participants: A total of 769 persons aged 65 years or above living in the community-dwelling of the Algarve region.Methods: We study eighteen categories of Personal and Environmental Factors agreement of the International Classification of Functioning (ICF) and their relationship with six categories of the Mobility domain. Multiple logistic regression was used in analyzing functional outcomes in the Mobility.Main Results: The proportion of older adults reporting disability in Mobility activities ranged from 17.4% (Moving Around Within the Home) and 53.2% (Using Private or Public Motorized Transportation). The Contextual Factors with a greater impact in explaining the limitations in Mobility outcomes were Assistance Activities of Daily Living (OR = 3.0 to OR = 11.9), JobWithout Qualification (OR=2.5 toOR=6.3), Inadequate Nr of Meals (OR = 2.6 to OR = 3.8) and Self-Rated Physical Health (OR = 2.1 to OR = 3.1). The variable sex contributed to explaining the results of the most difficult activities to perform as Moving Around Outside the Home, Climbing and Use of Transports. The contribution of age was observed only in the Use of Transports.Conclusions: Contextual Factors are important predictors of Mobility functioning, namely, those related to Behaviors and Health Events but also those related to Social and Cultural variables.
目的:探讨社区居住老年人活动能力限制与环境因素的关系。设计:这是一项横断面研究。参与者:居住在阿尔加维地区社区住宅的65岁或以上的共有769人。方法:研究国际功能分类(ICF)中18类个人与环境因素的一致性及其与6类活动域的关系。运用多元逻辑回归分析移动性患者的功能结局。主要结果:老年人在移动活动中报告残疾的比例为17.4%(在家中移动)和53.2%(使用私人或公共机动交通工具)。在解释活动能力结果限制方面影响较大的背景因素是日常生活辅助活动(OR= 3.0至OR= 11.9)、无资格工作(OR=2.5至OR=6.3)、膳食Nr不足(OR= 2.6至OR= 3.8)和自评身体健康(OR= 2.1至OR= 3.1)。可变的性别有助于解释最难进行的活动的结果,如在家外走动、攀登和使用交通工具。年龄的影响只体现在交通工具的使用上。结论:环境因素是运动功能的重要预测因素,即与行为和健康事件相关的因素,以及与社会和文化变量相关的因素。
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引用次数: 0
Toxic Effect of Green Leaf Color as Food Dye on Liver, Kidney, and Intestinal Tissues in Animal Mice Model 绿叶色素对动物小鼠肝、肾、肠组织的毒性作用
Pub Date : 2023-08-16 DOI: 10.34104/ejmhs.023.0930100
Food dye is a synthetic chemical that restores natural color that is lost during processing and enhances the color, flavor, and taste of food. It mostly affects youngsters and produces a variety of health issues. This investigation was conducted to examine the deleterious effects of the unclassified dye "green leaf color" on the liver, kidney, and intestine tissues of a mouse model. Fifteen adult mice were separated into two groups: control and treatment. The treatment groups were fed standard poultry feed with dye in 20µl and 10µl (1.0mg/kg/bw and 2.0mg/kg/bw, respectively). At the conclusion of the 90 days experiment, animals were euthanized and sacrificed, and pieces of liver, kidneys, and intestine were collected and histologically processed for visualization under a light microscope. Feeding of green leaf color induced a range of histological changes in all treated mice compared with their control group. Results from the histopathological examination showed mainly vacuolization of renal tubules, raising space between the walls of Bowman’s capsule, shrinkage of glomeruli and glomerular necrosis, congestion of tubules, inflammatory cellular infiltration, dilation of tubular lumen, and hemorrhage in renal tissues. In the case of the liver, congestion of the central vein, vacuolization of hepatic cells, pyknotic nuclei, karyorrhexis, karyolysis, and inflammatory cellular infiltration were observed. Similarly, significant histopathological alterations were identified in the intestinal section including disrupted brush border, necrosis, vacuolization, swelling, uncontrolled cell proliferation, disrupted mucosa, and submucosa. Therefore, we strongly recommend here the ban of unclassified dye green leaf color to use as a color additive.
食用染料是一种合成化学物质,可以恢复在加工过程中失去的自然颜色,增强食物的颜色、风味和味道。它主要影响年轻人,并产生各种健康问题。本研究旨在研究未分类染料“绿叶色”对小鼠模型肝、肾和肠组织的有害作用。将15只成年小鼠分为对照组和治疗组。试验组饲喂含20µl和10µl染料的标准家禽饲料(分别为1.0mg/kg/bw和2.0mg/kg/bw)。90天实验结束后,对大鼠实施安乐死并处死,取肝、肾、肠切片,在光镜下进行组织学处理。与对照组相比,饲喂绿叶色可引起所有实验组小鼠的一系列组织学变化。组织病理学检查主要表现为肾小管空泡化,鲍曼囊壁间隙增大,肾小球缩小,肾小球坏死,小管充血,炎症细胞浸润,小管腔扩张,肾组织出血。肝脏可见中央静脉充血、肝细胞空泡化、核收缩、核分裂、核溶解、炎性细胞浸润。同样,在肠切片中发现了显著的组织病理学改变,包括刷状边界破坏、坏死、空泡化、肿胀、细胞增殖不受控制、粘膜和粘膜下层破坏。因此,我们强烈建议在此禁用未分类染料绿叶色作为颜色添加剂使用。
{"title":"Toxic Effect of Green Leaf Color as Food Dye on Liver, Kidney, and Intestinal Tissues in Animal Mice Model","authors":"","doi":"10.34104/ejmhs.023.0930100","DOIUrl":"https://doi.org/10.34104/ejmhs.023.0930100","url":null,"abstract":"Food dye is a synthetic chemical that restores natural color that is lost during processing and enhances the color, flavor, and taste of food. It mostly affects youngsters and produces a variety of health issues. This investigation was conducted to examine the deleterious effects of the unclassified dye \"green leaf color\" on the liver, kidney, and intestine tissues of a mouse model. Fifteen adult mice were separated into two groups: control and treatment. The treatment groups were fed standard poultry feed with dye in 20µl and 10µl (1.0mg/kg/bw and 2.0mg/kg/bw, respectively). At the conclusion of the 90 days experiment, animals were euthanized and sacrificed, and pieces of liver, kidneys, and intestine were collected and histologically processed for visualization under a light microscope. Feeding of green leaf color induced a range of histological changes in all treated mice compared with their control group. Results from the histopathological examination showed mainly vacuolization of renal tubules, raising space between the walls of Bowman’s capsule, shrinkage of glomeruli and glomerular necrosis, congestion of tubules, inflammatory cellular infiltration, dilation of tubular lumen, and hemorrhage in renal tissues. In the case of the liver, congestion of the central vein, vacuolization of hepatic cells, pyknotic nuclei, karyorrhexis, karyolysis, and inflammatory cellular infiltration were observed. Similarly, significant histopathological alterations were identified in the intestinal section including disrupted brush border, necrosis, vacuolization, swelling, uncontrolled cell proliferation, disrupted mucosa, and submucosa. Therefore, we strongly recommend here the ban of unclassified dye green leaf color to use as a color additive.","PeriodicalId":113708,"journal":{"name":"European Journal of Medical and Health Sciences","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123806688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
European Journal of Medical and Health Sciences
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