Pub Date : 2013-05-20DOI: 10.1002/9781118572610.CH23
Tadataka Yamada, J. Inadomi, R. Bhattacharya, J. Dominitz, J. Hwang
This collective review includes all available case reports of smooth muscle (stromal) tumors of the stomach in the world literature from 1762 to 1996. It updates our previous review from 1767 to 1959. Overall, we identified 2189 patients with leiomyoma (LM) and 1594 with leiomyosarcoma (LMS). The peak age of incidence of LM was 50 to 59 years, while LMS was most frequently seen between ages 60 and 69. Women were more likely to develop LM, and men more commonly presented with malignant smooth muscle tumors of the stomach. Concerning the patterns of growth, LMs were more likely to grow intraluminally (endogastric), whereas LMSs were predominantly exogastric. The most common site of LMs was on the anterior or posterior wall of the body of the stomach; LMSs were most likely found along the greater curve. The presenting symptoms of both types of smooth muscle tumors were similar; in decreasing order of frequency they were bleeding, pain, palpable mass, and weight loss. Interestingly, there was no correlation between the size of the tumor and signs or symptoms of bleeding, pain, weight loss, or ulceration, although patients with LMSs were more likely to report weight loss than patients with benign tumors. For LMS, there seemed to be no correlation between tumor size or location and rate of metastasis, although the tumors that grew in a dumbbell shape (i.e., both intraluminally and extraluminally) had a higher frequency of metastasis than other growth patterns. Overall, the rate of metastasis at diagnosis was 35.4%, with the liver, spleen, and regional lymph nodes the most common sites. Carcinoma is responsible for 92% to 99% of all malignant gastric neoplasms. Of the noncarcinomatous malignancies, lymphomas are the most frequent as reported by Marshall and Meissner [1]. The remaining are predominantly LMSs with an incidence as high as 25% of all noncarcinomatous malignancies. Other rare sarcomas include rhabdomyosarcoma, neurofibrosarcoma, fibroliposarcoma, fibrosarcoma, and hemangiosarcoma. Pathologists have begun to shift from the terms leiomyoma and leiomyosarcoma to the term stromal cell tumor. They might additionally use the smooth muscle terminology of leiomyoma or leiomyosarcoma if there is clear evidence for this differentiation [2]. Almost all the cases in this review were reported prior to widespread recognition that many of the tumors formerly called smooth muscle tumors lack the immunohistochemical or ultrastructural features characteristic of smooth muscle. Nevertheless, as yet there is no indication that the presence or absence of true smooth muscle features has any prognostic importance. Thus we believe the collective data of tumors classified as LM or LMS reported here have clinical importance. Smooth muscle tumors of the stomach originate from the smooth musculature of the gastric wall and proliferate toward the lumen, toward the serosa, or in both directions; or they remain small and within the gastric wall itself. Both benign and mal
{"title":"[TUMORS of the stomach].","authors":"Tadataka Yamada, J. Inadomi, R. Bhattacharya, J. Dominitz, J. Hwang","doi":"10.1002/9781118572610.CH23","DOIUrl":"https://doi.org/10.1002/9781118572610.CH23","url":null,"abstract":"This collective review includes all available case reports of smooth muscle (stromal) tumors of the stomach in the world literature from 1762 to 1996. It updates our previous review from 1767 to 1959. Overall, we identified 2189 patients with leiomyoma (LM) and 1594 with leiomyosarcoma (LMS). The peak age of incidence of LM was 50 to 59 years, while LMS was most frequently seen between ages 60 and 69. Women were more likely to develop LM, and men more commonly presented with malignant smooth muscle tumors of the stomach. Concerning the patterns of growth, LMs were more likely to grow intraluminally (endogastric), whereas LMSs were predominantly exogastric. The most common site of LMs was on the anterior or posterior wall of the body of the stomach; LMSs were most likely found along the greater curve. The presenting symptoms of both types of smooth muscle tumors were similar; in decreasing order of frequency they were bleeding, pain, palpable mass, and weight loss. Interestingly, there was no correlation between the size of the tumor and signs or symptoms of bleeding, pain, weight loss, or ulceration, although patients with LMSs were more likely to report weight loss than patients with benign tumors. For LMS, there seemed to be no correlation between tumor size or location and rate of metastasis, although the tumors that grew in a dumbbell shape (i.e., both intraluminally and extraluminally) had a higher frequency of metastasis than other growth patterns. Overall, the rate of metastasis at diagnosis was 35.4%, with the liver, spleen, and regional lymph nodes the most common sites. Carcinoma is responsible for 92% to 99% of all malignant gastric neoplasms. Of the noncarcinomatous malignancies, lymphomas are the most frequent as reported by Marshall and Meissner [1]. The remaining are predominantly LMSs with an incidence as high as 25% of all noncarcinomatous malignancies. Other rare sarcomas include rhabdomyosarcoma, neurofibrosarcoma, fibroliposarcoma, fibrosarcoma, and hemangiosarcoma. Pathologists have begun to shift from the terms leiomyoma and leiomyosarcoma to the term stromal cell tumor. They might additionally use the smooth muscle terminology of leiomyoma or leiomyosarcoma if there is clear evidence for this differentiation [2]. Almost all the cases in this review were reported prior to widespread recognition that many of the tumors formerly called smooth muscle tumors lack the immunohistochemical or ultrastructural features characteristic of smooth muscle. Nevertheless, as yet there is no indication that the presence or absence of true smooth muscle features has any prognostic importance. Thus we believe the collective data of tumors classified as LM or LMS reported here have clinical importance. Smooth muscle tumors of the stomach originate from the smooth musculature of the gastric wall and proliferate toward the lumen, toward the serosa, or in both directions; or they remain small and within the gastric wall itself. Both benign and mal","PeriodicalId":11384,"journal":{"name":"Die Medizinische","volume":"16 1","pages":"2423-5"},"PeriodicalIF":0.0,"publicationDate":"2013-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81300506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-10-01DOI: 10.1142/9789812388919_0007
K. Nobuhara
{"title":"[Diseases of the shoulder].","authors":"K. Nobuhara","doi":"10.1142/9789812388919_0007","DOIUrl":"https://doi.org/10.1142/9789812388919_0007","url":null,"abstract":"","PeriodicalId":11384,"journal":{"name":"Die Medizinische","volume":"15 1","pages":"553-6"},"PeriodicalIF":0.0,"publicationDate":"2003-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73004313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Necessity and methods of family planning in industrial and developing countries].","authors":"G Fromm, S Klug","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11384,"journal":{"name":"Die Medizinische","volume":"22 10","pages":"434-8"},"PeriodicalIF":0.0,"publicationDate":"1968-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22010096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[On the differential diagnosis and treatment of bacterial dermatoses in the facial region].","authors":"W J UHLMANN","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11384,"journal":{"name":"Die Medizinische","volume":"52 ","pages":"2569-75"},"PeriodicalIF":0.0,"publicationDate":"1959-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23431985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Clinical experiences with taxilan in the treatment of psychiatric states].","authors":"O SCHAEPPERLE, W OSTERMANN","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11384,"journal":{"name":"Die Medizinische","volume":"No 52 ","pages":"2579-82"},"PeriodicalIF":0.0,"publicationDate":"1959-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23958895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[From acceleration to weightlessness. A space-medical talk on the \"eve\" of the first space flight].","authors":"von DIRINGSHOFEN","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11384,"journal":{"name":"Die Medizinische","volume":"52 ","pages":"2586-92"},"PeriodicalIF":0.0,"publicationDate":"1959-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23409391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[A contribution to the prednisone therapy of Boeck's disease].","authors":"P H SCHAPER, H SCHNELL","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11384,"journal":{"name":"Die Medizinische","volume":"No 52 ","pages":"2575-9"},"PeriodicalIF":0.0,"publicationDate":"1959-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23961235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The treatment of hepatic coma with antibiotics (chlortetracycline, neomycin)].","authors":"G A MARTINI, G STROHMEYER, W DOELLE","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11384,"journal":{"name":"Die Medizinische","volume":"No 52 ","pages":"2549-53"},"PeriodicalIF":0.0,"publicationDate":"1959-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23941612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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