Poor in vivo characteristics of gambogic acid (GA) and difficulties in industrial manufacturing of its nanocarriers have hindered its clinical translation. Therefore, a reproducible nano‐drug delivery system must be developed to realize simpler manufacture and address inherent defects of GA, such as short circulation and severe side effects, in order to facilitate its clinical application. Herein, a drug self‐assembled nanoparticles (NPs) consisting of a hydrophobic prodrug based on GA and oleyl alcohol (OA), as well as vitamin E‐polyethylene glycol succinate (TPGS) as a shield to improve the stability of the NPs is reported. The preparation method is simple enough to stably facilitate large‐scale manufacturing. The self‐assembled NPs exhibit a remarkably high drug‐loading capacity, and their prolonged circulation enables the NPs to demonstrate superior antitumor efficacy in both cellular and animal models. The flexible hydrophobic long chain wraps GA groups, which mitigates vascular irritation and reduces hemolysis rates. Consequently, the prodrug nano‐system addresses GA‐related concerns regarding stability, efficacy, and safety, offering a simple, stable, and secure nano‐platform for similar candidate drugs.
甘草酸（GA）的体内特性差，其纳米载体的工业化生产困难重重，阻碍了其临床转化。因此，必须开发一种可重复的纳米给药系统，以实现更简单的制造，并解决甘草酸固有的缺陷，如循环时间短、副作用大等，从而促进其临床应用。本文报道了一种药物自组装纳米粒子（NPs），它由基于 GA 和油醇（OA）的疏水性原药以及维生素 E-聚乙二醇琥珀酸酯（TPGS）组成，后者作为保护层可提高 NPs 的稳定性。该制备方法非常简单，可稳定地促进大规模生产。自组装的 NPs 表现出极高的药物负载能力，其长时间的循环使 NPs 在细胞和动物模型中都表现出卓越的抗肿瘤功效。柔性疏水长链包裹着 GA 基团，从而减轻了对血管的刺激，降低了溶血率。因此，该原药纳米系统解决了与 GA 有关的稳定性、药效和安全性问题，为类似候选药物提供了一个简单、稳定和安全的纳米平台。
{"title":"Simplified Gambogic Acid Prodrug Nanoparticles to Improve Efficiency and Reduce Toxicity for Clinical Translation Potential","authors":"Ruyi Wang, Yuxiao Xiao, Zhongtao Zhang, Xiaoxian Huang, Wanfang Zhu, Xiao Ma, Feng Feng, Wenyuan Liu, Lingfei Han, Wei Qu","doi":"10.1002/adhm.202401950","DOIUrl":"https://doi.org/10.1002/adhm.202401950","url":null,"abstract":"Poor in vivo characteristics of gambogic acid (GA) and difficulties in industrial manufacturing of its nanocarriers have hindered its clinical translation. Therefore, a reproducible nano‐drug delivery system must be developed to realize simpler manufacture and address inherent defects of GA, such as short circulation and severe side effects, in order to facilitate its clinical application. Herein, a drug self‐assembled nanoparticles (NPs) consisting of a hydrophobic prodrug based on GA and oleyl alcohol (OA), as well as vitamin E‐polyethylene glycol succinate (TPGS) as a shield to improve the stability of the NPs is reported. The preparation method is simple enough to stably facilitate large‐scale manufacturing. The self‐assembled NPs exhibit a remarkably high drug‐loading capacity, and their prolonged circulation enables the NPs to demonstrate superior antitumor efficacy in both cellular and animal models. The flexible hydrophobic long chain wraps GA groups, which mitigates vascular irritation and reduces hemolysis rates. Consequently, the prodrug nano‐system addresses GA‐related concerns regarding stability, efficacy, and safety, offering a simple, stable, and secure nano‐platform for similar candidate drugs.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":null,"pages":null},"PeriodicalIF":10.0,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142259678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinically, conventional sutures for repair of short‐distance nerve injuries (< 5 mm) may contribute to uncontrolled inflammation and scar formation, thus negatively impacting nerve regeneration. To repair transected peripheral nerves with short distances, a rapid‐forming, robust adhesive chitosan hydrogel is prepared by synthesizing maleic and dopamine bi‐functionalized fungal‐sourced chitosan (DM) and subsequently photopolymerizing DM precursor solution. The hydrogel rapidly polymerized under UV light irradiation (≈2 s) and possessed a strong adhesive strength (273.33 ± 55.07 kPa), facilitating a fast bonding of nerve stump. Especially, its tailored degradation profile over 28 days supported both early gap bridging and subsequent nerve regeneration. Furthermore, deferoxamine (DFO), a pro‐angiogenic drug, is loaded into the hydrogel to reach sustainable release, accelerating axonal growth synergistically. A 3 mm long sciatic nerve defects model in rats is used to investigate the efficacy of DM@DFO hydrogel for repairing peripheral nerve defects. After 60 days, the DM@DFO hydrogel significantly outperformed conventional sutures and fibrin glue, improving motor and sensory recovery by reducing inflammation, inhibiting scar formation, and accelerating vascular regeneration within 14 days post‐repair. This work highlights the DM@DFO hydrogel as a promising tissue adhesive for effective short‐distance peripheral nerve repair.
{"title":"Rapid Forming, Robust Adhesive Fungal‐Sourced Chitosan Hydrogels Loaded with Deferoxamine for Sutureless Short‐Gap Peripheral Nerve Repair","authors":"Qi Dong, Kai Shi, Junjie Ai, Junfeng Yang, Kaidan Yang, Ruina Chen, Yachao Wang, Yingshan Zhou","doi":"10.1002/adhm.202401412","DOIUrl":"https://doi.org/10.1002/adhm.202401412","url":null,"abstract":"Clinically, conventional sutures for repair of short‐distance nerve injuries (< 5 mm) may contribute to uncontrolled inflammation and scar formation, thus negatively impacting nerve regeneration. To repair transected peripheral nerves with short distances, a rapid‐forming, robust adhesive chitosan hydrogel is prepared by synthesizing maleic and dopamine bi‐functionalized fungal‐sourced chitosan (DM) and subsequently photopolymerizing DM precursor solution. The hydrogel rapidly polymerized under UV light irradiation (≈2 s) and possessed a strong adhesive strength (273.33 ± 55.07 kPa), facilitating a fast bonding of nerve stump. Especially, its tailored degradation profile over 28 days supported both early gap bridging and subsequent nerve regeneration. Furthermore, deferoxamine (DFO), a pro‐angiogenic drug, is loaded into the hydrogel to reach sustainable release, accelerating axonal growth synergistically. A 3 mm long sciatic nerve defects model in rats is used to investigate the efficacy of DM@DFO hydrogel for repairing peripheral nerve defects. After 60 days, the DM@DFO hydrogel significantly outperformed conventional sutures and fibrin glue, improving motor and sensory recovery by reducing inflammation, inhibiting scar formation, and accelerating vascular regeneration within 14 days post‐repair. This work highlights the DM@DFO hydrogel as a promising tissue adhesive for effective short‐distance peripheral nerve repair.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":null,"pages":null},"PeriodicalIF":10.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142259676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dye‐based fluorescent organic nanoparticles are a specific class of nanoparticles obtained by nanoprecipitation in water of pure dyes only. While the photophysical and colloidal properties of the nanoparticles strongly depend on the nature of the aggregated dyes, their excellent brightness in the visible and in the near infrared make these nanoparticles a unique and versatile platform for in vivo application. This article examines the promising utilization of these nanoparticles for in vivo optogenetics applications. Their photophysical properties as well as their biocompatibility and their capacity to activate Chrimson opsin in vivo through the fluorescence reabsorption process are demonstrated. Additionally, an illustrative example of employing these nanoparticles in fear reduction in mice through closed‐loop stimulation is presented. Through an optogenetic methodology, the nanoparticles demonstrate an ability to selectively manipulate neurons implicated in the fear response and diminish the latter. Dye‐based fluorescent organic nanoparticles represent a promising and innovative strategy for optogenetic applications, holding substantial potential in the domain of translational neuroscience. This work paves the way for novel therapeutic modalities for neurological and neuropsychiatric disorders.
{"title":"Dye‐Based Fluorescent Organic Nanoparticles, New Promising Tools for Optogenetics","authors":"Jérémy Lesas, Thomas C.M. Bienvenu, Eleonore Kurek, Jean‐Baptiste Verlhac, Zoé Grivet, Maude Têtu, Delphine Girard, Frédéric Lanore, Mireille Blanchard‐Desce, Cyril Herry, Jonathan Daniel, Cyril Dejean","doi":"10.1002/adhm.202402132","DOIUrl":"https://doi.org/10.1002/adhm.202402132","url":null,"abstract":"Dye‐based fluorescent organic nanoparticles are a specific class of nanoparticles obtained by nanoprecipitation in water of pure dyes only. While the photophysical and colloidal properties of the nanoparticles strongly depend on the nature of the aggregated dyes, their excellent brightness in the visible and in the near infrared make these nanoparticles a unique and versatile platform for in vivo application. This article examines the promising utilization of these nanoparticles for in vivo optogenetics applications. Their photophysical properties as well as their biocompatibility and their capacity to activate Chrimson opsin in vivo through the fluorescence reabsorption process are demonstrated. Additionally, an illustrative example of employing these nanoparticles in fear reduction in mice through closed‐loop stimulation is presented. Through an optogenetic methodology, the nanoparticles demonstrate an ability to selectively manipulate neurons implicated in the fear response and diminish the latter. Dye‐based fluorescent organic nanoparticles represent a promising and innovative strategy for optogenetic applications, holding substantial potential in the domain of translational neuroscience. This work paves the way for novel therapeutic modalities for neurological and neuropsychiatric disorders.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":null,"pages":null},"PeriodicalIF":10.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142222705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yiyong Wu, Lulu Wang, Mengying Yan, Xufang Wang, Xin Liao, Cheng Zhong, Dingning Ke, Yi Lu
Neural Electrode Interface
In article 2400836, Dingning Ke, Yi Lu, and co-workers develop a highly robust electrode-neural interface using an in situ electrochemical deposition strategy combined with negatively charged group doping. This neural electrode boasts remarkable electrochemical and mechanical stability, as well as excellent biocompatibility, enabling long-term tracking and electrophysiological recording of neuronal activity in free-behaving animals.
{"title":"Poly(3,4-Ethylenedioxythiophene)/Functional Gold Nanoparticle films for Improving the Electrode-Neural Interface (Adv. Healthcare Mater. 23/2024)","authors":"Yiyong Wu, Lulu Wang, Mengying Yan, Xufang Wang, Xin Liao, Cheng Zhong, Dingning Ke, Yi Lu","doi":"10.1002/adhm.202470143","DOIUrl":"https://doi.org/10.1002/adhm.202470143","url":null,"abstract":"<p><b>Neural Electrode Interface</b></p><p>In article 2400836, Dingning Ke, Yi Lu, and co-workers develop a highly robust electrode-neural interface using an in situ electrochemical deposition strategy combined with negatively charged group doping. This neural electrode boasts remarkable electrochemical and mechanical stability, as well as excellent biocompatibility, enabling long-term tracking and electrophysiological recording of neuronal activity in free-behaving animals.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":null,"pages":null},"PeriodicalIF":10.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202470143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kenneth J. De Jesus Morales, Utari Santosa, Olga Brazhkina, Pranshu Rajurkar, Hanjoong Jo, Michael E. Davis
3D Bioprinting
Illustration of the 3D bioprinting process of biomaterials utilized to replicate the extracellular matrix (ECM) environment of an aortic valve leaflet. It showcases the precise layering of bioinks, which include primary cells and supportive scaffold components, to recreate the complex microstructure and functionality of heart valve ECM for advanced tissue engineering applications. More details can be found in article 2303972 by Michael E. Davis and co-workers. Created with BioRender.com.
三维生物打印生物材料的三维生物打印过程示意图，用于复制主动脉瓣叶的细胞外基质 (ECM) 环境。它展示了生物墨水的精确分层，其中包括原始细胞和支持性支架成分，从而为先进的组织工程应用再现心脏瓣膜 ECM 的复杂微观结构和功能。更多详情，请参阅 Michael E. Davis 及其合作者撰写的 2303972 号文章。使用 BioRender.com 创建。
{"title":"A Biomimetic Leaflet Scaffold for Aortic Valve Remodeling (Adv. Healthcare Mater. 23/2024)","authors":"Kenneth J. De Jesus Morales, Utari Santosa, Olga Brazhkina, Pranshu Rajurkar, Hanjoong Jo, Michael E. Davis","doi":"10.1002/adhm.202470146","DOIUrl":"https://doi.org/10.1002/adhm.202470146","url":null,"abstract":"<p><b>3D Bioprinting</b></p><p>Illustration of the 3D bioprinting process of biomaterials utilized to replicate the extracellular matrix (ECM) environment of an aortic valve leaflet. It showcases the precise layering of bioinks, which include primary cells and supportive scaffold components, to recreate the complex microstructure and functionality of heart valve ECM for advanced tissue engineering applications. More details can be found in article 2303972 by Michael E. Davis and co-workers. Created with BioRender.com.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":null,"pages":null},"PeriodicalIF":10.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202470146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiangfeng Lai, Lei Yu, Xiangyi Huang, Wil Gardner, Sarah E. Bamford, Paul J. Pigram, Shuhong Wang, Anton P. Le Brun, Benjamin W. Muir, Jiangning Song, Yajun Wang, Hsien‐Yi Hsu, Philip Wai Hong Chan, Hsin‐Hui Shen
In the current battle against antibiotic resistance, the resilience of Gram‐negative bacteria against traditional antibiotics is due not only to their protective outer membranes but also to mechanisms like efflux pumps and enzymatic degradation of drugs, underscores the urgent need for innovative antimicrobial tactics. Herein, this study presents an innovative method involving the synthesis of three furoxan derivatives engineered to self‐assemble into nitric oxide (NO) donor nanoparticles (FuNPs). These FuNPs, notably supplied together with polymyxin B (PMB), achieve markedly enhanced bactericidal efficacy against a wide spectrum of bacterial phenotypes at considerably lower NO concentrations (0.1–2.8 µg mL−1), which is at least ten times lower than the reported data for NO donors (≥200 µg mL−1). The bactericidal mechanism is elucidated using confocal, scanning, and transmission electron microscopy techniques. Neutron reflectometry confirms that FuNPs initiate membrane disruption by specifically engaging with the polysaccharides on bacterial surfaces, causing structural perturbations. Subsequently, PMB binds to lipid A on the outer membrane, enhancing permeability and resulting in a synergistic bactericidal action with FuNPs. This pioneering strategy underscores the utility of self‐assembly in NO delivery as a groundbreaking paradigm to circumvent traditional antibiotic resistance barriers, marking a significant leap forward in the development of next‐generation antimicrobial agents.
在当前与抗生素耐药性的斗争中，革兰氏阴性细菌对传统抗生素的抵抗力不仅取决于其保护性外膜，还取决于药物的外排泵和酶降解等机制，因此迫切需要创新的抗菌策略。在此，本研究提出了一种创新方法，涉及合成三种呋喃类衍生物，并将其设计为能自我组装成一氧化氮（NO）供体纳米粒子（FuNPs）。这些 FuNPs 特别是与多粘菌素 B (PMB) 一起使用时，在相当低的一氧化氮浓度（0.1-2.8 µg mL-1）下对多种细菌表型的杀菌效力明显增强，这比一氧化氮供体的报告数据（≥200 µg mL-1）至少低十倍。利用共焦、扫描和透射电子显微镜技术阐明了杀菌机制。中子反射仪证实，FuNPs 通过与细菌表面的多糖特异性结合，导致结构紊乱，从而引发膜破坏。随后，PMB 与外膜上的脂质 A 结合，增强了渗透性，从而与 FuNPs 形成协同杀菌作用。这一开创性战略强调了自组装在 NO 递送中的实用性，是规避传统抗生素耐药性障碍的开创性范例，标志着下一代抗菌剂开发的重大飞跃。
{"title":"Enhanced Nitric Oxide Delivery Through Self‐Assembling Nanoparticles for Eradicating Gram‐Negative Bacteria","authors":"Xiangfeng Lai, Lei Yu, Xiangyi Huang, Wil Gardner, Sarah E. Bamford, Paul J. Pigram, Shuhong Wang, Anton P. Le Brun, Benjamin W. Muir, Jiangning Song, Yajun Wang, Hsien‐Yi Hsu, Philip Wai Hong Chan, Hsin‐Hui Shen","doi":"10.1002/adhm.202403046","DOIUrl":"https://doi.org/10.1002/adhm.202403046","url":null,"abstract":"In the current battle against antibiotic resistance, the resilience of Gram‐negative bacteria against traditional antibiotics is due not only to their protective outer membranes but also to mechanisms like efflux pumps and enzymatic degradation of drugs, underscores the urgent need for innovative antimicrobial tactics. Herein, this study presents an innovative method involving the synthesis of three furoxan derivatives engineered to self‐assemble into nitric oxide (NO) donor nanoparticles (FuNPs). These FuNPs, notably supplied together with polymyxin B (PMB), achieve markedly enhanced bactericidal efficacy against a wide spectrum of bacterial phenotypes at considerably lower NO concentrations (0.1–2.8 µg mL<jats:sup>−1</jats:sup>), which is at least ten times lower than the reported data for NO donors (≥200 µg mL<jats:sup>−1</jats:sup>). The bactericidal mechanism is elucidated using confocal, scanning, and transmission electron microscopy techniques. Neutron reflectometry confirms that FuNPs initiate membrane disruption by specifically engaging with the polysaccharides on bacterial surfaces, causing structural perturbations. Subsequently, PMB binds to lipid A on the outer membrane, enhancing permeability and resulting in a synergistic bactericidal action with FuNPs. This pioneering strategy underscores the utility of self‐assembly in NO delivery as a groundbreaking paradigm to circumvent traditional antibiotic resistance barriers, marking a significant leap forward in the development of next‐generation antimicrobial agents.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":null,"pages":null},"PeriodicalIF":10.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142222707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhicheng Zhang, Junjie Ma, Tao Xu, Tao Wang, Xueying Jia, Jiawei Lin, Chang Lv, Liang Cao, Yulong Ying, Lvlv Ji, Sheng Wang, Caiyun Fu
Biomimetic Fabric Dressing
In article 2401005, Sheng Wang, Caiyun Fu, and co-workers present a novel biomimetic fabric inspired by plant transpiration, aimed to enhancing diabetic wound healing. The fabric integrates asymmetrically grown TiO2 micro/nanostructures with commercial textiles, emulating critical plant features: hierarchically porous networks and hydrophilic water conduction channels. The composite fabric provides superior exudate management and antibacterial properties to effectively tackle chronic wound challenges.
Baohong Chen, Bingzhi He, Alexander M. Tucker, Ian Biluck, Thomas H. Leung, Thomas P. Schaer, Shu Yang
Reversible adhesives for wound care improve patient experiences by permitting reuse and minimizing further tissue injury. Existing reversible bandages are vulnerable to water and can undergo unwanted deformation during removal and readdressing procedures. Here, a biocompatible, multilayered, reversible wound dressing film that conforms to skin and is waterproof is designed. The inner layer is capable of instant adhesion to various substrates upon activation of the dynamic boronic ester bonds by water; intermediate hydrogel layer and outer silicone backing layer can enhance the dressing's elasticity and load distribution for adhesion, and the silicone outer layer protects the dressing from exposure to water. The adhesive layer is found to be biocompatible with mouse skin. Skin injuries on the mouse skin heal more rapidly with the film compared to no dressing controls. Evaluations of the film on skin of freshly euthanized minipigs corroborate the findings in the mouse model. The film remains attached to skins without delamination despite subjecting to various degrees of deformation. Exposure to water softens the film to allow removal from the skin without pulling any hair off. The multilayered design considers soft mechanics in each layer and will offer new insights to improve wound dressing performance and patient comfort.
{"title":"An Environmentally Stable, Biocompatible, and Multilayered Wound Dressing Film with Reversible and Strong Adhesion","authors":"Baohong Chen, Bingzhi He, Alexander M. Tucker, Ian Biluck, Thomas H. Leung, Thomas P. Schaer, Shu Yang","doi":"10.1002/adhm.202400827","DOIUrl":"https://doi.org/10.1002/adhm.202400827","url":null,"abstract":"Reversible adhesives for wound care improve patient experiences by permitting reuse and minimizing further tissue injury. Existing reversible bandages are vulnerable to water and can undergo unwanted deformation during removal and readdressing procedures. Here, a biocompatible, multilayered, reversible wound dressing film that conforms to skin and is waterproof is designed. The inner layer is capable of instant adhesion to various substrates upon activation of the dynamic boronic ester bonds by water; intermediate hydrogel layer and outer silicone backing layer can enhance the dressing's elasticity and load distribution for adhesion, and the silicone outer layer protects the dressing from exposure to water. The adhesive layer is found to be biocompatible with mouse skin. Skin injuries on the mouse skin heal more rapidly with the film compared to no dressing controls. Evaluations of the film on skin of freshly euthanized minipigs corroborate the findings in the mouse model. The film remains attached to skins without delamination despite subjecting to various degrees of deformation. Exposure to water softens the film to allow removal from the skin without pulling any hair off. The multilayered design considers soft mechanics in each layer and will offer new insights to improve wound dressing performance and patient comfort.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":null,"pages":null},"PeriodicalIF":10.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142222710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A dual-wavelength differential background noise suppressed photoacoustic tomography is developed for accurate drug monitoring. This technique can help to avoid damage to healthy tissues during treatment. More details can be found in article number 2400517 by Haobin Chen, Jiaying Xiao, and co-workers.
双波长差分光声层析成像技术
{"title":"Semiconducting Polymer Dots for Dual-Wavelength Differential Background-Suppressed Photoacoustic Imaging (Adv. Healthcare Mater. 23/2024)","authors":"Bo Wang, Lingfeng Li, Ye Liu, Zhuojun Xie, Sile Deng, Xiaoju Men, Changfeng Wu, Haobin Chen, Jiaying Xiao","doi":"10.1002/adhm.202470144","DOIUrl":"10.1002/adhm.202470144","url":null,"abstract":"<p><b>Dual-Wavelength Differential Photoacoustic Tomography</b></p><p>A dual-wavelength differential background noise suppressed photoacoustic tomography is developed for accurate drug monitoring. This technique can help to avoid damage to healthy tissues during treatment. More details can be found in article number 2400517 by Haobin Chen, Jiaying Xiao, and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":null,"pages":null},"PeriodicalIF":10.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202470144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142227606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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