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Comparative analysis of extraction methods, proximate composition, and physicochemical and functional properties of fruit seed proteins: A comprehensive review 水果种子蛋白的提取方法、基本成分、理化性质和功能特性的比较分析
Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2023-10-24 DOI: 10.1002/efd2.117
Adharsh Ashok N., Manmath Sontakke

This comprehensive review delves into the realm of fruit seed proteins, examining their extraction methods, physicochemical properties, and functional characteristics. These proteins exhibit tremendous potential for diverse applications within the food industry. By gaining insights into efficient extraction techniques and understanding the physicochemical and functional properties of fruit seed proteins, researchers and industry professionals can harness their advantages to develop innovative food products. Various extraction methods, such as acid alkali, microwave-assisted, ultrasound-assisted, reverse micelle extraction, and the Box–Behnken experimental design, have been used for extracting proteins from a range of fruit seeds, including jackfruit, kiwi, watermelon, date palm, and grape seeds. The selection of these methods was based on their efficiency, protein yield, and compatibility with fruit seed proteins, with any associated limitations duly acknowledged by the researchers. The review also explores physicochemical characterization techniques such as Fourier transform infrared, thermogravimetric analysis, differential scanning calorimetry, and scanning electron microscopy, used specifically for jackfruit seed protein, while delving into essential functional properties including solubility, water-binding capacity, oil-binding capacity, emulsifying capacity, foaming capacity, and bulk density. These properties play a crucial role in determining the suitability of fruit seed proteins for various food applications, significantly impacting factors like texture, crispiness, and color. Waste fruit seeds, often overlooked, can serve as a valuable source of proteins, possessing multifunctional properties encompassing nutrition, structure, enzymes, emulsification, foaming, gelation, and thickening. However, compared to other protein sources, fruit seed proteins have received limited scientific attention, rendering this review a distinctive and valuable contribution to the existing literature by offering comprehensive insights into extraction methods and properties.

这篇综合综述深入到水果种子蛋白质的领域,检查他们的提取方法,理化性质和功能特征。这些蛋白质在食品工业的各种应用中显示出巨大的潜力。通过深入了解有效的提取技术和了解水果种子蛋白质的物理化学和功能特性,研究人员和行业专业人员可以利用他们的优势开发创新的食品。各种提取方法,如酸碱、微波辅助、超声辅助、反胶束提取和Box-Behnken实验设计,已被用于从一系列水果种子中提取蛋白质,包括菠萝蜜、猕猴桃、西瓜、枣椰树和葡萄籽。这些方法的选择是基于它们的效率、蛋白质产量和与水果种子蛋白质的相容性,以及研究人员适当承认的任何相关局限性。本文还探讨了用于菠萝蜜种子蛋白的傅立叶变换红外、热重分析、差示扫描量热法和扫描电子显微镜等理化表征技术,同时深入研究了菠萝蜜种子蛋白的基本功能特性,包括溶解度、水结合力、油结合力、乳化能力、发泡能力和体积密度。这些特性在决定水果种子蛋白在各种食品应用中的适用性方面起着至关重要的作用,对质地、松脆度和颜色等因素有重大影响。经常被忽视的废弃水果种子可以作为蛋白质的宝贵来源,具有多种功能,包括营养、结构、酶、乳化、发泡、凝胶和增稠。然而,与其他蛋白质来源相比,水果种子蛋白质受到的科学关注有限,因此本综述通过对提取方法和性质的全面见解,对现有文献做出了独特而有价值的贡献。
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引用次数: 0
Pomegranate peel polyphenols as an antioxidant additive for the development and characterization of a new active pectin edible film 石榴皮多酚抗氧化添加剂用于新型活性果胶食用膜的研制与表征
Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2023-10-19 DOI: 10.1002/efd2.115
Rene Diaz-Herrera, Olga B. Alvarez-Pérez, Janeth Ventura-Sobrevilla, Alberto Ascacio-Valdés, Miguel A. Aguilar-Gonzalez, Juan Buenrostro-Figueroa, Cristobal N. Aguilar

Natural origin products are an appealing substitute for nonbiodegradable materials in the production of new materials to improve the packaging properties and to extend the shelf life quality of foods. The objective of this study was to formulate, elaborate, select, partially characterize, and evaluate the biological properties of an edible film based on pectin, candelilla wax, and glycerol, added with pomegranate peel polyphenols (PPP). An exploratory design 2k Box Hunter and Hunter was made, followed by a Box-Behnken design 3k to evaluate the properties of water vapor permeability (WVP) of the film, resulting in the film with 0.75% w/v of pectin, 0.2% w/v of candelilla wax, 0.05% v/v of glycerol and 0.02% w/v of PPP with one of the lowest values of WVP (1.78E−10 g/m.s.Pa). After characterization, this treatment showed good structural and optical properties and low humidity values compared to a control film. PPP showed the inhibitory capacity for DPPH (61.2%) and ABTS (48.5%) radicals and reducing activity with the reduction of ferric ion (FRAP) reaching a value of 1676.5 mg TE/g PPP.

在生产新材料以改善包装性能和延长食品保质期的过程中,天然产品是非生物降解材料的一种有吸引力的替代品。本研究的目的是制备、阐述、选择、部分表征和评估一种以果胶、蜜蜡和甘油为基础,添加石榴皮多酚(PPP)的可食用薄膜的生物学特性。进行了探索性设计2k Box Hunter和Hunter,然后进行了Box Behnken设计3k,以评估薄膜的水蒸气渗透性(WVP g/m.s.Pa)。在表征之后,与对照膜相比,该处理显示出良好的结构和光学性能以及低湿度值。PPP对DPPH(61.2%)和ABTS(48.5%)自由基具有抑制作用,对铁离子(FRAP)的还原活性达到1676.5 mg TE/g PPP。
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引用次数: 0
Evaluation of food μPADs with the new tech perspectives and future prospects 食品μPAD的新技术评价及未来展望
Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2023-10-19 DOI: 10.1002/efd2.116
Nagihan Okutan Arslan, Levent Trabzon

Food microfluidic paper-based analytical devices (µPADs) are powerful tools to create total analysis systems and have long been demonstrated to be useful for safety and quality applications. Thanks to new technological innovations food µPADs offer exciting new possibilities. This review introduces how µPADs are obtained from chromatography, filter, or office papers and detect analytes from a food sample. We introduce the most current developments in the use of µPADs with an emphasis on paper types, adapted new technologies, and detection limits. Classifications are also made on food µPADs according to applied innovations and adapted novel technologies. In the first section, simple forms of µPADs for the detection of pathogen, mycotoxin, pesticides, and other food components are discussed with technical details. Then, we introduce multisensing approaches for high throughput analysis and a concise summary will be given. In the case of three-dimensional (3D) µPADs, the use of 3D is discussed and compared to 2D µPADs in terms of its advantageous with the example of a food colorant test device. In the following section, smartphone adoption to µPADs is introduced in detail with eight different assay examples. Centrifugal platform for nickel assay is demonstrated as an enabling approach with shortened assay times by rotational velocity. The potential of user-friendly hybrid devices is also summarized in the last part. Finally, we present an outlook to underline the opportunities created by smartphone-based and intelligent µPADs for food safety and quality with real success perspectives

食品微流体纸基分析设备(µPAD)是创建全面分析系统的强大工具,长期以来一直被证明对安全和质量应用有用。由于新的技术创新,食品µPAD提供了令人兴奋的新可能性。这篇综述介绍了如何从色谱、过滤器或办公文件中获得µPAD,并检测食品样品中的分析物。我们介绍了µPAD使用的最新进展,重点介绍了纸张类型、适用的新技术和检测极限。还根据应用创新和适应的新技术对食品µPAD进行了分类。在第一节中,讨论了用于检测病原体、真菌毒素、农药和其他食品成分的简单形式的µPAD,并提供了技术细节。然后,我们介绍了用于高通量分析的多感知方法,并将给出简要总结。在三维(3D)µPAD的情况下,讨论了3D的使用,并以食品着色剂测试装置为例,将其与2DµPAD进行了比较。在下一节中,通过八个不同的分析示例详细介绍了智能手机在µPAD中的应用。用于镍测定的离心平台被证明是一种通过旋转速度缩短测定时间的可行方法。最后一部分还总结了用户友好型混合设备的潜力。最后,我们展望了基于智能手机和智能µPAD在食品安全和质量方面创造的机会,并从真正的成功角度进行了展望
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引用次数: 0
Nutritional exploration of foxtail millet (Setaria italica) in addressing food security and its utilization trends in food system 谷子应对粮食安全的营养探索及其在粮食系统中的利用趋势
Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2023-09-27 DOI: 10.1002/efd2.111
Rhythm Kalsi, Jasleen Kaur Bhasin

Millets are recognized as nutritional grains that have been important for preventing the malnutrition and significantly enhancing the human health. Foxtail millet (Setaria italica) is a C4, self pollinating millet species belonging to family Poaceae; acknowledged as Italian millet, Chinese millet or German millet. Being the oldest crops to be cultivated and produced, it is also utilized as a bird feed in African regions of the world. As far as the nutritional content is concerned, it has substantial amounts of carbohydrates (60–65 g), protein (12.3 g), fiber (6 g), minerals (Phosphorous, calcium, iron, zinc, magnesium, sodium), and phytochemicals (Phenols, Ferulic, chlorogenic acids, and p-coumaric, flavonoids, carotenoids, tocopherol, and tocotrienol). Additionally foxtail millet is reported to have anti inflammatory, antioxidant, anticancerous, antihypolipidemic antihyperglycemic properties that may serve well with respect to pharmacological relevance. Apart from the medicinal prospect, its food utilization for making bakery, weaning, fermented as well as extruded goods are studied in the literature. Thus it can be mentioned that foxtail millet has a promising position in strengthening dietary quality and food security of world, thereby functioning as an emissary crop to replenish other economically valuable crops against environmental constraints even while supplying food for people and livestock via biotechnological techniques.

小米是公认的营养谷物,对预防营养不良和显著改善人类健康具有重要意义。狐尾小米(Setaria italica)是一个C4,自花授粉的小米属植物;公认为意大利小米、中国小米或德国小米。作为种植和生产的最古老的作物,它在世界的非洲地区也被用作鸟类饲料。就营养成分而言,它含有大量的碳水化合物(60-65 g) ,蛋白质(12.3 g) ,纤维(6 g) ,矿物质(磷、钙、铁、锌、镁、钠)和植物化学物质(酚类、阿魏酸、绿原酸和对香豆素类、黄酮类、类胡萝卜素、生育酚和生育三烯酚)。此外,据报道,小米具有抗炎、抗氧化、抗癌、抗低血压、抗高血糖的特性,在药理学方面可能很好。除了药用前景外,文献中还对其在面包、断奶、发酵和挤压制品中的应用进行了研究。由此可见,小米在加强世界膳食质量和粮食安全方面具有很好的地位,从而成为一种使者作物,在不受环境限制的情况下补充其他有经济价值的作物,即使是通过生物技术为人类和牲畜提供食物。
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引用次数: 0
Curcumin-loaded nanomedicines as therapeutic strategy in malaria management 姜黄素负载纳米药物在疟疾管理中的治疗策略
Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2023-09-18 DOI: 10.1002/efd2.113
Ruhul Amin, Chanam Melody Devi, Dona Sarkar, Javad Sharifi-Rad, Eda Sönmez Gürer, Anca Oana Docea, Daniela Calina

Malaria, a parasitic protozoan disease widespread in tropical climates, is transmitted by Plasmodium spp. Many people are affected by this significant public health disease, which has a high incidence of illness and mortality worldwide. Because drug-resistant parasites are on the rise, there are not enough controls on mosquitoes, and there are not any malaria vaccinations. Malaria is particularly challenging in developing countries. Antimalarial drugs approved by Food and Drug Administration are the main options for combating and preventing malaria; also the control of transmission at the level of mosquitoes is important. Current antimalarial chemotherapeutic therapies have significant clinical flaws such as Plasmodium resistance, the drugs that call for the development of novel drug candidates. To combat malaria, nanotechnology may give a viable alternative that is both more effective and safer than current treatment options. Nanotechnology-based curcumin formulations have proved to overcome the limitations of current therapies in terms of optimum therapeutic benefits, safety, and cost-efficiency, which increases a patient's capacity to adhere to prescribed medicine. The limits of current malaria therapies and the need to employ nanotechnological curcumin to treat malaria were addressed and discussed in this paper.

疟疾是一种广泛分布在热带气候中的寄生原生动物疾病,由疟原虫传播。许多人受到这种重要的公共卫生疾病的影响,这种疾病在全球范围内发病率和死亡率都很高。由于抗药性寄生虫正在增加,对蚊子的控制不够,也没有接种任何疟疾疫苗。疟疾在发展中国家尤其具有挑战性。经美国食品药品监督管理局批准的抗疟疾药物是防治疟疾的主要选择;在蚊子层面控制传播也很重要。目前的抗疟化疗疗法存在显著的临床缺陷,如疟原虫耐药性,这些药物需要开发新的候选药物。为了对抗疟疾,纳米技术可能会提供一种可行的替代方案,比目前的治疗方案更有效、更安全。基于纳米技术的姜黄素制剂已被证明在最佳治疗效果、安全性和成本效益方面克服了当前疗法的局限性,从而提高了患者坚持处方药的能力。本文讨论了当前疟疾疗法的局限性以及使用纳米技术姜黄素治疗疟疾的必要性。
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引用次数: 0
Banana and its by-products: A comprehensive review on its nutritional composition and pharmacological benefits 香蕉及其副产品的营养成分和药理作用综述
Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2023-09-13 DOI: 10.1002/efd2.110
Payal Kumari, Supriya S. Gaur, Ravindra K. Tiwari

Bananas are widely popular as a key member of the Musaceae family and also considered a rich source of several nutrients, especially bioactive compounds. Besides, bananas are extensively grown in tropical and subtropical regions and are easily available for various use cases, that is, food industry and health benefits. Other than banana, its by-products such as peel, pseudo-stems, leaves, and blossoms are also rich in several nutrients, for example, carbohydrates, protein, dietary fiber, vitamins, and so on. Moreover, their consumption intends to provide several therapeutic benefits, particularly the dietary fiber and phenolic compounds. Furthermore, bananas and their by-products have been found to possess antimicrobial, anticancer, and antioxidant activities. In spite of countless benefits, these residues are often discarded as waste. Observing these benefits, the current review focuses on the broad range of bioactive chemical and pharmacological elements in bananas and their by-products. Also, this work focuses on their use in several food industries. As a result of the findings, the presented review reveals several innovative aspects of bananas and their products which can be utilized as a sustainable source of income for the agriculture industry.

香蕉作为Musaceae家族的关键成员而广受欢迎,也被认为是多种营养物质的丰富来源,尤其是生物活性化合物。此外,香蕉广泛生长在热带和亚热带地区,很容易用于各种用途,即食品工业和健康益处。除香蕉外,香蕉的副产品,如果皮、假茎、叶子和花朵,也富含多种营养素,如碳水化合物、蛋白质、膳食纤维、维生素等。此外,食用香蕉还具有多种治疗功效,特别是膳食纤维和酚类化合物。此外,香蕉及其副产品已被发现具有抗菌、抗癌和抗氧化活性。尽管有无数好处,但这些残留物经常被当作废物丢弃。鉴于这些益处,目前的综述集中在香蕉及其副产品中广泛的生物活性化学和药理学元素上。此外,这项工作重点关注它们在几个食品行业中的应用。作为研究结果的结果,本综述揭示了香蕉及其产品的几个创新方面,这些方面可以作为农业的可持续收入来源。
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引用次数: 0
Advances in the natural α-glucosidase inhibitors 天然α-葡萄糖苷酶抑制剂研究进展
Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2023-09-12 DOI: 10.1002/efd2.112
Didem Şöhretoğlu, Gülin Renda, Randolph Arroo, Jianbo Xiao, Suat Sari

α-Glucosidase (AG) inhibitors, one of the classes of oral antidiabetics used to treat type 2 diabetes mellitus, delay digestion and absorption of glucose, which in turn, has a lowering effect on postprandial blood glucose and insulin levels. Natural products are a great source for the development of new AG inhibitory drug candidates. We aim to summarize advances in natural AG inhibitors according to their secondary metabolite groups in the last decade. Their mechanisms of action and structure–activity relationships will especially be discussed.

α-葡萄糖苷酶(AG)抑制剂是一类用于治疗2型糖尿病的口服抗糖尿病药物,可延迟葡萄糖的消化和吸收,进而降低餐后血糖和胰岛素水平。天然产物是开发新的AG抑制候选药物的重要来源。我们的目的是根据天然AG抑制剂的次级代谢产物组总结过去十年来的进展。将特别讨论它们的作用机制和结构-活动关系。
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引用次数: 0
A review on flaxseeds: Nutritional profile, health benefits, value added products, and toxicity 亚麻籽综述:营养概况、健康益处、附加值产品和毒性
Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2023-09-07 DOI: 10.1002/efd2.114
Jhilam Pramanik, Akash Kumar, Bhupendra Prajapati

Flaxseed has been consumed by people for a very long time due to its nutritional value and medicinal applications. In India, flaxseed is used for both culinary and medicinal reasons. About 45% of alpha-linolenic acid (ALA), 28%–30% protein, and 35% fiber are present in flaxseeds. The finest source of omega-3 fatty acids for those who do not consume seafood is flaxseed. Flaxseeds have lignin, of which primary lignan is secoisolariciresinol diglycoside, with low amounts of isolariciresinol, lariciresinol, pinoresinol, and matairesinol. Flaxseed is probably safe for most grown-ups. The daily number of bowel movements may increase if flaxseed is included in the diet. Additionally, it may result in side effects such as gas, bloating, stomach pain, and nausea. Higher dosages are probably going to cause more secondary effects. Due to the nutritional profile of flaxseeds, they exhibit various health benefits which include; improving cardiac health, improving brain development, improving skin health, improving gut health, maintaining blood sugar level, reducing the risk of renal diseases, and several types of cancers. The purpose of this study is to provide a general overview of the nutritional profile, health benefits, value-added products, and toxicity of flaxseeds.

亚麻籽因其营养价值和药用价值而被人们长期食用。在印度,亚麻籽被用于烹饪和药用。亚麻籽中含有约45%的α-亚麻酸(ALA)、28%–30%的蛋白质和35%的纤维。对于那些不吃海鲜的人来说,ω-3脂肪酸的最佳来源是亚麻籽。亚麻籽具有木质素,其中初级木脂素是仲蓖麻油醇-二甘糖苷,具有少量的异蓖麻油醇、拉里西醇、皮诺树脂醇和马泰瑞西诺。亚麻籽对大多数成年人来说可能是安全的。如果饮食中含有亚麻籽,每天排便次数可能会增加。此外,它可能会导致副作用,如气体、腹胀、胃痛和恶心。更高的剂量可能会导致更多的副作用。由于亚麻籽的营养特性,它们表现出多种健康益处,包括:;改善心脏健康,改善大脑发育,改善皮肤健康,改善肠道健康,保持血糖水平,降低肾脏疾病和几种癌症的风险。本研究的目的是对亚麻籽的营养状况、健康益处、附加值产品和毒性进行概述。
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引用次数: 0
Alginate/guacamole edible films as moisture barrier layers in multicomponent foods 海藻酸盐/鳄梨酱可食用薄膜在多组分食品中的防潮层作用
Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2023-08-30 DOI: 10.1002/efd2.109
Matheus Carvalho de Matos, Jackson Andson de Medeiros, Leticia Bueno Santos, Henriette M. C. de Azeredo

In multicomponent foods having both moist and dry components (e.g., pizzas and tacos), moisture migration between components causes undesirable texture changes (e.g., loss of crispiness of the dry component). In this study, different proportions of alginate (film matrix), guacamole (hydrophobic component with sensory appeal), and glycerol (plasticizer) were combined to form edible films to be used as a moisture barrier between moist and dry components of multicomponent foods. Alginate was the component that most contributed to increase the film strength and to reduce its water vapor permeability (WVP). Guacamole, due to the presence of avocado lipids, enhanced the film hydrophobicity, although not having decreased the WVP (as expected), since it promoted discontinuities in the alginate structure. The film with the lowest WVP (containing an alginate/guacamole/glycerol dry mass ratio of 25/60/15) was inserted between nachos and tomato sauce, being able to reduce the crispiness loss of nachos during a 50-min storage.

在同时含有潮湿和干燥成分的多组分食品(如披萨和玉米卷)中,成分之间的水分迁移会导致不希望的质地变化(如干燥成分的脆度损失)。在这项研究中,不同比例的藻酸盐(膜基质)、鳄梨酱(具有感官吸引力的疏水成分)和甘油(增塑剂)被结合形成可食用的膜,用作多组分食品中潮湿和干燥成分之间的水分屏障。海藻酸盐是对提高膜强度和降低其水蒸气渗透性(WVP)贡献最大的组分。由于鳄梨脂质的存在,鳄梨酱增强了膜的疏水性,尽管没有降低WVP(如预期的那样),因为它促进了藻酸盐结构的不连续性。将WVP最低的薄膜(含有25/60/15的藻酸盐/鳄梨酱/甘油干质量比)插入玉米片和番茄酱之间,能够减少玉米片在50分钟储存期间的脆度损失。
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引用次数: 0
LC-MS based metabolite profiling, in-vitro antioxidant and in-vivo antihyperlipidemic activity of Nigella sativa extract 基于LC-MS的Nigella sativa提取物代谢产物分析、体外抗氧化和体内抗高血压活性
Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2023-07-28 DOI: 10.1002/efd2.107
Amit Kumar Shrivastava, Laxmi Shrestha, Buddhi Raj Pokhrel, Bishal Joshi, Gopal Lamichhane, Bojana Vidović, Niranjan Koirala

The aim of this study was to identify the bioactive phytoconstituents present in the aqueous extract of Nigella sativa and also, to evaluate the antioxidant and antihyperlipidemic activity in Wistar rats. The LC-MS/MS analysis was assessed for the determination of different bioactive compounds present in N. sativa extract. Total phenolic and flavonoid content were determined by using validated Folin-Ciocalteu and Aluminum chloride colorimetric methods, respectively. The in-vitro antioxidant and in-vivo antihyperlipidemic activity in Wistar rats were also evaluated. Preliminary phytochemical screening of the extract showed the presence of alkaloids, flavonoids, phenols, glycosides, and amino acids in the aqueous extract. The bioactive compounds of the aqueous extract were identified through LC-MS/MS analysis. The in-vitro antioxidant activity of N. sativa showed the highest free radical scavenging capacity in DPPH, H2O2, and OH radical scavenging assays with IC50 values 11.916 ± 2.828, 30.294 ± 13.790, and 12.048 ± 2.828 µg/mL, respectively. Evaluation of antihyperlipidemic activity of extract in Wistar rats showed that a high dose (800 mg/kg) of extract significantly decreased total cholesterol (TC) 71.76 ± 6.91 mg/dL, TG 83.6 ± 8.09 mg/dL, low-density lipoproteins (LDL-c) 33.86 ± 6.05 mg/dL, very low-density lipoproteins (VLDL-c) 16.72 ± 1.61 mg/dL level in blood. However, the HDL-C level was significantly improved (21.18 ± 1.80 mg/dL) as compared to HFD-induced control rats (11.76 ± 1.14 mg/dL) after 28 days of treatment. Also, at the same dose, animal body weight was also decreased to 162.6 ± 16.40 g compared with control 184.4 ± 10.24 g. The aqueous extract of N. sativa was found to be an effective natural source of antioxidant and hypolipidemic agents. This activity was attributed to the presence of diverse bioactive compounds in it.

本研究的目的是鉴定黑草水提物中存在的生物活性成分,并评价其抗氧化和抗高脂血症的活性。采用LC-MS/MS分析方法测定了苜蓿提取物中不同生物活性成分的含量。采用经验证的福林比色法和氯化铝比色法分别测定总酚和类黄酮含量。并对其体外抗氧化和体内抗高脂血症活性进行了评价。初步的植物化学筛选表明,水提物中存在生物碱、类黄酮、酚类、苷类和氨基酸。通过LC-MS/MS分析鉴定了水提物的生物活性成分。对DPPH、H2O2和OH自由基的清除能力最强,IC50值分别为11.916±2.828、30.294±13.790和12.048±2.828µg/mL。高剂量(800 mg/kg)提取液可显著降低Wistar大鼠血中总胆固醇(TC) 71.76±6.91 mg/dL, TG 83.6±8.09 mg/dL,低密度脂蛋白(LDL-c) 33.86±6.05 mg/dL,极低密度脂蛋白(VLDL-c) 16.72±1.61 mg/dL。然而,在治疗28天后,与hfd诱导的对照组大鼠(11.76±1.14 mg/dL)相比,HDL-C水平显著提高(21.18±1.80 mg/dL)。在相同剂量下,动物体重由对照组的184.4±10.24 g降至162.6±16.40 g。苜蓿的水提取物被发现是一种有效的抗氧化剂和降血脂剂的天然来源。这种活性归因于其中存在多种生物活性化合物。
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引用次数: 0
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