Nguyen Minh Tri, V. N. Toan, H. M. Linh, Ngô Thị Thanh Mai, Tran Thi-Hai-Yen, Ngo Thi Thuy, Nguyen Thi Thu Huong, Pham Thi Thuy Van, T. P. H. Yen, Nguyen Thi Quynh Giang, H. T. Van, N. Thanh
: Azide derivatives of isatins were the initial materials needed for click chemistry, so as to form 1,2,3-triazoles in order to synthesize the hybrid compounds of 1,2,3-triazole–isatin with monosaccharide moieties. The required substituted isatins were prepared according to the Sandmeyer method from corresponding substituted anilines. N -( ω -bromoalkyl) isatins were prepared through the nucleophilic reaction, S N 2, of (un)substituted isatins with appropriate dibromoalkanes. Some ω -azidoalkylisatins were synthesized by the reaction of corresponding ω -bromoalkylisatins with sodium azide. The reactions were performed in dry DMF as solvents in the presence of K 2 CO 3 as the base and KI as the promoting agent. The product yields reached 30–85%.
{"title":"Reaction of Some Substituted (Un)Substituted Isatins with 1,ω-Alkanes and Their Products with Sodium Azide","authors":"Nguyen Minh Tri, V. N. Toan, H. M. Linh, Ngô Thị Thanh Mai, Tran Thi-Hai-Yen, Ngo Thi Thuy, Nguyen Thi Thu Huong, Pham Thi Thuy Van, T. P. H. Yen, Nguyen Thi Quynh Giang, H. T. Van, N. Thanh","doi":"10.3390/ecsoc-25-11716","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11716","url":null,"abstract":": Azide derivatives of isatins were the initial materials needed for click chemistry, so as to form 1,2,3-triazoles in order to synthesize the hybrid compounds of 1,2,3-triazole–isatin with monosaccharide moieties. The required substituted isatins were prepared according to the Sandmeyer method from corresponding substituted anilines. N -( ω -bromoalkyl) isatins were prepared through the nucleophilic reaction, S N 2, of (un)substituted isatins with appropriate dibromoalkanes. Some ω -azidoalkylisatins were synthesized by the reaction of corresponding ω -bromoalkylisatins with sodium azide. The reactions were performed in dry DMF as solvents in the presence of K 2 CO 3 as the base and KI as the promoting agent. The product yields reached 30–85%.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87368892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Squeo, Elisa Lassi, C. Botta, S. Luzzati, B. Vercelli, S. Zappia, M. Pasini
A single paragraph of about 100 words to give a brief introduction to your work.
用100字左右的一段话简要介绍你的作品。
{"title":"Weak Donor, Strong Acceptor Thienopyrazine-Based Polymers for Fine Tuning of LUMO Levels—Suitable Materials for Energy and Storage Solutions","authors":"B. Squeo, Elisa Lassi, C. Botta, S. Luzzati, B. Vercelli, S. Zappia, M. Pasini","doi":"10.3390/ecsoc-25-11742","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11742","url":null,"abstract":"A single paragraph of about 100 words to give a brief introduction to your work.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86993960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Reaction of NaCN with N -(tosylmethyl)ureas, prepared by condensation of urea with aldehydes and p -toluenesulfinic acid, has been studied. Generally, this reaction afforded the corresponding α -ureido nitriles. Some mechanistic aspects of cyanide-anion amidoalkylation with N -(to-sylmethyl)ureas were discussed based on DFT calculations.
{"title":"Reaction of N-(tosylmethyl)ureas with NaCN: Synthetic and Mechanistic Aspects","authors":"A. Fesenko, A. Shutalev","doi":"10.3390/ecsoc-25-11759","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11759","url":null,"abstract":": Reaction of NaCN with N -(tosylmethyl)ureas, prepared by condensation of urea with aldehydes and p -toluenesulfinic acid, has been studied. Generally, this reaction afforded the corresponding α -ureido nitriles. Some mechanistic aspects of cyanide-anion amidoalkylation with N -(to-sylmethyl)ureas were discussed based on DFT calculations.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76657907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Catarina M. M. Coelho, M. J. Fernandes, David M. Pereira, R. Pereira, A. Fortes, M. S. T. Gonçalves, E. M. Castanheira
{"title":"Synthesis, Insecticidal Activity and Nanoencapsulation Studies of Alkoxy Alcohols from Eugenol","authors":"Catarina M. M. Coelho, M. J. Fernandes, David M. Pereira, R. Pereira, A. Fortes, M. S. T. Gonçalves, E. M. Castanheira","doi":"10.3390/ecsoc-25-11788","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11788","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82974901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: In the present work we have synthesized fluorescent carbon dots (CDs) through solvothermal treatment of Buchnania lanzan leaves extract at 160 °C for 4 h in oven. Here, Buchnania lanzan leaves serve as a renewable source of carbon. The obtained blackish brown CDs solution was centrifuged and the supernatant was filtered through syringe filter (0.22 µm). Further, the CDs solution was dried in vacuum oven to obtain powder. The synthesized CDs were characterized by different techniques including UV-Visible spectroscopy, fluorescence spectroscopy, fourier trans-form infrared (FTIR), zeta potential, x-ray diffraction (XRD). The as prepared CDs solution was found brownish colored in day light while exhibited green fluorescence under UV light. UV-Visible absorption spectrum displayed characteristic shoulder peaks of CDs at 257 nm and at 356 nm. In the fluorescence spectra, excitation dependent emission behaviour of CDs was seen, which is one of the distinct characteristics of CDs. The negative zeta potential and characteristic peaksin FTIR, suggested presence of carbonyl, amine and hydroxyl functional groups on the CDs surface. XRD spectrum exhibited broad peak at 2θ=19°, suggesting amorphous nature of CDs similar as reported in earlier works. As we have synthesized surface functionalized fluorescent carbon dots from a renewable and abundant precursor, this method can be highly useful in large scale synthesis of carbon dots with reduced costs and will find potential applications in the field of drug delivery,
{"title":"Green Synthesis of Fluorescent Carbon Dots through Solvothermal Treatment of Buchnania lanzan Leaf Extract","authors":"P. Jana, A. Dev","doi":"10.3390/ecsoc-25-11648","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11648","url":null,"abstract":": In the present work we have synthesized fluorescent carbon dots (CDs) through solvothermal treatment of Buchnania lanzan leaves extract at 160 °C for 4 h in oven. Here, Buchnania lanzan leaves serve as a renewable source of carbon. The obtained blackish brown CDs solution was centrifuged and the supernatant was filtered through syringe filter (0.22 µm). Further, the CDs solution was dried in vacuum oven to obtain powder. The synthesized CDs were characterized by different techniques including UV-Visible spectroscopy, fluorescence spectroscopy, fourier trans-form infrared (FTIR), zeta potential, x-ray diffraction (XRD). The as prepared CDs solution was found brownish colored in day light while exhibited green fluorescence under UV light. UV-Visible absorption spectrum displayed characteristic shoulder peaks of CDs at 257 nm and at 356 nm. In the fluorescence spectra, excitation dependent emission behaviour of CDs was seen, which is one of the distinct characteristics of CDs. The negative zeta potential and characteristic peaksin FTIR, suggested presence of carbonyl, amine and hydroxyl functional groups on the CDs surface. XRD spectrum exhibited broad peak at 2θ=19°, suggesting amorphous nature of CDs similar as reported in earlier works. As we have synthesized surface functionalized fluorescent carbon dots from a renewable and abundant precursor, this method can be highly useful in large scale synthesis of carbon dots with reduced costs and will find potential applications in the field of drug delivery,","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80092845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Invasive fungal infections require a long treatment schedule; however, treatment has become more cumbersome due to the development of resistance. Most antifungal moieties show systemic toxicity upon oral administration, leading to delivery of antifungal moieties via a topical route. Eberconazole (EBZ) is a BCS class II drug that has poor solubility and high permeability. It is a broad-spectrum imidazole derivative, which acts as a both fungicidal and fungistatic drug by inhibiting ergosterol synthesis. Various topical creams of EBZ are available in the market, but the lack of a proper dosing schedule and rapid removal lead to poor bioavailability. Niosomes are vesicular carriers that can entrap both hydrophilic and lipophilic drugs. Niosomal formulations have been prepared using Span20 (nonionic surfactant) and cholesterol by thin-film hydration (TFH) technique. During preformulation studies, the purity of EBZ was ascertained using FT-IR and melting point studies, while the standard calibration curve was prepared using UV-visible spectroscopy. The prepared niosomal formulations were characterized for their morphology, entrapment efficiency, particle size, and zeta potential. The formulation has shown 86 ± 0.85% entrapment efficiency, while the noisome appeared in a ring-like structure during its microscopic evaluation. Further evaluations of in vitro and in vivo release studies will be performed in the future for its efficacy and antifungal activity.
{"title":"Development and Evaluation of Eberconazole-Loaded Niosomes","authors":"Priyadarshi Aparajay, A. Dev","doi":"10.3390/ecsoc-25-11664","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11664","url":null,"abstract":": Invasive fungal infections require a long treatment schedule; however, treatment has become more cumbersome due to the development of resistance. Most antifungal moieties show systemic toxicity upon oral administration, leading to delivery of antifungal moieties via a topical route. Eberconazole (EBZ) is a BCS class II drug that has poor solubility and high permeability. It is a broad-spectrum imidazole derivative, which acts as a both fungicidal and fungistatic drug by inhibiting ergosterol synthesis. Various topical creams of EBZ are available in the market, but the lack of a proper dosing schedule and rapid removal lead to poor bioavailability. Niosomes are vesicular carriers that can entrap both hydrophilic and lipophilic drugs. Niosomal formulations have been prepared using Span20 (nonionic surfactant) and cholesterol by thin-film hydration (TFH) technique. During preformulation studies, the purity of EBZ was ascertained using FT-IR and melting point studies, while the standard calibration curve was prepared using UV-visible spectroscopy. The prepared niosomal formulations were characterized for their morphology, entrapment efficiency, particle size, and zeta potential. The formulation has shown 86 ± 0.85% entrapment efficiency, while the noisome appeared in a ring-like structure during its microscopic evaluation. Further evaluations of in vitro and in vivo release studies will be performed in the future for its efficacy and antifungal activity.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87873277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Amide-Stabilized Enols in the Enol-Ugi Reaction: A Five-Component Synthesis of Triamides","authors":"A. Neo, M. Castellano, J. L. Ramiro, C. Marcos","doi":"10.3390/ecsoc-25-11665","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11665","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78124630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Sadretdinova, A. Akhmetov, L. Dzhemileva, V. D’yakonov, A. Tuktarov, U. Dzhemilev
{"title":"Fullerenyl-1,2,3-Triazoles: Synthesis and Cytotoxic Activity","authors":"Z. Sadretdinova, A. Akhmetov, L. Dzhemileva, V. D’yakonov, A. Tuktarov, U. Dzhemilev","doi":"10.3390/ecsoc-25-11659","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11659","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75038447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Palladacycles as Functionalized Metal-Ligand Precursors, Contain Tridentate [Csp2, N, S] Ligands","authors":"Basma Al Janabi, J. M. Vila, J. M. Ortigueira","doi":"10.3390/ecsoc-25-11663","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11663","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89000220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation of the Effect of Selected Piperazine-2,5-Diones on Cartilage-Related Cells","authors":"J. Jampílek, J. Hošek, P. Bobál","doi":"10.3390/ecsoc-25-11650","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11650","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86126496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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