IF 3.5 2区医学 Q2 ONCOLOGY

Ejso

Pub Date : 2024-09-06 DOI: 10.1016/j.ejso.2024.108654

引用次数: 0

Vaginal surgery for cervical cancer based on the recent results of LACC, SHAPE, SUCCOR and ConCerv trials

IF 3.5 2区医学 Q2 ONCOLOGY

Ejso

Pub Date : 2024-09-06 DOI: 10.1016/j.ejso.2024.108655

引用次数: 0

“Enhancing diagnostic accuracy for primary bone tumors: The role of expert histological analysis and AI-driven deep learning models” "提高原发性骨肿瘤的诊断准确性：专家组织学分析和人工智能驱动的深度学习模型的作用"

IF 3.5 2区医学 Q2 ONCOLOGY

Ejso

Pub Date : 2024-09-05 DOI: 10.1016/j.ejso.2024.108671

引用次数: 0

Low pneumoperitoneum pressure on venous thromboembolism in laparoscopic colorectal cancer surgery: A randomized controlled study 低腹腔积气压力对腹腔镜结直肠癌手术中静脉血栓栓塞的影响：随机对照研究

IF 3.5 2区医学 Q2 ONCOLOGY

Ejso

Pub Date : 2024-09-05 DOI: 10.1016/j.ejso.2024.108672

Introduction

Venous thromboembolism (VTE) poses a significant risk in colorectal cancer surgeries due to hypercoagulability and the anatomical challenges of the pelvic cavity. With the advancement of minimally invasive techniques, intraoperative strategies for preventing VTE may prove to be effective. This study explores the effects of intraoperative pneumoperitoneum pressures on VTE incidence following colorectal cancer surgeries.

Methods

This single center parallel randomized controlled double-blind, trial involved 302 patients undergoing elective laparoscopic or robotic colorectal surgery. Patients were randomized to either a standard pneumoperitoneum pressure group (SP: 15 mmHg) or a low-pressure group (LP: 10 mmHg). Primary outcomes measured were the incidence of VTE, including symptomatic and asymptomatic DVT and PE. Secondary outcomes included postoperative D-dimer levels, surgery duration, blood loss, surgeon satisfaction, and oncological quality.

Results

Out of 302 randomized patients, 275 were evaluable post exclusions, with 138 in the SP group and 137 in the LP group. The incidence of VTE was 10.9 % in the SP and 13.9 % in the LP group, with no significant difference between the two (P = 0.450). Secondary outcomes such as D-dimer levels, surgery duration, and blood loss showed no significant differences between two groups. Surgeon satisfaction and oncological outcomes were similarly comparable.

Conclusions

The trial demonstrated no significant difference in the incidence of VTE between standard and low pneumoperitoneum pressures. This suggests that lower pressures may not necessarily provide a benefit in reducing postoperative VTE in colorectal cancer surgeries.

导言：由于高凝状态和盆腔解剖上的挑战，静脉血栓栓塞（VTE）在结直肠癌手术中构成了重大风险。随着微创技术的发展，术中预防 VTE 的策略可能会被证明是有效的。这项研究探讨了术中腹腔积气压力对结直肠癌手术后 VTE 发生率的影响。方法这项单中心平行随机对照双盲试验涉及 302 名接受择期腹腔镜或机器人结直肠手术的患者。患者被随机分配到标准腹腔积气压力组（SP：15 mmHg）或低压组（LP：10 mmHg）。测量的主要结果是 VTE 的发生率，包括有症状和无症状的深静脉血栓和 PE。次要结果包括术后D-二聚体水平、手术时间、失血量、外科医生满意度和肿瘤学质量。结果在302名随机患者中，有275人在排除后可进行评估，其中SP组138人，LP组137人。SP组和LP组的VTE发生率分别为10.9%和13.9%，两者之间无显著差异（P = 0.450）。D-二聚体水平、手术时间和失血量等次要结果显示，两组间无明显差异。结论该试验表明，标准腹腔积气压力和低腹腔积气压力在 VTE 发生率方面没有明显差异。这表明，较低的气腹压力并不一定能降低结直肠癌手术术后 VTE 的发生率。

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引用次数: 0

Tumor budding is associated with poor prognosis and clinicopathologic factors in esophageal carcinoma: A meta-analysis 肿瘤出芽与食管癌的不良预后和临床病理因素有关：一项荟萃分析

IF 3.5 2区医学 Q2 ONCOLOGY

Ejso

Pub Date : 2024-09-04 DOI: 10.1016/j.ejso.2024.108668

Background and objective

Tumor budding is associated with the prognosis of several solid cancers, but further evidence is needed to identify its relation with esophageal cancer. Our study aims to assess the relationship between tumor budding and overall survival, disease-free survival, and clinicopathologic variables in EC.

Methods

Multiple electronic databases were searched and 20 relevant studies containing 3370 patients were identified. The fixed effects and a random-effects model were used to perform a meta-analysis.

Result

Tumor budding was associated with poor overall survival in EC in both univariate analyses (HR:2.63; 95 % CI 2.06–3.38; p < 0.001) and multivariate analysis (HR: 2.00; 95 % CI 1.68 to 2.39; P < 0.001). Tumor budding was also associated with poor overall survival in subtypes of EC in subgroup analyses i.e. ESCC (HR:3.26; 95 % CI 2.48 to 4.29; P < 0.001), and EAC (HR:2.00; 95 % CI 1.36 to 2.95; P < 0.001) in univariate analysis and ESCC (HR: 2.95; 95 % CI 2.18 to 3.99; P < 0.001) and EAC (HR: 1.65; 95 % CI 1.33 to 2.04; P < 0.001) in multivariate analyses. In addition, tumor budding was also associated with poor DFS (HR: 3.39; 95 % CI 2.1 to 5.48; P < 0.001). Furthermore, tumor budding was associated with poor clinicopathologic factors like advanced T-stage, lymph node metastasis, lymphatic invasion, and venous invasion.

Conclusion

The findings of our study suggest that tumor budding is a promising independent prognostic factor and is correlated with poor clinicopathologic variables of esophageal carcinoma. The inclusion of tumor budding in future grading systems may help in improving currently available staging systems of esophageal carcinoma.

背景和目的肿瘤萌芽与多种实体瘤的预后有关，但需要进一步的证据来确定其与食管癌的关系。我们的研究旨在评估食管癌中肿瘤出芽与总生存期、无病生存期和临床病理变量之间的关系。方法检索了多个电子数据库，并确定了包含 3370 名患者的 20 项相关研究。结果在单变量分析（HR：2.63；95 % CI 2.06-3.38；P <；0.001）和多变量分析（HR：2.00；95 % CI 1.68-2.39；P <；0.001）中，肿瘤萌芽与EC总生存率低有关。在亚组分析中，肿瘤出芽也与EC亚型（即ESCC（HR：3.26；95 % CI 2.48至4.29；P <；0.001）和EAC（HR：2.00；95 % CI 1.36 to 2.95; P <0.001），多变量分析中ESCC（HR: 2.95; 95 % CI 2.18 to 3.99; P <0.001）和EAC（HR: 1.65; 95 % CI 1.33 to 2.04; P <0.001）。此外，肿瘤出芽还与不良的 DFS 相关（HR：3.39；95 % CI 2.1 至 5.48；P <；0.001）。此外，肿瘤出芽还与晚期T期、淋巴结转移、淋巴浸润和静脉浸润等不良临床病理因素相关。结论：我们的研究结果表明，肿瘤出芽是一个有希望的独立预后因素，与食管癌的不良临床病理变量相关。将肿瘤出芽纳入未来的分级系统可能有助于改善现有的食管癌分期系统。

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引用次数: 0

Preoperative nutritional status is a useful predictor of the feasibility of postoperative treatment in octogenarian-plus pancreatic ductal adenocarcinoma patients 术前营养状况可有效预测八旬以上胰腺导管腺癌患者术后治疗的可行性

IF 3.5 2区医学 Q2 ONCOLOGY

Ejso

Pub Date : 2024-09-04 DOI: 10.1016/j.ejso.2024.108650

Background

The suitability of radical surgery for very elderly pancreatic cancer (PC) patients remains controversial due to concerns about postoperative functional reserve. Inflammatory-nutritional status may help identify elderly patients at risk of compromised postoperative treatment tolerance.

Methods

This retrospective analysis included 121 patients over eighty who were diagnosed with PC in 2010–2019, 40 of whom underwent radical surgery. Surgical outcomes were compared with those of 205 younger patients (under 80 years-old) who underwent radical surgery. K-means cluster analysis was conducted with four inflammatory-nutritional indices (NLR, PLR, PNI, and mGPS) to define, and the indices using ordinal logistic analysis were evaluated in each cluster to create a formula named ‘nutritional index (NTI)’, which was then used to redefine the clusters. The predictive ability of the NTI was validated in other octogenarians who underwent pancreatectomy for PC between 2020 and 2023.

Results

Patients older than eighty exhibited comparable overall survival to younger patients (median survival time, 30.7/37.1 months, p = 0.20). However, octogenarian-plus patients had lower rates of adjuvant chemotherapy (AC) initiation (45/80 %) and treatment upon recurrence (52/84 %), resulting in shorter survival after recurrence (7.4/11.1 months, p = 0.06). Inflammatory-nutritional status was significantly associated with overall survival, with poor nutritional status being linked to lower rates of AC initiation and/or treatment upon recurrence. NTI effectively predicted AC feasibility.

Conclusions

Radical surgery for octogenarian-plus PC patients meeting the current criteria was safe, but lower rates of postoperative treatment initiation may lead to poorer outcomes after recurrence. Inflammatory-nutritional status assessment could enhance surgical eligibility in octogenarian-plus PC patients.

背景由于对术后功能储备的担忧，高龄胰腺癌（PC）患者是否适合接受根治性手术仍存在争议。方法这项回顾性分析纳入了 2010-2019 年期间确诊为 PC 的 121 例 80 岁以上患者，其中 40 例接受了根治手术。手术结果与205名接受根治术的年轻患者（80岁以下）的手术结果进行了比较。K-means聚类分析使用四种炎症-营养指数（NLR、PLR、PNI和mGPS）进行定义，并使用序数逻辑分析对每个聚类中的指数进行评估，创建名为 "营养指数（NTI）"的公式，然后使用该公式重新定义聚类。结果80岁以上患者的总生存期与年轻患者相当（中位生存期分别为30.7个月和37.1个月，P = 0.20）。然而，八十岁以上患者的辅助化疗（AC）启动率（45/80%）和复发后治疗率（52/84%）较低，导致复发后生存期缩短（7.4/11.1 个月，p = 0.06）。炎症-营养状况与总生存期显著相关，营养状况差的患者开始接受 AC 和/或复发后接受治疗的比例较低。结论对符合当前标准的八旬以上 PC 患者进行根治性手术是安全的，但术后开始治疗的比例较低可能会导致复发后的预后较差。炎症-营养状况评估可提高八旬以上 PC 患者的手术资格。

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引用次数: 0

Prognosis and treatment of uterine sarcoma found incidentally after myomectomy 子宫肌瘤切除术后偶然发现的子宫肉瘤的预后和治疗。

IF 3.5 2区医学 Q2 ONCOLOGY

Ejso

Pub Date : 2024-09-03 DOI: 10.1016/j.ejso.2024.108652

Objective

To determine prognosis and factors associated with survival of women with uterine sarcoma found incidentally after myomectomy.

Methods

We performed a retrospective study for patients who had previously undergone myomectomy for presumed benign uterine fibroid disease and were found to have uterine confined sarcoma after myomectomy surgery.

Results

In total, 50 patients were identified. There were 23 (46.0 %) patients undergoing myomectomy were performed by minimal invasive surgery: laparoscopic (Lap, n = 22, 44.0 %) or transvaginal (TV, n = 1, 2.0 %) approach; while, 24 (48.0 %) and 3 (6.0 %) patients had myomectomy through abdominal (Abd) or hysteroscopic (Hys) approach. All patients received the re-exploration and staging surgery in our center. The median time from myomectomy to the staging surgery was 43 days (range 15–90 days). 17 patients had remnant sarcomas on the remaining uterus and 6 patients had disseminated disease after re-exploration. In the entire cohort, 5-year RFS and 5-year OS was 79.4 % and 88.0 %, respectively. Patients who received initial Lap/TV myomectomy had a tendency towards a worse 5-year RFS compared with Abd/Hys approach (63.0 % vs 88.9 %, P = 0.080). No difference in 5-year OS was found between the two groups (90.3 % vs 91.8 %, P = 0.768). For stage I disease (n = 44), patients who received Lap/TV myomectomy had a worse 5-year RFS compared with Abd/Hys approach (58.3 % vs 95.7 %, P = 0.009). No difference in 5-year OS was found (P = 0.121).

Conclusion

Patients with incidental uterine sarcoma who received primary Lap/TV myomectomy may have a worse RFS. Re-exploration can detect remnant or disseminated sarcomas.

摘要确定子宫肌瘤切除术后偶然发现子宫肉瘤的妇女的预后以及与生存相关的因素：我们对曾因假定的良性子宫肌瘤疾病接受子宫肌瘤剔除术，但在子宫肌瘤剔除术后发现患有子宫局限性肉瘤的患者进行了回顾性研究：共发现 50 例患者。其中23例（46.0%）患者通过微创手术：腹腔镜（Lap，n = 22，44.0%）或经阴道（TV，n = 1，2.0%）方法进行子宫肌瘤剔除术；24例（48.0%）和3例（6.0%）患者通过腹腔镜（Abd）或宫腔镜（Hys）方法进行子宫肌瘤剔除术。所有患者都在本中心接受了再探查和分期手术。从子宫肌瘤切除术到分期手术的中位时间为 43 天（15-90 天不等）。17名患者的残余子宫上有残余肉瘤，6名患者在再次探查后出现播散性疾病。所有患者的 5 年 RFS 和 5 年 OS 分别为 79.4% 和 88.0%。与Abd/Hys方法相比，初次接受Lap/TV子宫肌瘤剔除术的患者5年RFS较差（63.0% vs 88.9%，P = 0.080）。两组患者的 5 年 OS 无差异（90.3% vs 91.8%，P = 0.768）。对于 I 期疾病（n = 44），与 Abd/Hys 方法相比，接受 Lap/TV 子宫肌瘤剔除术的患者 5 年 RFS 较差（58.3% vs 95.7%，P = 0.009）。5年OS无差异（P = 0.121）：结论：接受腹/电视子宫肌瘤剔除术的偶发性子宫肉瘤患者的RFS可能较差。再次探查可发现残余或扩散的肉瘤。

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引用次数: 0

Risk stratification models incorporating oxidative stress factors to predict survival and recurrence in patients with gastric cancer after radical gastrectomy: A real-world multicenter study 结合氧化应激因素的风险分层模型，预测胃癌根治术后患者的生存率和复发率：一项真实世界多中心研究

IF 3.5 2区医学 Q2 ONCOLOGY

Ejso

Pub Date : 2024-09-03 DOI: 10.1016/j.ejso.2024.108658

Background

Oxidative stress significantly influences the development and progression of gastric cancer (GC). It remains unreported whether incorporating oxidative stress factors into nomograms can improve the predictive accuracy for survival and recurrence risk in GC patients.

Methods

3498 GC patients who underwent radical gastrectomy between 2009 and 2017 were enrolled and randomly divided into training cohort (TC) and internal validation cohort (IVC). Cox regression analysis model was used to evaluate six preoperative oxidative stress indicators to formulate the Systemic oxidative stress Score (SOSS). Two nomograms based on SOSS was constructed by multivariate Cox regression and validated using 322 patients from another two hospitals.

Results

A total of 3820 patients were included. The SOSS, composed of three preoperative indicators—fibrinogen, albumin, and cholesterol—was an independent prognostic factor for both overall survival (OS) and disease-free survival (DFS). The two nomograms based on SOSS showed a significantly higher AUC than the pTNM stage (OS: 0.830 vs. 0.778, DFS: 0.824 vs. 0.775, all P < 0.001) and were validated in the IVC and EVC (all P < 0.001). The local recurrence rate, peritoneal recurrence rate, distant recurrence rate and multiple recurrence rate in high-risk group were significantly higher than those in low-risk group (P < 0.05).

Conclusions

The two novel nomograms based on SOSS which was a combination score of three preoperative blood indicators, demonstrated outstanding predictive abilities for both survival and recurrence in GC patients with different risk groups, which may potentially improve survival through perioperatively active intervention strategies and individualized postoperatively close surveillance.

背景氧化应激严重影响胃癌（GC）的发生和发展。将氧化应激因素纳入提名图是否能提高胃癌患者生存和复发风险预测的准确性，目前仍未得到报道。方法 3498 名在 2009 年至 2017 年间接受根治性胃切除术的胃癌患者被纳入研究，并随机分为训练队列（TC）和内部验证队列（IVC）。采用 Cox 回归分析模型对术前六项氧化应激指标进行评估，以制定全身氧化应激评分（SOSS）。通过多变量 Cox 回归，基于 SOSS 建立了两个提名图，并使用另外两家医院的 322 名患者进行了验证。SOSS 由纤维蛋白原、白蛋白和胆固醇三项术前指标组成，是总生存期（OS）和无病生存期（DFS）的独立预后因素。基于 SOSS 的两个提名图的 AUC 明显高于 pTNM 分期（OS：0.830 vs. 0.778，DFS：0.824 vs. 0.775，均为 P < 0.001），并在 IVC 和 EVC 中得到验证（均为 P < 0.001）。结论这两种基于 SOSS（术前三项血液指标的综合评分）的新型提名图对不同风险组别的 GC 患者的生存率和复发率均有出色的预测能力，通过围手术期积极的干预策略和术后个体化的密切监测，有可能提高患者的生存率。

{"title":"Risk stratification models incorporating oxidative stress factors to predict survival and recurrence in patients with gastric cancer after radical gastrectomy: A real-world multicenter study","authors":"","doi":"10.1016/j.ejso.2024.108658","DOIUrl":"10.1016/j.ejso.2024.108658","url":null,"abstract":"<div><h3>Background</h3><p>Oxidative stress significantly influences the development and progression of gastric cancer (GC). It remains unreported whether incorporating oxidative stress factors into nomograms can improve the predictive accuracy for survival and recurrence risk in GC patients.</p></div><div><h3>Methods</h3><p>3498 GC patients who underwent radical gastrectomy between 2009 and 2017 were enrolled and randomly divided into training cohort (TC) and internal validation cohort (IVC). Cox regression analysis model was used to evaluate six preoperative oxidative stress indicators to formulate the Systemic oxidative stress Score (SOSS). Two nomograms based on SOSS was constructed by multivariate Cox regression and validated using 322 patients from another two hospitals.</p></div><div><h3>Results</h3><p>A total of 3820 patients were included. The SOSS, composed of three preoperative indicators—fibrinogen, albumin, and cholesterol—was an independent prognostic factor for both overall survival (OS) and disease-free survival (DFS). The two nomograms based on SOSS showed a significantly higher AUC than the pTNM stage (OS: 0.830 vs. 0.778, DFS: 0.824 vs. 0.775, all P < 0.001) and were validated in the IVC and EVC (all P < 0.001). The local recurrence rate, peritoneal recurrence rate, distant recurrence rate and multiple recurrence rate in high-risk group were significantly higher than those in low-risk group (P < 0.05).</p></div><div><h3>Conclusions</h3><p>The two novel nomograms based on SOSS which was a combination score of three preoperative blood indicators, demonstrated outstanding predictive abilities for both survival and recurrence in GC patients with different risk groups, which may potentially improve survival through perioperatively active intervention strategies and individualized postoperatively close surveillance.</p></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142148310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High prevalence of erectile dysfunction within the first year after surgery for rectal cancer: A systematic review and meta-analysis 直肠癌术后第一年内勃起功能障碍的高发率：系统回顾和荟萃分析

IF 3.5 2区医学 Q2 ONCOLOGY

Ejso

Pub Date : 2024-09-03 DOI: 10.1016/j.ejso.2024.108662

Objective

We aimed to determine the prevalence of erectile dysfunction following rectal cancer surgery within the first year.

Summary background data

Erectile dysfunction is a late complication of surgery for rectal cancer. Intraoperative mechanical nerve damage is a probable cause, but it can also be attributed to radio- and chemotherapy.

Methods

We conducted a systematic review per our protocol (CRD42023472998), searching PubMed, Embase, and Cochrane CENTRAL in August 2023. We included studies reporting on men having surgery for rectal cancer and providing a prevalence of erectile dysfunction based on validated questionnaires published after 1997. The prevalence was estimated through forest plots. Bias was evaluated according to a checklist from the Joanna Briggs Institute.

Results

Of the 4105 records identified in the search, we included 74 studies reporting on 9006 patients operated for rectal cancer. The studies evaluated erectile dysfunction through six validated questionnaires, especially the International Index of Erectile Function (IIEF) version 5 or 15 (84 %). The meta-analysis on 22 studies using IIEF showed that the prevalence of moderate to severe erectile dysfunction was 35 % (95 % CI 24–47 %) within the first year after surgery with very low certainty of evidence. Meta-regression on the prevalence of moderate to severe erectile dysfunction did not show a decrease in erectile dysfunction within the first year postoperatively.

Conclusions

Around every third patient experienced moderate to severe erectile dysfunction within the first year after surgery for rectum cancer, and the prevalence of erectile dysfunction did not improve within the first year after surgery.

Mini-abstract

This is a meta-analysis investigating the prevalence of erectile dysfunction following rectal cancer surgery within the first year. Erectile dysfunction was determined on the base of validated self-administered questionnaires. Moderate to severe erectile dysfunction was seen in one-third of patients within the first year after surgery for rectal cancer.

背景数据摘要勃起功能障碍是直肠癌手术的晚期并发症。勃起功能障碍是直肠癌手术的晚期并发症，术中机械性神经损伤可能是其原因之一，但也可能与放疗和化疗有关。方法我们根据我们的协议（CRD42023472998）进行了一项系统性综述，于 2023 年 8 月检索了 PubMed、Embase 和 Cochrane CENTRAL。我们纳入了 1997 年后发表的、报告男性直肠癌手术治疗情况的研究，这些研究根据有效问卷提供了勃起功能障碍的患病率。患病率通过森林图进行估算。根据乔安娜-布里格斯研究所（Joanna Briggs Institute）的检查表对偏倚进行了评估。结果在搜索到的 4105 条记录中，我们纳入了 74 项研究，报告了 9006 名直肠癌手术患者的情况。这些研究通过六种有效问卷对勃起功能障碍进行了评估，尤其是国际勃起功能指数（IIEF）第 5 版或第 15 版（84%）。对 22 项使用 IIEF 的研究进行的荟萃分析表明，术后第一年内中度至重度勃起功能障碍的发生率为 35%（95% CI 24-47%），证据的确定性很低。对中重度勃起功能障碍患病率的元回归结果显示，术后第一年内勃起功能障碍的患病率并没有下降。结论直肠癌术后第一年内，大约每三分之一的患者会出现中重度勃起功能障碍，术后第一年内勃起功能障碍的患病率并没有改善。勃起功能障碍是根据有效的自填问卷调查确定的。三分之一的患者在直肠癌手术后第一年内出现中度至重度勃起功能障碍。

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引用次数: 0

Surgical resection and reconstruction techniques for jugular foramen schwannoma 颈静脉裂孔瘤的手术切除和重建技术

IF 3.5 2区医学 Q2 ONCOLOGY

Ejso

Pub Date : 2024-09-03 DOI: 10.1016/j.ejso.2024.108646

Introduction

Jugular foramen schwannomas present formidable challenges due to their deep-seated location and complex anatomical constraints, leading to significant difficulties in tumor excision, postoperative complications further hinder surgical interventions in this area. We aim to explore and summarize surgical and reconstruction techniques for jugular foramen schwannomas to enhance patient outcomes.

Materials and methods

In a retrospective analysis, we reviewed the surgical approaches and reconstruction techniques utilized in 31 patients undergoing surgical resection for jugular foramen schwannomas from January 2018 to the present. Our goal was to summarize the materials and methods used for skull base reconstruction in this region and propose a clinically applicable procedural framework for surgical intervention.

Results

Results revealed that 28 patients underwent treatment via the far lateral paracondylar approach, while 3 patients opted for the suboccipital retrosigmoid approach. Among them, 15 patients underwent surgical cavity tamponade. Additionally, we summarized three methods of dural reconstruction in the surgical area. Postoperative temporary complications showed varying degrees of improvement during follow-up, leading to an overall favorable prognosis.

Conclusion

Our study presents clinical insights into the surgical resection and skull base reconstruction of jugular foramen schwannomas. We discuss the selection of surgical approaches, intraoperative landmarks, and reconstruction techniques aimed at improving patient outcomes effectively.

引言颈静脉裂孔型神经管瘤因其深部位置和复杂的解剖限制而带来了巨大的挑战，导致肿瘤切除困难重重，术后并发症进一步阻碍了这一领域的手术治疗。我们旨在探索和总结颈静脉裂孔瘤的手术和重建技术，以提高患者的预后。材料和方法在一项回顾性分析中，我们回顾了自 2018 年 1 月至今接受手术切除颈静脉裂孔瘤的 31 例患者所采用的手术方法和重建技术。我们的目标是总结该区域颅底重建所使用的材料和方法，并提出临床适用的手术干预程序框架。结果结果显示，28 名患者通过远外侧髁旁入路接受治疗，3 名患者选择枕下后穹隆入路。其中，15 名患者接受了手术腔填塞。此外，我们还总结了手术区域硬膜重建的三种方法。术后暂时性并发症在随访期间均有不同程度的改善，总体预后良好。我们讨论了手术方法、术中标记和重建技术的选择，旨在有效改善患者的预后。

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引用次数: 0