Pub Date : 2026-03-04DOI: 10.1186/s13550-026-01400-4
Jacques Darcourt, Pierre-Malick Koulibaly, Aurélie Schiazza, Victor Comte, Olivier Humbert
{"title":"Assessment of striatal and extrastriatal [<sup>18</sup>F]fluoroDOPA uptake by a Silicon Photomultiplier PET camera in Parkinson's disease.","authors":"Jacques Darcourt, Pierre-Malick Koulibaly, Aurélie Schiazza, Victor Comte, Olivier Humbert","doi":"10.1186/s13550-026-01400-4","DOIUrl":"https://doi.org/10.1186/s13550-026-01400-4","url":null,"abstract":"","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-03DOI: 10.1186/s13550-026-01407-x
Emil Novruzov, Gabriel Sheikh, Anna Feisthauer, Dominik Schmitt, Katalin Mattes-György, Christina Antke, Julian Kuhlmann, Yuriko Mori, Jan Henke, Jens Cardinale, Matthias Boschheidgen, Jan Philipp Radtke, Günter Niegisch, Peter Albers, Gerald Antoch, Rudolf A Werner, Frederik L Giesel, Eduards Mamlins
{"title":"Enhancing reader confidence through dual-time imaging and alternative reconstruction algorithms with [<sup>18</sup>F]PSMA-1007 PET/CT imaging in local relapsed castration-sensitive prostate cancer?","authors":"Emil Novruzov, Gabriel Sheikh, Anna Feisthauer, Dominik Schmitt, Katalin Mattes-György, Christina Antke, Julian Kuhlmann, Yuriko Mori, Jan Henke, Jens Cardinale, Matthias Boschheidgen, Jan Philipp Radtke, Günter Niegisch, Peter Albers, Gerald Antoch, Rudolf A Werner, Frederik L Giesel, Eduards Mamlins","doi":"10.1186/s13550-026-01407-x","DOIUrl":"https://doi.org/10.1186/s13550-026-01407-x","url":null,"abstract":"","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-27DOI: 10.1186/s13550-026-01403-1
May Sadik, Johanna Mörk, Jesus Lopez Urdaneta, Malin Lewold, Måns Larsson, Olof Enqvist, Sally F Barrington, Lars Edenbrandt, Elin Trägårdh
{"title":"Automated RECOMIA AI-based total metabolic tumor volume in lymphoma - a retrospective study.","authors":"May Sadik, Johanna Mörk, Jesus Lopez Urdaneta, Malin Lewold, Måns Larsson, Olof Enqvist, Sally F Barrington, Lars Edenbrandt, Elin Trägårdh","doi":"10.1186/s13550-026-01403-1","DOIUrl":"https://doi.org/10.1186/s13550-026-01403-1","url":null,"abstract":"","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-25DOI: 10.1186/s13550-026-01402-2
Fei Liu, Hongxing Yang, Jianping Zhang, Jindian Li, Ying Qiao, Jie Chen, Shaoli Song
Background: The aim of this study was to evaluate the efficacy of neuroendocrine neoplasms (NENs) patients treated with peptide receptor radionuclide therapy (PRRT), and to investigate the relationships among the absorbed dose of the tumor target lesions, standardized uptake value (SUV), and the therapeutic efficacy of the patients. A total of 22 NENs patients who received [177Lu]Lu-DOTA-TATE treatment and underwent consecutive single-photon emission computed tomography/computed tomography (SPECT/CT) imaging after drug administration were included in this study. After the SPECT/CT imaging, the volume of interest (VOI) of the target organs and the target lesions were delineated using the Hermes Internal Radiation Dosimetry (HIRD) software, and their absorbed doses were calculated. The SUV of the target lesions was measured on the reconstructed SPECT/CT fusion images. We conducted studies on the correlations between the absorbed dose, SUV, and the therapeutic efficacy of the patients respectively.
Results: After the patients received [177Lu]Lu-DOTA-TATE treatment in cycles 1 to 4, the absorbed doses of the tumor target lesions were 21.0, 16.0, 11.4, and 8.8 Gy respectively. The results of the correlations between the absorbed dose, SUV, and the therapeutic efficacy of the patients showed that both the absorbed dose and SUV had an "S"-shaped curve relationship with the tumor partial response (PR) rate. In addition, for the 1st to 4th PRRT treatments, the absorbed dose and SUV were linearly correlated with R2 of 0.7, 0.8, 0.8, and 0.9, respectively.
Conclusions: Through the calculation and analysis of the radionuclide therapy dosimetry based on the SPECT/CT images throughout the PRRT treatment of the patients, the absorbed dose and SUV of the patients can provide important dose guidance for radionuclide therapy, which is helpful to improve the treatment efficacy of the patients.
Trial registration: A Study Comparing Treatment With Lutetium[177Lu] Oxodotreotide Injection to Octreotide LAR in Patients With GEP-NETs, NCT05459844. Registered 5 July 2022, https://clinicaltrials.gov/study/NCT05459844?cond=NCT05459844&rank=1.
{"title":"Relationship between absorbed dose and SUV derived from SPECT/CT imaging and dose-response in patients with neuroendocrine tumors treated with [¹⁷⁷Lu]Lu-DOTA-TATE.","authors":"Fei Liu, Hongxing Yang, Jianping Zhang, Jindian Li, Ying Qiao, Jie Chen, Shaoli Song","doi":"10.1186/s13550-026-01402-2","DOIUrl":"https://doi.org/10.1186/s13550-026-01402-2","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to evaluate the efficacy of neuroendocrine neoplasms (NENs) patients treated with peptide receptor radionuclide therapy (PRRT), and to investigate the relationships among the absorbed dose of the tumor target lesions, standardized uptake value (SUV), and the therapeutic efficacy of the patients. A total of 22 NENs patients who received [<sup>177</sup>Lu]Lu-DOTA-TATE treatment and underwent consecutive single-photon emission computed tomography/computed tomography (SPECT/CT) imaging after drug administration were included in this study. After the SPECT/CT imaging, the volume of interest (VOI) of the target organs and the target lesions were delineated using the Hermes Internal Radiation Dosimetry (HIRD) software, and their absorbed doses were calculated. The SUV of the target lesions was measured on the reconstructed SPECT/CT fusion images. We conducted studies on the correlations between the absorbed dose, SUV, and the therapeutic efficacy of the patients respectively.</p><p><strong>Results: </strong>After the patients received [<sup>177</sup>Lu]Lu-DOTA-TATE treatment in cycles 1 to 4, the absorbed doses of the tumor target lesions were 21.0, 16.0, 11.4, and 8.8 Gy respectively. The results of the correlations between the absorbed dose, SUV, and the therapeutic efficacy of the patients showed that both the absorbed dose and SUV had an \"S\"-shaped curve relationship with the tumor partial response (PR) rate. In addition, for the 1st to 4th PRRT treatments, the absorbed dose and SUV were linearly correlated with R<sup>2</sup> of 0.7, 0.8, 0.8, and 0.9, respectively.</p><p><strong>Conclusions: </strong>Through the calculation and analysis of the radionuclide therapy dosimetry based on the SPECT/CT images throughout the PRRT treatment of the patients, the absorbed dose and SUV of the patients can provide important dose guidance for radionuclide therapy, which is helpful to improve the treatment efficacy of the patients.</p><p><strong>Trial registration: </strong>A Study Comparing Treatment With Lutetium[177Lu] Oxodotreotide Injection to Octreotide LAR in Patients With GEP-NETs, NCT05459844. Registered 5 July 2022, https://clinicaltrials.gov/study/NCT05459844?cond=NCT05459844&rank=1.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-24DOI: 10.1186/s13550-026-01394-z
Fadi Khreish, Florian Rosar, Caroline Burgard, Sven Petto, Stephan Maus, Tobias Stemler, Mark Bartholomä, Amir Sabet, Andrea Schaefer-Schuler, Samer Ezziddin
{"title":"Dosimetric analysis reveals rapid clearance and low absorbed dose of [¹⁷⁷Lu]Lu-PSMA-617 in non-prostate cancers with high PSMA expression.","authors":"Fadi Khreish, Florian Rosar, Caroline Burgard, Sven Petto, Stephan Maus, Tobias Stemler, Mark Bartholomä, Amir Sabet, Andrea Schaefer-Schuler, Samer Ezziddin","doi":"10.1186/s13550-026-01394-z","DOIUrl":"https://doi.org/10.1186/s13550-026-01394-z","url":null,"abstract":"","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Machine learning-based model for prediction of KCNJ5 mutation in unilateral primary aldosteronism based on [<sup>68</sup>Ga]Ga-Pentixafor PET/CT.","authors":"Rui Zuo, Zhaoming Chen, Zhengjie Wang, Shenglong Li, Wenbo Li, Zhu Xia, Hua Pang, Lu Xu","doi":"10.1186/s13550-026-01389-w","DOIUrl":"https://doi.org/10.1186/s13550-026-01389-w","url":null,"abstract":"","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号