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Discrimination of benign, atypical, and malignant peripheral nerve sheath tumours in neurofibromatosis type 1 - intraindividual comparison of positron emission computed tomography and diffusion-weighted magnetic resonance imaging. 1型神经纤维瘤病良性、非典型和恶性周围神经鞘肿瘤的鉴别——正电子发射计算机断层扫描与扩散加权磁共振成像的个体比较
IF 3.1 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-27 DOI: 10.1186/s13550-024-01189-0
Inka Ristow, Ivayla Apostolova, Michael G Kaul, Maria Stark, Antonia Zapf, Marie-Lena Schmalhofer, Victor F Mautner, Said Farschtschi, Gerhard Adam, Peter Bannas, Johannes Salamon, Lennart Well

Background: To intraindividually compare the diagnostic performance of positron emission computed tomography (F-18-FDG-PET/CT) and diffusion-weighted magnetic resonance imaging (DW-MRI) in a non-inferiority design for the discrimination of peripheral nerve sheath tumours as benign (BPNST), atypical (ANF), or malignant (MPNST) in patients with neurofibromatosis type 1 (NF1).

Results: In this prospective single-centre study, thirty-four NF1 patients (18 male; 30 ± 11 years) underwent F-18-FDG-PET/CT and multi-b-value DW-MRI (11 b-values 0 - 800 s/mm²) at 3T. Sixty-six lesions corresponding to 39 BPNST, 11 ANF, and 16 MPNST were evaluated. Two radiologists independently assessed the maximum standardized uptake value (SUVmax) and mean and minimum apparent diffusion coefficient (ADCmean/min) as well as the ADC in areas of lowest signal intensity in each lesion (ADCdark). The AUCs of DW-MRI and F-18-FDG-PET/CT were compared to determine whether the ADC is non-inferior to SUVmax (non-inferiority margin equal to -10%). Follow-up of ≥ 24 months (BPNST) or histopathological evaluation (MPNST + ANF) served as diagnostic reference standard. Both SUVmax and ADC parameters demonstrated good diagnostic accuracy (AUCSUVmax 94.0%; AUCADCmean/min/dark 91.6% / 90.1% / 92.5%). However, non-inferiority could not be demonstrated for any of the three ADC parameters (lower limits of the confidence intervals of the difference between the AUC of ADCmean/min/dark and SUVmax -12.9% / -14.5% / -11.6%). Inter-rater reliability was excellent for both imaging techniques (Krippendorff's alpha all > 0.94).

Conclusions: Both PET/CT-derived SUVmax and MRI-derived ADC allow sensitive and non-invasive differentiation of benign and (pre)-malignant peripheral nerve sheath tumours. Nevertheless, DW-MRI cannot be considered as non-inferior to F-18-FDG-PET/CT in this prospective single-centre study.

背景:在一项非效性设计中,比较正电子发射计算机断层扫描(F-18-FDG-PET/CT)和扩散加权磁共振成像(DW-MRI)对1型神经纤维瘤病(NF1)患者周围神经鞘肿瘤良性(BPNST)、非典型(ANF)或恶性(MPNST)的诊断性能。结果:在这项前瞻性单中心研究中,34例NF1患者(18例男性;30±11岁)在3T行F-18-FDG-PET/CT和多b值DW-MRI (11 b值0 - 800 s/mm²)检查。66个病灶对应39个BPNST, 11个ANF和16个MPNST进行了评估。两名放射科医生独立评估了最大标准化摄取值(SUVmax)、平均和最小表观扩散系数(ADCmean/min)以及每个病变中最低信号强度区域的ADC (ADCdark)。比较DW-MRI和F-18-FDG-PET/CT的aus,确定ADC是否不劣于SUVmax(非劣效裕度为-10%)。随访≥24个月(BPNST)或组织病理学评价(MPNST + ANF)作为诊断参考标准。SUVmax和ADC参数均显示出良好的诊断准确性(AUCSUVmax为94.0%;AUCADCmean/min/dark 91.6% / 90.1% / 92.5%)。然而,三个ADC参数中的任何一个都不能证明非劣效性(ADCmean/min/dark与SUVmax AUC差异的置信区间下限为-12.9% / -14.5% / -11.6%)。两种成像技术的内部信度都很好(Krippendorff's alpha均为0.94)。结论:PET/ ct衍生的SUVmax和mri衍生的ADC都可以对良性和(前)恶性周围神经鞘肿瘤进行敏感和无创的区分。然而,在这项前瞻性单中心研究中,DW-MRI不能被认为不次于F-18-FDG-PET/CT。
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引用次数: 0
In vitro and ex vivo evaluation of preclinical models for FAP-targeted theranostics: differences and relevance for radiotracer evaluation. fap靶向治疗临床前模型的体外和离体评估:放射性示踪剂评估的差异和相关性
IF 3.1 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-24 DOI: 10.1186/s13550-024-01191-6
Circe D van der Heide, Joana D Campeiro, Eline A M Ruigrok, Lilian van den Brink, Shashikanth Ponnala, Shawn M Hillier, Simone U Dalm

Background: Fibroblast activation protein (FAP) is an attractive target for cancer theranostics. Although FAP-targeted nuclear imaging demonstrated promising clinical results, only sub-optimal results are reported for targeted radionuclide therapy (TRT). Preclinical research is crucial in selecting promising FAP-targeted radiopharmaceuticals and for obtaining an increased understanding of factors essential for FAP-TRT improvement. FAP is mainly expressed by cancer-associated fibroblasts in the tumor stroma and less on cancer cells themselves. Therefore, other (complex) factors impact FAP-TRT efficacy compared to currently clinically applied TRT strategies. For accurate evaluation of these aspects, selection of a representative preclinical model is important. Currently mainly human cancer cell lines transduced to (over)express FAP are applied, lacking clinical representation. It is unclear how these and more physiological FAP-expressing models compare to each other, and whether/how the model influences the study outcome. We aimed to address this by comparing FAP tracer behavior in FAP-transduced HT1080-huFAP and HEK293-huFAP cells, and endogenous FAP-expressing U-87 MG cancer cells and PS-1 pancreatic stellate cells. [111In]In-FAPI-46 and a fluorescent FAP-targeted tracer (RTX-1370S) were used to compare tracer binding/uptake and localization in vitro and ex vivo. Additionally, FAP expression was determined with RT-qPCR and anti-FAP IHC.

Results: Although FAP expression was highest in HEK293-huFAP cells and cell line derived xenografts, this did not result in the highest tracer uptake. [111In]In-FAPI-46 uptake was highest in HT1080-huFAP, closely followed by HEK293-huFAP, and a 6-10-fold lower uptake for U-87 MG and PS-1 cells. However, ex vivo U-87 MG xenografts only showed a 2-fold lower binding compared to HT1080-huFAP and HEK293-huFAP xenografts, mainly because the cell line attracts murine fibroblasts as demonstrated in our RT-qPCR and IHC studies.

Conclusions: The interaction between FAP and FAP-targeted tracers differs between models, indicating the need for appropriate model selection and that comparing results across studies using different models is difficult.

背景:成纤维细胞活化蛋白(FAP)是癌症治疗中一个有吸引力的靶点。尽管fap靶向核成像显示出有希望的临床结果,但靶向放射性核素治疗(TRT)的结果仅为次优。临床前研究对于选择有前途的靶向fap的放射性药物和获得对改善FAP-TRT的必要因素的更多了解至关重要。FAP主要在肿瘤基质中的癌相关成纤维细胞中表达,在癌细胞本身中表达较少。因此,与目前临床应用的TRT策略相比,其他(复杂)因素会影响FAP-TRT的疗效。为了准确评估这些方面,选择具有代表性的临床前模型是很重要的。目前主要应用于(过)表达FAP的人类癌细胞系,缺乏临床代表性。目前尚不清楚这些和更多的生理fap表达模型如何相互比较,以及模型是否/如何影响研究结果。我们的目的是通过比较FAP示踪剂在FAP转导的HT1080-huFAP和HEK293-huFAP细胞以及内源性表达FAP的U-87 MG癌细胞和PS-1胰腺星状细胞中的行为来解决这个问题。[111]用in - fapi -46和荧光fap靶向示踪剂(RTX-1370S)比较了示踪剂在体外和离体的结合/摄取和定位。此外,采用RT-qPCR和抗FAP免疫组化检测FAP的表达。结果:虽然FAP在HEK293-huFAP细胞和细胞系衍生的异种移植物中表达最高,但这并没有导致最高的示踪剂摄取。[111] in - fapi -46的摄取在HT1080-huFAP中最高,其次是HEK293-huFAP, U-87 MG和PS-1细胞的摄取低6-10倍。然而,与HT1080-huFAP和HEK293-huFAP异种移植物相比,体外U-87 MG异种移植物的结合仅低2倍,这主要是因为我们的RT-qPCR和IHC研究表明,该细胞系吸引了小鼠成纤维细胞。结论:FAP和FAP靶向示踪剂之间的相互作用在不同的模型中是不同的,这表明需要适当的模型选择,并且使用不同模型的研究之间比较结果是困难的。
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引用次数: 0
cfDNA fragmentation patterns correlate with tumor burden measured via PSMA PET/CT volumetric parameters in patients with biochemical recurrence of prostate cancer. 前列腺癌生化复发患者的cfDNA片段化模式与PSMA PET/CT体积参数测量的肿瘤负荷相关。
IF 3.1 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-18 DOI: 10.1186/s13550-024-01170-x
Gary Amseian, Marcel Figueras, Joel Mases, Lourdes Mengual, Maria-Jose Ribal, Katherine Quintero, Rita Pages, Mercedes Ingelmo-Torres, Fiorella-Lizzeth Roldan, Rocío Caratini, David Fuster, Antonio Alcaraz, Laura Izquierdo, Pilar Paredes

Background: Prostate cancer recurrence following primary treatment poses a significant clinical challenge, particularly when detected through biochemical recurrence at low PSA levels. Conventional imaging modalities often fail to localize the disease at this early stage. PSMA PET has demonstrated superior sensitivity in detecting recurrent lesions, even in patients with low PSA. Concurrently, liquid biopsy, through analysis of cell-free DNA (cfDNA), offers a minimally invasive approach for monitoring disease. There is scarce evidence about the association between liquid biopsy and PSMA PET/CT findings. This study aimed to assess the correlation between liquid biopsy and tumor burden assessed by PSMA PET/CT in early recurring prostate cancer patients.

Results: PSMA PET/CT and liquid biopsies of 32 patients in biochemical recurrence were analyzed. 12 patients (37.5%) had no PSMA PET-measurable disease. Four patients (12.5%) presented local recurrence, seven (21.9%) had recurrence in pelvic lymph nodes, one of whom also had local recurrence. Nine patients (28.1%) presented metastatic recurrence, with or without local or nodal recurrence. PSA levels correlated with molecular imaging data (p < 0.05), including whole body PSMA-TV, whole body PSMA-TL, whole body SUVmean and whole body SUVmax. The mean cfDNA fragment size fraction was inversely correlated with tumour burden measured with whole body PSMA-TV, with a Spearman correlation coefficient of -0.451 and a p-value of 0.009. No correlation was found between cfDNA concentration and PET-PSMA data.

Conclusion: This prospective study demonstrated a statistically significant negative correlation between cfDNA fragmentation patterns and PSMA PET/CT volumetric parameters in patients with presumed localized prostate cancer with early biochemical recurrence. These findings underscore the potential of liquid biopsy as a biomarker and a complementary tool to PSMA PET/CT to assess disease progression during the follow-up of these patients.

背景:原发性前列腺癌治疗后复发是一个重大的临床挑战,特别是当通过低PSA水平的生化复发检测时。常规的成像方式往往不能在早期阶段定位疾病。PSMA PET在检测复发性病变方面表现出优越的敏感性,即使在低PSA患者中也是如此。同时,液体活检,通过分析无细胞DNA (cfDNA),提供了一种微创的方法来监测疾病。很少有证据表明液体活检与PSMA PET/CT表现之间存在关联。本研究旨在评估PSMA PET/CT评估的早期复发前列腺癌患者液体活检与肿瘤负荷的相关性。结果:对32例生化复发患者的PSMA PET/CT及液体活检进行分析。12例(37.5%)患者无PSMA pet可测量疾病。局部复发4例(12.5%),盆腔淋巴结复发7例(21.9%),其中局部复发1例。9例患者(28.1%)出现转移性复发,伴有或不伴有局部或淋巴结复发。结论:本前瞻性研究表明,在推测为局限性前列腺癌的早期生化复发患者中,cfDNA片段模式与PSMA PET/CT体积参数之间存在统计学上显著的负相关。这些发现强调了液体活检作为生物标志物和PSMA PET/CT的补充工具在这些患者随访期间评估疾病进展的潜力。
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引用次数: 0
P2X 7-receptor binding in new-onset and secondary progressive MS - a [11C]SMW139 PET study. P2X 7受体结合在新发和继发性进展性MS中的作用- [11C]SMW139 PET研究。
IF 3.1 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-05 DOI: 10.1186/s13550-024-01186-3
Jussi Lehto, Richard Aarnio, Jouni Tuisku, Marcus Sucksdorff, Esa Mikko Koivumäki, Marjo Nylund, Semi Helin, Johan Rajander, Jonathan Danon, Jayson Gilchrist, Michael Kassiou, Vesa Oikonen, Laura Airas

Background: PET imaging of activated microglia has improved our understanding of the pathology behind disability progression in MS, and pro-inflammatory microglia at 'smoldering' lesion rims have been implicated as drivers of disability progression. The P2X 7R is upregulated in the cellular membranes of activated microglia. A single-tissue dual-input model was applied to quantify P2X 7R binding in the normal appearing white matter, perilesional areas and thalamus among progressive MS patients, healthy controls and newly diagnosed relapsing MS patients.

Results: Overall, tracer uptake in the MS brain was not significantly higher compared to HCs. In the 3 mm perilesional rim of all T1 lesions, tracer binding was higher among relapsing patients compared to progressive patients. Tracer binding was higher in males compared to females. Disease duration correlated with tracer binding in the normal appearing white matter. Age correlated negatively with tracer binding in the perilesional rims.

Conclusions: Even as binding estimates obtained with the dual-input model were consistent with the expected distribution of P2X 7Rs in the MS brain, the small free fraction of the parent tracer may limit its accuracy and applicability, and binding estimates between subjects were highly variable. Conclusive evidence for the applicability of [11C]SMW139 to detect MS-related diffuse smoldering inflammation was not obtained.

背景:激活的小胶质细胞的PET成像提高了我们对MS中残疾进展背后的病理的理解,并且“阴燃”病变边缘的促炎小胶质细胞被认为是残疾进展的驱动因素。P2X 7R在活化的小胶质细胞细胞膜中表达上调。采用单组织双输入模型定量分析进展性MS患者、健康对照组和新诊断的复发性MS患者的P2X 7R在外观正常的白质、病灶周围区域和丘脑中的结合情况。结果:总体而言,与hc相比,MS脑中的示踪剂摄取并未显著增加。在所有T1病变的3mm病灶周围,复发患者的示踪剂结合高于进展患者。与女性相比,男性的示踪剂结合更高。疾病持续时间与示踪剂在正常白质中的结合相关。年龄与示踪剂在病灶周围的结合呈负相关。结论:尽管双输入模型得到的结合估计值与MS大脑中P2X 7Rs的预期分布一致,但亲本示踪剂的游离量小可能会限制其准确性和适用性,并且受试者之间的结合估计值差异很大。[11C]SMW139检测ms相关弥漫性阴燃炎症的适用性尚无确凿证据。
{"title":"P2X <sub>7</sub>-receptor binding in new-onset and secondary progressive MS - a [<sup>11</sup>C]SMW139 PET study.","authors":"Jussi Lehto, Richard Aarnio, Jouni Tuisku, Marcus Sucksdorff, Esa Mikko Koivumäki, Marjo Nylund, Semi Helin, Johan Rajander, Jonathan Danon, Jayson Gilchrist, Michael Kassiou, Vesa Oikonen, Laura Airas","doi":"10.1186/s13550-024-01186-3","DOIUrl":"10.1186/s13550-024-01186-3","url":null,"abstract":"<p><strong>Background: </strong>PET imaging of activated microglia has improved our understanding of the pathology behind disability progression in MS, and pro-inflammatory microglia at 'smoldering' lesion rims have been implicated as drivers of disability progression. The P2X <sub>7</sub>R is upregulated in the cellular membranes of activated microglia. A single-tissue dual-input model was applied to quantify P2X <sub>7</sub>R binding in the normal appearing white matter, perilesional areas and thalamus among progressive MS patients, healthy controls and newly diagnosed relapsing MS patients.</p><p><strong>Results: </strong>Overall, tracer uptake in the MS brain was not significantly higher compared to HCs. In the 3 mm perilesional rim of all T1 lesions, tracer binding was higher among relapsing patients compared to progressive patients. Tracer binding was higher in males compared to females. Disease duration correlated with tracer binding in the normal appearing white matter. Age correlated negatively with tracer binding in the perilesional rims.</p><p><strong>Conclusions: </strong>Even as binding estimates obtained with the dual-input model were consistent with the expected distribution of P2X <sub>7</sub>Rs in the MS brain, the small free fraction of the parent tracer may limit its accuracy and applicability, and binding estimates between subjects were highly variable. Conclusive evidence for the applicability of [<sup>11</sup>C]SMW139 to detect MS-related diffuse smoldering inflammation was not obtained.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"14 1","pages":"123"},"PeriodicalIF":3.1,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil. [11C]氟马西尼对胰岛GABAA受体的PET成像。
IF 3.1 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-02 DOI: 10.1186/s13550-024-01176-5
Faïza Maloum-Rami, Pierre Cheung, Gunnar Antoni, Zhe Jin, Olof Eriksson, Daniel Espes

Background: Type 1 diabetes (T1D) is an autoimmune disease characterized by a progressive β-cell destruction. There are no clinically established methods for quantifying endocrine cells of the pancreas and current knowledge is almost exclusively based on autopsy material and functional measurements. Based on the expression of the γ-aminobutyric acid A receptors (GABAARs) in pancreatic islets and the fact that GABAAR agonists are being explored as treatment for T1D, we hypothesized that the positron emission tomography (PET) tracer [11C]flumazenil ([11C]FMZ) could serve as a marker of the endocrine mass of the pancreas. The in vivo uptake of [11C]FMZ in pig pancreas was evaluated by PET/CT, either tracer alone or after blockade of GABAAR by unlabeled flumazenil. The pancreatic binding of [11C]FMZ was investigated in vitro with frozen sections of pig pancreas as well as human organ donors, in addition to isolated mouse and human islets and exocrine preparations. The expression of GABAAR subunits in pig, human and mouse pancreas was explored by immunohistochemistry.

Results: Strong specific in vivo uptake of [11C]FMZ was observed in the pig brain as expected, but in the pancreas the signal was moderate and only partially reduced by blockade. In vitro experiments revealed a positive but weak and variable binding of [11C]FMZ in islets compared to exocrine tissue in the mouse, pig and human pancreas. In pig and mouse pancreatic islets we identified the GABAAR subunits β2 and γ2 but not α2. In the human pancreas from non-diabetic donors, we have identified the α2, β2 (although weak) and γ2 subunits, whereas from a T2D donor the α2 subunit was missing.

Conclusions: Our findings suggest that [11C]FMZ bind to GABAARs in the islets, but not with a sufficient contrast or magnitude to be implemented as an in vivo PET marker for the endocrine mass of the pancreas. However, GABAARs with different subunits are widely expressed in the endocrine cells within the pancreas in pig, human and mouse. Hence, the GABAAR could still be a potential imaging target for the endocrine cells of the pancreas but would require tracers with higher affinity and selectivity for individual GABAAR subunits.

背景:1型糖尿病(T1D)是一种以进行性β细胞破坏为特征的自身免疫性疾病。临床上还没有建立定量胰腺内分泌细胞的方法,目前的知识几乎完全基于尸检材料和功能测量。基于胰岛γ-氨基丁酸A受体(γ-氨基丁酸A receptor, GABAARs)的表达,以及GABAAR激动剂正在探索作为T1D治疗的事实,我们假设正电子发射断层扫描(PET)示踪剂[11C]氟马西尼([11C]FMZ)可以作为胰腺内分泌肿块的标志物。通过PET/CT评估猪胰腺对[11C]FMZ的体内摄取,无论是单独示踪剂还是未标记的氟马西尼阻断GABAAR后。体外研究了[11C]FMZ与猪胰腺、人类器官供体、小鼠和人离体胰岛和外分泌制剂的冷冻切片对胰腺的结合。采用免疫组化方法研究GABAAR亚基在猪、人和小鼠胰腺中的表达。结果:与预期一样,在猪脑中观察到强烈的[11C]FMZ的体内特异性摄取,但在胰腺中,信号是中等的,仅部分被阻断。体外实验显示,与小鼠、猪和人胰腺的外分泌组织相比,[11C]FMZ在胰岛中的结合呈阳性,但弱且可变。在猪和小鼠胰岛中,我们发现了GABAAR亚基β2和γ2,但未发现α2。在非糖尿病供者的胰腺中,我们发现了α2、β2(虽然较弱)和γ2亚基,而在T2D供者的胰腺中,α2亚基缺失。结论:我们的研究结果表明[11C]FMZ与胰岛中的GABAARs结合,但没有足够的对比度或强度作为胰腺内分泌肿块的体内PET标记物。然而,不同亚基的GABAARs在猪、人和小鼠胰腺内的内分泌细胞中广泛表达。因此,GABAAR仍可能是胰腺内分泌细胞的潜在成像靶标,但需要对GABAAR亚基具有更高亲和力和选择性的示踪剂。
{"title":"PET imaging of GABA<sub>A</sub> receptors in pancreatic islets by [<sup>11</sup>C]flumazenil.","authors":"Faïza Maloum-Rami, Pierre Cheung, Gunnar Antoni, Zhe Jin, Olof Eriksson, Daniel Espes","doi":"10.1186/s13550-024-01176-5","DOIUrl":"10.1186/s13550-024-01176-5","url":null,"abstract":"<p><strong>Background: </strong>Type 1 diabetes (T1D) is an autoimmune disease characterized by a progressive β-cell destruction. There are no clinically established methods for quantifying endocrine cells of the pancreas and current knowledge is almost exclusively based on autopsy material and functional measurements. Based on the expression of the γ-aminobutyric acid A receptors (GABA<sub>A</sub>Rs) in pancreatic islets and the fact that GABA<sub>A</sub>R agonists are being explored as treatment for T1D, we hypothesized that the positron emission tomography (PET) tracer [<sup>11</sup>C]flumazenil ([<sup>11</sup>C]FMZ) could serve as a marker of the endocrine mass of the pancreas. The in vivo uptake of [<sup>11</sup>C]FMZ in pig pancreas was evaluated by PET/CT, either tracer alone or after blockade of GABA<sub>A</sub>R by unlabeled flumazenil. The pancreatic binding of [<sup>11</sup>C]FMZ was investigated in vitro with frozen sections of pig pancreas as well as human organ donors, in addition to isolated mouse and human islets and exocrine preparations. The expression of GABA<sub>A</sub>R subunits in pig, human and mouse pancreas was explored by immunohistochemistry.</p><p><strong>Results: </strong>Strong specific in vivo uptake of [<sup>11</sup>C]FMZ was observed in the pig brain as expected, but in the pancreas the signal was moderate and only partially reduced by blockade. In vitro experiments revealed a positive but weak and variable binding of [<sup>11</sup>C]FMZ in islets compared to exocrine tissue in the mouse, pig and human pancreas. In pig and mouse pancreatic islets we identified the GABA<sub>A</sub>R subunits β2 and γ2 but not α2. In the human pancreas from non-diabetic donors, we have identified the α2, β2 (although weak) and γ2 subunits, whereas from a T2D donor the α2 subunit was missing.</p><p><strong>Conclusions: </strong>Our findings suggest that [<sup>11</sup>C]FMZ bind to GABA<sub>A</sub>Rs in the islets, but not with a sufficient contrast or magnitude to be implemented as an in vivo PET marker for the endocrine mass of the pancreas. However, GABA<sub>A</sub>Rs with different subunits are widely expressed in the endocrine cells within the pancreas in pig, human and mouse. Hence, the GABA<sub>A</sub>R could still be a potential imaging target for the endocrine cells of the pancreas but would require tracers with higher affinity and selectivity for individual GABA<sub>A</sub>R subunits.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"14 1","pages":"122"},"PeriodicalIF":3.1,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging tumor and ascites-associated macrophages in a mouse model of metastatic ovarian cancer. 转移性卵巢癌小鼠模型中肿瘤和腹水相关巨噬细胞的成像。
IF 3.1 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-11-29 DOI: 10.1186/s13550-024-01157-8
Catherine A Foss, Flonné Wildes, Delia Mezzanzanica, Franca Podo, Chien-Fu Hung, Santosh Yadav, Marie-France Penet Vidaver

Background: Tumor-Associated Macrophages (TAMs) play a critical role in the pathogenesis and progression of ovarian cancer, a lethal gynecologic malignancy. [124I]iodo-DPA-713 is a PET radiotracer that is selectively trapped within reactive macrophages. We have employed this radioligand here as well as a fluorescent analog to image TAMs associated with primary tumors, secondary pulmonary metastases and gastrointestinal tract-associated macrophages, associated with ascites accumulation in a syngeneic mouse model of metastatic ovarian cancer. Intact female C57BL/6 mice were engrafted with ID8-Defb29-VEGF tumor pieces. One month after engraftment, the mice were selected for positive bioluminescence to show primary and secondary tumor burden and were then scanned by PET/MRI with [124I]iodo-DPA-713, observing a 24 h uptake time. PET data were overlayed with T2-weighted MRI data to facilitate PET uptake tissue identity. Additionally, mice were imaged ex vivo using Near IR Fluorescence (NIRF), capturing the uptake and sequestration of DPA-713-IRDye800CW, a fluorescent analog of the radioligand used here. Additionally, cell culture uptake of DPA-713-IRDye680LT in ID8-DEFb29-VEGF, IOSE hTERT and RAW264.7 cells was conducted to measure tracer uptake in ovarian cancer cells, ovarian epithelial cells and macrophage.

Results: PET/MRI data show an intense ring of radiotracer uptake surrounding primary tumors. PET uptake is also associated with lung metastases, but not healthy lung. Mice displaying ascites also display PET uptake along the gastrointestinal tract while sham-operated mice show minimal gastrointestinal uptake. All mice show specific kidney uptake. Mice imaged by NIRF confirmed TAMs uptake mostly at the rim of primary tumors while 1 mm secondary tumors in the lungs displayed robust, homogeneous uptake of the radio- and fluorescent analog. Ex vivo biodistribution of [124I]iodo-DPA-713 showed that contralateral ovaries in middle-stage disease had the highest probe uptake with tissues sampled in mid- and late-stage disease showing increasing uptake.

Conclusion: [124I]iodo-DPA-713 and DPA-713-IRDye800CW sensitively identify and locate TAMs in a syngeneic mouse model of metastatic ovarian cancer.

背景:肿瘤相关巨噬细胞(Tumor-Associated Macrophages, tam)在卵巢癌(一种致死性妇科恶性肿瘤)的发病和进展中起着关键作用。[124I]碘- dpa -713是一种PET放射性示踪剂,可选择性捕获在反应性巨噬细胞内。我们在转移性卵巢癌的同基因小鼠模型中使用了这种放射配体以及荧光模拟物来成像与原发性肿瘤、继发性肺转移和胃肠道相关巨噬细胞相关的tam,这些巨噬细胞与腹水积累相关。将完整雌性C57BL/6小鼠植入ID8-Defb29-VEGF肿瘤块。植入1个月后,选择阳性生物发光小鼠显示原发性和继发性肿瘤负荷,然后用[124I]iodo-DPA-713进行PET/MRI扫描,观察24 h的摄取时间。PET数据与t2加权MRI数据叠加,以方便PET摄取组织识别。此外,使用近红外荧光(NIRF)对小鼠进行离体成像,捕捉DPA-713-IRDye800CW的摄取和隔离,DPA-713-IRDye800CW是本文使用的放射性配体的荧光模拟物。此外,在ID8-DEFb29-VEGF、IOSE hTERT和RAW264.7细胞中进行DPA-713-IRDye680LT的细胞培养摄取,以测量卵巢癌细胞、卵巢上皮细胞和巨噬细胞对示踪剂的摄取。结果:PET/MRI数据显示原发肿瘤周围有强烈的放射性示踪剂摄取环。PET摄取也与肺转移有关,但与健康肺无关。显示腹水的小鼠也显示PET沿胃肠道摄取,而假手术小鼠显示胃肠道摄取最小。所有小鼠均表现出特定的肾脏摄取。用NIRF成像的小鼠证实,TAMs主要在原发肿瘤的边缘摄取,而肺部1毫米的继发肿瘤显示出强劲、均匀的放射性和荧光类似物摄取。[124I]碘- dpa -713的体外生物分布表明,疾病中期对侧卵巢对探针的摄取最高,中晚期采集的组织对探针的摄取增加。结论:[124I]碘- dpa -713和dpa -713- irdye - 800cw对转移性卵巢癌小鼠模型中的tam具有较强的识别和定位能力。
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引用次数: 0
Impact of cognitive impairment on heart failure prognosis: insights into central nervous system mechanism. 认知障碍对心力衰竭预后的影响:中枢神经系统机制的见解。
IF 3.1 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-11-28 DOI: 10.1186/s13550-024-01183-6
Zhiyong Shi, Mingkai Yun, Binbin Nie, Enjun Zhu, Wei Fu, Baoci Shan, Sijin Li, Xiaoli Zhang, Xiang Li

Background: Epidemiological studies have indicated that patients with heart failure (HF) who experience cognitive impairment (CI) have a poor prognosis. While poor self-management and compliance are suggested as contributing factors, they do not fully explain the underlying mechanisms of high risk of cardiac events in HF patients with CI. Given the interconnectedness of CI and the autonomic nervous system (ANS), both regulated by the central nervous system, this study investigated the relationship among cognitive function, metabolism in ANS-related brain regions, and major arrhythmic events (MAEs) in patients with HF with reduced ejection fraction (HFrEF).

Results: We retrospectively enrolled 72 patients with HFrEF who underwent gated myocardial perfusion imaging, heart and brain 18F-FDG positron emission tomography/computed tomography imaging, and cognitive testing. Cognitive function was evaluated using the Mini-Mental State Examination. During the follow-up period, 13 patients (17.8%) experienced MAEs. Patients with MAEs exhibited decreased cognitive function across various domains, including orientation, registration, and language and praxis (all p < 0.05). Patients with CI displayed a prolonged heart rate-corrected QT (QTc) interval and hypometabolism in the left hippocampus and bilateral caudate nuclei (all p < 0.05). Significant correlations were observed between cognitive function, QTc interval, and metabolism in ANS-related brain regions (all p < 0.05). Cox regression model analysis showed that the predictive value of cognitive function is not independent of the QTc interval and there is a significant interaction. The mediation analyses suggested that a prolonged QTc interval resulting from ANS disorder increased risk of MAEs in HFrEF patients with CI. Patients with CI exhibited reduced central autonomic network (CAN) connectivity.

Conclusion: ANS dysfunction, exacerbated by reduced metabolism in ANS-related brain regions and CAN connectivity, contributed to an increased risk of MAEs in HFrEF patients with CI.

背景:流行病学研究表明,心力衰竭(HF)患者认知功能障碍(CI)预后较差。虽然不良的自我管理和依从性被认为是促成因素,但它们并不能完全解释心力衰竭合并CI患者心脏事件高风险的潜在机制。鉴于CI和自主神经系统(ANS)均受中枢神经系统的调控,本研究探讨了心力衰竭伴射血分数降低(HFrEF)患者的认知功能、自主神经相关脑区代谢和主要心律失常事件(MAEs)之间的关系。结果:我们回顾性地纳入了72例HFrEF患者,他们接受了门控心肌灌注成像、心脑18F-FDG正电子发射断层扫描/计算机断层扫描成像和认知测试。使用简易精神状态检查评估认知功能。随访期间13例(17.8%)发生MAEs。患有MAEs的患者表现出不同领域的认知功能下降,包括定向、定位、语言和实践(所有p结论:ANS功能障碍,由ANS相关脑区代谢减少和CAN连接加剧,导致HFrEF合并CI患者发生MAEs的风险增加。
{"title":"Impact of cognitive impairment on heart failure prognosis: insights into central nervous system mechanism.","authors":"Zhiyong Shi, Mingkai Yun, Binbin Nie, Enjun Zhu, Wei Fu, Baoci Shan, Sijin Li, Xiaoli Zhang, Xiang Li","doi":"10.1186/s13550-024-01183-6","DOIUrl":"10.1186/s13550-024-01183-6","url":null,"abstract":"<p><strong>Background: </strong>Epidemiological studies have indicated that patients with heart failure (HF) who experience cognitive impairment (CI) have a poor prognosis. While poor self-management and compliance are suggested as contributing factors, they do not fully explain the underlying mechanisms of high risk of cardiac events in HF patients with CI. Given the interconnectedness of CI and the autonomic nervous system (ANS), both regulated by the central nervous system, this study investigated the relationship among cognitive function, metabolism in ANS-related brain regions, and major arrhythmic events (MAEs) in patients with HF with reduced ejection fraction (HFrEF).</p><p><strong>Results: </strong>We retrospectively enrolled 72 patients with HFrEF who underwent gated myocardial perfusion imaging, heart and brain <sup>18</sup>F-FDG positron emission tomography/computed tomography imaging, and cognitive testing. Cognitive function was evaluated using the Mini-Mental State Examination. During the follow-up period, 13 patients (17.8%) experienced MAEs. Patients with MAEs exhibited decreased cognitive function across various domains, including orientation, registration, and language and praxis (all p < 0.05). Patients with CI displayed a prolonged heart rate-corrected QT (QTc) interval and hypometabolism in the left hippocampus and bilateral caudate nuclei (all p < 0.05). Significant correlations were observed between cognitive function, QTc interval, and metabolism in ANS-related brain regions (all p < 0.05). Cox regression model analysis showed that the predictive value of cognitive function is not independent of the QTc interval and there is a significant interaction. The mediation analyses suggested that a prolonged QTc interval resulting from ANS disorder increased risk of MAEs in HFrEF patients with CI. Patients with CI exhibited reduced central autonomic network (CAN) connectivity.</p><p><strong>Conclusion: </strong>ANS dysfunction, exacerbated by reduced metabolism in ANS-related brain regions and CAN connectivity, contributed to an increased risk of MAEs in HFrEF patients with CI.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"14 1","pages":"120"},"PeriodicalIF":3.1,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiation exposure and protection advice after [177Lu]Lu-DOTA-TATE therapy in China. 中国[177Lu]Lu-DOTA-TATE治疗后的辐射照射和防护建议。
IF 3.1 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-11-28 DOI: 10.1186/s13550-024-01185-4
Fei Liu, Panli Li, Junyan Xu, Jianping Zhang, Xiaoping Xu, Zhihao Chen, Ying Qiao, Yun Liang, Jie Chen, Shaoli Song

Background: We conducted a study on radiation exposure in patients with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) treated with [177Lu]Lu-DOTA-TATE in China for the first time, aiming to provide guidance and reference for radiation protection in this regard. A total of 30 GEP-NENs patients who received [177Lu]Lu-DOTA-TATE therapy were recruited in the study. We measured the external dose rate (EDR) values of each patient during the injection and 0-6 h post-administration period, as well as the radiation dose (RD) values to healthcare nurses and the surrounding environment. We performed a double exponential curve fitting and estimated the RD to the public from patients discharged at different times after [177Lu]Lu-DOTA-TATE therapy.

Results: Among the 30 patients, 27 patients completed 4 cycles of [177Lu]Lu-DOTA-TATE treatments, the estimated RD to the public indicated that for adult family members, children above 10 years old, children aged 3-10 and coworkers of the patients, patients could begin daily contact at least 24 h, 48 h, 144 h and 192 h after injection to ensure that the total RD values after four treatments not exceed the limit. During the hospitalization of patients receiving [177Lu]Lu-DOTA-TATE, the cumulative dose received by the administering nurses and to the ward environment were both well below the national RD limits.

Conclusions: This study conducted a fitting analysis of the decay pattern of EDR values in GEP-NENs patients undergoing [177Lu]Lu-DOTA-TATE therapy, in order to establish guidelines for patient discharge timing and provide recommendations for radiation protection for the general public after patient discharge. Trial registration A Study Comparing Treatment With Lutetium[177Lu] Oxodotreotide Injection to Octreotide LAR in Patients With GEP-NETs, NCT05459844. https://clinicaltrials.gov/study/NCT05459844?cond=NCT05459844&rank=1 . Registered 5 July 2022.

背景:我们首次在中国开展了一项关于胃肠胰神经内分泌肿瘤(GEP-NENs)患者接受[177Lu]Lu-DOTA-TATE治疗后辐射暴露的研究,旨在为这方面的辐射防护提供指导和参考。本研究共招募了30名接受[177Lu]Lu-DOTA-TATE治疗的GEP-NENs患者。我们测量了每位患者在注射期间和用药后0-6 h的外剂量率(EDR)值,以及医护人员和周围环境的辐射剂量(RD)值。我们对[177Lu]Lu-DOTA-TATE治疗后不同时间出院的患者进行了双指数曲线拟合,并估算了公众的辐射剂量:30例患者中,有27例患者完成了4个周期的[177Lu]Lu-DOTA-TATE治疗,估算出的对公众的RD表明,对于患者的成年家属、10岁以上儿童、3-10岁儿童和同事,患者可在注射后至少24 h、48 h、144 h和192 h开始日常接触,以确保4次治疗后的总RD值不超标。在接受[177Lu]Lu-DOTA-TATE治疗的患者住院期间,给药护士和病房环境接受的累积剂量均远低于国家RD限值:本研究对接受[177Lu]Lu-DOTA-TATE治疗的GEP-NENs患者的EDR值衰减模式进行了拟合分析,以制定患者出院时间指南,并为患者出院后的公众辐射防护提供建议。试验注册:GEP-NETs 患者使用镥[177Lu]奥曲肽注射液与奥曲肽 LAR 治疗的比较研究,NCT05459844。https://clinicaltrials.gov/study/NCT05459844?cond=NCT05459844&rank=1 。2022 年 7 月 5 日注册。
{"title":"Radiation exposure and protection advice after [<sup>177</sup>Lu]Lu-DOTA-TATE therapy in China.","authors":"Fei Liu, Panli Li, Junyan Xu, Jianping Zhang, Xiaoping Xu, Zhihao Chen, Ying Qiao, Yun Liang, Jie Chen, Shaoli Song","doi":"10.1186/s13550-024-01185-4","DOIUrl":"10.1186/s13550-024-01185-4","url":null,"abstract":"<p><strong>Background: </strong>We conducted a study on radiation exposure in patients with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) treated with [<sup>177</sup>Lu]Lu-DOTA-TATE in China for the first time, aiming to provide guidance and reference for radiation protection in this regard. A total of 30 GEP-NENs patients who received [<sup>177</sup>Lu]Lu-DOTA-TATE therapy were recruited in the study. We measured the external dose rate (EDR) values of each patient during the injection and 0-6 h post-administration period, as well as the radiation dose (RD) values to healthcare nurses and the surrounding environment. We performed a double exponential curve fitting and estimated the RD to the public from patients discharged at different times after [<sup>177</sup>Lu]Lu-DOTA-TATE therapy.</p><p><strong>Results: </strong>Among the 30 patients, 27 patients completed 4 cycles of [<sup>177</sup>Lu]Lu-DOTA-TATE treatments, the estimated RD to the public indicated that for adult family members, children above 10 years old, children aged 3-10 and coworkers of the patients, patients could begin daily contact at least 24 h, 48 h, 144 h and 192 h after injection to ensure that the total RD values after four treatments not exceed the limit. During the hospitalization of patients receiving [<sup>177</sup>Lu]Lu-DOTA-TATE, the cumulative dose received by the administering nurses and to the ward environment were both well below the national RD limits.</p><p><strong>Conclusions: </strong>This study conducted a fitting analysis of the decay pattern of EDR values in GEP-NENs patients undergoing [<sup>177</sup>Lu]Lu-DOTA-TATE therapy, in order to establish guidelines for patient discharge timing and provide recommendations for radiation protection for the general public after patient discharge. Trial registration A Study Comparing Treatment With Lutetium[177Lu] Oxodotreotide Injection to Octreotide LAR in Patients With GEP-NETs, NCT05459844. https://clinicaltrials.gov/study/NCT05459844?cond=NCT05459844&rank=1 . Registered 5 July 2022.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"14 1","pages":"119"},"PeriodicalIF":3.1,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction Note: Neuromelanin-targeted 18 F-P3BZA PET/MR imaging of the substantia nigra in rhesus macaques. 撤稿说明:猕猴黑质的神经络氨酸靶向 18 F-P3BZA PET/MR 成像。
IF 3.1 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-11-27 DOI: 10.1186/s13550-024-01184-5
Hongyan Feng, Ning Tu, Ke Wang, Xiaowei Ma, Zhentao Zhang, Zhongchun Liu, Zhen Cheng, Lihong Bu
{"title":"Retraction Note: Neuromelanin-targeted 18 F-P3BZA PET/MR imaging of the substantia nigra in rhesus macaques.","authors":"Hongyan Feng, Ning Tu, Ke Wang, Xiaowei Ma, Zhentao Zhang, Zhongchun Liu, Zhen Cheng, Lihong Bu","doi":"10.1186/s13550-024-01184-5","DOIUrl":"10.1186/s13550-024-01184-5","url":null,"abstract":"","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"14 1","pages":"118"},"PeriodicalIF":3.1,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11602884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Machine learning for prognostic prediction in coronary artery disease with SPECT data: a systematic review and meta-analysis. 利用 SPECT 数据进行冠心病预后预测的机器学习:系统综述和荟萃分析。
IF 3.1 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-11-26 DOI: 10.1186/s13550-024-01179-2
Vedat Cicek, Ezgi Hasret Kozan Cikirikci, Mert Babaoğlu, Almina Erdem, Yalcin Tur, Mohamed Iesar Mohamed, Tufan Cinar, Hatice Savas, Ulas Bagci

Background: Single-photon emission computed tomography (SPECT) analysis relies on qualitative visual assessment or semi-quantitative measures like total perfusion deficit that play a critical role in the non-invasive diagnosis of coronary artery disease by assessing regional blood flow abnormalities. Recently, machine learning (ML) -based analysis of SPECT images for coronary artery disease diagnosis has shown promise, with its utility in predicting long-term patient outcomes (prognosis) remaining an active area of investigation. In this review, we comprehensively examine the current landscape of ML-based analysis of SPECT imaging with an emphasis on prognostication of coronary artery disease.

Main body: Our systematic search yielded twelve retrospective studies, investigating SPECT-based ML models for prognostic prediction in coronary artery disease patients, with a total sample size of 73,023 individuals. Several of these studies demonstrate the superior prognostic capabilities of ML models over traditional logistic regression (LR) models and total perfusion deficit, especially when incorporating demographic data alongside SPECT imaging. Meta-analysis of 6 studies revealed promising performance of the included ML models, with sensitivity and specificity exceeding 65% for major adverse cardiovascular events and all-cause mortality. Notably, the integration of demographic information with SPECT imaging in ML frameworks shows statistically significant improvements in prognostic performance.

Conclusion: Our review suggests that ML models either independently or in combination with demographic data enhance prognostic prediction in coronary artery disease.

背景:单光子发射计算机断层扫描(SPECT)分析依赖于定性视觉评估或半定量测量,如总灌注缺失,通过评估区域血流异常,在冠状动脉疾病的无创诊断中发挥着至关重要的作用。最近,基于机器学习(ML)的冠状动脉疾病诊断 SPECT 图像分析已显示出良好的前景,但其在预测患者长期预后(预后)方面的实用性仍是一个活跃的研究领域。在这篇综述中,我们全面考察了基于 ML 的 SPECT 成像分析的现状,重点是冠状动脉疾病的预后:我们通过系统检索获得了 12 项回顾性研究,这些研究调查了基于 SPECT 的 ML 模型对冠心病患者的预后预测,总样本量为 73023 人。其中几项研究表明,ML模型的预后能力优于传统的逻辑回归(LR)模型和总灌注缺失,尤其是在结合人口统计学数据和SPECT成像的情况下。对 6 项研究进行的元分析表明,所纳入的 ML 模型性能良好,对主要不良心血管事件和全因死亡率的敏感性和特异性均超过 65%。值得注意的是,将人口统计学信息与 SPECT 成像整合到 ML 框架中,可在统计学上显著改善预后效果:我们的综述表明,ML 模型无论是单独使用还是与人口统计学数据相结合,都能提高冠心病的预后预测能力。
{"title":"Machine learning for prognostic prediction in coronary artery disease with SPECT data: a systematic review and meta-analysis.","authors":"Vedat Cicek, Ezgi Hasret Kozan Cikirikci, Mert Babaoğlu, Almina Erdem, Yalcin Tur, Mohamed Iesar Mohamed, Tufan Cinar, Hatice Savas, Ulas Bagci","doi":"10.1186/s13550-024-01179-2","DOIUrl":"10.1186/s13550-024-01179-2","url":null,"abstract":"<p><strong>Background: </strong>Single-photon emission computed tomography (SPECT) analysis relies on qualitative visual assessment or semi-quantitative measures like total perfusion deficit that play a critical role in the non-invasive diagnosis of coronary artery disease by assessing regional blood flow abnormalities. Recently, machine learning (ML) -based analysis of SPECT images for coronary artery disease diagnosis has shown promise, with its utility in predicting long-term patient outcomes (prognosis) remaining an active area of investigation. In this review, we comprehensively examine the current landscape of ML-based analysis of SPECT imaging with an emphasis on prognostication of coronary artery disease.</p><p><strong>Main body: </strong>Our systematic search yielded twelve retrospective studies, investigating SPECT-based ML models for prognostic prediction in coronary artery disease patients, with a total sample size of 73,023 individuals. Several of these studies demonstrate the superior prognostic capabilities of ML models over traditional logistic regression (LR) models and total perfusion deficit, especially when incorporating demographic data alongside SPECT imaging. Meta-analysis of 6 studies revealed promising performance of the included ML models, with sensitivity and specificity exceeding 65% for major adverse cardiovascular events and all-cause mortality. Notably, the integration of demographic information with SPECT imaging in ML frameworks shows statistically significant improvements in prognostic performance.</p><p><strong>Conclusion: </strong>Our review suggests that ML models either independently or in combination with demographic data enhance prognostic prediction in coronary artery disease.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"14 1","pages":"117"},"PeriodicalIF":3.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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