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Epilepsy Currents最新文献

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Exploring Dendritic and Spine Structural Profiles in Epilepsy: Insights From Human Studies and Experimental Animal Models. 探索癫痫的树突和脊柱结构特征：人类研究和实验动物模型的启示。
IF 3.6 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2023-12-27 eCollection Date: 2024-01-01 DOI: 10.1177/15357597231218603
Shikha Kumari, Amy L Brewster

Dendrites are tree-like structures with tiny spines specialized to receive excitatory synaptic transmission. Spino-dendritic plasticity, driven by neural activity, underlies the maintenance of neuronal connections crucial for proper circuit function. Abnormalities in dendritic morphology are frequently seen in epilepsy. However, the exact etiology or functional implications are not yet known. Therefore, to better comprehend the structure-function significance of this dendritic pathology in epilepsy, it is necessary to identify the common spino-dendritic disturbances present in both human and experimental models. Here, we describe the dendritic and spine structural profiles found across human refractory epilepsy as well as in animal models of developmental, acquired, and genetic epilepsies.

树突是一种树状结构，具有专门接收兴奋性突触传递的微小棘突。神经活动驱动的棘突-树突可塑性是维持神经元连接的基础，而神经元连接对电路功能的正常发挥至关重要。树突形态异常经常见于癫痫。然而，确切的病因或功能影响尚不清楚。因此，为了更好地理解这种树突病理学在癫痫中的结构-功能意义，有必要确定人类和实验模型中常见的棘树突紊乱。在这里，我们描述了在人类难治性癫痫以及发育性、获得性和遗传性癫痫动物模型中发现的树突和棘突结构特征。
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引用次数: 0
Unspooling the Thread: VIP Interneurons Linked With Autism Spectrum Disorder Behaviors but Not Seizures in Dravet Syndrome. 解开螺纹：VIP中间神经元与自闭症谱系障碍行为有关，但与德雷维特综合征的癫痫发作无关
IF 3.6 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2023-12-27 eCollection Date: 2024-01-01 DOI: 10.1177/15357597231218876
Raquel Miralles, Manoj K Patel

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引用次数: 0
Get Out the Door: Ambulatory EEG Trumps Routine EEG in the Detection of Interictal Epileptiform Abnormalities After a First Unprovoked Seizure 走出家门：在首次无诱因癫痫发作后检测发作间期癫痫样异常时，动态脑电图胜过常规脑电图
IF 3.6 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2023-12-13 DOI: 10.1177/15357597231217647
R. Marawar
[Box: see text]
[方框：见正文]
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引用次数: 0
Seizing the Brain Networks in Lesional Focal Epilepsies 抓住病灶性癫痫的大脑网络
IF 3.6 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2023-12-12 DOI: 10.1177/15357597231216917
Ifrah Zawar
[Box: see text]
[方框：见正文]
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引用次数: 0
The “Curious Case of Postictal Oxygen Dissipation”: Could ROS Be the Culprit? 发作后氧耗散奇案"：ROS 会是罪魁祸首吗？
IF 3.6 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2023-12-12 DOI: 10.1177/15357597231216921
Ashwini Sri Hari, Cameron S. Metcalf
[Box: see text]
[方框：见正文]
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引用次数: 0
Beyond Seizures: The Usefulness of EEG in Septic Patients 超越癫痫发作：脑电图对败血症患者的作用
IF 3.6 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2023-12-12 DOI: 10.1177/15357597231217652
Samuel Lapalme-Remis
[Box: see text]
[方框：见正文]
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引用次数: 0
Only Hit the Bad Guys: A Gene Therapy Approach to Selectively Silence Highly Active Neurons Reduces Chronic Seizures in Epileptic Mice 只打坏人：选择性沉默高活性神经元的基因疗法可减少癫痫小鼠的慢性癫痫发作
IF 3.6 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2023-12-12 DOI: 10.1177/15357597231210253
Tristan Shuman
[Box: see text]
[方框：见正文]
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引用次数: 0
“T” Times: Revisiting the Timing of Neuronal Injury in Status Epilepticus T "时代：重新审视癫痫状态中神经元损伤的时机
IF 3.6 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2023-12-08 DOI: 10.1177/15357597231216003
A. Husain
[Box: see text]
[方框:见文本]
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引用次数: 0
Epilepsy and Anti-Seizure Medications: Secret Agents for Endocrine Disruption 癫痫和抗癫痫药物：内分泌干扰的秘密特工
IF 3.6 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2023-12-06 DOI: 10.1177/15357597231213248
M. Sazgar, L. Mnatsakanyan, Alison M. Pack, Cynthia L. Harden
There is a reciprocal relationship between epilepsy and reproductive endocrine disorders. Seizures and anti-seizure medications (ASMs) can contribute to reproductive and endocrine dysfunction and reproductive dysfunction may exacerbate seizures. Epilepsy via neuroendocrine mechanisms affects the hypothalamic–pituitary-ovarian (HPO) axis, disrupting the regulation of gonadotropin secretion, and resulting in dystrophic effects on the ovaries and early menopause. Anti-seizure medications have endocrine-related side effects on sexual function and bone health. Long-term use of ASMs may result in menstrual irregularities, sexual dysfunction, anovulatory cycles, polycystic ovaries, and reduced fertility. Some ASMs also interfere with bone metabolism. Epilepsy patients treated with ASMs are at risk for bone loss and fractures. This article explores the endocrine and hormonal effects of seizures and ASMs.
癫痫与生殖内分泌紊乱之间存在着相互关系。癫痫发作和抗癫痫药物(asm)可导致生殖和内分泌功能障碍，生殖功能障碍可加剧癫痫发作。癫痫通过神经内分泌机制影响下丘脑-垂体-卵巢(HPO)轴，破坏促性腺激素分泌的调节，导致卵巢营养不良和早期绝经。抗癫痫药物对性功能和骨骼健康有内分泌方面的副作用。长期使用asm可能导致月经不规律、性功能障碍、无排卵周期、多囊卵巢和生育能力下降。一些asm还会干扰骨骼代谢。接受抗痉挛药物治疗的癫痫患者有骨质流失和骨折的风险。本文探讨了癫痫发作和痉挛的内分泌和激素影响。
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引用次数: 0
The Temporal Lobe Club: Newer Approaches to Treat Temporal Lobe Epilepsy 颞叶俱乐部：治疗颞叶癫痫的新方法
IF 3.6 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2023-12-06 DOI: 10.1177/15357597231213161
Michael R. Sperling, Chengyuan Wu, Joon Kang, J. Makhalova, Fabrice Bartolomei, Derek Southwell
This brief review summarizes presentations at the Temporal Lobe Club Special Interest Group session held in December 2022 at the American Epilepsy Society meeting. The session addressed newer methods to treat temporal epilepsy, including methods currently in clinical use and techniques under investigation. Brief summaries are provided for each of 4 lectures. Dr Chengyuan Wu discussed ablative techniques such as laser interstitial thermal ablation, radiofrequency ablation, focused ultrasound; Dr Joon Kang reviewed neuromodulation techniques including electrical stimulation and focused ultrasound; Dr Julia Makhalova discussed network effects of the aforementioned techniques; and Dr Derek Southwell reviewed inhibitory interneuron transplantation. These summaries are intended to provide a brief overview and references are provided for the reader to learn more about each topic.
这篇简短的综述总结了2022年12月在美国癫痫协会会议上举行的颞叶俱乐部特别兴趣小组会议上的演讲。会议讨论了治疗颞叶癫痫的新方法，包括目前临床使用的方法和正在研究的技术。每节课提供简短的总结。吴成元博士讨论了激光间质热消融、射频消融、聚焦超声等消融技术;Joon Kang博士回顾了包括电刺激和聚焦超声在内的神经调节技术;Julia Makhalova博士讨论了上述技术的网络效应;Derek Southwell博士回顾了抑制性中间神经元移植。这些摘要旨在提供一个简短的概述，并为读者提供参考资料，以了解每个主题的更多信息。
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