Pub Date : 2024-05-06DOI: 10.1177/15357597241250275
Austin W. Drake, Steve C. Danzer
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{"title":"Chemogenetic Seizure Control: Keeping the Horses in the BARN(I)","authors":"Austin W. Drake, Steve C. Danzer","doi":"10.1177/15357597241250275","DOIUrl":"https://doi.org/10.1177/15357597241250275","url":null,"abstract":"[Box: see text]","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"46 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140884866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-30DOI: 10.1177/15357597241249037
Karin Borges
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{"title":"The Benefits of “Spoilt Milk”: Lactic Acid Can Limit Excitability via HCAR1","authors":"Karin Borges","doi":"10.1177/15357597241249037","DOIUrl":"https://doi.org/10.1177/15357597241249037","url":null,"abstract":"[Box: see text]","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"23 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140840013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-30DOI: 10.1177/15357597241235785
Peter Widdess-Walsh
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{"title":"River Epilepsy—A Preventable Form of Epilepsy","authors":"Peter Widdess-Walsh","doi":"10.1177/15357597241235785","DOIUrl":"https://doi.org/10.1177/15357597241235785","url":null,"abstract":"[Box: see text]","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"50 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140840692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-30DOI: 10.1177/15357597241242250
John Stern, Susan Stanton, Laura Howe-Martin, Chadrick Lane, Christine Sports, Barry Gidal, Meghann Soby, Rohit R. Das
Optimal care for people with epilepsy (PwE) requires a multidisciplinary patient-oriented team, a concept that emerged from oncology. This article reviews the role of advanced practice providers, dieticians, psychologists, pharmacists, psychiatrists, and social workers in working alongside neurologists in caring for PwE. The article examines training and licensure requirements, clinical needs, and scope of practice for these disciplines. The review concludes by providing recommendations and a framework for multidisciplinary care for PwE.
{"title":"The Multidisciplinary Team in the Treatment of Patients With Epilepsy","authors":"John Stern, Susan Stanton, Laura Howe-Martin, Chadrick Lane, Christine Sports, Barry Gidal, Meghann Soby, Rohit R. Das","doi":"10.1177/15357597241242250","DOIUrl":"https://doi.org/10.1177/15357597241242250","url":null,"abstract":"Optimal care for people with epilepsy (PwE) requires a multidisciplinary patient-oriented team, a concept that emerged from oncology. This article reviews the role of advanced practice providers, dieticians, psychologists, pharmacists, psychiatrists, and social workers in working alongside neurologists in caring for PwE. The article examines training and licensure requirements, clinical needs, and scope of practice for these disciplines. The review concludes by providing recommendations and a framework for multidisciplinary care for PwE.","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"20 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140840026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-30DOI: 10.1177/15357597241242238
Melissa Barker-Haliski, Ana Beatriz DePaula-Silva, Julika Pitsch, Harald Sontheimer, Lawrence J. Hirsch, Aristea S. Galanopoulou, Jennifer A. Kearney
Roughly 80% of the global burden of epilepsy resides in low- and middle-income countries (LMICs; WHO, 2022). Despite numerous new therapies for the treatment of epilepsy, the number of patients who remain resistant to available medications is unchanged. Additionally, no therapy has yet been clinically proven to prevent or attenuate the development of epilepsy in at-risk individuals. Unfortunately, access to next generation therapies in LMICs is low, the stigma associated with epilepsy remains high, and access to adequate resources is unchanged. Thus, the global epilepsy burden disproportionately falls on LMICs such that strategies to conscientiously integrate global epilepsy risk factors into preclinical research may meaningfully advance 21st century epilepsy therapies. Brain infections are one of the main risk factors for epilepsy in resource-poor settings. Further, both infection- and autoimmune-associated encephalitis contribute to worldwide epilepsy risk and remain relatively understudied. For example, clinical SARS CoV-2 infection can induce rare instances of encephalopathy and acute seizures. Among viruses known to cause acute brain infection, enteroviruses increase risk for encephalitis-induced epilepsy, but are not associated with risk for other neurodevelopmental disorders (eg, autism spectrum or attentional deficit hyperactivity disorders). Naturally occurring models of viral infection-induced epilepsy therefore provide an exquisite opportunity to uncover novel contributors to epileptogenesis. Moreover, the convergent neuroinflammatory pathways that are associated with viral infection-induced encephalitis and autoimmune encephalitis reflect an untapped therapeutic opportunity to meaningfully reduce the global burden of epilepsy. This review summarizes the latest advances in translational research integrating encephalitis-induced seizure and epilepsy models, in tandem with progress in clinical diagnosis of inflammation and virally mediated epilepsy. This improved awareness of the shared biological underpinnings of epileptogenesis following brain infection or autoimmune encephalitis is anticipated to beneficially impact the global burden of epilepsy.
{"title":"Brain on Fire: How Brain Infection and Neuroinflammation Drive Worldwide Epilepsy Burden","authors":"Melissa Barker-Haliski, Ana Beatriz DePaula-Silva, Julika Pitsch, Harald Sontheimer, Lawrence J. Hirsch, Aristea S. Galanopoulou, Jennifer A. Kearney","doi":"10.1177/15357597241242238","DOIUrl":"https://doi.org/10.1177/15357597241242238","url":null,"abstract":"Roughly 80% of the global burden of epilepsy resides in low- and middle-income countries (LMICs; WHO, 2022). Despite numerous new therapies for the treatment of epilepsy, the number of patients who remain resistant to available medications is unchanged. Additionally, no therapy has yet been clinically proven to prevent or attenuate the development of epilepsy in at-risk individuals. Unfortunately, access to next generation therapies in LMICs is low, the stigma associated with epilepsy remains high, and access to adequate resources is unchanged. Thus, the global epilepsy burden disproportionately falls on LMICs such that strategies to conscientiously integrate global epilepsy risk factors into preclinical research may meaningfully advance 21st century epilepsy therapies. Brain infections are one of the main risk factors for epilepsy in resource-poor settings. Further, both infection- and autoimmune-associated encephalitis contribute to worldwide epilepsy risk and remain relatively understudied. For example, clinical SARS CoV-2 infection can induce rare instances of encephalopathy and acute seizures. Among viruses known to cause acute brain infection, enteroviruses increase risk for encephalitis-induced epilepsy, but are not associated with risk for other neurodevelopmental disorders (eg, autism spectrum or attentional deficit hyperactivity disorders). Naturally occurring models of viral infection-induced epilepsy therefore provide an exquisite opportunity to uncover novel contributors to epileptogenesis. Moreover, the convergent neuroinflammatory pathways that are associated with viral infection-induced encephalitis and autoimmune encephalitis reflect an untapped therapeutic opportunity to meaningfully reduce the global burden of epilepsy. This review summarizes the latest advances in translational research integrating encephalitis-induced seizure and epilepsy models, in tandem with progress in clinical diagnosis of inflammation and virally mediated epilepsy. This improved awareness of the shared biological underpinnings of epileptogenesis following brain infection or autoimmune encephalitis is anticipated to beneficially impact the global burden of epilepsy.","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"11 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140840331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-30DOI: 10.1177/15357597241250161
Ioannis Karakis
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{"title":"Genetic Testing in the Presurgical Evaluation of Drug-Resistant Epilepsy: Bells and Whistles or Nuts and Bolts?","authors":"Ioannis Karakis","doi":"10.1177/15357597241250161","DOIUrl":"https://doi.org/10.1177/15357597241250161","url":null,"abstract":"[Box: see text][Box: see text]","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"1 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140840191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-30DOI: 10.1177/15357597241249045
Carl E. Stafstrom
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{"title":"Cyclin-Dependent Kinase-Like 5 Deficiency Disorder: A Calcium Channelopathy?","authors":"Carl E. Stafstrom","doi":"10.1177/15357597241249045","DOIUrl":"https://doi.org/10.1177/15357597241249045","url":null,"abstract":"[Box: see text]","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"11 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140840396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-30DOI: 10.1177/15357597241250159
Jay A. Salpekar, D. Dilara Ertenu
Epilepsy and psychiatric illness have been long studied and today are better accepted as co-occurring than as discrete illnesses that are independent even if associated. Common pathophysiology may not be easily explained, but clearly exists given the significant overrepresentation of psychiatric illness among individuals with epilepsy. Conditions like autism spectrum disorder, anxiety, depression, and attention deficit hyperactivity disorder are prevalent in pediatric epilepsy much more than expected, even in the context of chronic neurologic disease. The interplay between pediatric epilepsy and neuropsychiatric symptoms represents a complex clinical circumstance that is not well subtended by the chasm-like division of labor between psychiatrists and neurologists. The unfortunate result is that children and families often experience care that is fractured and at worst, counterproductive for their quality of life. A neuropsychiatric paradigm is essential to address epilepsy and its intrinsic psychiatric symptoms. Practical strategies will be discussed to address this challenge.
{"title":"Common Ground: We Can Comprehensively Treat Pediatric Epilepsy and Psychiatric Comorbidities","authors":"Jay A. Salpekar, D. Dilara Ertenu","doi":"10.1177/15357597241250159","DOIUrl":"https://doi.org/10.1177/15357597241250159","url":null,"abstract":"Epilepsy and psychiatric illness have been long studied and today are better accepted as co-occurring than as discrete illnesses that are independent even if associated. Common pathophysiology may not be easily explained, but clearly exists given the significant overrepresentation of psychiatric illness among individuals with epilepsy. Conditions like autism spectrum disorder, anxiety, depression, and attention deficit hyperactivity disorder are prevalent in pediatric epilepsy much more than expected, even in the context of chronic neurologic disease. The interplay between pediatric epilepsy and neuropsychiatric symptoms represents a complex clinical circumstance that is not well subtended by the chasm-like division of labor between psychiatrists and neurologists. The unfortunate result is that children and families often experience care that is fractured and at worst, counterproductive for their quality of life. A neuropsychiatric paradigm is essential to address epilepsy and its intrinsic psychiatric symptoms. Practical strategies will be discussed to address this challenge.","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"105 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140840506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-17DOI: 10.1177/15357597241242241
Jeanne T. Paz
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{"title":"Seizing the Future: Predicting Epilepsy After TBI","authors":"Jeanne T. Paz","doi":"10.1177/15357597241242241","DOIUrl":"https://doi.org/10.1177/15357597241242241","url":null,"abstract":"[Box: see text]","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"26 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140617392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-17DOI: 10.1177/15357597241242243
Anthony Fine
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{"title":"Any Way You Slice It: Corpus Callosotomy in Pediatric Drug-Resistant Epilepsy","authors":"Anthony Fine","doi":"10.1177/15357597241242243","DOIUrl":"https://doi.org/10.1177/15357597241242243","url":null,"abstract":"[Box: see text]","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"2013 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140617540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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