Pub Date : 2024-09-28eCollection Date: 2024-09-01DOI: 10.1177/15357597241279767
Gordon F Buchanan
{"title":"Assessment of Cellular End of Life Management in Acute Brain Injury: Clearing Dying Cells After Injury.","authors":"Gordon F Buchanan","doi":"10.1177/15357597241279767","DOIUrl":"10.1177/15357597241279767","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 5","pages":"353-354"},"PeriodicalIF":5.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-28eCollection Date: 2024-11-01DOI: 10.1177/15357597241279744
Sarah F Muldoon
{"title":"Predicting the Path: How Machine Learning Can Identify Subtypes of Epilepsy and Predict Disease Progression.","authors":"Sarah F Muldoon","doi":"10.1177/15357597241279744","DOIUrl":"10.1177/15357597241279744","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 6","pages":"423-425"},"PeriodicalIF":5.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-28eCollection Date: 2024-11-01DOI: 10.1177/15357597241279758
Sara Eyal
{"title":"When Non-Promising Findings Also Go From Aquarium to Bedside: The Importance of Rigorous Preclinical Analyses of ASM Candidates.","authors":"Sara Eyal","doi":"10.1177/15357597241279758","DOIUrl":"10.1177/15357597241279758","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 6","pages":"426-428"},"PeriodicalIF":5.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-28eCollection Date: 2024-11-01DOI: 10.1177/15357597241279761
Liviu-Gabriel Bodea, Karin Borges
{"title":"DREADD Microglia? Targeted Microglial Gi Activation in the Acute Phase can Reduce Seizure Severity, but is Detrimental in the Long Term.","authors":"Liviu-Gabriel Bodea, Karin Borges","doi":"10.1177/15357597241279761","DOIUrl":"10.1177/15357597241279761","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 6","pages":"420-422"},"PeriodicalIF":5.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-28DOI: 10.1177/15357597241280055
Mario Arturo Alonso Vanegas, Kayela Arrotta, Kathryn Davis, Barbara C Jobst, Prakash Kotagal, Annapurna Poduri, Ignacio Valencia
Despite great progress in imaging, genetics, surgery, and therapeutics, frontal lobe epilepsy (FLE) continues to be a challenge for neurologists and epileptologists. This manuscript summarizes the latest advancements in FLE discussed at the 2023 Epilepsy Specialist Symposium during the American Epilepsy Society Annual meeting. Correlation between stereoelectroencephalography and clinical symptoms has reinvigorated symptomatology literature in FLE, allowing for more precise aura anatomical localization. Neuropsychological assessments permit the identification of different FLE cognitive phenotypes, with language being the most prominent domain-specific impairment. These tests can help develop psychotherapeutic and cognitive support systems for these patients. Genetic and molecular studies have uncovered specific genes associated with FLE susceptibility, offering prospects for targeted therapies. Advanced neuroimaging techniques such as high field magnetic resonance imaging (MRI), functional MRI (fMRI), magnetoencephalography and colocalization of multiple imaging techniques have led to more precise localization of the epileptogenic zone providing insights into the dynamic neural networks underlying frontal lobe seizures. This has facilitated guided therapeutic surgical interventions that can be employed around the world, expanding access of these technologies to multiple populations. Despite many advances, prognosis of FLE remains poor for some patients. The biggest determinant for poor prognosis continues to be nonlesional FLE. Newer technological advancements aim to pass these barriers and offer FLE patients a better quality of life with lower seizure burden and higher cognitive outcomes.
{"title":"Frontal Lobe Epilepsy: Bermuda's Triangle.","authors":"Mario Arturo Alonso Vanegas, Kayela Arrotta, Kathryn Davis, Barbara C Jobst, Prakash Kotagal, Annapurna Poduri, Ignacio Valencia","doi":"10.1177/15357597241280055","DOIUrl":"10.1177/15357597241280055","url":null,"abstract":"<p><p>Despite great progress in imaging, genetics, surgery, and therapeutics, frontal lobe epilepsy (FLE) continues to be a challenge for neurologists and epileptologists. This manuscript summarizes the latest advancements in FLE discussed at the 2023 Epilepsy Specialist Symposium during the American Epilepsy Society Annual meeting. Correlation between stereoelectroencephalography and clinical symptoms has reinvigorated symptomatology literature in FLE, allowing for more precise aura anatomical localization. Neuropsychological assessments permit the identification of different FLE cognitive phenotypes, with language being the most prominent domain-specific impairment. These tests can help develop psychotherapeutic and cognitive support systems for these patients. Genetic and molecular studies have uncovered specific genes associated with FLE susceptibility, offering prospects for targeted therapies. Advanced neuroimaging techniques such as high field magnetic resonance imaging (MRI), functional MRI (fMRI), magnetoencephalography and colocalization of multiple imaging techniques have led to more precise localization of the epileptogenic zone providing insights into the dynamic neural networks underlying frontal lobe seizures. This has facilitated guided therapeutic surgical interventions that can be employed around the world, expanding access of these technologies to multiple populations. Despite many advances, prognosis of FLE remains poor for some patients. The biggest determinant for poor prognosis continues to be nonlesional FLE. Newer technological advancements aim to pass these barriers and offer FLE patients a better quality of life with lower seizure burden and higher cognitive outcomes.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597241280055"},"PeriodicalIF":5.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-28eCollection Date: 2024-11-01DOI: 10.1177/15357597241279753
Samuel W Terman
{"title":"Hope for the Best but Plan for the Worst: Seizure Action Plans in Adult Epilepsy Clinics.","authors":"Samuel W Terman","doi":"10.1177/15357597241279753","DOIUrl":"10.1177/15357597241279753","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 6","pages":"398-399"},"PeriodicalIF":5.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01DOI: 10.1177/15357597241260546
Heidi M. Munger Clary
[Box: see text]
[方框：见正文]
{"title":"Preventing Verbal Memory Decline: Anatomic Clues to Predict Risk of Laser Ablation Versus Resection?","authors":"Heidi M. Munger Clary","doi":"10.1177/15357597241260546","DOIUrl":"https://doi.org/10.1177/15357597241260546","url":null,"abstract":"[Box: see text]","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"55 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141881664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01DOI: 10.1177/15357597241261917
Nicolas Gaspard
[Box: see text]
[方框：见正文]
{"title":"In-hospital Management of Status Epilepticus: Does Uniformity Mean Quality?","authors":"Nicolas Gaspard","doi":"10.1177/15357597241261917","DOIUrl":"https://doi.org/10.1177/15357597241261917","url":null,"abstract":"[Box: see text]","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"7 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141881663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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