Pub Date : 2024-12-01Epub Date: 2024-09-09DOI: 10.1080/15592294.2024.2392401
Yingqi Xu, Xiang Weng, Jiacong Qiu, Shizhi Wang
This study aimed to explore whether m6A modification affects the biogenesis of circRBM33, which is involved in the progression of abdominal aortic aneurysm (AAA). For in vitro experiments, vascular smooth muscle cells (VSMCs) were treated with Ang II. MeRIP‒PCR was used to assess m6A modification of circRBM33. Gene expression was measured using RT‒qPCR and Western blotting. For in vivo experiments, a mouse model of AAA was established via Ang II infusion. HE, Sirius Red and TUNEL staining was performed to evaluate pathological changes and cell apoptosis in aortic vessels. The results showed that the m6A level of circRBM33 was abnormally increased in Ang II-induced VSMCs. In addition, METTL3 positively regulated circRBM33 expression. YTHDC1 deficiency decreased circRBM33 expression but had no effect on RBM33 mRNA expression. Notably, neither METTL3 nor YTHDC1 influenced the stability of circRBM33 or RBM33 mRNA. The interaction between circRBM33 and METTL3/YTHDC1 was verified by RIP analysis. Moreover, the Ang II-induced increase in circRBM33 expression was reversed by cycloleucine (an inhibitor of m6A methylation). Importantly, the m6A modification and expression of circRBM33 in the circRBM33-m6A-mut2-expressing VSMCs were not altered by METTL3 silencing. Mechanistically, METTL3/YTHDC1 modulates the biogenesis of circRBM33 in an m6A-dependent manner. In addition, circRBM33 knockdown alleviated AAA by reducing ECM degradation in the Ang II-infused mice. In conclusion, this study demonstrated that METTL3/YTHDC1-mediated m6A modification modulates the biogenesis of circRBM33 from exons of the RBM33 gene. Moreover, knockdown of circRBM33 alleviated AAA by reducing ECM degradation, which may provide a novel therapeutic strategy for treating AAA.
本研究旨在探讨 m6A 修饰是否会影响 circRBM33 的生物生成，而 circRBM33 与腹主动脉瘤（AAA）的进展有关。在体外实验中，用 Ang II 处理血管平滑肌细胞（VSMC）。MeRIP-PCR 用于评估 circRBM33 的 m6A 修饰。使用 RT-qPCR 和 Western 印迹法测量基因表达。在体内实验中，通过 Ang II 输注建立了 AAA 小鼠模型。用 HE、天狼星红和 TUNEL 染色法评估主动脉血管的病理变化和细胞凋亡。结果显示，在 Ang II 诱导的 VSMCs 中，circRBM33 的 m6A 水平异常升高。此外，METTL3 能正向调节 circRBM33 的表达。YTHDC1 缺乏会降低 circRBM33 的表达，但对 RBM33 mRNA 的表达没有影响。值得注意的是，METTL3 和 YTHDC1 都不会影响 circRBM33 或 RBM33 mRNA 的稳定性。circRBM33 与 METTL3/YTHDC1 之间的相互作用通过 RIP 分析得到了验证。此外，环亮氨酸（m6A 甲基化抑制剂）可逆转 Ang II 诱导的 circRBM33 表达增加。重要的是，在表达 circRBM33-m6A-mut2- 的 VSMCs 中，m6A 修饰和 circRBM33 的表达不会因 METTL3 沉默而改变。从机制上讲，METTL3/YTHDC1 以 m6A 依赖性方式调节 circRBM33 的生物生成。此外，circRBM33 基因敲除可减少血管紧张素 II 注入小鼠体内 ECM 的降解，从而缓解 AAA。总之，本研究证明了 METTL3/YTHDC1 介导的 m6A 修饰调节了来自 RBM33 基因外显子的 circRBM33 的生物生成。此外，敲除 circRBM33 可通过减少 ECM 降解缓解 AAA，这可能为治疗 AAA 提供了一种新的治疗策略。
{"title":"Biogenesis of circRBM33 mediated by N6-methyladenosine and its function in abdominal aortic aneurysm.","authors":"Yingqi Xu, Xiang Weng, Jiacong Qiu, Shizhi Wang","doi":"10.1080/15592294.2024.2392401","DOIUrl":"10.1080/15592294.2024.2392401","url":null,"abstract":"<p><p>This study aimed to explore whether m6A modification affects the biogenesis of circRBM33, which is involved in the progression of abdominal aortic aneurysm (AAA). For <i>in vitro</i> experiments, vascular smooth muscle cells (VSMCs) were treated with Ang II. MeRIP‒PCR was used to assess m6A modification of circRBM33. Gene expression was measured using RT‒qPCR and Western blotting. For <i>in vivo</i> experiments, a mouse model of AAA was established via Ang II infusion. HE, Sirius Red and TUNEL staining was performed to evaluate pathological changes and cell apoptosis in aortic vessels. The results showed that the m6A level of circRBM33 was abnormally increased in Ang II-induced VSMCs. In addition, METTL3 positively regulated circRBM33 expression. YTHDC1 deficiency decreased circRBM33 expression but had no effect on RBM33 mRNA expression. Notably, neither METTL3 nor YTHDC1 influenced the stability of circRBM33 or RBM33 mRNA. The interaction between circRBM33 and METTL3/YTHDC1 was verified by RIP analysis. Moreover, the Ang II-induced increase in circRBM33 expression was reversed by cycloleucine (an inhibitor of m6A methylation). Importantly, the m6A modification and expression of circRBM33 in the circRBM33-m6A-mut2-expressing VSMCs were not altered by METTL3 silencing. Mechanistically, METTL3/YTHDC1 modulates the biogenesis of circRBM33 in an m6A-dependent manner. In addition, circRBM33 knockdown alleviated AAA by reducing ECM degradation in the Ang II-infused mice. In conclusion, this study demonstrated that METTL3/YTHDC1-mediated m6A modification modulates the biogenesis of circRBM33 from exons of the RBM33 gene. Moreover, knockdown of circRBM33 alleviated AAA by reducing ECM degradation, which may provide a novel therapeutic strategy for treating AAA.</p>","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"19 1","pages":"2392401"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11385162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-18DOI: 10.1080/15592294.2024.2404198
Elizabeth C Anderson,Helen B Foley,Joshua J Levy,Megan E Romano,Jiang Gui,Jessica L Bentz,Luis E Maldonado,Shohreh F Farzan,Theresa M Bastain,Carmen J Marsit,Carrie V Breton,Caitlin G Howe
Maternal hyperglycemia during pregnancy adversely affects maternal and child outcomes. While mechanisms are not fully understood, maternal circulating miRNAs may play a role. We examined whether continuous glucose levels and hyperglycemia subtypes (gestational diabetes, type 2 diabetes, and glucose intolerance) were associated with circulating miRNAs during late pregnancy. Seven miRNAs (hsa-miR-107, hsa-let-7b-5p, hsa-miR-126-3p, hsa-miR-181a-5p, hsa-miR-374a-5p, hsa-miR-382-5p, and hsa-miR-337-5p) were associated (p < 0.05) with either hyperglycemia or continuous glucose levels prior to multiple testing correction. These miRNAs target genes involved in pathways relevant to maternal and child health, including insulin signaling, placental development, energy balance, and appetite regulation.
{"title":"Maternal glucose levels and late pregnancy circulating extracellular vesicle and particle miRNAs in the MADRES pregnancy cohort.","authors":"Elizabeth C Anderson,Helen B Foley,Joshua J Levy,Megan E Romano,Jiang Gui,Jessica L Bentz,Luis E Maldonado,Shohreh F Farzan,Theresa M Bastain,Carmen J Marsit,Carrie V Breton,Caitlin G Howe","doi":"10.1080/15592294.2024.2404198","DOIUrl":"https://doi.org/10.1080/15592294.2024.2404198","url":null,"abstract":"Maternal hyperglycemia during pregnancy adversely affects maternal and child outcomes. While mechanisms are not fully understood, maternal circulating miRNAs may play a role. We examined whether continuous glucose levels and hyperglycemia subtypes (gestational diabetes, type 2 diabetes, and glucose intolerance) were associated with circulating miRNAs during late pregnancy. Seven miRNAs (hsa-miR-107, hsa-let-7b-5p, hsa-miR-126-3p, hsa-miR-181a-5p, hsa-miR-374a-5p, hsa-miR-382-5p, and hsa-miR-337-5p) were associated (p < 0.05) with either hyperglycemia or continuous glucose levels prior to multiple testing correction. These miRNAs target genes involved in pathways relevant to maternal and child health, including insulin signaling, placental development, energy balance, and appetite regulation.","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"13 1","pages":"2404198"},"PeriodicalIF":3.7,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A differential diet with royal jelly (RJ) during early larval development in honeybees shapes the phenotype, which is probably mediated by epigenetic regulation of gene expression. Evidence indicates that small molecules in RJ can modulate gene expression in mammalian cells, such as the fatty acid 10-hydroxy-2-decenoic acid (10-HDA), previously associated with the inhibition of histone deacetylase enzymes (HDACs). Therefore, we combined computational (molecular docking simulations) and experimental approaches for the screening of potential HDAC inhibitors (HDACi) among 32 RJ-derived fatty acids. Biochemical assays and gene expression analyses (Reverse Transcriptase - quantitative Polymerase Chain Reaction) were performed to evaluate the functional effects of the major RJ fatty acids, 10-HDA and 10-HDAA (10-hydroxy-decanoic acid), in two human cancer cell lines (HCT116 and MDA-MB-231). The molecular docking simulations indicate that these fatty acids might interact with class I HDACs, specifically with the catalytic domain of human HDAC2, likewise well-known HDAC inhibitors (HDACi) such as SAHA (suberoylanilide hydroxamic acid) and TSA (Trichostatin A). In addition, the combined treatment with 10-HDA and 10-HDAA inhibits the activity of human nuclear HDACs and leads to a slight increase in the expression of HDAC-coding genes in cancer cells. Our findings indicate that royal jelly fatty acids collectively contribute to HDAC inhibition and that 10-HDA and 10-HDAA are weak HDACi that facilitate the acetylation of lysine residues of chromatin, triggering an increase in gene expression levels in cancer cells.
{"title":"Exploring fatty acids from royal jelly as a source of histone deacetylase inhibitors: from the hive to applications in human well-being and health.","authors":"Fernanda Aparecida Dos Santos France,Debora Kazumi Maeda,Ana Beatriz Rodrigues,Mai Ono,Franciele Lopes Nogueira Marchetti,Marcos Martins Marchetti,Allana Cristina Faustino Martins,Roberto da Silva Gomes,Cláudia Aparecida Rainho","doi":"10.1080/15592294.2024.2400423","DOIUrl":"https://doi.org/10.1080/15592294.2024.2400423","url":null,"abstract":"A differential diet with royal jelly (RJ) during early larval development in honeybees shapes the phenotype, which is probably mediated by epigenetic regulation of gene expression. Evidence indicates that small molecules in RJ can modulate gene expression in mammalian cells, such as the fatty acid 10-hydroxy-2-decenoic acid (10-HDA), previously associated with the inhibition of histone deacetylase enzymes (HDACs). Therefore, we combined computational (molecular docking simulations) and experimental approaches for the screening of potential HDAC inhibitors (HDACi) among 32 RJ-derived fatty acids. Biochemical assays and gene expression analyses (Reverse Transcriptase - quantitative Polymerase Chain Reaction) were performed to evaluate the functional effects of the major RJ fatty acids, 10-HDA and 10-HDAA (10-hydroxy-decanoic acid), in two human cancer cell lines (HCT116 and MDA-MB-231). The molecular docking simulations indicate that these fatty acids might interact with class I HDACs, specifically with the catalytic domain of human HDAC2, likewise well-known HDAC inhibitors (HDACi) such as SAHA (suberoylanilide hydroxamic acid) and TSA (Trichostatin A). In addition, the combined treatment with 10-HDA and 10-HDAA inhibits the activity of human nuclear HDACs and leads to a slight increase in the expression of HDAC-coding genes in cancer cells. Our findings indicate that royal jelly fatty acids collectively contribute to HDAC inhibition and that 10-HDA and 10-HDAA are weak HDACi that facilitate the acetylation of lysine residues of chromatin, triggering an increase in gene expression levels in cancer cells.","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"2 1","pages":"2400423"},"PeriodicalIF":3.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142222205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-27DOI: 10.1080/15592294.2024.2380930
Andy Madrid, Joyce Koueik, Ligia A. Papale, Roy Chebel, Isabelle Renteria, Emily Cannon, Kirk J. Hogan, Reid S. Alisch, Bermans J. Iskandar
In mammals, the molecular mechanisms underlying transgenerational inheritance of phenotypic traits in serial generations of progeny after ancestral environmental exposures, without variation in DNA...
在哺乳动物中，表型性状在祖先暴露于环境后的连续几代后代中发生跨代遗传的分子机制，DNA...
{"title":"Folate-mediated transgenerational inheritance of sperm DNA methylation patterns correlate with spinal axon regeneration","authors":"Andy Madrid, Joyce Koueik, Ligia A. Papale, Roy Chebel, Isabelle Renteria, Emily Cannon, Kirk J. Hogan, Reid S. Alisch, Bermans J. Iskandar","doi":"10.1080/15592294.2024.2380930","DOIUrl":"https://doi.org/10.1080/15592294.2024.2380930","url":null,"abstract":"In mammals, the molecular mechanisms underlying transgenerational inheritance of phenotypic traits in serial generations of progeny after ancestral environmental exposures, without variation in DNA...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"31 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141783799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Previous studies have indicated that histone methylations act as mediators in the relationship between oestrogen receptor (ER) and breast cancer prognosis, yet the mediating role has never been ass...
{"title":"H4K20me3, H3K4me2 and H3K9me2 mediate the effect of ER on prognosis in breast cancer","authors":"Cheng-Kun Xiao, Yuexiang Ren, Qianxin Chen, Yuanzhong Yang, Luying Tang, Lin Xu, Zefang Ren","doi":"10.1080/15592294.2024.2343593","DOIUrl":"https://doi.org/10.1080/15592294.2024.2343593","url":null,"abstract":"Previous studies have indicated that histone methylations act as mediators in the relationship between oestrogen receptor (ER) and breast cancer prognosis, yet the mediating role has never been ass...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"9 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140636791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-14DOI: 10.1080/15592294.2024.2341578
Xin Li, Shan-Shan Xing, Sheng-Bo Meng, Zhong-Yi Hou, Lei Yu, Meng-Juan Chen, Dong-Dong Yuan, Hui-Fen Xu, Han-Fang Cai, Ming Li
Long non-coding RNAs (lncRNAs) have been shown to be involved in the regulation of skeletal muscle development through multiple mechanisms. The present study revealed that the lncRNA SOX6 AU (SRY-b...
{"title":"SOX6 AU controls myogenesis by cis-modulation of SOX6 in cattle","authors":"Xin Li, Shan-Shan Xing, Sheng-Bo Meng, Zhong-Yi Hou, Lei Yu, Meng-Juan Chen, Dong-Dong Yuan, Hui-Fen Xu, Han-Fang Cai, Ming Li","doi":"10.1080/15592294.2024.2341578","DOIUrl":"https://doi.org/10.1080/15592294.2024.2341578","url":null,"abstract":"Long non-coding RNAs (lncRNAs) have been shown to be involved in the regulation of skeletal muscle development through multiple mechanisms. The present study revealed that the lncRNA SOX6 AU (SRY-b...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"77 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140602907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-09DOI: 10.1080/15592294.2024.2337085
Xueli Liu, Qina Chen, Xudong Yin, Xiao Wang, Jinshan Ran, Wei Yu, Bin Wang
The PhiC31 integration system allows for targeted and efficient transgene integration and expression by recognizing pseudo attP sites in mammalian cells and integrating the exogenous genes into the...
{"title":"Study on chromatin regulation patterns of expression vectors in the PhiC31 integration site","authors":"Xueli Liu, Qina Chen, Xudong Yin, Xiao Wang, Jinshan Ran, Wei Yu, Bin Wang","doi":"10.1080/15592294.2024.2337085","DOIUrl":"https://doi.org/10.1080/15592294.2024.2337085","url":null,"abstract":"The PhiC31 integration system allows for targeted and efficient transgene integration and expression by recognizing pseudo attP sites in mammalian cells and integrating the exogenous genes into the...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"45 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140573747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-07DOI: 10.1080/15592294.2024.2337142
Nour El Osmani, Corinne Prévostel, Laurence Picque Lasorsa, Mohammad El Harakeh, Zeina Radwan, Hiba Mawlawi, Marwan El Sabban, Margret Shirinian, Zeina Dassouki
Deregulation of ten-eleven Translocation protein 1 (TET1) is commonly reported to induce imbalances in gene expression and subsequently to colorectal cancer development (CRC). On the other hand, vi...
{"title":"Vitamin C enhances co-localization of novel TET1 nuclear bodies with both Cajal and PML bodies in colorectal cancer cells","authors":"Nour El Osmani, Corinne Prévostel, Laurence Picque Lasorsa, Mohammad El Harakeh, Zeina Radwan, Hiba Mawlawi, Marwan El Sabban, Margret Shirinian, Zeina Dassouki","doi":"10.1080/15592294.2024.2337142","DOIUrl":"https://doi.org/10.1080/15592294.2024.2337142","url":null,"abstract":"Deregulation of ten-eleven Translocation protein 1 (TET1) is commonly reported to induce imbalances in gene expression and subsequently to colorectal cancer development (CRC). On the other hand, vi...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"8 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140573552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-05DOI: 10.1080/15592294.2024.2333654
Stefanie Pilkay, Andie Riffer, Andrew Carroll
Many people experience traumatic or negative events, but few develop mental health issues as a result. This study investigated whether newborn DNA methylation (DNAm) previously associated with mate...
{"title":"Trauma context exerts intergenerational effects on child mental health via DNA methylation","authors":"Stefanie Pilkay, Andie Riffer, Andrew Carroll","doi":"10.1080/15592294.2024.2333654","DOIUrl":"https://doi.org/10.1080/15592294.2024.2333654","url":null,"abstract":"Many people experience traumatic or negative events, but few develop mental health issues as a result. This study investigated whether newborn DNA methylation (DNAm) previously associated with mate...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"8 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140573730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-03DOI: 10.1080/15592294.2024.2333668
Jessica I. Lundin, Ulrike Peters, Yao Hu, Farah Ammous, Christy L. Avery, Emelia J. Benjamin, Joshua C. Bis, Jennifer A. Brody, Chris Carlson, Mary Cushman, Chris Gignoux, Xiuqing Guo, Jeff Haessler, Chris Haiman, Roby Joehanes, Silva Kasela, Eimear Kenny, Tuuli Lapalainien, Daniel Levy, Chunyu Liu, Yongmei Liu, Ruth J.F. Loos, Ake Lu, Tara Matise, Kari E. North, Sungshim L. Park, Scott M. Ratliff, Alex Reiner, Stephen S. Rich, Jerome I. Rotter, Jennifer A. Smith, Nona Sotoodehnia, Russell Tracy, David Van den Berg, Huichun Xu, Ting Ye, Wei Zhao, Laura M. Raffield, Charles Kooperberg, On Behalf of the PAGE Study
Systemic low-grade inflammation is a feature of chronic disease. C-reactive protein (CRP) is a common biomarker of inflammation and used as an indicator of disease risk; however, the role of inflam...
{"title":"Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations","authors":"Jessica I. Lundin, Ulrike Peters, Yao Hu, Farah Ammous, Christy L. Avery, Emelia J. Benjamin, Joshua C. Bis, Jennifer A. Brody, Chris Carlson, Mary Cushman, Chris Gignoux, Xiuqing Guo, Jeff Haessler, Chris Haiman, Roby Joehanes, Silva Kasela, Eimear Kenny, Tuuli Lapalainien, Daniel Levy, Chunyu Liu, Yongmei Liu, Ruth J.F. Loos, Ake Lu, Tara Matise, Kari E. North, Sungshim L. Park, Scott M. Ratliff, Alex Reiner, Stephen S. Rich, Jerome I. Rotter, Jennifer A. Smith, Nona Sotoodehnia, Russell Tracy, David Van den Berg, Huichun Xu, Ting Ye, Wei Zhao, Laura M. Raffield, Charles Kooperberg, On Behalf of the PAGE Study","doi":"10.1080/15592294.2024.2333668","DOIUrl":"https://doi.org/10.1080/15592294.2024.2333668","url":null,"abstract":"Systemic low-grade inflammation is a feature of chronic disease. C-reactive protein (CRP) is a common biomarker of inflammation and used as an indicator of disease risk; however, the role of inflam...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"8 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140573550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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