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Association of physical and sexual assault with mortality in two British birth cohorts 英国两个出生队列中身体攻击和性攻击与死亡率的关系
Pub Date : 2024-03-01 DOI: 10.1136/bmjph-2023-000285
Vishal Bhavsar, J. Das-Munshi, J. H. MacCabe, Ioannis Bakolis, William Lee
The association of assault in adulthood with all-cause mortality, and the relevance of intermediate psychological distress, alcohol use and cigarette smoking, is poorly understood. We used data from British birth cohorts (the 1958 National Child Development Study referred to as the 1958 birth cohort and the 1970 British Birth Cohort Study) to investigate association between assault and mortality, employing a formal approach for the identification of psychological distress, alcohol use and cigarette smoking as mediators.Associations (HRs), between assault and mortality were estimated with Cox regressions, adjusting for potential confounders. Mediation via intermediate psychological distress, alcohol use and cigarette smoking was explored using the gformula approach. The birth cohorts were analysed separately, and together estimating interaction between exposure and cohort year.Results were based on 353 deaths in 19 725 individuals. Based on multiply imputed data, the fully adjusted estimate for assault on mortality was 1.72 (95% CI 1.22 to 2.42) in the combined cohorts, 1.53 (95% CI 0.97 to 2.40) in the 1958 birth cohort and 2.05 (95% CI 1.20 to 1.50) in the 1970 birth cohort. The fully adjusted estimate for the association of sexual assault with mortality was 3.17 (95% CI 1.17 to 8.60) in the combined cohorts, 1.36 (95% CI 0.19 to 9.81) in the 1958 birth cohort and 6.02 (95% CI 1.84 to 19.69) in the 1970 birth cohort. The fully adjusted mortality HR for one additional assault was 1.46 (95% CI 1.23 to 1.73) in the combined cohorts, 1.34 (95% CI 0.99 to 1.82) in the 1958 birth cohort and 1.53 (95% CI 1.25 to 1.87) in the 1970 birth cohort. Greater need for medical treatment for assault was associated with a fully adjusted mortality HR of 1.56 (95% CI 1.19 to 2.05) in the combined cohorts, 1.43 (95% CI 1.00 to 2.05) in the 1958 birth cohort and 1.79 (95% CI 1.18 to 2.74) in the 1970 birth cohort.There was statistical evidence on combining the two birth cohorts, and on analysing the 1970 birth cohort, that assault in adulthood is associated with mortality. Understanding mechanisms underlying this relationship could benefit violence reduction strategies for public health.
人们对成年后遭受攻击与全因死亡率之间的关系,以及中间的心理压力、酗酒和吸烟的相关性知之甚少。我们利用英国出生队列研究(1958 年全国儿童发展研究,简称 1958 年出生队列研究和 1970 年英国出生队列研究)的数据调查了袭击与死亡率之间的关系,并采用正式方法将心理困扰、酗酒和吸烟确定为中介因素。使用 gformula 方法探讨了中间心理困扰、饮酒和吸烟的中介作用。对出生队列进行了单独分析,并对暴露与队列年份之间的交互作用进行了共同估算。根据多重估算数据,在合并队列中,完全调整后的死亡率攻击估计值为 1.72(95% CI 1.22 至 2.42),在 1958 年出生队列中为 1.53(95% CI 0.97 至 2.40),在 1970 年出生队列中为 2.05(95% CI 1.20 至 1.50)。在合并队列中,性侵犯与死亡率的完全调整估计值为 3.17(95% CI 1.17 至 8.60),在 1958 年出生队列中为 1.36(95% CI 0.19 至 9.81),在 1970 年出生队列中为 6.02(95% CI 1.84 至 19.69)。在合并队列中,多发生一次袭击事件的完全调整死亡率 HR 为 1.46(95% CI 1.23 至 1.73),1958 年出生队列为 1.34(95% CI 0.99 至 1.82),1970 年出生队列为 1.53(95% CI 1.25 至 1.87)。在合并的队列中,因袭击而需要更多治疗与完全调整后的死亡率HR值1.56(95% CI 1.19至2.05)相关,在1958年出生的队列中为1.43(95% CI 1.00至2.05),在1970年出生的队列中为1.79(95% CI 1.18至2.74)。了解这种关系的内在机制有助于减少暴力的公共卫生战略。
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引用次数: 0
Subjective social status and trajectories of frailty: findings from the English Longitudinal Study of Ageing 主观社会地位与虚弱轨迹:英国老龄化纵向研究的发现
Pub Date : 2024-03-01 DOI: 10.1136/bmjph-2023-000629
Asri Maharani, Lindsay Richards, P. Präg
Subjective social status is a known antecedent for many health outcomes, but little research has examined the association between subjective status and frailty among older people. Using longitudinal data, the goal of this study was, first, to identify latent trajectories of frailty over time, and second, to investigate the relationship between subjective social status and frailty trajectory.Data were drawn from the 2002–2019 surveys of the English Longitudinal Study of Ageing, involving 9484 individuals aged 50+ years at baseline. Group-based trajectory models were used to identify frailty trajectories over the 18-year period, and multinomial regression models were used to investigate the relationship between subjective social status and frailty trajectory membership. Controls were included for confounding factors, including a range of socioeconomic indicators and health behaviours.Four trajectories of the frailty index were retained: low frailty (53% of participants), progressive mild frailty (25%), progressive moderate frailty (15%) and high frailty (6%). Higher subjective social status is associated with higher probabilities of being in the low-frailty group and lower probabilities of being in one of the progressive or high-frailty groups.Subjective social status is significantly associated with being in a milder frailty trajectory after controlling for age, health behaviours and a wide range of objective socioeconomic status markers.
众所周知,主观社会地位是许多健康结果的先决条件,但很少有研究探讨老年人的主观社会地位与虚弱之间的关系。利用纵向数据,本研究的目标首先是确定虚弱随时间变化的潜在轨迹,其次是调查主观社会地位与虚弱轨迹之间的关系。数据来自 2002-2019 年英国老龄化纵向研究的调查,涉及 9484 名基线年龄在 50 岁以上的人。我们使用基于群体的轨迹模型来识别18年间的虚弱轨迹,并使用多项式回归模型来研究主观社会地位与虚弱轨迹成员之间的关系。研究保留了虚弱指数的四个轨迹:低度虚弱(53% 的参与者)、进行性轻度虚弱(25%)、进行性中度虚弱(15%)和高度虚弱(6%)。主观社会地位越高,跻身低度虚弱组的概率越高,跻身渐进或高度虚弱组的概率越低。在控制了年龄、健康行为和各种客观社会经济地位指标后,主观社会地位与跻身较轻度虚弱轨迹显著相关。
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引用次数: 0
Sleep patterns and long-term mortality among older Israeli adults: a population-based study 以色列老年人的睡眠模式和长期死亡率:一项基于人口的研究
Pub Date : 2024-03-01 DOI: 10.1136/bmjph-2023-000651
Saar Ashri, Gali Cohen, T. Hasin, Lital Keinan-Boker, Yariv Gerber
The joint association of night-time sleep duration and daytime napping (siesta) with mortality remains elusive. We explored sleep patterns and long-term mortality in older adults and tested whether the relationship is modified by cognitive function.We analysed data from 1519 participants in the National Health and Nutrition Survey of older adults aged 65+ years (‘Mabat Zahav’), conducted by the Israel Center for Disease Control during 2005–2006. A detailed questionnaire was administered at study entry to gather information on sleeping habits, including night-time sleep duration and siesta. A Mini-Mental State Examination was administered to assess cognitive status (score <27 considered impaired). Mortality data were obtained from the Ministry of Health (last follow-up: June 2019; 782 deaths). Cox models were constructed to estimate the HRs for mortality associated with sleep patterns, defined according to night sleep duration (>8 vs ≤8 hours) and siesta (Y/N). Spline regression models were constructed to examine the linearity of the association across cognitive statuses.Sleep categories among participants (mean age 75; 53% women) included 291 (19.2%) with long night sleep and siesta, 139 (9.1%) with long night sleep and no siesta, 806 (53.1%) with short night sleep and siesta, and 283 (18.6%) with short night sleep and no siesta. HRs for mortality were 2.07 (95% CI: 1.63 to 2.62), 1.63 (95% CI: 1.22 to 2.18) and 1.43 (95% CI: 1.16 to 1.76) in the former three versus latter sleep patterns, respectively. Multivariable adjustment for sociodemographic, behavioural and clinical covariates attenuated the HRs to 1.27–1.41 (all p<0.05). The relationship between night sleep duration and mortality was linear (plinearity=0.047) among cognitively preserved individuals and U-shaped (pnon-linearity<0.001) among cognitively impaired ones.Prolonged night sleep and siesta were associated with increased mortality, a relationship that varied by cognitive performance.
夜间睡眠时间和白天小睡(午睡)与死亡率之间的关系仍然难以捉摸。我们分析了以色列疾病控制中心在 2005-2006 年期间针对 65 岁以上老年人进行的全国健康与营养调查("Mabat Zahav")中 1519 名参与者的数据。研究开始时进行了详细的问卷调查,以收集有关睡眠习惯的信息,包括夜间睡眠时间和午睡时间。研究人员还进行了迷你精神状态检查,以评估认知状况(8 分与≤8 小时)和午睡情况(是/否)。参与者(平均年龄 75 岁;53% 为女性)的睡眠类别包括:291 人(19.2%)夜间睡眠时间长且有午睡;139 人(9.1%)夜间睡眠时间长且无午睡;806 人(53.1%)夜间睡眠时间短且有午睡;283 人(18.6%)夜间睡眠时间短且无午睡。前三种睡眠模式与后一种睡眠模式相比,死亡率的HR值分别为2.07(95% CI:1.63至2.62)、1.63(95% CI:1.22至2.18)和1.43(95% CI:1.16至1.76)。对社会人口、行为和临床协变量进行多变量调整后,HRs 降至 1.27-1.41(均 p<0.05)。在认知能力保持良好的个体中,夜间睡眠时间与死亡率之间呈线性关系(线性度=0.047),而在认知能力受损的个体中呈 U 型关系(非线性度<0.001)。
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引用次数: 0
Modelling the potential clinical and economic impact of universal antenatal hepatitis C (HCV) screening and providing treatment for pregnant women with HCV and their infants in Egypt: a cost-effectiveness study 为埃及普及产前丙型肝炎(HCV)筛查并为感染 HCV 的孕妇及其婴儿提供治疗的潜在临床和经济影响建模:成本效益研究
Pub Date : 2024-03-01 DOI: 10.1136/bmjph-2023-000517
N. Hachicha-Maalej, Clotilde Lepers, I. Collins, Aya Mostafa, Anthony E Ades, Ali Judd, Karen Scott, Diana Gibb, Sarah Pett, Giuseppe Indolfi, Y. Yazdanpanah, Manal H El Sayed, S. Deuffic-Burban
Pregnant women and children are not included in Egypt’s hepatitis C virus (HCV) elimination programmes. This study assesses the cost-effectiveness of several screening and treatment strategies for pregnant women and infants in Egypt.A Markov model was developed to simulate the cascade of care and HCV disease progression among pregnant women and their infants according to different screening and treatment strategies, which included: targeted versus universal antenatal screening; treatment of women in pregnancy or deferred till after breast feeding; treatment of infected children at 3 years vs 12 years. Current practice is targeted antenatal screening with deferred treatment for the mother and child. We also explored prophylactic treatment after birth for children of diagnosed HCV-infected women. Discounted lifetime cost, life expectancy (LE) and disability-adjusted life-years (DALYs) were calculated separately for women and their infants, and then combined.Current practice led to the highest cost (US$314.0), the lowest LE (46.3348 years) and the highest DALYs (0.0512 years) per mother–child pair. Universal screening and treatment during pregnancy followed by treatment of children at 3 years would be less expensive and more effective (cost saving) compared with current practice (US$219.3, 46.3525 and 0.0359 years). Prophylactic treatment at birth for infants born to HCV RNA-positive mothers would also be similarly cost saving, even with treatment uptake as low as 15% (US$218.6, 46.3525 and 0.0359 years). Findings were robust to reasonable changes in parameters.Universal screening and treatment of HCV in pregnancy, with treatment of infected infants at age 3 years is cost saving compared with current practice in the Egyptian setting.
孕妇和儿童未被纳入埃及的丙型肝炎病毒(HCV)消除计划。这项研究评估了埃及孕妇和婴儿筛查和治疗策略的成本效益。研究人员开发了一个马尔可夫模型,根据不同的筛查和治疗策略模拟孕妇及其婴儿的护理和丙型肝炎病毒疾病进展情况,这些策略包括:产前筛查的针对性与普遍性;对孕期妇女的治疗或推迟到哺乳期后;对感染儿童的 3 岁治疗与 12 岁治疗。目前的做法是进行有针对性的产前筛查,同时推迟对母亲和儿童的治疗。我们还探讨了已确诊感染 HCV 的妇女所生子女出生后的预防性治疗。我们分别计算了妇女及其婴儿的贴现终生成本、预期寿命和残疾调整寿命年数,然后进行了合并计算。与目前的做法相比,在孕期进行普遍筛查和治疗,然后在儿童 3 岁时进行治疗,成本更低,效果更好(节省成本)(219.3 美元、46.3525 年和 0.0359 年)。对于 HCV RNA 阳性母亲所生的婴儿,在出生时进行预防性治疗也同样可以节约成本,即使治疗率低至 15%(218.6 美元、46.3525 和 0.0359 年)。与埃及目前的做法相比,在妊娠期普遍筛查和治疗 HCV,并在受感染婴儿 3 岁时进行治疗可节约成本。
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引用次数: 0
Exposure to famine during early life and the risk of MAFLD during adulthood: evidence from the China Multi-Ethnic Cohort (CMEC) study 早年遭遇饥荒与成年后罹患 MAFLD 的风险:来自中国多民族队列(CMEC)研究的证据
Pub Date : 2024-03-01 DOI: 10.1136/bmjph-2023-000114
J. Yin, Nichang Zhang, Yuemei Feng, Qiong Meng, Teng Zhang, Rudan Hong, Xuehui Zhang
Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common chronic liver disease, affecting nearly one-third of the global population. The relationship between early-life famine exposure and MAFLD remains unclear in the multiethnic region of less-developed southwest China.A total of 18 558 participants who came from the baseline survey of the China Multi-Ethnic Cohort Study in Yunnan were included. Participants were divided into four groups according to birth year, including non-exposed (1962–1978 and 1939–1943), fetal exposed (1959–1961), childhood exposed (1949–1958) and adolescence exposed (1943–1949). Logistic regression analysis was used to explore the relationship between famine exposure in early life and the risk of MAFLD in adulthood.Experiencing the shock of early-life exposure to famine would affect adulthood MAFLD. Exposure to famine during fetal life and childhood increased the risk of MAFLD in adulthood, with this association being particularly pronounced in Bai populations. Moreover, famine exposure in males during fetal life raised the risk of MAFLD in adulthood.We suggest that adequate nutrition in early life may be beneficial in preventing MAFLD in adulthood. The prevention of chronic liver disease should adopt a whole-life strategy by extending the prevention window beginning from fetal life.
代谢功能障碍相关性脂肪肝(MAFLD)是最常见的慢性肝病,影响着全球近三分之一的人口。在中国欠发达的西南多民族地区,早期饥荒暴露与代谢性脂肪肝之间的关系仍不清楚。根据出生年份将参与者分为四组,包括非暴露组(1962-1978 年和 1939-1943 年)、胎儿暴露组(1959-1961 年)、儿童暴露组(1949-1958 年)和青少年暴露组(1943-1949 年)。采用逻辑回归分析法探讨了早年遭受饥荒与成年后罹患MAFLD风险之间的关系。在胎儿期和儿童期遭受饥荒会增加成年后罹患MAFLD的风险,这种关联在白种人中尤为明显。此外,男性在胎儿期遭受饥荒也会增加成年后患MAFLD的风险。慢性肝病的预防应采取全生命周期策略,将预防窗口期从胎儿期延长至成年期。
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引用次数: 0
Vision impairment and differential access to eye health services in Aotearoa New Zealand: a scoping review 新西兰奥特亚罗瓦的视力障碍和获得眼保健服务的差异:范围界定审查
Pub Date : 2024-03-01 DOI: 10.1136/bmjph-2023-000313
J. T. Rogers, Joanna Black, M. Harwood, Ben Wilkinson, Himal Kandel, Jacqueline Ramke
In Aotearoa New Zealand, Māori and Pacific People experience worse health outcomes compared with other New Zealanders. No population-based eye health survey has been conducted, and eye health services do not generate routine monitoring reports, so the extent of eye health inequality is unknown. This information is required to plan equitable eye health services. In this scoping review, we aimed to summarise the nature and extent of the evidence reporting vision impairment, its main causes and access to eye health services by ethnicity in New Zealand.This scoping review was reported according to Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews. An information specialist conducted a search on MEDLINE and Embase databases in October 2022. Included studies reported outcomes among any population group resident in New Zealand or attendees at New Zealand health facilities. Data screening, full-text review and data extraction were performed independently by two authors. We summarised the characteristics of studies and outcomes, and the results were synthesised narratively.Our search identified 2711 reports, of which 53 (from 47 studies) were included. We mapped 72 outcomes, many of which were access-related (n=32), published since 2000 (n=28) and largely focused on diabetic retinopathy (n=21) or cataract (n=13) in facility-based settings (n=18). Over two-thirds of reported outcomes were disaggregated by at least two ethnicities. When outcomes were disaggregated by ethnicity, Māori and Pacific People were consistently included, and experienced worse access and outcomes compared with other New Zealanders.The findings of this review highlight the presence of ethnic disparity in access to diabetic retinopathy and cataract services. Closing the evidence gap identified for refractive error, glaucoma and macular degeneration service coverage could be a priority for future research. Furthermore, future research can be strengthened to enable consistent monitoring of eye health service coverage over time.
在新西兰奥特亚罗瓦,毛利人和太平洋岛民的健康状况比其他新西兰人差。目前还没有开展过基于人口的眼健康调查,眼健康服务机构也没有生成常规监测报告,因此眼健康不平等的程度尚不得而知。要规划公平的眼健康服务,就需要这些信息。在本次范围界定综述中,我们旨在总结报告视力损伤的证据的性质和程度、其主要原因以及新西兰各民族获得眼健康服务的情况。信息专家于 2022 年 10 月在 MEDLINE 和 Embase 数据库中进行了检索。纳入的研究报告了居住在新西兰或在新西兰医疗机构就诊的任何人群的结果。数据筛选、全文审阅和数据提取由两位作者独立完成。我们总结了研究和结果的特点,并对结果进行了叙述性综合。我们的搜索发现了 2711 篇报告,其中 53 篇(来自 47 项研究)被纳入。我们绘制了 72 项成果图,其中许多成果与获取相关(32 项),发表于 2000 年之后(28 项),主要集中在设施环境中的糖尿病视网膜病变(21 项)或白内障(13 项)(18 项)。超过三分之二的报告结果至少按两个种族分列。当结果按种族分列时,毛利人和太平洋岛屿族裔人一直被包括在内,与其他新西兰人相比,他们获得的服务和结果都较差。缩小屈光不正、青光眼和黄斑变性服务覆盖面方面的证据差距是未来研究的重点。此外,还可以加强未来的研究,以便对眼科健康服务的覆盖范围进行长期持续的监测。
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引用次数: 0
Ten-year (2009–2019) epidemiological study of head and neck, salivary glands and upper aerodigestive tract cancers, and overall survival outcomes in the Northern Territory of Australia 澳大利亚北部地区头颈部、唾液腺和上消化道癌症的十年(2009-2019 年)流行病学研究及总体生存结果
Pub Date : 2024-03-01 DOI: 10.1136/bmjph-2023-000551
Nayellin Reyes-Chicuellar, Kate Thimbleby, Bhavya Balasubramanya, Hemi Patel, Suresh Mahendran
Head and neck, salivary glands and aerodigestive tract cancers (HNACs) rank sixth in cancer incidence in Australia, posing significant public health and economic challenges. However, data on HNACs in the Northern Territory (NT) are lacking, crucial for healthcare planning.This study aims to analyse HNACs epidemiology, risk factors and survival outcomes in the NT, focusing on Indigenous and non-Indigenous Australians.We conducted a retrospective analysis (2009–2019) of HNACs cases from the NT Cancer Registry. Ethically approved, the study assessed incidence, mortality, risk factors and survival across ethnic populations.Of 612 potential cases, 524 were analysed, with 35.5% identifying as Aboriginal or Torres Strait Islanders. Predominantly affecting males (median age: 62 years), HNACs showed an age-standardised incidence of 21.9 per 100 000, with stable trends. The 5-year survival rate was 39.6%, notably lower in Indigenous Australians (25%) and remote areas (18%) vs the national average (68%). Oropharyngeal malignancies were common (36% survival). High-risk behaviours such as alcohol use (73%) and smoking (91%) prevailed. Most patients (73%) presented with advanced disease (stages III–IV), with one-third offered palliative care at diagnosis. P16-negative tumours predominated, with increasing P16-positive cases in non-Indigenous patients.HNACs survival rates in the NT are significantly lower than the national average, especially among Indigenous Australians and remote residents. Targeted interventions are needed to improve service planning and delivery, considering identified risk factors and cultural sensitivities, and promoting Indigenous participation.
头颈部、唾液腺和消化道癌症(HNAC)在澳大利亚癌症发病率中排名第六,给公共卫生和经济带来了巨大挑战。本研究旨在分析北领地 HNACs 的流行病学、风险因素和生存结果,重点关注土著和非土著澳大利亚人。在612例潜在病例中,有524例接受了分析,其中35.5%为原住民或托雷斯海峡岛民。HNAC主要影响男性(中位年龄:62岁),其年龄标准化发病率为每10万人21.9例,且趋势稳定。5年存活率为39.6%,澳大利亚土著居民(25%)和偏远地区(18%)的存活率明显低于全国平均水平(68%)。口咽恶性肿瘤很常见(存活率为 36%)。酗酒(73%)和吸烟(91%)等高风险行为普遍存在。大多数患者(73%)为晚期疾病(III-IV期),三分之一的患者在确诊时已接受姑息治疗。P16阴性肿瘤占多数,非土著患者中P16阳性病例有所增加。需要采取有针对性的干预措施来改善服务规划和提供,同时考虑到已确定的风险因素和文化敏感性,并促进土著居民的参与。
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引用次数: 0
Factors influencing food preferences and eating behaviour among the Forcibly Displaced Myanmar Nationals (FDMN) adolescents in Cox’s Bazar, Bangladesh: a cross-sectional survey 影响孟加拉国考克斯巴扎尔缅甸被迫流离失所者(FDMN)青少年食物偏好和饮食行为的因素:横断面调查
Pub Date : 2024-02-01 DOI: 10.1136/bmjph-2023-000237
Rashedul Islam, Nahid Hasan, Nusrat Jahan Ferdous, A. B. Sharif, Mahamudul Hasan, Dr Azaz Bin
Adolescence is a pivotal period for physical, mental, social and behavioural development, so it is crucial to understand the factors influencing adolescent food preferences and eating behaviour. This study aimed to investigate the factors that influence adolescents’ food preferences and eating behaviours in the Forcibly Displaced Myanmar Nationals (FDMN) camp in Cox’s Bazar, Bangladesh.A cross-sectional study was conducted in the FDMN camp, recruiting 545 adolescents. The purposive sampling technique was applied. First, 12 camps in the Ukhiya region were randomly selected. Adolescents of both sexes, aged between 10 and 19, were included in the study. Respondents’ sociodemographic characteristics and dietary patterns, as well as the participant’s nutritional status, were recorded. Descriptive statistics were used to present the baseline characteristics, while Pearson’s χ2test was used to assess the relationship between food preference and baseline characteristics.A significant number of participants failed to meet their daily requirements for essential nutrients, including protein (89.9%), vegetables (82.8%) and dairy products (90.8%). Additionally, 58.9% of the respondents did not consume adequate water daily. Food preferences and eating behaviours among FDMN adolescents in Cox’s Bazar were found to be influenced by a range of factors, including peer influence, access to nutritional education, food sources, cultural beliefs, ration sufficiency, food prices as well as age, gender, education level and household income.In conclusion, understanding and addressing the multifaceted factors that influence the food preferences of FDMN adolescents is crucial for developing targeted interventions and comprehensive nutritional programmes.
青春期是身体、心理、社会和行为发展的关键时期,因此了解影响青少年食物偏好和饮食行为的因素至关重要。本研究旨在调查影响孟加拉国考克斯巴扎尔缅甸被迫流离失所者(FDMN)营地青少年食物偏好和饮食行为的因素。研究采用了目的性抽样技术。首先,随机抽取了 Ukhiya 地区的 12 个营地。研究对象包括 10 至 19 岁的男女青少年。受访者的社会人口特征、饮食模式以及营养状况均被记录在案。研究采用了描述性统计来显示基线特征,并采用皮尔逊χ2检验来评估食物偏好与基线特征之间的关系。此外,58.9%的受访者每天的饮水量不足。研究发现,科克斯巴扎尔地区营养不良青少年的食物偏好和饮食行为受到一系列因素的影响,包括同伴影响、营养教育机会、食物来源、文化信仰、口粮充足性、食品价格以及年龄、性别、教育水平和家庭收入。
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引用次数: 0
Qualitative focus group discussions exploring PrEP method and service delivery preferences among female sex workers and their managers in four Zambian provinces 焦点小组定性讨论,探讨赞比亚四个省的女性性工作者及其管理者对 PrEP 方法和服务提供的偏好
Pub Date : 2024-02-01 DOI: 10.1136/bmjph-2023-000483
E. Evens, Tendai Munthali, Featherstone G. Mangunje, Mercy L Kotaka, Holly M. Burke, Bupe Musonda, Musonda Musonda, Catherine S. Todd
To describe the experiences of oral HIV pre-exposure prophylaxis (PrEP) use, preferences comparing oral PrEP to future long-acting PrEP products (the dapivirine vaginal ring (PrEP ring) and injectable cabotegravir (CAB PrEP)), and service provision preferences among female sex workers (FSWs) and their managers.Qualitative formative focus group discussions were conducted in two urban (Copperbelt, Lusaka) and two rural (Central, Luapula) provinces in Zambia. Consenting participants included 43 FSWs and 36 sex work managers. Eligible participants self-identified as FSWs or sex work managers, were 18 years or older and spoke English, Nyanja or Bemba.FSWs had a median age of 28 years and 60% reported ever using oral PrEP. Among potential future HIV prevention options, most FSWs preferred longer acting PrEP methods, mainly CAB PrEP over the PrEP ring. This preference was consistent across provinces. Many FSWs had personal oral PrEP experience and appreciated the high effectiveness but conveyed that the realities of daily use, including pill visibility, and attributed side effects did not meet their needs. FSWs and managers also identified frequent stigma and misinformation-related barriers to PrEP access and use at community and facility levels. Most FSWs and managers agreed that informing non-paying or long-term partners of PrEP use was acceptable. Participants offered recommendations for greater sensitisation and peer-led services or service extension through trusted figures in the community.Zambian FSWs and their managers preferred longer acting PrEP methods, particularly CAB PrEP, as part of comprehensive HIV prevention method choice, with little difference between provinces. PrEP programming led by FSW peers, managers or other trusted figures was recommended to address misinformation, sensitise partners and potentially deliver services to circumvent perceived stigma at health facilities.
在赞比亚的两个城市省(铜带省和卢萨卡省)和两个农村省(中央省和卢阿普拉省)开展了定性形成性焦点小组讨论。征得同意的参与者包括 43 名性工作者和 36 名性工作管理者。符合条件的参与者自我认同为女性外阴残割者或性工作管理者,年龄在 18 岁或以上,会讲英语、尼扬贾语或本巴语。女性外阴残割者的年龄中位数为 28 岁,60% 的人表示曾经使用过口服 PrEP。在未来潜在的艾滋病毒预防方案中,大多数女性外阴残割者更倾向于使用长效的 PrEP 方法,主要是 CAB PrEP,而不是 PrEP 环。各省的这一偏好是一致的。许多社会福利工作者有过口服 PrEP 的亲身经历,并对其高效性表示赞赏,但表示日常使用的实际情况(包括药片的可见度)和可归因于药片的副作用并不能满足他们的需求。在社区和医疗机构层面上,社会福利工作者和管理人员还发现了在获取和使用 PrEP 方面经常出现的与污名化和错误信息有关的障碍。大部分的社会福利工作者和管理人员都认为,将 PrEP 的使用情况告知非付费伴侣或长期伴侣是可以接受的。赞比亚的女性外 勤工作者及其管理人员更倾向于选择长效的 PrEP 方法,尤其是 CAB PrEP,将其作为综合艾滋病 预防方法选择的一部分,各省之间的差异不大。建议由女性外阴残割者的同伴、管理者或其他可信赖的人物领导 PrEP 计划的制定,以解决误导问题,提高合作伙伴的敏感性,并有可能提供服务,以避免在卫生设施中被认为是污名化。
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引用次数: 0
Predicting the effects of introducing an emergency transport system in low-income and middle-income countries: a spatial-epidemiological modelling study 预测在中低收入国家引入紧急运输系统的影响:空间流行病学建模研究
Pub Date : 2024-02-01 DOI: 10.1136/bmjph-2023-000321
Katie Scandrett, R. Lilford, Dmitri Nepogodiev, S. Katikireddi, Justine Davies, Stephen Tabiri, Samuel I Watson
Many low-income and middle-income countries lack an organised emergency transportation system, leaving people to arrange informal transport to hospital in the case of a medical emergency. Estimating the effect of implementing an emergency transport system is impractical and expensive, so there is a lack of evidence to support policy and investment decisions. Alternative modelling strategies may be able to fill this gap.We have developed a spatial-epidemiological model of emergency transport for life-threatening conditions. The model incorporates components to both predict travel times across an area of interest under different scenarios and predict survival for emergency conditions as a function of time to receive care. We review potentially relevant data sources for different model parameters. We apply the model to the illustrative case study of providing emergency transport for postpartum haemorrhage in Northern Ghana.The model predicts that the effects of an ambulance service are likely to be ephemeral, varying according to local circumstances such as population density and road networks. In our applied example, the introduction of the ambulance service may save 40 lives (95% credible interval 5 to 111), or up to 107 lives (95% credible interval −293 to –13) may be lost across the region in a year, dependent on various model assumptions and parameter specifications. Maps showing the probability of reduced transfer time with the ambulance service may be particularly useful and allow for resource allocation planning.Although there is scope for improvement in our model and in the data available to populate the model and inform parameter choices, we believe this work provides a foundation for pioneering methodology to predict the effect of introducing an ambulance system. Our spatial-epidemiological model includes much oppurtunity for flexibility and can be updated as required to best represent a chosen case study.
许多低收入和中等收入国家缺乏有组织的紧急运输系统,人们只能在发生医疗紧急情况时安排非正式的交通工具前往医院。对实施紧急交通系统的效果进行估算既不现实又昂贵,因此缺乏支持政策和投资决策的证据。我们开发了一个危及生命的紧急交通空间流行病学模型。该模型包含多个组成部分,既可预测不同情况下相关区域内的旅行时间,也可预测作为接受治疗时间函数的紧急状况下的存活率。我们回顾了不同模型参数的潜在相关数据源。我们将该模型应用于加纳北部产后出血急救运输的示例研究中。该模型预测,救护车服务的效果可能是短暂的,会根据当地情况(如人口密度和道路网络)而变化。在我们的应用实例中,救护车服务的引入可能会在一年内挽救 40 条生命(95% 可信区间为 5 至 111),也可能会在一年内使整个地区失去多达 107 条生命(95% 可信区间为-293 至-13),这取决于各种模型假设和参数规格。虽然我们的模型以及用于填充模型和通知参数选择的可用数据还有待改进,但我们相信这项工作为开创预测引入救护车系统影响的方法奠定了基础。我们的空间流行病学模型具有很大的灵活性,可根据需要进行更新,以最好地体现所选案例研究。
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引用次数: 0
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BMJ Public Health
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