European Journal of Epidemiology最新文献

{"title":"Re: Liu et al., “On the reported methodology in published TriNetX-based studies: an analysis of impossible index event designs”","authors":"Sarah E. Williford, K. Arnold Chan, Jeffrey S. Brown","doi":"10.1007/s10654-026-01374-6","DOIUrl":"https://doi.org/10.1007/s10654-026-01374-6","url":null,"abstract":"","PeriodicalId":11907,"journal":{"name":"European Journal of Epidemiology","volume":"332 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146231115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence, mortality, and cumulative risk of cancer in adolescents and young adults in Switzerland","authors":"Céline Bolliger, Eleftheria Michalopoulou, Christian Kreis, Matthias Lorez, Christina Schindera, Benjamin Kasenda, Claudia E. Kuehni, Daniela Dyntar, Katharina Roser, Ben D. Spycher","doi":"10.1007/s10654-026-01363-9","DOIUrl":"https://doi.org/10.1007/s10654-026-01363-9","url":null,"abstract":"Cancers in adolescents and young adults (AYAs, aged 15–39 years) have distinct features and distribution of cancer types. This study investigated incidence, mortality, and cumulative risk of AYA cancers in Switzerland. Data on adolescent cancers (15–19 years; Swiss Childhood Cancer Registry) and young adult cancers (20–39 years; National Agency for Cancer Registration) were combined. We calculated age-standardized incidence and mortality rates, and accounted for incomplete regional coverage of cancer registration. We used joinpoint regression to investigate cancer incidence and mortality trends and estimate average annual percent changes. We included 44,048 cancers recorded between 1980 and 2019 and, after adjusting for incomplete coverage, we estimated a total of 69,901 cancers. Cancer incidence increased from 56.6 [95% confidence interval: 55.3, 58.0] per 100,000 person-years in 1980–1989 to 72.2 [71.1, 73.3] in 2010–2019, with a steeper increase for females. The most common cancers were carcinomas, mainly of the breast (9,629 cancers estimated), gastrointestinal tract (5,033) and thyroid (4,785), gonadal and related tumors (11,303), melanomas (9,695), and lymphomas (8,208). There were 9,865 AYA cancer deaths recorded over the study period. The age-standardized mortality rate declined from 13.3 [12.8, 13.7] per 100,000 person-years in 1980–1989 to 6.2 [5.9, 6.5] in 2010–2019, showing similar decreases in both sexes. This first comprehensive, nationwide study of AYA cancers in Switzerland showed increasing incidence and declining mortality, potentially due to changes in lifestyle or improved cancer registration and screening practices. Our results emphasize the need for ongoing surveillance and preventive strategies with a focus on AYAs.","PeriodicalId":11907,"journal":{"name":"European Journal of Epidemiology","volume":"547 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146231112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the reported methodology in published TriNetX-based studies: an analysis of impossible index event designs","authors":"Yu-Jung Lin, Kuo-Wang Tsai, Kuo-Cheng Lu, Joshua Wang","doi":"10.1007/s10654-025-01342-6","DOIUrl":"https://doi.org/10.1007/s10654-025-01342-6","url":null,"abstract":"","PeriodicalId":11907,"journal":{"name":"European Journal of Epidemiology","volume":"52 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146231111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Night shift work, dietary patterns, and coronary heart disease","authors":"Diana A. Nôga, Elisa M. S. Meth, André P. Pacheco, Jonathan Cedernaes, Pei Xue, Christian Benedict","doi":"10.1007/s10654-026-01362-w","DOIUrl":"https://doi.org/10.1007/s10654-026-01362-w","url":null,"abstract":"Shift workers exhibit a higher incidence of coronary heart disease (CHD) than daytime workers. We examined whether this difference in CHD incidence between shift workers and daytime workers is associated with two dietary factors linked to lower CHD risk—daily fiber intake and meat avoidance—using UK Biobank data. The study included 222,801 participants (53.8% women; mean age 52.6 years), categorized as daytime workers, shift workers with no or occasional night shifts, or regular night shift workers. Dietary habits were assessed via touchscreen dietary questionnaires. During a median follow-up of 12.6 years, 12,265 fatal and non-fatal CHD events occurred. Compared with daytime workers, regular night shift work—but not shift work with no or occasional night shifts—was associated with higher CHD incidence (hazard ratio [HR] 1.10, 95% CI 1.01–1.20). HRs for CHD were higher (vs. daytime work) in both shift work groups among participants with lower daily fiber intake, whereas they were attenuated among those with higher fiber intake (p < 0.05 for interaction). Meat avoidance was associated with a 10.4% lower CHD HR compared with meat consumption (p = 0.020), although no significant interaction with work schedule was observed. In summary, while our finding that meat avoidance is associated with modestly lower CHD HR across work schedules aligns with established cardiovascular recommendations, our observation that higher fiber intake may reduce CHD differences specifically linked to night shift work highlights an additional, shift-specific dietary consideration that could complement the American Heart Association’s Life’s Essential 8.","PeriodicalId":11907,"journal":{"name":"European Journal of Epidemiology","volume":"8 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146231113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A newly developed circadian imbalance index (CII) and risk of cardiovascular-kidney-metabolic disease in the UK biobank","authors":"Jing Zhang, Dat Thien Tran, Tala El Ghoul, Susanne Strohmaier, Magdalena Żebrowska, Susan Redline, Richa Saxena, Martin K. Rutter, Eva S. Schernhammer","doi":"10.1007/s10654-026-01373-7","DOIUrl":"https://doi.org/10.1007/s10654-026-01373-7","url":null,"abstract":"","PeriodicalId":11907,"journal":{"name":"European Journal of Epidemiology","volume":"402 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Danish Chronic Disease Cohort: using digital footprints to identify chronic disease patterns","authors":"Ann Taber, Ricco N. H. Flyckt, Margrethe H. B. Henriksen, Kaire Innos, Wenche Nystad, Lars J. Kjerpeseth, Brit L. Sandgren, Claus Varnum, Malene R. V. Pedersen, Christopher Johansen, Torben F. Hansen, Claus L. Brasen","doi":"10.1007/s10654-025-01354-2","DOIUrl":"https://doi.org/10.1007/s10654-025-01354-2","url":null,"abstract":"","PeriodicalId":11907,"journal":{"name":"European Journal of Epidemiology","volume":"1 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of epidemiological studies into daylight-saving time & health identifying beneficial & adverse effects","authors":"Aiste Steponenaite, Jonas P. Wallraff, Ursula Wild, Lorna Brown, Ben Bullock, Gurprit S. Lall, Sally Ferguson, Russell G. Foster, Jennifer Walsh, Greg Murray, Thomas C. Erren, Philip Lewis","doi":"10.1007/s10654-026-01372-8","DOIUrl":"https://doi.org/10.1007/s10654-026-01372-8","url":null,"abstract":"Our objective was to systematically review the epidemiological evidence regarding health effects of daylight-saving time (DST) practices – the abolition of which have been called for without the epidemiology having been comprehensively reviewed. We searched PubMed, Web of Science, Scopus, PsychINFO, and EconLit up to June 2025. The primary inclusion criterion was human studies that consider either acute effects of transitions or DST vs standard time at a given time of year. Included studies were critically appraised using the Joanna Briggs Institute Critical Appraisal Checklist for Quasi-Experimental Studies. We narratively synthesize by broader outcome categories in Supplementary Material and provide a synthesis of syntheses in the main text. From 157 studies of varying designs and quality from 36 countries, we find that the messaging of transitions and DST during summer months being uniformly detrimental is not supported. DST-Onset transitions appear associated with increased acute myocardial infarction and fatal traffic accidents, but also with decreased crimes involving physical harm. DST-Offset transitions appear associated with decreased all-cause mortality and workplace accidents, but also with increased crimes involving physical harm. Living with DST (compared to Standard Time) appears associated with decreased all-cause mortality and traffic accidents in summer. Standard Time appears is potentially associated with decreased sleep duration during winter. No clear and consistent effects on psychiatric outcomes are identified. Limited studies prevent clear conclusions being drawn regarding other sleep parameters or circadian rhythms. This review indicates that transitions and living with DST (as opposed to Standard Time) during summer months are not uniformly detrimental; however, the evidence base remains limited and heterogeneous. Rather than advocating for maintaining or removing transitions, our synthesis supports a balanced approach. We recommend recognising both adverse and beneficial patterns and prioritising strategies to mitigate risks while awaiting more robust evidence. <jats:italic>Registration</jats:italic> <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"https://doi.org/10.17605/OSF.IO/R4W6M\" ext-link-type=\"uri\">https://doi.org/10.17605/OSF.IO/R4W6M</jats:ext-link>","PeriodicalId":11907,"journal":{"name":"European Journal of Epidemiology","volume":"59 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146231107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can paternal pre-pregnancy cannabis use impact outcomes among offspring?","authors":"Jesse J Norris","doi":"10.1007/s10654-025-01331-9","DOIUrl":"https://doi.org/10.1007/s10654-025-01331-9","url":null,"abstract":"","PeriodicalId":11907,"journal":{"name":"European Journal of Epidemiology","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146219056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 vaccination and short-term mortality risk: a nationwide self-controlled case series study in The Netherlands.","authors":"Isabel A L Slurink, Annemarijn R de Boer, Marc J M Bonten, Miriam C J M Sturkenboom, Patricia C J L Bruijning-Verhagen","doi":"10.1007/s10654-025-01334-6","DOIUrl":"10.1007/s10654-025-01334-6","url":null,"abstract":"<p><p>Excess mortality during the COVID-19 pandemic partly exceeded COVID-19-related deaths, indicating that other causes may have contributed. We conducted a retrospective data-linkage study including all Dutch inhabitants to investigate the impact of COVID-19 vaccination on excess mortality using a modified self-controlled case series method. We found a 44% lower relative incidence of all-cause deaths in the first three weeks after the primary vaccination compared to more than three weeks after vaccination (IRR 0.56, 95%CI 0.54-0.57). This lower incidence was consistent across vaccine types, doses, genders, age groups, and individuals with or without prior SARS-CoV-2 infection or comorbidities, and for non-COVID-19 related deaths. For booster vaccinations, the relative incidence was similar (IRR 0.49, 95%CI 0.49-0.50). In comparison, we observed a 16-fold higher incidence of all-cause deaths in the three weeks following a registered positive SARS-CoV-2 infection compared to more than three weeks after infection (IRR 16.19, 95%CI 15.78-16.60). A lower relative incidence of short-term deaths following COVID-19 vaccination support that COVID-19 vaccination is not associated with the observed excess mortality.</p>","PeriodicalId":11907,"journal":{"name":"European Journal of Epidemiology","volume":" ","pages":"173-184"},"PeriodicalIF":5.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12975842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-level exposure to arsenic in drinking water and risk of type 2 diabetes: a systematic review and meta-analysis.","authors":"Paolo Boffetta,Giulia Collatuzzo,K M Venkat Narayan","doi":"10.1007/s10654-026-01365-7","DOIUrl":"https://doi.org/10.1007/s10654-026-01365-7","url":null,"abstract":"The association between diabetes and low-level arsenic exposure in drinking water has not been adequately investigated. We conducted a two-stage meta-analysis of dose-response relationships from studies reporting incidence or prevalence of diabetes with average exposure up to 150 µg/L arsenic in drinking water. We conducted a literature search and included cross-sectional, case control and cohort studies and we extracted results for exposure to arsenic up to average concentration of 150 µg/L water. Prevalence and incidence were generically referred to as risk. We conducted study-specific linear regression to estimate the relative risk (RR) of diabetes for a 10 µg/L increase of arsenic, and combined the study-specific results in a random-effect meta-analysis. We addressed publication bias by excluding studies with the largest standard error; and identified a subset of high-quality studies. We also performed a one-stage meta-regression. We selected 11 studies including 12 populations from seven countries. The meta-analysis of their results yielded a relative risk (RR) of type 2 diabetes for a 10 µg/L arsenic increase within the range 0-150 µg/L equal to 1.07 (95% confidence interval [CI] 1.02-1.21, p heterogeneity = 0.006). There was evidence of publication bias (p = 0.004); after accounting for publication bias, the summary RR was 1.02 (95% CI 0.99-1.06, eight studies). The RR based on the high-quality studies was 1.03 (95% CI 0.97-1.09, five studies). The corresponding RR of the meta-regression was 1.007 (95% CI 0.998-1.017, 32 risk estimates). Accounting for publication bias and study quality, and considering heterogeneity of risk estimates, our two-stage meta-analysis supports a null association between low levels of arsenic in drinking water and type 2 diabetes.","PeriodicalId":11907,"journal":{"name":"European Journal of Epidemiology","volume":"78 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146056881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}