Pub Date : 2026-01-12DOI: 10.1007/s00259-025-07736-8
Otto M Henriksen,Oriol P Calvo,Frederik J Bruun,Marie Bruun,Steen G Hasselbalch,Kristian S Frederiksen,Adam E Hansen,Ian Law,Ulrich Lindberg
PURPOSETo assess the quantitative and visual concordance of multiple post-labelling delay (multi-PLD) arterial spin labelling (ASL) MRI cerebral blood flow (CBF) measurements and [18F]-fluoro-deoxyglucose (FDG) PET in a mixed memory clinic population.METHODSHybrid [18F]FDG PET/MRI including multi-PLD pseudo continuous ASL from 96 memory clinic patients and 38 elderly controls were analysed along with ASL data from 12 healthy young volunteers. ASL image interpretability, concordance with [18F]FDG PET, and value of Z-score maps were rated visually. Regional associations of CBF with [18F]FDG uptake ratio (SUVr) were investigated by univariate regression and mixed linear models. Also influences of age, disease stage and vascular pathology on ASL interpretability and concordance, and whole cortex spatial coefficient of variation (sCOV) were analysed.RESULTSASL CBF maps were non-comparable to [18F]FDG PET, i.e. uninterpretable or discordant, in 53% of patients, 37% of elderly controls, and 8% of young controls. Only 14% of patient ASL MRI scans were concordant with [18F]FDG PET. Z-score maps were mainly of value in partially concordant scans. Increasing sCOV was strongly associated both with disease severity and with decreasing ASL interpretability and concordance, and allowed for identification of uninterpretable scans with 95% sensitivity and 90% specificity. Whole cortex CBF and [18F]FDG SUVr values showed similar distribution across groups, but low to moderate regional associations.CONCLUSIONSMulti-PLD ASL provided quantitative CBF measurements correlating with disease severity, but poor image quality and low regional concordance in head-to-head comparison with [18F]FDG PET imaging restricts the clinical use in memory clinic patients.
{"title":"Simultaneous multiple post-labelling delay ASL MRI and [18F]FDG PET in a mixed memory clinic population and healthy controls.","authors":"Otto M Henriksen,Oriol P Calvo,Frederik J Bruun,Marie Bruun,Steen G Hasselbalch,Kristian S Frederiksen,Adam E Hansen,Ian Law,Ulrich Lindberg","doi":"10.1007/s00259-025-07736-8","DOIUrl":"https://doi.org/10.1007/s00259-025-07736-8","url":null,"abstract":"PURPOSETo assess the quantitative and visual concordance of multiple post-labelling delay (multi-PLD) arterial spin labelling (ASL) MRI cerebral blood flow (CBF) measurements and [18F]-fluoro-deoxyglucose (FDG) PET in a mixed memory clinic population.METHODSHybrid [18F]FDG PET/MRI including multi-PLD pseudo continuous ASL from 96 memory clinic patients and 38 elderly controls were analysed along with ASL data from 12 healthy young volunteers. ASL image interpretability, concordance with [18F]FDG PET, and value of Z-score maps were rated visually. Regional associations of CBF with [18F]FDG uptake ratio (SUVr) were investigated by univariate regression and mixed linear models. Also influences of age, disease stage and vascular pathology on ASL interpretability and concordance, and whole cortex spatial coefficient of variation (sCOV) were analysed.RESULTSASL CBF maps were non-comparable to [18F]FDG PET, i.e. uninterpretable or discordant, in 53% of patients, 37% of elderly controls, and 8% of young controls. Only 14% of patient ASL MRI scans were concordant with [18F]FDG PET. Z-score maps were mainly of value in partially concordant scans. Increasing sCOV was strongly associated both with disease severity and with decreasing ASL interpretability and concordance, and allowed for identification of uninterpretable scans with 95% sensitivity and 90% specificity. Whole cortex CBF and [18F]FDG SUVr values showed similar distribution across groups, but low to moderate regional associations.CONCLUSIONSMulti-PLD ASL provided quantitative CBF measurements correlating with disease severity, but poor image quality and low regional concordance in head-to-head comparison with [18F]FDG PET imaging restricts the clinical use in memory clinic patients.","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"15 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-12DOI: 10.1007/s00259-025-07758-2
Luigi Mansi
{"title":"Kalevi Kairemo. Prostate cancer from a nuclear oncology perspective. A personal journey. Springer Nature Switzerland AG 2025, ISBN: 978-3-031-90336-6","authors":"Luigi Mansi","doi":"10.1007/s00259-025-07758-2","DOIUrl":"https://doi.org/10.1007/s00259-025-07758-2","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"9 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145955132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-10DOI: 10.1007/s00259-025-07722-0
Phyo H. Khaing, Mark G. MacAskill, Jianfei Xiao, Shichao Liu, Zhuqin Gu, Xiaohiu Sun, Tao Xu, Norman Koglin, Andrew W. Stephens, David E. Newby, Yihui Guan, Holly McErlain, Andrew Sutherland, Gilles D. Tamagnan, Fang Xie, Adriana Alexandre S. Tavares
Purpose The 18 kDa translocator protein (TSPO) has been a central molecular target for imaging inflammation in the preclinical and clinical research settings across a plethora of applications, including neuroinflammation, cardiovascular inflammation and cancer. Recently, we reported the development of [ 18 F]LW223 as a third-generation TSPO positron emission tomography (PET) radiotracer with binding to human TSPO independent of the rs6971 genetic polymorphism. This study reports the first whole-body human analysis, including biodistribution and dosimetry calculations, following intravenous administration of [ 18 F]LW223. Methods Whole-body PET images were acquired over 250 min after intravenous bolus injection of 184.3 ± 20.2 MBq of [ 18 F]LW223 in healthy adult human volunteers. Volumes of interest (VOIs) in different source organs were manually delineated by three independent observers, then time-activity curves were generated for residency times calculations for subsequent quantification of radiation equivalent and effective doses using OLINDA/EXM 2.2 software. Results The radiotracer biodistribution in humans recapitulated known TSPO expression in various tissues. The main elimination route was found to be hepatobiliary, and the critical organ was the intestine. The cumulated radioactivity excreted by the kidneys was < 10% over the measurement period and no bone uptake suggestive of in vivo defluorination was observed in any of the study subjects. The effective dose ranged between 11.8 ± 0.9 and 12.5 ± 0.9 µSv/MBq. Inter-observer VOI variability had no impact on estimated organ and whole-body effective doses. Conclusion [ 18 F]LW223 is predominantly excreted by the hepatobiliary route with no evidence of in vivo defluorination but demonstrates marked uptake into tissues with known TSPO expression. It complies with radiation limits and guidelines recommended by regulatory authorities and is in line with previously reported [ 18 F]-labelled radiotracers, such as [ 18 F]fluorodeoxyglucose. [ 18 F]LW223 is suitable for translation into human clinical studies.
{"title":"First human whole-body biodistribution and dosimetry analysis of [18F]LW223, a novel TSPO PET radiotracer","authors":"Phyo H. Khaing, Mark G. MacAskill, Jianfei Xiao, Shichao Liu, Zhuqin Gu, Xiaohiu Sun, Tao Xu, Norman Koglin, Andrew W. Stephens, David E. Newby, Yihui Guan, Holly McErlain, Andrew Sutherland, Gilles D. Tamagnan, Fang Xie, Adriana Alexandre S. Tavares","doi":"10.1007/s00259-025-07722-0","DOIUrl":"https://doi.org/10.1007/s00259-025-07722-0","url":null,"abstract":"Purpose The 18 kDa translocator protein (TSPO) has been a central molecular target for imaging inflammation in the preclinical and clinical research settings across a plethora of applications, including neuroinflammation, cardiovascular inflammation and cancer. Recently, we reported the development of [ <jats:sup>18</jats:sup> F]LW223 as a third-generation TSPO positron emission tomography (PET) radiotracer with binding to human TSPO independent of the rs6971 genetic polymorphism. This study reports the first whole-body human analysis, including biodistribution and dosimetry calculations, following intravenous administration of [ <jats:sup>18</jats:sup> F]LW223. Methods Whole-body PET images were acquired over 250 min after intravenous bolus injection of 184.3 ± 20.2 MBq of [ <jats:sup>18</jats:sup> F]LW223 in healthy adult human volunteers. Volumes of interest (VOIs) in different source organs were manually delineated by three independent observers, then time-activity curves were generated for residency times calculations for subsequent quantification of radiation equivalent and effective doses using OLINDA/EXM 2.2 software. Results The radiotracer biodistribution in humans recapitulated known TSPO expression in various tissues. The main elimination route was found to be hepatobiliary, and the critical organ was the intestine. The cumulated radioactivity excreted by the kidneys was < 10% over the measurement period and no bone uptake suggestive of in vivo defluorination was observed in any of the study subjects. The effective dose ranged between 11.8 ± 0.9 and 12.5 ± 0.9 µSv/MBq. Inter-observer VOI variability had no impact on estimated organ and whole-body effective doses. Conclusion [ <jats:sup>18</jats:sup> F]LW223 is predominantly excreted by the hepatobiliary route with no evidence of in vivo defluorination but demonstrates marked uptake into tissues with known TSPO expression. It complies with radiation limits and guidelines recommended by regulatory authorities and is in line with previously reported [ <jats:sup>18</jats:sup> F]-labelled radiotracers, such as [ <jats:sup>18</jats:sup> F]fluorodeoxyglucose. [ <jats:sup>18</jats:sup> F]LW223 is suitable for translation into human clinical studies.","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"13 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The predictive value of 18F-FAPI PET/CT and voxel-based tumor absorbed dose for the response and clinical outcome of unresectable hepatocellular carcinoma patients treated with Yttrium-90 resin microsphere selective internal radiation therapy","authors":"Huanyu Gong, Yong Cheng, Qiang Li, Yulong Liu, Jingjie Shang, Yingxin Li, Lu Kuang, Xueying Ling, Changjing Zuo, Lu Wang, Jian Gong, Hao Xu","doi":"10.1007/s00259-025-07717-x","DOIUrl":"https://doi.org/10.1007/s00259-025-07717-x","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"363 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-10DOI: 10.1007/s00259-025-07724-y
Mick M. Welling, Cathryn H. S. Driver, Palesa C. Koatale, Tricia Naicker, Thomas Ebenhan
Multimodal imaging using hybrid imaging agents is a promising strategy for diagnosing and evaluating pathologies after image-guided surgical interventions. Combining optical and radioactive imaging techniques provides a comprehensive approach to monitoring and diagnosing infections, which would be more effective than routine nuclear clinical tracers for SPECT or PET imaging, thereby enabling more effective treatment as in image-guided surgery. This review summarizes the latest developments in hybrid imaging agents and vectors for radioactive and optical imaging of bacterial, fungal, and viral infections. We pinpoint the pitfalls in the current preclinical landscape for developing infection imaging tracers. Besides diagnosing and tracking pathogens, the role of optical imaging in diagnosing and aiding antimicrobial interventions, including image-guided surgery, is discussed. Finally, practical considerations are addressed for multimodal workflow challenges in preclinical infection imaging with hybrid tracers.
{"title":"Recent advances in multimodal imaging of infections: research highlights using Nuclear-Optical imaging","authors":"Mick M. Welling, Cathryn H. S. Driver, Palesa C. Koatale, Tricia Naicker, Thomas Ebenhan","doi":"10.1007/s00259-025-07724-y","DOIUrl":"https://doi.org/10.1007/s00259-025-07724-y","url":null,"abstract":"Multimodal imaging using hybrid imaging agents is a promising strategy for diagnosing and evaluating pathologies after image-guided surgical interventions. Combining optical and radioactive imaging techniques provides a comprehensive approach to monitoring and diagnosing infections, which would be more effective than routine nuclear clinical tracers for SPECT or PET imaging, thereby enabling more effective treatment as in image-guided surgery. This review summarizes the latest developments in hybrid imaging agents and vectors for radioactive and optical imaging of bacterial, fungal, and viral infections. We pinpoint the pitfalls in the current preclinical landscape for developing infection imaging tracers. Besides diagnosing and tracking pathogens, the role of optical imaging in diagnosing and aiding antimicrobial interventions, including image-guided surgery, is discussed. Finally, practical considerations are addressed for multimodal workflow challenges in preclinical infection imaging with hybrid tracers.","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"57 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-08DOI: 10.1007/s00259-025-07714-0
Hannelore I Coerts, Folkert J van Kemenade, Tessa M van Ginhoven, Menno R Vriens, M Medici, D Vriens, Bart de Keizer, Frederik A Verburg
{"title":"The malignancy risk of thyroid incidentalomas detected by [<sup>18</sup>F]FDG PET/CT lower than expected: a nationwide observational study in the Netherlands.","authors":"Hannelore I Coerts, Folkert J van Kemenade, Tessa M van Ginhoven, Menno R Vriens, M Medici, D Vriens, Bart de Keizer, Frederik A Verburg","doi":"10.1007/s00259-025-07714-0","DOIUrl":"https://doi.org/10.1007/s00259-025-07714-0","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.1007/s00259-025-07731-z
Jiangyu Ma, Chu Wang, Miao Wang, Chao Ren, Zhenghai Huang, Yonghui Chen, Shuaitao Xiong, Jingxin Yang, Ming Liu, Li Huo
{"title":"The integrated diagnostic strategy of performing PSMA PET/CT followed by MRI improves the diagnostic accuracy of prostate cancer","authors":"Jiangyu Ma, Chu Wang, Miao Wang, Chao Ren, Zhenghai Huang, Yonghui Chen, Shuaitao Xiong, Jingxin Yang, Ming Liu, Li Huo","doi":"10.1007/s00259-025-07731-z","DOIUrl":"https://doi.org/10.1007/s00259-025-07731-z","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"40 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.1007/s00259-025-07728-8
Elske Quak, Audrey Lasne-Cardon, Marie Cavarec, Franck Jegoux, Clémence Guery, Jean-Michel Grellard, Guy Thomas, Lawrence Nadin, Bénédicte Clarisse, Celia Berchi
{"title":"First-line [18F]F-choline PET/CT in primary hyperparathyroidism: a cost-effectiveness study from the diagnostic randomized APACH2 trial","authors":"Elske Quak, Audrey Lasne-Cardon, Marie Cavarec, Franck Jegoux, Clémence Guery, Jean-Michel Grellard, Guy Thomas, Lawrence Nadin, Bénédicte Clarisse, Celia Berchi","doi":"10.1007/s00259-025-07728-8","DOIUrl":"https://doi.org/10.1007/s00259-025-07728-8","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"40 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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