PURPOSEProstate-specific membrane antigen (PSMA) PET/CT enhances prostate cancer (PCa) diagnosis. The newly developed PSMA probe, [68Ga]Ga-P16-093, with low urinary excretion, has shown superior diagnostic efficacy compared to conventional PSMA probes. This study aims to assess the diagnostic efficacy and local-regional staging performance of [68Ga]Ga-P16-093 in PCa lesions of newly diagnosed patients, using histopathology as the gold standard for validation.METHODSThis prospective study enrolled newly diagnosed PCa patients (April 2022-November 2023). All patients underwent [68Ga]Ga-P16-093 PET imaging, and a subset also received [68Ga]Ga-PSMA-11 PET/CT within one week. Radical prostatectomy within two weeks post-PET provided complete pathological specimens from all patients. The diagnostic efficacy and locoregional staging performance of [68Ga]Ga-P16-093 were statistically compared with that of [68Ga]Ga-PSMA-11, using histopathology as the gold standard.RESULTSFifty-six treatment-naïve male patients (mean age 67 ± 6 years; range 52-77) were prospectively enrolled. A subgroup of 37 patients who underwent both [⁶⁸Ga]Ga-P16-093 and [68Ga]Ga-PSMA-11 PET/CT was analyzed for direct comparison. [68Ga]Ga-P16-093 PET/CT demonstrated superior diagnostic performance in primary prostate cancer evaluation, with sensitivity of 74.44% (201/270, 95% CI: 68.38-80.50%), specificity of 96.26% (387/402, 95% CI: 94.39-98.15%), and accuracy of 87.50% (588/672, 95% CI: 85.05-89.95%). Compared with [68Ga]Ga-PSMA-11 PET/CT, [68Ga]Ga-P16-093 PET/CT showed higher tracer uptake, with SUVmax of 9.86 ± 6.82 vs. 6.74 ± 1.89 (P = 0.041), SUVmean of 5.81 ± 4.03 vs. 3.98 ± 1.04 (P = 0.037), and T/B ratio of 23.19 ± 17.51 vs. 16.04 ± 7.75 (P = 0.042). Additionally, ROC analysis revealed a significantly greater AUC for P16-093 (0.85 vs. 0.75, P < 0.05). Moreover, locoregional staging accuracy was higher at 59.46% (22/37) compared with 32.43% (12/37) for [68Ga]Ga-PSMA-11 PET/CT.CONCLUSION[68Ga]Ga-P16-093 PET/CT exhibits high diagnostic performance in the diagnosis of primary PCa and shows significant advantages in identifying local tumor segments. [68Ga]Ga-P16-093 may serve as an alternative to [68Ga]Ga-PSMA-11 in the future diagnosis of PCa.TRIAL REGISTRATIONClinicalTrials.gov, NCT05324332. Registered 04 March 2022. URL OF REGISTRY: https://clinicaltrials.gov/ct2/show/NCT05324332.
{"title":"[68Ga]Ga-P16-093 PET/CT in newly diagnosed prostate cancer: Histopathological validation and comparison with [68Ga]Ga-PSMA-11.","authors":"Jiarou Wang,Linlin Li,Jingci Chen,Rongxi Wang,Jialin Xiang,Xingtong Peng,Yanwei Wang,Yaping Luo,Lin Zhu,Hank F Kung,Zhien Zhou,Yu Xiao,Zhaohui Zhu","doi":"10.1007/s00259-025-07687-0","DOIUrl":"https://doi.org/10.1007/s00259-025-07687-0","url":null,"abstract":"PURPOSEProstate-specific membrane antigen (PSMA) PET/CT enhances prostate cancer (PCa) diagnosis. The newly developed PSMA probe, [68Ga]Ga-P16-093, with low urinary excretion, has shown superior diagnostic efficacy compared to conventional PSMA probes. This study aims to assess the diagnostic efficacy and local-regional staging performance of [68Ga]Ga-P16-093 in PCa lesions of newly diagnosed patients, using histopathology as the gold standard for validation.METHODSThis prospective study enrolled newly diagnosed PCa patients (April 2022-November 2023). All patients underwent [68Ga]Ga-P16-093 PET imaging, and a subset also received [68Ga]Ga-PSMA-11 PET/CT within one week. Radical prostatectomy within two weeks post-PET provided complete pathological specimens from all patients. The diagnostic efficacy and locoregional staging performance of [68Ga]Ga-P16-093 were statistically compared with that of [68Ga]Ga-PSMA-11, using histopathology as the gold standard.RESULTSFifty-six treatment-naïve male patients (mean age 67 ± 6 years; range 52-77) were prospectively enrolled. A subgroup of 37 patients who underwent both [⁶⁸Ga]Ga-P16-093 and [68Ga]Ga-PSMA-11 PET/CT was analyzed for direct comparison. [68Ga]Ga-P16-093 PET/CT demonstrated superior diagnostic performance in primary prostate cancer evaluation, with sensitivity of 74.44% (201/270, 95% CI: 68.38-80.50%), specificity of 96.26% (387/402, 95% CI: 94.39-98.15%), and accuracy of 87.50% (588/672, 95% CI: 85.05-89.95%). Compared with [68Ga]Ga-PSMA-11 PET/CT, [68Ga]Ga-P16-093 PET/CT showed higher tracer uptake, with SUVmax of 9.86 ± 6.82 vs. 6.74 ± 1.89 (P = 0.041), SUVmean of 5.81 ± 4.03 vs. 3.98 ± 1.04 (P = 0.037), and T/B ratio of 23.19 ± 17.51 vs. 16.04 ± 7.75 (P = 0.042). Additionally, ROC analysis revealed a significantly greater AUC for P16-093 (0.85 vs. 0.75, P < 0.05). Moreover, locoregional staging accuracy was higher at 59.46% (22/37) compared with 32.43% (12/37) for [68Ga]Ga-PSMA-11 PET/CT.CONCLUSION[68Ga]Ga-P16-093 PET/CT exhibits high diagnostic performance in the diagnosis of primary PCa and shows significant advantages in identifying local tumor segments. [68Ga]Ga-P16-093 may serve as an alternative to [68Ga]Ga-PSMA-11 in the future diagnosis of PCa.TRIAL REGISTRATIONClinicalTrials.gov, NCT05324332. Registered 04 March 2022. URL OF REGISTRY: https://clinicaltrials.gov/ct2/show/NCT05324332.","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"140 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-09DOI: 10.1007/s00259-025-07699-w
Laura Evangelista, Carlo Vallone, Priscilla Guglielmo, Sara Damiani, Jelena Jandric, Andrea Brignoli, Manuela Marenco, Francesco Martino, Luciana Di Cristina, Ciro Franzese, Rosario Mazzola
{"title":"PSMA PET/CT for the detection of prostate cancer biochemical recurrence after primary radiation therapy: is it time to review the Phoenix criteria?","authors":"Laura Evangelista, Carlo Vallone, Priscilla Guglielmo, Sara Damiani, Jelena Jandric, Andrea Brignoli, Manuela Marenco, Francesco Martino, Luciana Di Cristina, Ciro Franzese, Rosario Mazzola","doi":"10.1007/s00259-025-07699-w","DOIUrl":"https://doi.org/10.1007/s00259-025-07699-w","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"20 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145703876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1007/s00259-025-07701-5
Jan Wuestemann,Elisabeth Eppard,Daniel Hescheler,Joanna Wybranska,Dennis Kupitz,Falco Reissig,Frankis G Almaguel,Akram Al-Ibraheem,Johannes Notni,Michael C Kreissl
{"title":"Radioligand therapy of pancreatic ductal adenocarcinoma using an αvβ6-integrin targeting 68Ga / 177Lu labeled theranostic pair.","authors":"Jan Wuestemann,Elisabeth Eppard,Daniel Hescheler,Joanna Wybranska,Dennis Kupitz,Falco Reissig,Frankis G Almaguel,Akram Al-Ibraheem,Johannes Notni,Michael C Kreissl","doi":"10.1007/s00259-025-07701-5","DOIUrl":"https://doi.org/10.1007/s00259-025-07701-5","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"4 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-06DOI: 10.1007/s00259-025-07698-x
Yan Zhang, Mei Xin, Cheng Wang, Zhoumi Hu, Yue Wang, Hongda Shao, Jianjun Liu, Chenpeng Zhang
{"title":"Correction to: Neuronal intranuclear inclusion disease with cerebellar white matter tau uptake and incidental meningioma","authors":"Yan Zhang, Mei Xin, Cheng Wang, Zhoumi Hu, Yue Wang, Hongda Shao, Jianjun Liu, Chenpeng Zhang","doi":"10.1007/s00259-025-07698-x","DOIUrl":"https://doi.org/10.1007/s00259-025-07698-x","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"78 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145680145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-06DOI: 10.1007/s00259-025-07665-6
Emily Martin, Christopher R. McMaster, Aurora MT Poon, Saskia J. Rowson, Bonnia Liu, Jessica L. Leung, David FL Liew, Andrew M. Scott, Claire E. Owen
{"title":"Polymyalgia rheumatica patients presenting with atypical clinical features still exhibit characteristic 18F-FDG PET/CT findings","authors":"Emily Martin, Christopher R. McMaster, Aurora MT Poon, Saskia J. Rowson, Bonnia Liu, Jessica L. Leung, David FL Liew, Andrew M. Scott, Claire E. Owen","doi":"10.1007/s00259-025-07665-6","DOIUrl":"https://doi.org/10.1007/s00259-025-07665-6","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"11 21 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145680146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-06DOI: 10.1007/s00259-025-07586-4
Meixin Zhao, Hui Wei, Meng Wang, Zeyang Wang, Xinwei Li, Hui Li, Annan Zhang, Song Xue, Marcus Hacker, Weifang Zhang, Rong Mu, Xiang Li
{"title":"Molecular imaging of fibroblast activation in systemic sclerosis using [18F]AlF-NOTA-FAPI-04 PET/CT: a prospective cohort study","authors":"Meixin Zhao, Hui Wei, Meng Wang, Zeyang Wang, Xinwei Li, Hui Li, Annan Zhang, Song Xue, Marcus Hacker, Weifang Zhang, Rong Mu, Xiang Li","doi":"10.1007/s00259-025-07586-4","DOIUrl":"https://doi.org/10.1007/s00259-025-07586-4","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"5 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145680144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-06DOI: 10.1007/s00259-025-07663-8
Yibo He, Huaping Gao, Haojun Yu, Florent L. Besson, Lorenzo Nardo, Yu Lin, Akram Al-Ibraheem, Hubing Wu, Wei Fan, Mike Sathekge, Xinming Zhao, Jiefu Zheng, Axel Rominger, Denis Agostini, Wenxin Tang, Runjun Yang, Yiqiu Zhang, Pengcheng Hu, Ruimin Wang, Baixuan Xu, Zhi Yang, Yunze Xie, Hongcheng Shi
{"title":"Exploring the feasibility of a 40-minute uptake time for long axial field of view [18F]FDG PET/CT tumour scan: an evidence-based single-center study","authors":"Yibo He, Huaping Gao, Haojun Yu, Florent L. Besson, Lorenzo Nardo, Yu Lin, Akram Al-Ibraheem, Hubing Wu, Wei Fan, Mike Sathekge, Xinming Zhao, Jiefu Zheng, Axel Rominger, Denis Agostini, Wenxin Tang, Runjun Yang, Yiqiu Zhang, Pengcheng Hu, Ruimin Wang, Baixuan Xu, Zhi Yang, Yunze Xie, Hongcheng Shi","doi":"10.1007/s00259-025-07663-8","DOIUrl":"https://doi.org/10.1007/s00259-025-07663-8","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"19 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145680147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-05DOI: 10.1007/s00259-025-07690-5
Koen Van Laere,Donatienne Van Weehaeghe
{"title":"Eagle eyes on the human brain and beyond: PET at ultra-high spatial resolution.","authors":"Koen Van Laere,Donatienne Van Weehaeghe","doi":"10.1007/s00259-025-07690-5","DOIUrl":"https://doi.org/10.1007/s00259-025-07690-5","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"201 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145674345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-05DOI: 10.1007/s00259-025-07685-2
Emran Askari,Atena Aghaee,Luca Giovanella
{"title":"Redefining standard of care in thyroid cancer: Lessons from the IoN trial.","authors":"Emran Askari,Atena Aghaee,Luca Giovanella","doi":"10.1007/s00259-025-07685-2","DOIUrl":"https://doi.org/10.1007/s00259-025-07685-2","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"1 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145674346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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