European Journal of Nuclear Medicine and Molecular Imaging最新文献

{"title":"[⁶⁸Ga]Ga-PSMA PET/CT in active surveillance: From imaging to informed decision-making - a \"Whistling Arrow\" perspective.","authors":"Levent Kabasakal","doi":"10.1007/s00259-026-07806-5","DOIUrl":"https://doi.org/10.1007/s00259-026-07806-5","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147283033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An intra-patient contemporaneous comparison of ¹⁸F-piflufolastat and ¹⁸F-flotufolastat urinary radioactivity and pelvic region detection rates in men with low PSA biochemical recurrence of prostate cancer after radical prostatectomy.","authors":"Luke T Nordquist, Jack R Andrews, Phillip H Kuo, Benjamin A Gartrell, David Josephson, Andrei S Purysko, Daniel R Saltzstein, Ram A Pathak, Neal Shore, James Sykes, Ross Penny, Phillip Davis, Brian T Helfand","doi":"10.1007/s00259-025-07732-y","DOIUrl":"https://doi.org/10.1007/s00259-025-07732-y","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147270134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The confounding effects of microvascular physiology on the uptake and diagnostic accuracy of [18F]fluoroethyl-tyrosine positron emission tomography in gliomas","authors":"Otto M. Henriksen, Thomas L. Andersen, Karine Madsen, Benedikte Hasselbalch, Dorte S. Nørøxe, Vibeke A. Larsen, Ulrich Lindberg, Henrik B. W. Larsson, Adam E. Hansen, Ian Law","doi":"10.1007/s00259-026-07782-w","DOIUrl":"https://doi.org/10.1007/s00259-026-07782-w","url":null,"abstract":"Purpose To investigate the physiological influence of tissue perfusion and permeability on O-(2-[ <jats:sup>18</jats:sup> F]-fluoroethyl)-L-tyrosine ([ <jats:sup>18</jats:sup> F]FET) uptake in gliomas by simultaneous MRI dynamic contrast enhanced (DCE) perfusion imaging and the impact of vascular contributions on diagnostic accuracy. Methods Dynamic [ <jats:sup>18</jats:sup> F]FET PET/MRI scans from 50 patients with glioma WHO grade 2–4 were analysed. In each patient multiple subvolumes were delineated to account for intra-patient heterogeneity. Associations of 20–40 min. [ <jats:sup>18</jats:sup> F]FET tumour-to-background ratio (TBR <jats:sub>med</jats:sub> ) with median blood volume (CBV), blood flow (F), and permeability (Ki) within 134 lesion subvolumes were investigated in linear mixed models. Also, associations with initial area under curve (iAUC <jats:sub>120</jats:sub> ), time to peak (TTP) and slope (Slope <jats:sub>20 − 40</jats:sub> ) from time activity curve were investigated. The influence of adjusting TBR <jats:sub>med</jats:sub> for microvascular physiological parameters on the diagnostic accuracy for tumour recurrences was assessed in an independent dataset ( <jats:italic>n</jats:italic> = 61 lesions from 48 patients). Results CBV, F and Ki individually accounted for 42%, 36% and 26%, respectively, of the overall variance in TBR <jats:sub>med</jats:sub> . DCE metrics combined accounted for 49% of the total variance and for 65% of the regional variance in TBR <jats:sub>med</jats:sub> . All DCE metrics were associated positively with iAUC <jats:sub>120</jats:sub> and negatively with both Slope <jats:sub>20 − 40</jats:sub> and TTP ( <jats:italic>p</jats:italic> &lt; 0.001 for all). Adjusting TBR <jats:sub>med</jats:sub> for microvascular effects lowered TBR by 24% on average and reduced the diagnostic accuracy (ROC AUC) from 0.90 to 0.77 in the test dataset. Conclusion Microvascular properties may contribute to a considerable fraction of the clinical [ <jats:sup>18</jats:sup> F]FET measures in patients with gliomas, and contribute positively to diagnostic performance of [ <jats:sup>18</jats:sup> F]FET PET imaging.","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"1 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146231105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of a repeat 18F-flotufolastat PET scan following a negative scan in patients with suspected biochemical recurrence of prostate cancer after radical prostatectomy","authors":"Sonja Kirchhoff, Andreas Lederer, Theo Lorenzini, Michael Gammel, Daniel Sasse, Matthias Heck, Bernhard Haller, Wolfgang A. Weber, Matthias Eiber, Isabel Rauscher","doi":"10.1007/s00259-026-07786-6","DOIUrl":"https://doi.org/10.1007/s00259-026-07786-6","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"96 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SPECT and PET myocardial perfusion imaging in Austria, Germany, and Switzerland results of the 2nd joint survey 2024","authors":"Oliver Lindner, J. Bucerius, T. Derlin, W. Burchert, R. R. Buechel","doi":"10.1007/s00259-026-07790-w","DOIUrl":"https://doi.org/10.1007/s00259-026-07790-w","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"10 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of targeting CXCR4 with ⁶⁸Ga-Pentixafor PET/MRI for Cushing's disease: a retrospective cohort study.","authors":"Boyuan Yao, Yuyu Liu, Yanfei Wu, Mengxu Cui, Zengyi Ma, Nidan Qiao, Shuo Zhang, Yi Wang, Fang Xie, Yihui Guan, Zhenwei Yao, Zhaoyun Zhang, Hongying Ye, Yongfei Wang, Yao Zhao, Yue Wu, Qilin Zhang","doi":"10.1007/s00259-026-07821-6","DOIUrl":"https://doi.org/10.1007/s00259-026-07821-6","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146224979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lesion-level dual-tracer PET biomarkers predict prognosis in multiple myeloma treated with CXCR4-directed radiopharmaceutical therapy.","authors":"Song Xue, Sabrina Kraus, Johanna S Enke, Kerstin Michalski, Marcus Hacker, Hermann Einsele, Andreas K Buck, Constantin Lapa, Xiang Li, Niklas Dreher","doi":"10.1007/s00259-026-07814-5","DOIUrl":"https://doi.org/10.1007/s00259-026-07814-5","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;C-X-C motif chemokine receptor 4 (CXCR4)-directed radiopharmaceutical therapy (RPT) represents a promising option for hematologic malignancies. Nevertheless, responses in relapsed and refractory (r/r) multiple myeloma (MM) are heterogenous, emphasizing the need for optimized patient selection before RPT. Current approaches mostly rely on qualitative assessments, confirming relevant CXCR4-expression by CXCR4-directed PET in vital myeloma burden, the latter usually being determined by additional [&lt;sup&gt;18&lt;/sup&gt;F]FDG-PET.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;To evaluate whether quantitative imaging biomarkers derived from dual-tracer PET/CT can enhance patient stratification and predict therapeutic response and survival following CXCR4-RPT.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;22 patients with r/r MM who underwent CXCR4-directed [⁶⁸Ga]Ga-PentixaFor-PET/CT and [¹⁸F]FDG-PET/CT imaging prior to CXCR4-RPT were retrospectively analyzed. A fully automated pipeline performed deep-learning-based lesion segmentation and dual-tracer fusion; batch quality control and correction ensured segmentation accuracy and concordant-lesion adjudication (&gt; 10% volumetric overlap) prior to lesion-level feature extraction. Features included demographics, laboratory/genetic variables, and imaging metrics from FDG- and CXCR4-PET, stratified by anatomic site (medullary vs. extramedullary) and concordance (concordant vs. discordant as defined by comparing FDG- and CXCR4-positive myeloma lesions). Surface-standardized maximum inter-lesion distances (sDmax) were additionally computed. Endpoints were therapy response (responder vs. non-responder as defined by serological response assessment based on IMWG-criteria or PET/MRI based response assessment) and overall survival (OS). Group comparisons were performed using Welch's t-test/Chi-square; survival analysis was conducted applying Kaplan-Meier estimates and log-rank tests. Decision-tree models were interpreted with SHapley Additive exPlanations (SHAP).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Responders to RPT showed lower [&lt;sup&gt;18&lt;/sup&gt;F]FDG-SUV&lt;sub&gt;mean&lt;/sub&gt; in medullary and extramedullary concordant lesions (Welch's p = 0.03). In the response classifier, these metrics ranked among the top predictors by SHAP, alongside selected extramedullary CXCR4-dominant discordant features and high-risk cytogenetics. Shorter OS was associated with higher TLG[FDG medullary concordant], greater sDmax[FDG], and higher CXCR4-positive medullary burden (MTV/TLC) (log-rank p &lt; 0.05). SHAP directionality agreed with univariate trends. BMI showed a modest inverse association with early mortality in the 6-month survival model.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;In our exploratory analysis, [¹⁸F]FDG-uptake within medullary concordant lesions was linked to both response and survival, while CXCR4-expressing medullary volume and sDmax added survival information. Concordance-aware, lesion-level quantification from dual-tracer P","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146219010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring synaptic density patterns in cerebral small vessel disease: insights from [¹⁸F]SynVesT-1 PET imaging.","authors":"Ling Xiao, Tingting Zhao, Yi Yang, Jiayu Zhong, Di Liao, Boxin Zhang, Jiaxin Li, Ruxin Tu, Jiale Hou, Xingming Wang, Jie Feng, Ming Zhou, Shuo Hu, Jian Xia","doi":"10.1007/s00259-026-07808-3","DOIUrl":"https://doi.org/10.1007/s00259-026-07808-3","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146212433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of [18F]F-FAPI-FUSCC-07 PET/CT in characterizing solitary pulmonary nodules: a head-to-head comparison","authors":"Yuan Cheng, Nan Li, Bin Zhu, Xiaosheng Liu, Jianping Zhang, Xiaoping Xu, Silong Hu, Shaoli Song","doi":"10.1007/s00259-026-07819-0","DOIUrl":"https://doi.org/10.1007/s00259-026-07819-0","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"4 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146204937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning models classifiers enable a strong prediction of radioembolization-induced liver disease, and define a new bilirubin threshold for selection of patients","authors":"Itzel Rivera, Heloïse Bourien, Ewan Morel-Corlu, Alexandre Peinoit, Samuel Le Sourd, Yan Rolland, Etienne Garin, Oscar Acosta, Julien Edeline","doi":"10.1007/s00259-026-07803-8","DOIUrl":"https://doi.org/10.1007/s00259-026-07803-8","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"10 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146204939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}