Epilepsy Research最新文献

{"title":"Depressive symptoms in Chinese patients with epilepsy: Prevalence and clinical correlates","authors":"Yuwei Han ,&nbsp;Shun Gong ,&nbsp;Shimei Sun,&nbsp;Dan Yang,&nbsp;Bingying Zhang,&nbsp;Dandan Gao,&nbsp;Guanqian Yuan,&nbsp;Xiaoming Li,&nbsp;Guangzhi Hao,&nbsp;Guobiao Liang","doi":"10.1016/j.eplepsyres.2025.107624","DOIUrl":"10.1016/j.eplepsyres.2025.107624","url":null,"abstract":"<div><h3>Objective</h3><div>Depressive symptoms were a prevalent comorbidity among patients with epilepsy, significantly impacting their quality of life and treatment outcomes. This study aims to investigate the prevalence and clinical correlates of depressive symptoms in Chinese patients with epilepsy.</div></div><div><h3>Methods</h3><div>A descriptive cross-sectional study was conducted at the Department of Neurosurgery, General Hospital of Northern Theater Command, from January 2018 to June 2023. Patients diagnosed with epilepsy aged 16 years or older were included, excluding those with severe illnesses, substance abuse disorders, or severe cognitive impairments. Demographic and epilepsy-related information was collected using a standardized clinical data collection form. Depressive symptoms were assessed using the Beck Depression Inventory-II (BDI-II). Statistical analyses were performed using SPSS version 27.0.</div></div><div><h3>Results</h3><div>The study included 513 patients with epilepsy, with a mean age of 37.48 years (SD= 15.09). Among these, 65.9 % were male, and 62.6 % were aged 40 years or older. The majority of patients were single (50.9 %) and had formal education (57.1 %). The mean age of epilepsy onset was 21.96 years (SD = 12.83), and the mean duration of illness was 11.02 years (SD= 13.64). Generalized tonic-clonic seizures were the most common type (62.0 %), and 32.7 % of patients experienced very frequent seizures. Polytherapy was used by 63.5 % of patients. Depressive symptoms were present in 137 patients, representing a prevalence of 26.7 % (95 % CI: 20.51–31.89). The severity of depressive symptoms was categorized as mild in 62.0 %, mild to moderate in 18.2 %, moderate in 10.2 %, and severe in 9.5 %. The prevalence of depressive symptoms was higher among females, separated/widowed individuals, those with lower educational attainment, and unemployed patients. Significant associations were found between depressive symptoms and seizure frequency, duration of seizures, and polytherapy. Multivariate analysis identified seizure frequency, duration of seizures, and polytherapy as independent predictors of depressive symptoms.</div></div><div><h3>Conclusions</h3><div>Depressive symptoms were highly prevalent among Chinese patients with epilepsy, with significant associations found between depressive symptoms and several sociodemographic and clinical characteristics. Routine screening for depressive symptoms and tailored interventions are crucial for improving the quality of life and treatment outcomes in this population. Future research should focus on longitudinal studies to explore causal relationships and develop targeted interventions.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"217 ","pages":"Article 107624"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood-onset epilepsy: Longitudinal seizure outcomes in a large single-center cohort","authors":"Hyun-Jin Kim,&nbsp;Min-Jee Kim,&nbsp;Eon Ah Kim,&nbsp;Ohcheol Kwon,&nbsp;Yun Sung Nam,&nbsp;Mi-Sun Yum ,&nbsp;Tae-Sung Ko","doi":"10.1016/j.eplepsyres.2025.107622","DOIUrl":"10.1016/j.eplepsyres.2025.107622","url":null,"abstract":"<div><h3>Objectives</h3><div>Epilepsy is the most common serious neurological disorder in children; however, previous long-term studies are often limited by small sample sizes or methodological variability. This study aimed to assess the epidemiology, seizure outcomes, and prognostic factors of childhood-onset epilepsy over &gt; 10 years of follow-up at a single tertiary center.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed the medical records of 4248 patients diagnosed with epilepsy before age 19 between 1995 and 2017 at Asan Medical Center Children’s Hospital. All patients underwent at least one electroencephalogram (EEG) and received anti-seizure medications (ASMs) for &gt; 2 years.</div></div><div><h3>Results</h3><div>During a mean follow-up of 11.0 years, 43 patients (1.0 %) died. The median age at seizure onset was 7.2 years. Etiologies included unknown (52.5 %), structural (29.3 %), genetic/metabolic (23.4 %), and infectious/autoimmune (4.5 %). Focal epilepsy was the most common (63.4 %). Neurocognitive and psychological comorbidities were observed in 32.7 % and 20.6 % of patients, respectively. Seizure freedom for ≥ 2 years was achieved in 81.2 %, and terminal remission in 63.1 %. However, relapse occurred in 38.0 %, and 28.6 % developed intractable epilepsy. Prognostic factors included status epilepticus, intellectual disability, pretreatment seizure frequency, etiology, epilepsy syndromes, and EEG abnormalities.</div></div><div><h3>Conclusions</h3><div>This study reaffirms known risk factors while providing comprehensive insights into seizure trajectories, relapse patterns, and treatment responses in a large cohort. It highlights the clinical relevance of the 2-year seizure-free definition and underscores the need for early interventions in high-risk subgroups. Despite diagnostic advances, several cases remain etiologically unresolved, reinforcing the importance of expanding access to molecular and imaging tools in pediatric epilepsy care.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"217 ","pages":"Article 107622"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning models for predicting therapeutic response in drug-resistant epilepsy: A bivariate diagnostic meta-analysis","authors":"Anderson Matheus Pereira da Silva ,&nbsp;Victor Arthur Ohannesian ,&nbsp;Luciano Falcão ,&nbsp;Filipe Virgilio Ribeiro ,&nbsp;Isabelle Rodrigues Menezes ,&nbsp;Mariana Leticia de Bastos Maximiano ,&nbsp;Mariana Lee Han ,&nbsp;Lucas Silva Cabeça ,&nbsp;Pedro Lucas Machado Magalhães ,&nbsp;Gustavo Sousa Noleto ,&nbsp;Maria Bernadete de Sousa Maia ,&nbsp;Eryvelton de Souza Franco","doi":"10.1016/j.eplepsyres.2025.107623","DOIUrl":"10.1016/j.eplepsyres.2025.107623","url":null,"abstract":"<div><h3>Background</h3><div>Epilepsy affects approximately 6.4 per 1000 individuals worldwide. Despite advances in antiseizure medications (ASMs), nearly one-third of patients remain refractory to treatment, meeting criteria for drug-resistant epilepsy (DRE). This meta-analysis evaluated the performance of machine learning (ML) models in predicting therapeutic response in DRE based on ILAE-defined outcomes.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis were conducted in accordance with PRISMA-DTA guidelines. Studies applying ML algorithms to predict treatment response in DRE were included. Eligible designs comprised retrospective or prospective observational studies. Outcomes included seizure remission (ILAE Class 1), ≥ 50 % reduction in seizure frequency, treatment failure, and diagnostic accuracy metrics. A bivariate random-effects model was used to pool sensitivity, specificity, and diagnostic odds ratio (DOR). Heterogeneity was assessed (I², χ²), and subgroup and meta-regression analyses were performed. Likelihood ratios, area under the curve (AUC), and Bayesian post-test probabilities were estimated. Publication bias was evaluated with Deeks’ test.</div></div><div><h3>Results</h3><div>Eight studies (n = 1887) met inclusion criteria (Kappa=0.98). Pooled sensitivity and specificity were both 0.84 (95 % CI: 0.76–0.89 and 0.77–0.89, respectively), with an AUC of 0.91. DOR was 27; LR+ , 5.2; LR−, 0.19. Heterogeneity was high (χ²=22.7; p &lt; 0.001). Sensitivity was lower in prospective studies, prognostic models, and ASMs users, and higher with long-term follow-up. Meta-regression identified model type, study design, ASM exposure, and sample adequacy as key moderators.</div></div><div><h3>Conclusion</h3><div>ML models demonstrate high diagnostic accuracy in predicting therapeutic response in DRE. Findings support their potential clinical utility, provided external validation and methodological standardisation.</div></div><div><h3>Registration PROSPERO protocol number</h3><div>CRD 42024628323</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"217 ","pages":"Article 107623"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood-brain barrier impairment as an early marker of neurodegeneration in late-onset epilepsy of unknown origin","authors":"Silvia Maio ,&nbsp;Mariana Fernandes ,&nbsp;Fabio Placidi ,&nbsp;Francesca Izzi ,&nbsp;Alessandro Castelli ,&nbsp;Andrea Pagano ,&nbsp;Nicola Biagio Mercuri ,&nbsp;Claudio Liguori","doi":"10.1016/j.eplepsyres.2025.107614","DOIUrl":"10.1016/j.eplepsyres.2025.107614","url":null,"abstract":"<div><h3>Purpose</h3><div>Blood-brain barrier (BBB) plays a crucial role in maintaining brain health, and its dysfunction during the early stages of neurodegeneration may contribute to neuropathological processes. Patients with late-onset epilepsy with unknown etiology (LOEU) can present early signs of neurodegeneration and convert to an overt neurodegenerative disease longitudinally. This study analyzed cerebrospinal-fluid (CSF)/serum albumin ratio (Qalb), as a marker of BBB integrity, and assessed biomarkers of neurodegeneration in patients with LOEU compared to age- and sex-matched controls.</div></div><div><h3>Methods</h3><div>Patients diagnosed with LOEU were compared to a sex- and age-matched control group. All participants underwent a neurological visit, cognitive evaluation to exclude cognitive impairment, and a lumbar puncture for CSF biomarker analysis [β-Amyloid₄₂ (Aβ₄₂); total-Tau (t-Tau); phosphorylated-Tau at threonine 181 (p-Tau181); Qalb]. Lumbar puncture was performed within 2 months after epilepsy diagnosis, and at least 3 weeks after the last seizure.</div></div><div><h3>Results</h3><div>Twenty-eight LOEU patients (53.6 % female, mean age 68.79 ± 7.83 y) and twenty-five controls (52.0 % female, mean age 65.64 ± 8.10 y) were included. LOEU patients showed significantly higher Qalb values (<em>p</em> = 0.003), lower Aβ₄₂ CSF levels (<em>p</em> = 0.030), and higher t-Tau/Aβ₄₂ (<em>p</em> = 0.030) and p-Tau181/Aβ₄₂ ratios (<em>p</em> = 0.030) than controls. Qalb values did not significantly differ between patients with and without pathological AD biomarker profile.</div></div><div><h3>Conclusions</h3><div>LOEU patients show BBB dysfunction and early changes in CSF biomarker ratios pointing to AD pathology. Qalb increase seems to be unrelated to the pathological changes in CSF AD biomarkers. Future studies should be performed to better understand the neuropathological basis of LOEU and the risk for patients to develop a neurodegenerative disorder.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"217 ","pages":"Article 107614"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on the meta-analysis comparing phenobarbital and valproate for the treatment of generalized convulsive status epilepticus","authors":"Arkansh Sharma ,&nbsp;Vinay Suresh","doi":"10.1016/j.eplepsyres.2025.107674","DOIUrl":"10.1016/j.eplepsyres.2025.107674","url":null,"abstract":"","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"217 ","pages":"Article 107674"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reaffirming construct validity: A response to methodological concerns","authors":"Elif Sarac ,&nbsp;Esra Yildiz","doi":"10.1016/j.eplepsyres.2025.107619","DOIUrl":"10.1016/j.eplepsyres.2025.107619","url":null,"abstract":"","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"217 ","pages":"Article 107619"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A closer look at construct validity: Methodological pitfalls in the Turkish adaptation of the perceived disability scale","authors":"Prateek Kumar Panda,&nbsp;Indar Kumar Sharawat","doi":"10.1016/j.eplepsyres.2025.107618","DOIUrl":"10.1016/j.eplepsyres.2025.107618","url":null,"abstract":"","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"217 ","pages":"Article 107618"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between statin use and post-ischemic stroke epilepsy among older adults: A nested case-control study","authors":"R. Grace Couper ,&nbsp;Tresah C. Antaya ,&nbsp;Brooke Carter ,&nbsp;Salimah Z. Shariff ,&nbsp;Luciano A. Sposato ,&nbsp;Flory T. Muanda ,&nbsp;Jorge G. Burneo","doi":"10.1016/j.eplepsyres.2025.107617","DOIUrl":"10.1016/j.eplepsyres.2025.107617","url":null,"abstract":"<div><div>Our primary objective was to estimate the association between post-stroke statin use and post-stroke epilepsy (PSE) and assess whether sex modifies this association. Our second objective was to assess whether statin characteristics and other risk factors affect the risk of PSE overall and within groups defined by sex. We conducted a population-based nested case-control study, using linked health administrative data and including residents older than 65 of Ontario, Canada treated for an ischemic stroke between April 1, 2007, and March 31, 2017. Patients who developed epilepsy were matched with up to 10 controls on age, sex, and month. Multivariable conditional logistic regression models were used to estimate the adjusted odds ratios for PSE associated with post-stroke statin use and potential risk factors. We included 1009 patients with epilepsy and 6522 matched controls. Statin use was not associated with the risk of epilepsy in the entire cohort or in the sex-stratified analysis (IRR = 1.17; 95 % CI 0.95–1.43), and sex did not significantly modify the association (p-value=0.08). Statin characteristics did not affect the risk of epilepsy in the entire cohort; however, we observed an increased risk of PSE associated with the use of atorvastatin among females in the sex-stratified analyses (IRR = 1.26; 95 % CI 1.02–1.56). Although the risk of epilepsy did not significantly differ between statin users and non-users in the entire cohort or within groups defined by sex, atorvastatin was associated with an increased risk of PSE compared to statin non-users among women and should be further explored.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"217 ","pages":"Article 107617"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter integrity and its correlation to seizures in diffuse glioma","authors":"Ludwig Klein ,&nbsp;Gordian Prasse ,&nbsp;Alim E. Basaran ,&nbsp;Jost-Julian Rumpf ,&nbsp;Martin Vychopen ,&nbsp;Johannes Wach ,&nbsp;Erdem Güresir ,&nbsp;Tim Wende","doi":"10.1016/j.eplepsyres.2025.107627","DOIUrl":"10.1016/j.eplepsyres.2025.107627","url":null,"abstract":"<div><h3>Introduction</h3><div>Seizures are one of the most common symptoms in patients with diffuse glioma, occurring in 30–80 % of cases. Although seizure control can be achieved in up to 90 %, seizures remain a significant burden and are hardly predictable. The aim of this analysis was, therefore, to investigate the association between white matter integrity and seizure occurrence in patients with diffuse glioma using diffusion tensor imaging (DTI).</div></div><div><h3>Methods</h3><div>Patients with first diagnosis of diffuse glioma (WHO-grade 2, 3, 4) who received preoperative DTI sequences for surgical planning were analyzed. Tractography of corpus callosum and cingulum was carried out, extracting mean FA values of the resulting volumes.</div></div><div><h3>Results</h3><div>50 patients (17 female) were included with a mean age of 59.5 ± 2.2 years. Glioma WHO grade 4 was most common (82 %), followed by grade 3 (10 %) and grade 2 (8 %). Most gliomas were located left temporal (32 %) and bilateral frontal (each hemisphere 16 %). 16 % presented with multifocal glioma. 48 % had suffered seizures prior to surgery, and were thus diagnosed with structural epilepsy. 22 % of all patients presented recurring seizures despite surgery and anti-seizure medication, and 6 % developed new seizures after surgery. After correction for multiple comparisons, increased FA in the left parahippocampal cingulum was significantly associated with preoperative seizures (0.30 ± 0.01 versus 0.27 ± 0.01, p_corr = 0.007), while increased FA in the forceps minor of the corpus callosum correlated with postoperative seizures (0.49 ± 0.01 versus 0.43 ± 0.01, p_corr = 0.014).</div></div><div><h3>Conclusion</h3><div>Higher preoperative white matter integrity was associated with increased risk for occurrence of seizures in diffuse glioma. Further research is warranted to investigate the relation with tumor pathology.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"217 ","pages":"Article 107627"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seizure outcome and anti-seizure medication use in post-stroke epilepsy: A retrospective cohort study","authors":"Ahmed Khadija ,&nbsp;Jacques Theitler ,&nbsp;Revital Gandelman-Marton","doi":"10.1016/j.eplepsyres.2025.107616","DOIUrl":"10.1016/j.eplepsyres.2025.107616","url":null,"abstract":"<div><h3>Background</h3><div>Most patients with post-stroke epilepsy (PSE) are considered to be well controlled with anti-seizure medications (ASMs). First-generation ASMs with potent enzyme-inducing properties can reduce the efficacy of concomitant medications and were related to increased mortality in PSE.</div></div><div><h3>Objective</h3><div>To evaluate seizure outcome and patterns of ASM use in patients with PSE.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed the computerized database and the medical records of all the patients who had their first visit in our adult outpatient epilepsy clinic during a 10-year period (2012–2021), and identified 39 patients with PSE and 382 patients with focal epilepsy without a previous stroke (FEWS).</div></div><div><h3>Results</h3><div>The study group included 421 patients aged 18–90 years, 220 (52.3 %) men, follow-up duration 3.1 ± 2.9 years. At first observation, patients with PSE had lower rates of daily to monthly seizures (p = 0.023) and higher rates of a single seizure (p = 0.023) compared to patients with FEWS, and 66 % were treated with first-generation ASMs. At last observation, seizure frequency improved in fewer patients with PSE compared to FEWS (p = 0.042), with significant decrease in the rate of daily to monthly seizures in patients with FEWS (p = 0.0001).</div></div><div><h3>Conclusions</h3><div>Seizure outcome in patients with PSE may be less favorable than previously reported, and many were still treated with ASMs that can adversely affect vascular risk. Further studies are needed to evaluate therapeutic strategies that can improve seizure control and achieve higher rates of seizure freedom in patients with PSE.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"217 ","pages":"Article 107616"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}