Lifestyle is universally considered a fundamental issue in the preven¬tion and therapy of both type 2 diabetes and metabolic syndrome. However, implementation at a general population level of recom¬mendations resulting from available evidence is largely insufficient. In particular, only a limited fraction of the general population meets the recommended levels of aerobic physical activity, and individuals meeting the recommended levels of resistance physical activity are even less. Interestingly, there is further reduction in these proportions in subjects with prediabetes and especially in those with type 2 diabe¬tes. It is noteworthy that people with or at risk for diabetes represent a significant proportion of the general population, show objective evi¬dence of impaired exercise capacity, for different mechanisms, and fre¬quently have long-standing sedentary habits, difficult to be changed. All these aspects should be taken into account, when designing in-tervention programs aimed at improving the current situation. As re¬gards the possibility of a stable increase in physical exercise levels and reduction in sedentary habits of individuals with diabetes, available data are limited. However, they indicate that it is possible to improve these aspects in a significant proportion of subjects. Behavioral chan¬ges reported in studies are generally smaller than the prefixed impro¬vements, but sufficient to obtain favorable and clinically significant effects. Interventions applied in these programs show several shortco¬mings, indicating the need for a continuous revision of strategies.
{"title":"Possiamo ottenere un cambiamento dello stile di vita significativo e stabile nel tempo?","authors":"P. Moghetti","doi":"10.30682/ildia2301a","DOIUrl":"https://doi.org/10.30682/ildia2301a","url":null,"abstract":"Lifestyle is universally considered a fundamental issue in the preven¬tion and therapy of both type 2 diabetes and metabolic syndrome. However, implementation at a general population level of recom¬mendations resulting from available evidence is largely insufficient. In particular, only a limited fraction of the general population meets the recommended levels of aerobic physical activity, and individuals meeting the recommended levels of resistance physical activity are even less. Interestingly, there is further reduction in these proportions in subjects with prediabetes and especially in those with type 2 diabe¬tes. It is noteworthy that people with or at risk for diabetes represent a significant proportion of the general population, show objective evi¬dence of impaired exercise capacity, for different mechanisms, and fre¬quently have long-standing sedentary habits, difficult to be changed. All these aspects should be taken into account, when designing in-tervention programs aimed at improving the current situation. As re¬gards the possibility of a stable increase in physical exercise levels and reduction in sedentary habits of individuals with diabetes, available data are limited. However, they indicate that it is possible to improve these aspects in a significant proportion of subjects. Behavioral chan¬ges reported in studies are generally smaller than the prefixed impro¬vements, but sufficient to obtain favorable and clinically significant effects. Interventions applied in these programs show several shortco¬mings, indicating the need for a continuous revision of strategies.","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122015096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emanuele Fusi, Maria Vittoria Cicinelli, R. Lattanzio, F. Bandello
Diabetic retinopathy (DR) is the main ocular complication of diabetes. Among all the causes of blindness, it is the only one whose global pre-valence has increased over the past 30 years. DR prevalence is expected to increase in the upcoming years. Therefore, it is essential to establish cost-effective screening programs for early diagnosis of DR, which using new imaging systems, telemedicine and artificial intelligence prevent its evolution to advanced sight-threatening stages.
{"title":"Lo screening nella retinopatia diabetica","authors":"Emanuele Fusi, Maria Vittoria Cicinelli, R. Lattanzio, F. Bandello","doi":"10.30682/ildia2301f","DOIUrl":"https://doi.org/10.30682/ildia2301f","url":null,"abstract":"Diabetic retinopathy (DR) is the main ocular complication of diabetes. Among all the causes of blindness, it is the only one whose global pre-valence has increased over the past 30 years. DR prevalence is expected to increase in the upcoming years. Therefore, it is essential to establish cost-effective screening programs for early diagnosis of DR, which using new imaging systems, telemedicine and artificial intelligence prevent its evolution to advanced sight-threatening stages.","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114228228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Regular exercise is associated to several health benefits. However, only 39% of adults with type 2 diabetes reach the recommended goals for physical activity. Adherence to exercise needs removing barriers to behavioural changes by setting realistic goals. To make the chan¬ge lasting, group is fundamental and automatic behaviours must be created. However, the extent of the problem clearly indicates that a patient-centred approach is not enough. National policies including programs to encourage regular exercise are needed, with intensive in-terventions and investments.
{"title":"L’esercizio fisico nel diabete di tipo 2: come possiamo migliorare l’aderenza?","authors":"A. Corrado, G. Annuzzi","doi":"10.30682/ildia2301c","DOIUrl":"https://doi.org/10.30682/ildia2301c","url":null,"abstract":"\u0000Regular exercise is associated to several health benefits. However, only 39% of adults with type 2 diabetes reach the recommended goals for physical activity. Adherence to exercise needs removing barriers to behavioural changes by setting realistic goals. To make the chan¬ge lasting, group is fundamental and automatic behaviours must be created. However, the extent of the problem clearly indicates that a patient-centred approach is not enough. National policies including programs to encourage regular exercise are needed, with intensive in-terventions and investments. \u0000","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124037007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benedetta Russo, I. Malandrucco, Marika Menduni, Andrea Mari, Caterina Pelosini, Francesco Brancati, Maria Rosaria D’Apice, Fabiana Picconi, S. Frontoni
Familial partial lipodystrophy (FPLD) associated with LMNA gene mutations is a rare form of lipodystrophy disorder characterized by partial absence of subcutaneous adipose tissue and predisposition to develop metabolic complications related to insulin-resistance inclu-ding type 2 diabetes mellitus (T2D). Recently, this peculiar phenotype has been associated to atypical progeroid syndrome (APS). We present a case of 31-year-old woman with progeria features, partial lipodystro¬phy, type 2 diabetes mellitus (T2D), hypertriglyceridemia and hepatic steatosis. The baseline insulin sensitivity and secretion assessment showed strong insulin-resistance with hyperglycemia and elevated insulin secretion. Genetic analysis revealed a missense heterozygous LMNA mutation c.1045 C > T (p. Arg349Trp) that established APS diagnosis with FPLD, so far studied and described in only 10 patients worldwide. The patient was initially treated with metformin, fenofi¬brate, omega-3 and low carb and low fat diet with optimal results on metabolic control related to glycemic and lipid profile; later, liragluti¬de (Glucagon-Like Peptide-1 analog, GLP-1) therapy was added. Du¬ring the 6 month follow-up the anthropometric parameters improved, in particular a significant improvement in body composition with redi¬stribution of fat mass and a reduction of visceral fat and liver volume were observed. The improvements obtained were consolidated and maintained in the following years. However, with disease progression, focal segmental glomerulosclerosis (FSGS) and peripheral neuropathy developed. This case highlights the clinical and metabolic characteristics of this rare form of lipodystrophy and proposes an innovative therapeutic approach to manage the disease.
与LMNA基因突变相关的家族性部分脂肪营养不良(FPLD)是一种罕见的脂肪营养不良疾病，其特征是皮下脂肪组织部分缺失，易发生与胰岛素抵抗相关的代谢并发症，包括2型糖尿病(T2D)。最近，这种特殊的表型与非典型类早衰综合征(APS)有关。我们报告一例31岁女性，具有早衰特征，部分脂肪代谢不良，2型糖尿病(T2D)，高甘油三酯血症和肝脂肪变性。基线胰岛素敏感性和分泌评估显示强烈的胰岛素抵抗，伴有高血糖和胰岛素分泌升高。遗传分析显示一个错义杂合LMNA突变c.1045C > T (p. Arg349Trp)确定APS诊断为FPLD，迄今为止全球仅在10例患者中进行了研究和描述。患者最初接受二甲双胍、非诺菲酯、欧米伽-3和低碳水化合物低脂肪饮食治疗，在与血糖和血脂相关的代谢控制方面效果最佳;随后，利拉格鲁肽(胰高血糖素样肽-1类似物，GLP-1)治疗加入。在6个月的随访中，人体测量参数得到改善，特别是身体成分的显著改善，脂肪量的重新分布，内脏脂肪和肝脏体积的减少。取得的改进在随后几年得到巩固和维持。然而，随着疾病进展，局灶节段性肾小球硬化(FSGS)和周围神经病变发展。本病例强调了这种罕见形式的脂肪营养不良的临床和代谢特征，并提出了一种创新的治疗方法来控制这种疾病。
{"title":"Sindrome progeroide atipica con lipodistrofia parziale familiare, dovuta alla mutazione missenso c.1045 C > T (p.Arg349Trp) in eterozigosi del gene LMNA, e diabete mellito di tipo 2","authors":"Benedetta Russo, I. Malandrucco, Marika Menduni, Andrea Mari, Caterina Pelosini, Francesco Brancati, Maria Rosaria D’Apice, Fabiana Picconi, S. Frontoni","doi":"10.30682/ildia2301g","DOIUrl":"https://doi.org/10.30682/ildia2301g","url":null,"abstract":"Familial partial lipodystrophy (FPLD) associated with LMNA gene mutations is a rare form of lipodystrophy disorder characterized by partial absence of subcutaneous adipose tissue and predisposition to develop metabolic complications related to insulin-resistance inclu-ding type 2 diabetes mellitus (T2D). Recently, this peculiar phenotype has been associated to atypical progeroid syndrome (APS). We present a case of 31-year-old woman with progeria features, partial lipodystro¬phy, type 2 diabetes mellitus (T2D), hypertriglyceridemia and hepatic steatosis. The baseline insulin sensitivity and secretion assessment showed strong insulin-resistance with hyperglycemia and elevated insulin secretion. Genetic analysis revealed a missense heterozygous LMNA mutation c.1045 C > T (p. Arg349Trp) that established APS diagnosis with FPLD, so far studied and described in only 10 patients worldwide. The patient was initially treated with metformin, fenofi¬brate, omega-3 and low carb and low fat diet with optimal results on metabolic control related to glycemic and lipid profile; later, liragluti¬de (Glucagon-Like Peptide-1 analog, GLP-1) therapy was added. Du¬ring the 6 month follow-up the anthropometric parameters improved, in particular a significant improvement in body composition with redi¬stribution of fat mass and a reduction of visceral fat and liver volume were observed. The improvements obtained were consolidated and maintained in the following years. However, with disease progression, focal segmental glomerulosclerosis (FSGS) and peripheral neuropathy developed. \u0000This case highlights the clinical and metabolic characteristics of this rare form of lipodystrophy and proposes an innovative therapeutic approach to manage the disease.","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128152860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adopting and maintaining a physically active lifestyle provides si¬gnificant health benefits to people with diabetes and prediabetes by increasing energy expenditure, insulin sensitivity, and physical fitness and decreasing chronic low-grade inflammation. Physical activity (PA)/exercise favors control of hyperglycemia and other risk factors for cardiovascular disease (CVD) and, therefore, it is recommended for diabetes prevention and treatment and for improving overall health. According to current guidelines, people with type 2 diabetes are re-commended to perform at least 150 min/week of moderate-to-vigorous intensity aerobic exercise plus 2-3 sessions/week of resistance exercise on non-consecutive days. Unfortunately, these individuals are usually well below the recommended level of PA and, hence, it is difficult for them to put into action guideline recommendations for a number of external and internal barriers, thus suggesting the need for effective strategies to promote a sustained behavior change. Several randomi¬zed clinical trials have shown that supervised exercise programs are effective in improving surrogate endpoints such as blood glucose and other CVD risk factors, physical fitness, and well-being. However, such programs are not suitable for long-term implementation in rou¬tine clinical practice and adherence to PA/exercise is usually strictly dependent on participation to supervised sessions and falls once the intervention ends. In this regard, counseling interventions appear to be more feasible and adequate to promote a true, long-lasting beha¬vior change. A limited number of studies have tested the efficacy of counseling interventions designed to promote walking through the provision of pedometers. These interventions resulted in modest and transient increases in moderate-to-vigorous PA (MVPA) and, accor¬dingly, failed to significantly improve CVD risk factors and other sur¬rogate outcomes or to produce sustained increases in cardiorespiratory fitness. These results are in contrast with those of several epidemio¬logical surveys, showing that, in physically inactive and sedentary or unfit individuals, even modest amounts of (MV)PA, corresponding to one-third to one-half of those recommended by guidelines, exert a beneficial impact on morbidity and mortality. This discrepancy might be explained by the fact that walking-based interventions are focused only on leisure-time MPVA. Conversely, current guidelines consider also other domains, such as sedentary behavior and light-intensity PA (LPA), and other settings, such as home, work and commuting, as they recommend also to decrease the amount of sedentary (SED)-time and to interrupt prolonged sitting with bouts of LPA every 30 min. In fact, in the Italian Diabetes and Exercise Study 2 (IDES_2), a counse¬ling intervention targeting both MVPA and sedentary behavior was effective in promoting increases in MVPA, which were modest but sustained over a three-year follow-up and associated wit
{"title":"Il cambiamento che possiamo ottenere produce effetti clinicamente rilevanti?","authors":"G. Pugliese","doi":"10.30682/ildia2301b","DOIUrl":"https://doi.org/10.30682/ildia2301b","url":null,"abstract":"Adopting and maintaining a physically active lifestyle provides si¬gnificant health benefits to people with diabetes and prediabetes by increasing energy expenditure, insulin sensitivity, and physical fitness and decreasing chronic low-grade inflammation. Physical activity (PA)/exercise favors control of hyperglycemia and other risk factors for cardiovascular disease (CVD) and, therefore, it is recommended for diabetes prevention and treatment and for improving overall health. According to current guidelines, people with type 2 diabetes are re-commended to perform at least 150 min/week of moderate-to-vigorous intensity aerobic exercise plus 2-3 sessions/week of resistance exercise on non-consecutive days. Unfortunately, these individuals are usually well below the recommended level of PA and, hence, it is difficult for them to put into action guideline recommendations for a number of external and internal barriers, thus suggesting the need for effective strategies to promote a sustained behavior change. Several randomi¬zed clinical trials have shown that supervised exercise programs are effective in improving surrogate endpoints such as blood glucose and other CVD risk factors, physical fitness, and well-being. However, such programs are not suitable for long-term implementation in rou¬tine clinical practice and adherence to PA/exercise is usually strictly dependent on participation to supervised sessions and falls once the intervention ends. In this regard, counseling interventions appear to be more feasible and adequate to promote a true, long-lasting beha¬vior change. A limited number of studies have tested the efficacy of counseling interventions designed to promote walking through the provision of pedometers. These interventions resulted in modest and transient increases in moderate-to-vigorous PA (MVPA) and, accor¬dingly, failed to significantly improve CVD risk factors and other sur¬rogate outcomes or to produce sustained increases in cardiorespiratory fitness. These results are in contrast with those of several epidemio¬logical surveys, showing that, in physically inactive and sedentary or unfit individuals, even modest amounts of (MV)PA, corresponding to one-third to one-half of those recommended by guidelines, exert a beneficial impact on morbidity and mortality. This discrepancy might be explained by the fact that walking-based interventions are focused only on leisure-time MPVA. Conversely, current guidelines consider also other domains, such as sedentary behavior and light-intensity PA (LPA), and other settings, such as home, work and commuting, as they recommend also to decrease the amount of sedentary (SED)-time and to interrupt prolonged sitting with bouts of LPA every 30 min. In fact, in the Italian Diabetes and Exercise Study 2 (IDES_2), a counse¬ling intervention targeting both MVPA and sedentary behavior was effective in promoting increases in MVPA, which were modest but sustained over a three-year follow-up and associated wit","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":"102 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134476540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vittoria Cataldo, Lucia Scisciola, Martina Franzese, Armando Puocci, Michelangela Barbieri
The increased prevalence of diabetes (DM) constitutes a major public health problem, primarily due to its numerous comorbidity and complications. It is widely demonstrated that DM is a significant risk factor for the development of cognitive impairment. Metabolic diseases can influence cognitive functions through multiple interconnected mechanisms. Cerebral insulin resistance, oxidative stress, neuroinflammation, and neuroendocrine dysfunctions can further the development of neurodegeneration diseases. The identification of the molecular mechanisms involved represents the target for the founding of early potential markers and new therapeutic targets of neurodegenerative diseases.
{"title":"Meccanismi comuni tra diabete e declino cognitivo","authors":"Vittoria Cataldo, Lucia Scisciola, Martina Franzese, Armando Puocci, Michelangela Barbieri","doi":"10.30682/ildia2204a","DOIUrl":"https://doi.org/10.30682/ildia2204a","url":null,"abstract":"The increased prevalence of diabetes (DM) constitutes a major public health problem, primarily due to its numerous comorbidity and complications. It is widely demonstrated that DM is a significant risk factor for the development of cognitive impairment. Metabolic diseases can influence cognitive functions through multiple interconnected mechanisms. Cerebral insulin resistance, oxidative stress, neuroinflammation, and neuroendocrine dysfunctions can further the development of neurodegeneration diseases. The identification of the molecular mechanisms involved represents the target for the founding of early potential markers and new therapeutic targets of neurodegenerative diseases.","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116978895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"La terapia cellulare autologa è efficace nel trattamento delle ulcere del piede diabetico","authors":"","doi":"10.30682/ildia2204e","DOIUrl":"https://doi.org/10.30682/ildia2204e","url":null,"abstract":"","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":"150 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133812807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Despite its increasing prevalence, severity and mortality, the Diabetic Foot Syndrome (DFS) still remains an unaddressed critical issue in Diabetology. The management of DFS is adequately performed only in few Centres, and clinical outcomes vary, depending on the possibility of patients to access optimal standards of care. To rivitalize the debate upond DFS and to make concrete proposals to improve the quality of therapy and the accessibility to optimal care, we wrote this editorial.
{"title":"L’elefante nella stanza","authors":"A. Piaggesi, Roberto Ferraresi, Mauro Gargiulo","doi":"10.30682/ildia2204d","DOIUrl":"https://doi.org/10.30682/ildia2204d","url":null,"abstract":"Despite its increasing prevalence, severity and mortality, the Diabetic Foot Syndrome (DFS) still remains an unaddressed critical issue in Diabetology.\u0000The management of DFS is adequately performed only in few Centres, and clinical outcomes vary, depending on the possibility of patients to access optimal standards of care.\u0000To rivitalize the debate upond DFS and to make concrete proposals to improve the quality of therapy and the accessibility to optimal care, we wrote this editorial.","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114425371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mara Suleiman, Carmela De Luca, Silvia Del Guerra, Marta Tesi, L. Marselli
Type 2 diabetes (T2D) has been considered a relentlessly worsening disease, due to the progressive deterioration of the pancreatic beta cell functional mass. Evidence indicates that remission of T2D may occur in variable proportions of patients after specific treatments that are associated with recovery of beta cell function. The recovery of beta cells has been shown in human islets obtained from non-diabetic organ donors that recover from “lipo-glucotoxic” conditions, and human islets isolated from T2D organ donors exposed to specific treatments or by a period of exposure to a “non-diabetic” milieu. The improvement of insulin secretion and the associated molecular traits unveil the possibility to promote T2D remission by directly targeting pancreatic beta cells.
{"title":"Il ripristino della funzione beta cellulare nel diabete mellito di tipo 2: aspetti traslazionali","authors":"Mara Suleiman, Carmela De Luca, Silvia Del Guerra, Marta Tesi, L. Marselli","doi":"10.30682/ildia2204f","DOIUrl":"https://doi.org/10.30682/ildia2204f","url":null,"abstract":"Type 2 diabetes (T2D) has been considered a relentlessly worsening disease, due to the progressive deterioration of the pancreatic beta cell functional mass. Evidence indicates that remission of T2D may occur in variable proportions of patients after specific treatments that are associated with recovery of beta cell function. The recovery of beta cells has been shown in human islets obtained from non-diabetic organ donors that recover from “lipo-glucotoxic” conditions, and human islets isolated from T2D organ donors exposed to specific treatments or by a period of exposure to a “non-diabetic” milieu. The improvement of insulin secretion and the associated molecular traits unveil the possibility to promote T2D remission by directly targeting pancreatic beta cells.","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128795331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cristiana Randazzo, Carola Buscemi, Anna Maria Barile e Silvio Buscemi
Evidence has been accumulated that a different timing in the consumption of meals, namely the chrononutrition, is able to influence the daily metabolic biorhythms, influencing the onset and possibly the treatment of clinical conditions as obesity and diabetes, including the possibility of independently influencing the cardiovascular risk. Behaviors originating from new social customs are able to interfere with these physiological mechanisms activating of genes and proteins that make individuals more or less flexible, capable of adaptation. So, the inability to adapt could favor a higher risk to health. Therefore, chrononutrition is a characteristic of the diet that is important to address further to the amount of energy and macronutrient intake. Once again, even in this area, the Mediterranean dietary style proves to be a healthy reference approach.
{"title":"Crononutrizione: una tematica emergente nella gestione del diabete di tipo 2","authors":"Cristiana Randazzo, Carola Buscemi, Anna Maria Barile e Silvio Buscemi","doi":"10.30682/ildia2204c","DOIUrl":"https://doi.org/10.30682/ildia2204c","url":null,"abstract":"Evidence has been accumulated that a different timing in the consumption of meals, namely the chrononutrition, is able to influence the daily metabolic biorhythms, influencing the onset and possibly the treatment of clinical conditions as obesity and diabetes, including the possibility of independently influencing the cardiovascular risk. Behaviors originating from new social customs are able to interfere with these physiological mechanisms activating of genes and proteins that make individuals more or less flexible, capable of adaptation. So, the inability to adapt could favor a higher risk to health. Therefore, chrononutrition is a characteristic of the diet that is important to address further to the amount of energy and macronutrient intake. Once again, even in this area, the Mediterranean dietary style proves to be a healthy reference approach.","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130494368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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