Andrew James Murrell, B. Rimmer, Lizzie Dutton, Joanne Lewis, R. Burns, P. Gallagher, Sophie Williams, V. Araújo-Soares, Tracy Finch, L. Sharp
Objective. Those closest to the patients with low-grade glioma (LGG) often become informal caregivers (ICs). Caregiving demands can impact ICs’ wellbeing, meaning they themselves may require support. We explored the nature and quality of support from informal networks for ICs of LGG patients. Methods. In this cross-sectional qualitative study, semistructured interviews were conducted with individuals from the United Kingdom who currently, or in the past five years, informally cared for someone diagnosed with an LGG. Interviews explored ICs’ experiences of receiving support from informal networks. Thematic analysis was undertaken. Results. Nineteen ICs were interviewed (mean age 54.6 years; 5 males, 14 females). ICs received multiple forms of support from their informal networks: emotional (e.g., “opportunities to talk”), instrumental (e.g., “opportunities for relief”), information (e.g., “information from network contacts”), and appraisal (e.g., “comparisons with similar others”). Networks comprised strong/familiar (e.g., close friends) and weaker/unfamiliar (e.g., other ICs) ties. Supportive networks were perceived to help protect ICs’ wellbeing. Participants perceived challenges such as poor understanding and unsolicited advice to weaken the quality of support. Conclusion. Informal networks can provide wide-ranging support for ICs of the LGG patients. Different supports may be sought or provided from different contacts, highlighting the importance and value of extended networks.
{"title":"The Nature and Quality of Support from Informal Networks for Informal Caregivers of Low-Grade Glioma Patients: A Qualitative Analysis within the Ways Ahead Study","authors":"Andrew James Murrell, B. Rimmer, Lizzie Dutton, Joanne Lewis, R. Burns, P. Gallagher, Sophie Williams, V. Araújo-Soares, Tracy Finch, L. Sharp","doi":"10.1155/2023/4149412","DOIUrl":"https://doi.org/10.1155/2023/4149412","url":null,"abstract":"Objective. Those closest to the patients with low-grade glioma (LGG) often become informal caregivers (ICs). Caregiving demands can impact ICs’ wellbeing, meaning they themselves may require support. We explored the nature and quality of support from informal networks for ICs of LGG patients. Methods. In this cross-sectional qualitative study, semistructured interviews were conducted with individuals from the United Kingdom who currently, or in the past five years, informally cared for someone diagnosed with an LGG. Interviews explored ICs’ experiences of receiving support from informal networks. Thematic analysis was undertaken. Results. Nineteen ICs were interviewed (mean age 54.6 years; 5 males, 14 females). ICs received multiple forms of support from their informal networks: emotional (e.g., “opportunities to talk”), instrumental (e.g., “opportunities for relief”), information (e.g., “information from network contacts”), and appraisal (e.g., “comparisons with similar others”). Networks comprised strong/familiar (e.g., close friends) and weaker/unfamiliar (e.g., other ICs) ties. Supportive networks were perceived to help protect ICs’ wellbeing. Participants perceived challenges such as poor understanding and unsolicited advice to weaken the quality of support. Conclusion. Informal networks can provide wide-ranging support for ICs of the LGG patients. Different supports may be sought or provided from different contacts, highlighting the importance and value of extended networks.","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45309906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. O’Brien, L. Brennan, L. O’Neill, D. Connolly, E. Guinan, J. V. Reynolds, J. Hussey
Purpose. Multidisciplinary rehabilitation programmes providing exercise, nutrition support, education, and peer support can effectively meet the rehabilitation needs of upper gastrointestinal (UGI) cancer survivors. This study aimed to explore the experiences of participants who engaged in a telehealth, multidisciplinary rehabilitation programme for UGI cancer survivors. Methods. This single-arm feasibility study recruited participants who completed curative treatment for UGI cancer. Participants (n = 10, male = 9) aged 58–76 years were 5–17 months postsurgery. A 12-week telehealth rehabilitation programme was delivered via video call, consisting of group resistance training, remotely monitored aerobic training, 1 : 1 dietary counselling, 1 : 1 physiotherapy support, and group education sessions. Independent researchers conducted semistructured interviews at postintervention assessments. Transcripts were analysed using reflexive thematic analysis (RTA). Results. RTA of participant transcripts generated three overarching themes: (1) ReStOre@Home impacted psychosocial and physical needs by addressing a broad and meaningful gap in services, (2) paving a pathway towards prosperity, and (3) contrasting experiences with using technology. Participants’ preferences and recommendations for future telehealth programmes were discussed. Conclusions. A telehealth multidisciplinary rehabilitation programme supported participants in physical and psychosocial recovery. Qualitative analysis identified an important ongoing need for some in-person care and provided detailed insights into participant experiences during telehealth-delivered rehabilitation.
{"title":"Patient Experiences of a Telehealth Multidisciplinary Cancer Rehabilitation Programme: Qualitative Findings from the ReStOre@Home Feasibility Study","authors":"A. O’Brien, L. Brennan, L. O’Neill, D. Connolly, E. Guinan, J. V. Reynolds, J. Hussey","doi":"10.1155/2023/7998022","DOIUrl":"https://doi.org/10.1155/2023/7998022","url":null,"abstract":"Purpose. Multidisciplinary rehabilitation programmes providing exercise, nutrition support, education, and peer support can effectively meet the rehabilitation needs of upper gastrointestinal (UGI) cancer survivors. This study aimed to explore the experiences of participants who engaged in a telehealth, multidisciplinary rehabilitation programme for UGI cancer survivors. Methods. This single-arm feasibility study recruited participants who completed curative treatment for UGI cancer. Participants (n = 10, male = 9) aged 58–76 years were 5–17 months postsurgery. A 12-week telehealth rehabilitation programme was delivered via video call, consisting of group resistance training, remotely monitored aerobic training, 1 : 1 dietary counselling, 1 : 1 physiotherapy support, and group education sessions. Independent researchers conducted semistructured interviews at postintervention assessments. Transcripts were analysed using reflexive thematic analysis (RTA). Results. RTA of participant transcripts generated three overarching themes: (1) ReStOre@Home impacted psychosocial and physical needs by addressing a broad and meaningful gap in services, (2) paving a pathway towards prosperity, and (3) contrasting experiences with using technology. Participants’ preferences and recommendations for future telehealth programmes were discussed. Conclusions. A telehealth multidisciplinary rehabilitation programme supported participants in physical and psychosocial recovery. Qualitative analysis identified an important ongoing need for some in-person care and provided detailed insights into participant experiences during telehealth-delivered rehabilitation.","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46159609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cristian Orellana López, Jose Leyton Estéfane, Miguel Ramos Rosales, Claudio Vásquez Ramirez, Claudia Manriquez Arriagada, J. M. Argiles, F. López‐Soriano, F. Ortega González, Nicolás Yañez, S. Busquets
Introduction. Cachexia is a syndrome characterized by the loss of musculoskeletal mass, with or without adipose mass, which cannot be reversed by nutritional support. In Chile, there are no data on cachexia in cancer patients that allows for decision making on better interdisciplinary management. In this study, the prevalence of cachexia in inpatient and outpatient cancer patients was investigated. Methods. An observational, descriptive, and cross-sectional study was carried out. Eighty-six inpatients and outpatients were evaluated. Cachexia was evaluated by applying the miniCASCO tool, its weight by bioimpedance, and inflammation by blood parameters. Comparisons and correlations were made considering p < 0.05 as the threshold for statistical significance. Results. Forty patients met the inclusion criteria, 35% were men and 65% were women. In all, 27.5% of patients had cachexia secondary to cancer. Of the total number of patients with the syndrome, approximately 45.4% had mild cachexia, 36.3% had severe cachexia, and 18.1% had moderate cachexia. In addition, there was a significant positive correlation p = 0.0150 and moderately strong (r = 0.7209) match between the final scores and the stage of cancer. Conclusion. The prevalence of cachectic patients is reported for the first time through the application of the miniCASCO tool. A moderate positive match was detected between the final miniCASCO score and the stages of cancer patients. Finally, an early discovery of cachexia would allow therapeutic interventions aimed at improving the prognosis of cancer patients.
{"title":"Prevalence of Cachexia in Cancer Patients","authors":"Cristian Orellana López, Jose Leyton Estéfane, Miguel Ramos Rosales, Claudio Vásquez Ramirez, Claudia Manriquez Arriagada, J. M. Argiles, F. López‐Soriano, F. Ortega González, Nicolás Yañez, S. Busquets","doi":"10.1155/2023/5743872","DOIUrl":"https://doi.org/10.1155/2023/5743872","url":null,"abstract":"Introduction. Cachexia is a syndrome characterized by the loss of musculoskeletal mass, with or without adipose mass, which cannot be reversed by nutritional support. In Chile, there are no data on cachexia in cancer patients that allows for decision making on better interdisciplinary management. In this study, the prevalence of cachexia in inpatient and outpatient cancer patients was investigated. Methods. An observational, descriptive, and cross-sectional study was carried out. Eighty-six inpatients and outpatients were evaluated. Cachexia was evaluated by applying the miniCASCO tool, its weight by bioimpedance, and inflammation by blood parameters. Comparisons and correlations were made considering \u0000 \u0000 p\u0000 <\u0000 0.05\u0000 \u0000 as the threshold for statistical significance. Results. Forty patients met the inclusion criteria, 35% were men and 65% were women. In all, 27.5% of patients had cachexia secondary to cancer. Of the total number of patients with the syndrome, approximately 45.4% had mild cachexia, 36.3% had severe cachexia, and 18.1% had moderate cachexia. In addition, there was a significant positive correlation \u0000 \u0000 \u0000 \u0000 p\u0000 =\u0000 0.0150\u0000 \u0000 \u0000 \u0000 and moderately strong (r = 0.7209) match between the final scores and the stage of cancer. Conclusion. The prevalence of cachectic patients is reported for the first time through the application of the miniCASCO tool. A moderate positive match was detected between the final miniCASCO score and the stages of cancer patients. Finally, an early discovery of cachexia would allow therapeutic interventions aimed at improving the prognosis of cancer patients.","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43237289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background. Results from the studies investigating the impact of CC chemokine receptor 2 (CCR2) polymorphism on the risk of cancers are diverse. An updated meta-analysis was conducted to access the relationship between cancer risk and CCR2-V64I polymorphism. Methods. We performed a meta-analysis using STATA 11.0 based on a comprehensive retrieval in WanFang Data, PubMed, China National Knowledge Infrastructure, EMBASE, and Web of Science databases up to January 20, 2023. Results. We included 23 studies in our analysis. Overall, we found CCR2-V64I polymorphism was remarkably related to cancer risk (OR = 1.39, 95% CI = 1.14–1.70, and P = 0.001 for A vs G; OR = 1.87, 95% CI = 1.30–2.70, and P = 0.001 for AA vs GG; OR = 1.35, 95% CI = 1.03–1.78, and P = 0.032 for GA vs GG; OR = 1.45, 95% CI = 1.11–1.90, and P = 0.006 for AA + GA vs GG; OR = 1.69, 95% CI = 1.20–2.37, and P = 0.003 for AA vs GA + GG). In the ethnicity subgroup analysis, the relevancy between CCR2-V64I polymorphism and an increased cancer risk was discovered among Asians (OR = 1.57, 95% CI = 1.30–1.91, and P < 0.001 for A vs G; OR = 2.30, 95% CI = 1.64–3.24, and P < 0.001 for AA vs GG; OR = 1.35, 95% CI = 1.10–1.67, and P = 0.005 for GA vs GG; OR = 1.52, 95% CI = 1.25–1.87, and P < 0.001 for AA + GA vs GG; OR = 2.21, 95% CI = 1.58–3.08, and P < 0.001 for AA vs GA + GG). In addition, the subgroup analysis in the light of cancer types demonstrated that CCR2-V64I polymorphism was strongly correlated with bladder cancer (OR = 3.04, 95% CI = 1.09–8.45, and P = 0.033 for AA vs GG; OR = 2.84, 95% CI = 1.07–7.09, and P = 0.035 for AA vs GA + GG) and oral cancer (OR = 1.83, 95% CI = 1.39-2.42, and P < 0.001 for A vs G; OR = 2.04, 95% CI = 1.47–2.85, and P < 0.001 for GA vs GG; OR = 2.03, 95% CI = 1.48–2.79, and P < 0.001 for AA + GA vs GG). Conclusion. The meta-analysis suggested that CCR2-V64I polymorphism might be a high-risk factor for cancers among Asians, especially for bladder and oral cancers.
背景。研究CC趋化因子受体2 (CCR2)多态性对癌症风险影响的研究结果多种多样。我们进行了一项最新的荟萃分析，以获取癌症风险与CCR2-V64I多态性之间的关系。方法。我们基于截至2023年1月20日的万方数据、PubMed、中国国家知识基础设施、EMBASE和Web of Science数据库的综合检索，使用STATA 11.0进行了meta分析。结果。我们在分析中纳入了23项研究。总的来说，我们发现CCR2-V64I多态性与癌症风险显著相关(OR = 1.39, 95% CI = 1.14-1.70, P = 0.001);AA vs GG的OR = 1.87, 95% CI = 1.30-2.70, P = 0.001;GA vs GG的OR = 1.35, 95% CI = 1.03-1.78, P = 0.032;AA + GA vs GG的OR = 1.45, 95% CI = 1.11-1.90, P = 0.006;OR = 1.69, 95% CI = 1.20-2.37, P = 0.003 (AA vs GA + GG)。在种族亚组分析中，亚洲人发现CCR2-V64I多态性与癌症风险增加之间存在相关性(OR = 1.57, 95% CI = 1.30-1.91, A vs G的P < 0.001;AA vs GG的OR = 2.30, 95% CI = 1.64-3.24, P < 0.001;GA vs GG的OR = 1.35, 95% CI = 1.10-1.67, P = 0.005;AA + GA vs GG的OR = 1.52, 95% CI = 1.25-1.87, P < 0.001;OR = 2.21, 95% CI = 1.58-3.08, AA vs GA + GG的P < 0.001)。此外，针对不同癌症类型的亚组分析显示，CCR2-V64I多态性与膀胱癌密切相关(OR = 3.04, 95% CI = 1.09-8.45, P = 0.033);AA vs GA + GG的OR = 2.84, 95% CI = 1.07-7.09, P = 0.035)和口腔癌(OR = 1.83, 95% CI = 1.39-2.42, A vs G的P < 0.001;GA vs GG的OR = 2.04, 95% CI = 1.47-2.85, P < 0.001;OR = 2.03, 95% CI = 1.48-2.79, AA + GA vs GG的P < 0.001)。结论。荟萃分析表明，CCR2-V64I多态性可能是亚洲人患癌症的高危因素，尤其是膀胱癌和口腔癌。
{"title":"Effect of CCR2-V64I on the Susceptibility of Patients to Cancer","authors":"Xuerou Lu, Lin Li, Xiaoping Zhou","doi":"10.1155/2023/7630422","DOIUrl":"https://doi.org/10.1155/2023/7630422","url":null,"abstract":"Background. Results from the studies investigating the impact of CC chemokine receptor 2 (CCR2) polymorphism on the risk of cancers are diverse. An updated meta-analysis was conducted to access the relationship between cancer risk and CCR2-V64I polymorphism. Methods. We performed a meta-analysis using STATA 11.0 based on a comprehensive retrieval in WanFang Data, PubMed, China National Knowledge Infrastructure, EMBASE, and Web of Science databases up to January 20, 2023. Results. We included 23 studies in our analysis. Overall, we found CCR2-V64I polymorphism was remarkably related to cancer risk (OR = 1.39, 95% CI = 1.14–1.70, and \u0000 \u0000 P\u0000 =\u0000 0.001\u0000 \u0000 for A vs G; OR = 1.87, 95% CI = 1.30–2.70, and \u0000 \u0000 P\u0000 =\u0000 0.001\u0000 \u0000 for AA vs GG; OR = 1.35, 95% CI = 1.03–1.78, and \u0000 \u0000 P\u0000 =\u0000 0.032\u0000 \u0000 for GA vs GG; OR = 1.45, 95% CI = 1.11–1.90, and \u0000 \u0000 P\u0000 =\u0000 0.006\u0000 \u0000 for AA + GA vs GG; OR = 1.69, 95% CI = 1.20–2.37, and \u0000 \u0000 P\u0000 =\u0000 0.003\u0000 \u0000 for AA vs GA + GG). In the ethnicity subgroup analysis, the relevancy between CCR2-V64I polymorphism and an increased cancer risk was discovered among Asians (OR = 1.57, 95% CI = 1.30–1.91, and \u0000 \u0000 P\u0000 <\u0000 0.001\u0000 \u0000 for A vs G; OR = 2.30, 95% CI = 1.64–3.24, and \u0000 \u0000 P\u0000 <\u0000 0.001\u0000 \u0000 for AA vs GG; OR = 1.35, 95% CI = 1.10–1.67, and \u0000 \u0000 P\u0000 =\u0000 0.005\u0000 \u0000 for GA vs GG; OR = 1.52, 95% CI = 1.25–1.87, and \u0000 \u0000 P\u0000 <\u0000 0.001\u0000 \u0000 for AA + GA vs GG; OR = 2.21, 95% CI = 1.58–3.08, and \u0000 \u0000 P\u0000 <\u0000 0.001\u0000 \u0000 for AA vs GA + GG). In addition, the subgroup analysis in the light of cancer types demonstrated that CCR2-V64I polymorphism was strongly correlated with bladder cancer (OR = 3.04, 95% CI = 1.09–8.45, and \u0000 \u0000 P\u0000 =\u0000 0.033\u0000 \u0000 for AA vs GG; OR = 2.84, 95% CI = 1.07–7.09, and \u0000 \u0000 P\u0000 =\u0000 0.035\u0000 \u0000 for AA vs GA + GG) and oral cancer (OR = 1.83, 95% CI = 1.39-2.42, and \u0000 \u0000 P\u0000 <\u0000 0.001\u0000 \u0000 for A vs G; OR = 2.04, 95% CI = 1.47–2.85, and \u0000 \u0000 P\u0000 <\u0000 0.001\u0000 \u0000 for GA vs GG; OR = 2.03, 95% CI = 1.48–2.79, and \u0000 \u0000 P\u0000 <\u0000 0.001\u0000 \u0000 for AA + GA vs GG). Conclusion. The meta-analysis suggested that CCR2-V64I polymorphism might be a high-risk factor for cancers among Asians, especially for bladder and oral cancers.","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43185302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Finch, S. Cooper, R. Raine, R. Taylor, F. Gibson
Introduction. Ambulatory Care (AC), where patients receive inpatient cancer treatment on an outpatient basis, was introduced into the United Kingdom (UK) National Health Service (NHS) in 2004. Although now well established within some services, the development of AC across the NHS is yet to be described. We report findings of a scoping review that set out to understand the provenance of the clinical pathway, whilst exploring drivers for the development of AC in the UK. Methods. Using scoping review methods, database citation, and grey literature, searches were undertaken to map the storyline of AC’s development internationally. The Joanna Briggs Institute guidance was followed; this included consultation with six professionals considered critical to the development of AC. Results. From the 57 records identified between 1979 and 2022, four domains were identified through a narrative synthesis that reflected the following drivers for AC: financial; optimisation of bed capacity; advances in technology and supportive care; and professional motivation to improve patient experience. Conclusion. We report the first descriptive analysis of the international development of AC, locating the UK cancer service within its commissioning, operational, and philosophical foundations. The review additionally highlights limited research exploring the experience of the AC model from the patients’ perspective.
{"title":"The Development of Ambulatory Cancer Care in the UK: A Scoping Review of the Literature","authors":"A. Finch, S. Cooper, R. Raine, R. Taylor, F. Gibson","doi":"10.1155/2023/4589362","DOIUrl":"https://doi.org/10.1155/2023/4589362","url":null,"abstract":"Introduction. Ambulatory Care (AC), where patients receive inpatient cancer treatment on an outpatient basis, was introduced into the United Kingdom (UK) National Health Service (NHS) in 2004. Although now well established within some services, the development of AC across the NHS is yet to be described. We report findings of a scoping review that set out to understand the provenance of the clinical pathway, whilst exploring drivers for the development of AC in the UK. Methods. Using scoping review methods, database citation, and grey literature, searches were undertaken to map the storyline of AC’s development internationally. The Joanna Briggs Institute guidance was followed; this included consultation with six professionals considered critical to the development of AC. Results. From the 57 records identified between 1979 and 2022, four domains were identified through a narrative synthesis that reflected the following drivers for AC: financial; optimisation of bed capacity; advances in technology and supportive care; and professional motivation to improve patient experience. Conclusion. We report the first descriptive analysis of the international development of AC, locating the UK cancer service within its commissioning, operational, and philosophical foundations. The review additionally highlights limited research exploring the experience of the AC model from the patients’ perspective.","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46934640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hao Luo, D. Galvão, Robert U. Newton, Colin I. Tang, N. Spry, D. Taaffe
Purpose. Exercise is emerging as an adjunct therapy to cancer treatment; however, its role in older patients with advanced pancreatic cancer undergoing first-line chemotherapy is unclear. The aim of this study was to primarily provide evidence on feasibility with an exploratory examination of the initial efficacy of exercise in this clinical setting. Materials and Methods. Six patients aged 60–75 years with de novo or recurrent advanced pancreatic cancer undergoing first-line chemotherapy consented to participate in twice-weekly exercise that included resistance and aerobic training and boxing-related activities for up to 12 weeks. Patients were monitored for attendance, adherence, and adverse events. Body composition, muscle strength, functional ability, patient-reported outcome measures, and patient-reported experience measures were assessed at baseline and/or postintervention. Results. Of the 6 patients, 1 withdrew after baseline testing and 5 attended 42%–95% of planned sessions and adhered to 28%–83% of the prescribed exercise. There were no serious exercise-emergent adverse events. All 5 patients increased or maintained lean mass (0.1%–4.4%) and 4 reduced fat mass (−0.4%–−8.6%). Improvements were observed in 4 or all 5 patients for muscle strength (7.1%–75%), 5 times sit-to-stand (1.3%–21.4%), 6-m backward walk (16.5%–35.8%), and patient-reported outcomes. Furthermore, all patients perceived exercise as very helpful in managing their cancer and expressed a strong willingness to continue exercise in the future. Conclusion. A multimodal exercise program appears feasible with potential physical and psychological benefits for older patients with advanced pancreatic cancer undergoing first-line chemotherapy. Further research including a larger sample size is warranted.
{"title":"Multimodal Exercise in Older Patients with Advanced Pancreatic Cancer Undergoing First-Line Chemotherapy: A Case Series Examining Feasibility and Preliminary Efficacy","authors":"Hao Luo, D. Galvão, Robert U. Newton, Colin I. Tang, N. Spry, D. Taaffe","doi":"10.1155/2023/1179848","DOIUrl":"https://doi.org/10.1155/2023/1179848","url":null,"abstract":"Purpose. Exercise is emerging as an adjunct therapy to cancer treatment; however, its role in older patients with advanced pancreatic cancer undergoing first-line chemotherapy is unclear. The aim of this study was to primarily provide evidence on feasibility with an exploratory examination of the initial efficacy of exercise in this clinical setting. Materials and Methods. Six patients aged 60–75 years with de novo or recurrent advanced pancreatic cancer undergoing first-line chemotherapy consented to participate in twice-weekly exercise that included resistance and aerobic training and boxing-related activities for up to 12 weeks. Patients were monitored for attendance, adherence, and adverse events. Body composition, muscle strength, functional ability, patient-reported outcome measures, and patient-reported experience measures were assessed at baseline and/or postintervention. Results. Of the 6 patients, 1 withdrew after baseline testing and 5 attended 42%–95% of planned sessions and adhered to 28%–83% of the prescribed exercise. There were no serious exercise-emergent adverse events. All 5 patients increased or maintained lean mass (0.1%–4.4%) and 4 reduced fat mass (−0.4%–−8.6%). Improvements were observed in 4 or all 5 patients for muscle strength (7.1%–75%), 5 times sit-to-stand (1.3%–21.4%), 6-m backward walk (16.5%–35.8%), and patient-reported outcomes. Furthermore, all patients perceived exercise as very helpful in managing their cancer and expressed a strong willingness to continue exercise in the future. Conclusion. A multimodal exercise program appears feasible with potential physical and psychological benefits for older patients with advanced pancreatic cancer undergoing first-line chemotherapy. Further research including a larger sample size is warranted.","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48289407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim. This study investigated the effect of tumor size and other factors on the survival and prognosis of hepatocellular carcinoma (HCC). Methods. All HCC populations based on the National Cancer Institute’s SEER database to receive from 2010 to 2016 were employed in the study. Results. This study enrolled a total of 14,634 HCC. Among them, 1,686 patients had tumors ≤ 2 cm, 6,169 patients had tumors 2–5 cm, and 6,779 patients had tumors > 5 cm. The results using univariate analysis showed that all factors were significant prognostic factors for overall survival and specific survival. Patients with tumor size ≤ 2 cm were more likely to survive, while patients with tumor size > 5 cm had a lower survival rate. Patients who had surgery or surgery plus chemotherapy had a higher chance of survival in stages I-II, and the survival rate declined smoothly during the 80 months. The change rate of the mortality rate increased rapidly during the period of 1–12 cm; afterwards, the mortality rate’s HR was basically and smoothly maintained at a high level. Conclusions. Tumor size was positively correlated with the mortality rate of HCC. Survival rates were greater in patients with tumors ≤ 2 cm who underwent surgery or surgery plus chemotherapy. Patients with HCC in the early stage had a higher survival probability particularly when they had experienced surgery or surgery plus chemotherapy.
{"title":"Prognostic Analysis on Different Tumor Sizes for 14634 Hepatocellular Carcinoma Patients","authors":"Zilin Chen, Hexin Zheng, Wenshuai Zeng, Meng-Lu Liu, Yong Chen","doi":"10.1155/2023/1106975","DOIUrl":"https://doi.org/10.1155/2023/1106975","url":null,"abstract":"Aim. This study investigated the effect of tumor size and other factors on the survival and prognosis of hepatocellular carcinoma (HCC). Methods. All HCC populations based on the National Cancer Institute’s SEER database to receive from 2010 to 2016 were employed in the study. Results. This study enrolled a total of 14,634 HCC. Among them, 1,686 patients had tumors ≤ 2 cm, 6,169 patients had tumors 2–5 cm, and 6,779 patients had tumors > 5 cm. The results using univariate analysis showed that all factors were significant prognostic factors for overall survival and specific survival. Patients with tumor size ≤ 2 cm were more likely to survive, while patients with tumor size > 5 cm had a lower survival rate. Patients who had surgery or surgery plus chemotherapy had a higher chance of survival in stages I-II, and the survival rate declined smoothly during the 80 months. The change rate of the mortality rate increased rapidly during the period of 1–12 cm; afterwards, the mortality rate’s HR was basically and smoothly maintained at a high level. Conclusions. Tumor size was positively correlated with the mortality rate of HCC. Survival rates were greater in patients with tumors ≤ 2 cm who underwent surgery or surgery plus chemotherapy. Patients with HCC in the early stage had a higher survival probability particularly when they had experienced surgery or surgery plus chemotherapy.","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"1 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64789715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Román-Carlos Rodríguez-Rodríguez, A. Noreña-Peña, Teresa Chafer-Bixquert, J. González de Dios, A. G. Gutiérrez García, C. Solano Ruiz
Background. Children with cancer are subjected to aggressive tests and treatments that can affect their emotional states. Studies available in the academic literature analyse the effect of music therapy on the emotions of these patients are scarce. Objectives. The objective of this study was to explore and transform the emotional responses that may arise with the application of music therapy (MT) in children with oncological pathology. Methods. The methodology of this study was based on the participatory action research approach. Semistructured interviews were conducted with 27 children with cancer who participated in 65MT sessions. Interviews were also conducted with their families. Results. We conducted a thematic analysis using MAXQDA software. Three main categories emerged from this process as follows: (1) expression: children with cancer stated that MT made it easier for them to express their emotions, with indirect benefits to families; (2) participation: patients showed interest in the sessions; and (3) experiences: MT was valued and created a positive environment. The results of this research demonstrate the positive transformative power MT had on children with cancer in terms of their emotions. Conclusions. Positive results were achieved through MT that encouraged the expression of emotions by children with cancer and favoured and improved their moods. In addition, it also encouraged social interactions in the hospital and helped the children to better cope with their illness through self-awareness. Their families also benefited. Therefore, we encourage healthcare professionals to support the use of MT in paediatric oncology settings.
{"title":"The Value of Music Therapy in the Expression of Emotions in Children with Cancer","authors":"Román-Carlos Rodríguez-Rodríguez, A. Noreña-Peña, Teresa Chafer-Bixquert, J. González de Dios, A. G. Gutiérrez García, C. Solano Ruiz","doi":"10.1155/2023/2910350","DOIUrl":"https://doi.org/10.1155/2023/2910350","url":null,"abstract":"Background. Children with cancer are subjected to aggressive tests and treatments that can affect their emotional states. Studies available in the academic literature analyse the effect of music therapy on the emotions of these patients are scarce. Objectives. The objective of this study was to explore and transform the emotional responses that may arise with the application of music therapy (MT) in children with oncological pathology. Methods. The methodology of this study was based on the participatory action research approach. Semistructured interviews were conducted with 27 children with cancer who participated in 65MT sessions. Interviews were also conducted with their families. Results. We conducted a thematic analysis using MAXQDA software. Three main categories emerged from this process as follows: (1) expression: children with cancer stated that MT made it easier for them to express their emotions, with indirect benefits to families; (2) participation: patients showed interest in the sessions; and (3) experiences: MT was valued and created a positive environment. The results of this research demonstrate the positive transformative power MT had on children with cancer in terms of their emotions. Conclusions. Positive results were achieved through MT that encouraged the expression of emotions by children with cancer and favoured and improved their moods. In addition, it also encouraged social interactions in the hospital and helped the children to better cope with their illness through self-awareness. Their families also benefited. Therefore, we encourage healthcare professionals to support the use of MT in paediatric oncology settings.","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46244935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Döring, Stefanie Thiel, Dustin Werle, Johanna Xemaire, S. Joachim, P. Lang, R. Handgretinger, J. Svaldi, K. M. Cabanillas Stanchi
Background. Hematopoietic stem cell transplantation (HSCT) is a curative treatment option for malignant and nonmalignant diseases that is highly distressing, especially for children. A valid assessment of pediatric patients’ distress that is independent from their language skills would be beneficial. Research regarding HSCT-specific self-reporting or rater-reporting instruments is scarce. Method. In this single-center prospective study, pediatric patients and young adolescents undergoing HSCT were screened for mental and somatic distress using PO-Bado (Basic Documentation for Psycho-Oncology) ratings from parents and medical caregivers on eight observations days before, during, and up to 200 days after HSCT. Additionally, the stress biomarkers cortisol and α-amylase were monitored on the same observation days. Results. A total of 39 pediatric and young adult patients with a median age of 9.3 years (range 0.5–19.0), with 18 females (46%) and 21 males, were enrolled. The perceptions of the patients’ somatic and mental distress of parents and medical caregivers of patients were significantly correlated (mental subscale ((r(276) = 0.31, p < 0.001 ., 95% CI of the correlation: (0.20, 0.41)) and somatic subscale ((r(284) = 0.46, p < 0.001 ., 95% CI of the correlation: 0.36, 0.54)). The time period between the days of transplantation until day +10 was rated as the most mentally and somatically distressing. Conclusions. While the somatic burden declined over time, the mental distress in the patients remained at a stable level, emphasizing the importance of further psychological and psycho-oncological support in these patients. The use of salivary α-amylase as a suitable distress detection marker in pediatric patients undergoing HSCT should be further investigated.
{"title":"The Basic Documentation for Psycho-Oncology in Pediatric Stem Cell Transplantation Recipients: Ratings of Parents and Staff and the Profile of Salivary α-Amylase","authors":"M. Döring, Stefanie Thiel, Dustin Werle, Johanna Xemaire, S. Joachim, P. Lang, R. Handgretinger, J. Svaldi, K. M. Cabanillas Stanchi","doi":"10.1155/2023/9955216","DOIUrl":"https://doi.org/10.1155/2023/9955216","url":null,"abstract":"Background. Hematopoietic stem cell transplantation (HSCT) is a curative treatment option for malignant and nonmalignant diseases that is highly distressing, especially for children. A valid assessment of pediatric patients’ distress that is independent from their language skills would be beneficial. Research regarding HSCT-specific self-reporting or rater-reporting instruments is scarce. Method. In this single-center prospective study, pediatric patients and young adolescents undergoing HSCT were screened for mental and somatic distress using PO-Bado (Basic Documentation for Psycho-Oncology) ratings from parents and medical caregivers on eight observations days before, during, and up to 200 days after HSCT. Additionally, the stress biomarkers cortisol and α-amylase were monitored on the same observation days. Results. A total of 39 pediatric and young adult patients with a median age of 9.3 years (range 0.5–19.0), with 18 females (46%) and 21 males, were enrolled. The perceptions of the patients’ somatic and mental distress of parents and medical caregivers of patients were significantly correlated (mental subscale ((r(276) = 0.31, \u0000 \u0000 p\u0000 <\u0000 0.001\u0000 \u0000 ., 95% CI of the correlation: (0.20, 0.41)) and somatic subscale ((r(284) = 0.46, \u0000 \u0000 p\u0000 <\u0000 0.001\u0000 \u0000 ., 95% CI of the correlation: 0.36, 0.54)). The time period between the days of transplantation until day +10 was rated as the most mentally and somatically distressing. Conclusions. While the somatic burden declined over time, the mental distress in the patients remained at a stable level, emphasizing the importance of further psychological and psycho-oncological support in these patients. The use of salivary α-amylase as a suitable distress detection marker in pediatric patients undergoing HSCT should be further investigated.","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48431436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Birthe Thing Oggesen, Momena Akbar, Marie Louise Sjødin Hamberg, Thordis Thomsen, Anne Kjaergaard Danielsen, Jacob Rosenberg
Purpose. Treatment of late complications is not systematically provided in Denmark. We therefore established a clinic to treat patients’ late complications. With this study, we wanted to explore patients’ experiences with treatment and care in such a clinic, including their recommendations for the future organization and structure of the clinic. Methods. We conducted a qualitative semistructured interview study with 14 patients who had attended a late complication clinic after treatment for colorectal or anal cancer. We used a descriptive approach to describe the patients’ experiences. Results. We found four major categories: (1) benefitting from the late complication clinic, (2) confusion about which clinic they attended, (3) recommendations for the future of the clinic, and (4) preparation and delivery of the consultations. Patients benefitted from attending the late complication clinic, and some experienced complete relief from symptoms. Others did not, but they gained hope that they might be able to receive treatment in the future. Patients wished for more information about late complications, preferring that the most common symptoms were described along with patient-friendly treatment options. The patients were satisfied with telephone consultations, as they were easy to fit into a daily schedule, and patients found it easy to express themselves openly. Conclusions. Patients were satisfied with the late complication clinic as they felt it gave them a safety net. For the future, patients recommended provision of more information about late complications and possible treatments.
{"title":"Patients’ Experiences in a Newly Established Clinic for Late Complications after Colorectal and Anal Cancer Treatment: A Qualitative Study","authors":"Birthe Thing Oggesen, Momena Akbar, Marie Louise Sjødin Hamberg, Thordis Thomsen, Anne Kjaergaard Danielsen, Jacob Rosenberg","doi":"10.1155/2023/9924560","DOIUrl":"https://doi.org/10.1155/2023/9924560","url":null,"abstract":"Purpose. Treatment of late complications is not systematically provided in Denmark. We therefore established a clinic to treat patients’ late complications. With this study, we wanted to explore patients’ experiences with treatment and care in such a clinic, including their recommendations for the future organization and structure of the clinic. Methods. We conducted a qualitative semistructured interview study with 14 patients who had attended a late complication clinic after treatment for colorectal or anal cancer. We used a descriptive approach to describe the patients’ experiences. Results. We found four major categories: (1) benefitting from the late complication clinic, (2) confusion about which clinic they attended, (3) recommendations for the future of the clinic, and (4) preparation and delivery of the consultations. Patients benefitted from attending the late complication clinic, and some experienced complete relief from symptoms. Others did not, but they gained hope that they might be able to receive treatment in the future. Patients wished for more information about late complications, preferring that the most common symptoms were described along with patient-friendly treatment options. The patients were satisfied with telephone consultations, as they were easy to fit into a daily schedule, and patients found it easy to express themselves openly. Conclusions. Patients were satisfied with the late complication clinic as they felt it gave them a safety net. For the future, patients recommended provision of more information about late complications and possible treatments.","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"234 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135861521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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