Research'n Practical Medicine Journal最新文献

{"title":"FIBROSCLEROSIS AND SCLEROSING ADENOSIS WITH MICROCALCIFICATIONS IN THE BREAST. MOLECULAR PATHOGENESIS, TIMELY DIAGNOSIS AND TREATMENT","authors":"E. Muyzhnek, V. Kiselev, O. Jakobs, N. Rozhkova, A. Kaprin, I. I. Burdina, S. B. Zapirova, M. Mazo, S. Prokopenko, P. G. Labazanova","doi":"10.17709/2409-2231-2019-6-2-8","DOIUrl":"https://doi.org/10.17709/2409-2231-2019-6-2-8","url":null,"abstract":"A brief review of current data on the generality of the epidemiology and molecular pathogenesis of breast cancer and benign breast diseases is presented. Currently, a type of mastopathy, fibrosclerosis/sclerosing adenosis, ac­companied by the formation of microcalcifications, is considered as a benign pathological condition with a high risk of malignancy, and also as a pre-start condition of a possible transition of mastopathy to cancer. In the review is discussed the fundamental biological process of the epithelial-mesenchymal transition (EMT) as a molecular pathogenetic basis of this phenomenon. Identification of the above mentioned pathological changes using mam­mography and refined diagnostics using a vacuum aspiration biopsy allow timely treatment of fibrosclerosis and sclerosing adenosis with Indinol® Forto, a drug of pathogenetic action based on indole-3-carbinol, due to its mul­tiple anticancer and oncoprophylactic activity, including ability to reverse at the epigenetic level the EMT process abnormally proceeding in these benign breast diseases.","PeriodicalId":119961,"journal":{"name":"Research'n Practical Medicine Journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115098962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SIMULTANEOUS SURGICAL TREATMENT OF PATIENTS WITH PRIMARY MULTIPLE SYNCHRONOUS KIDNEY AND PROSTATE CANCER","authors":"N. V. Vorobev, A. Krasheninnikov, F. S. Ashyrova, P. Golubev, Y. Samsonov, A. Kaprin","doi":"10.17709/2409-2231-2019-6-2-12","DOIUrl":"https://doi.org/10.17709/2409-2231-2019-6-2-12","url":null,"abstract":"Presently primary-multiple malignancies are still poorly studied and represent a complex problem in clinical Oncology. The frequency of occurrence of primary-multiple metachronous or synchronous tumors remains at a high level. It is worth noting that about 1.5% of patients with primary multiple tumors had a malignant neoplasm of the prostate. Performing simultaneous laparoscopic operations allow to achieve rapid postoperative rehabilitation of the patient, to avoid the risk of re-operation and anesthesia, in addition, there is a clear economic benefit, there is no need for re-examination and preoperative preparation. This article demonstrates two clinical cases of simultaneous surgical treatment of patients with primary multiple tumors of the kidney and prostate.","PeriodicalId":119961,"journal":{"name":"Research'n Practical Medicine Journal","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132226051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ROLE OF PARASTERNAL MEDIASTINOTOMY IN THE DIAGNOSIS OF MEDIASTINAL TUMORS","authors":"O. Pikin, A. Ryabov, A. Alexandrov, D. Vursol, A. Amiraliev","doi":"10.17709/2409-2231-2019-6-2-1","DOIUrl":"https://doi.org/10.17709/2409-2231-2019-6-2-1","url":null,"abstract":"Parasternal mediastinotomy is a surgical method of morphological verification of mediastinal tumors, widely performed in oncological clinics. The article provides information about the method of implementation and the results of parasternal mediastinotomy for malignant tumors of the mediastinum.Purpose of the study. Evaluation of the results of parasternal mediastinotomy for morphological verification of mediastinal tumors.Patients and methods. The study included 77 patients who for the period from 2008 to 2018. 80 parasternal mediastinotomies were performed with a biopsy of a mediastinal tumor in the conditions of the Department of Thoracic Surgery of the P. Hertsen Moscow Oncology Research Institute. At the stage of preoperative examination, all patients underwent standard diagnostic studies: computed tomography of the chest, abdominal cavity, and a comprehensive ultrasound. In the case of the presence of the endobronchial component of the tumor, fibrobronchoscopy was performed. MRI of the brain was performed in patients with neurological symptoms. 12-lead ECG, echocardiography, and a study of the function of external respiration were performed to assess the functional status of patients.Results. The final histological diagnosis was made in 76 of 77 (99%) patients. The clinical diagnosis of lymphoma was set in 66, thymoma — in 6 patients, lung cancer with affection of mediastinal lymph nodes — in 4 patients, mediastinal tumor — in 4 patients. In 24 patients (31%), operations were preceded by other attempts at morphological verification. In 12 patients — mediastinal tumor biopsy under ultrasound control, in 3 — parasternal mediastinotomy, in 2 — transthoracic mediastinal tumor biopsy combined with biopsy of supraclavicular lymph node under ultrasound control, 2 — biopsy of supraclavicular lymph node under ultrasound control, in 1 — mediastinum tumor biopsy under control. — chest wall biopsy, in 1 — open biopsy with thoracotomic access, in 1 — tonsil biopsy, in 1 — trachea biopsy. In all cases, the indication for performing a parasternal mediastinotomy was an insufficient amount of material for carrying out a complete immunohistochemical study.Conclusion. Parasternal mediastinotomy is a safe and reliable method of morphological verification of the formations of the anterior mediastinum and para-aortic region. In case of the ineffectiveness of transthoracic biopsy under the control of ultrasound or CT navigation, the performing of parasternal mediastinotomy allows to establish a morphological diagnosis and to begin a specific treatment in the shortest possible time.","PeriodicalId":119961,"journal":{"name":"Research'n Practical Medicine Journal","volume":"127 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115615442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MEDICAL AND STATISTICAL CHARACTERISTICS OF BREAST CANCER IN ST. PETERSBURG FEMALE RESIDENTS","authors":"N. S. Romanenkov, V. Hizha, K. N. Movchan, U. M. Morozov, R. M. Gedgafov, A. S. Slobodkina","doi":"10.17709/2409-2231-2019-6-2-3","DOIUrl":"https://doi.org/10.17709/2409-2231-2019-6-2-3","url":null,"abstract":"Purpose. To analyze the main medical and statistical parameters, allowing to evaluate the results of breast cancer treatment. Patients and methods. Data on 4689 breast cancer (BC) patients were analyzed retrospectively. Inclusion criteria were: female, residence in St. Petersburg, diagnosis of BC established in 2011, 2012. The study also includes information on the options of BC surgical treatment, one-year mortality in breast cancer patients and index of the contingent accumulation in St. Petersburg in 2011–2017. For statistical data processing Statistica 12.0 for Windows, Population Cancer Register and MedInfo-4 were used. The differences in the groups of studies were considered statistically significant at p < 0.05.Results. The prevalence of breast cancer among women in St. Petersburg varies from 532.6 per 100 000 population in 2011 to 545.00/0000 in 2012. In 2011 the incidence of BC in women in St. Petersburg was 46.210/0000 (standard deviation 1.05) and in 2012 – 49.50/0000 (standard deviation 1.05). The mean age of breast cancer patients is 64 years (standard deviation 12.25). Localization of a tumor in one of the glands was found in 4617 (98.5%) clinical observations. In 2,846 (60.7%) cases, the tumor sizes varied from 2 to 5 cm. Signs of infiltrative ductal carcinoma were histologically verified in 3689 (80%) cases. The proportion of single-stage breast reconstruction after mastectomy in the overall structure of surgeries in breast cancer patients increased in 2011–2017 more than 6.5 times. The 5-year survival rate in study groups was 64.4% and 63.3%. Conclusions The main statistical parameters of medical care (MC) analysis in breast cancer patients in St. Petersburg in 2011–2017 allow to state generally positive trends in the anticancer fight organization. The increase of the breast cancer incidence rates is partly due to the improved quality of examination and treatment of patients through the creation in the city of a system of high-tech MC, as well as to the particularly wary of doctors in detecting breast tumors.","PeriodicalId":119961,"journal":{"name":"Research'n Practical Medicine Journal","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122842194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FEATURES OF THE TECHNOLOGICAL COMPONENT OF THE IVANOVO REGION HEALTH SYSTEM POLICY IN MALIGNANT TUMORS EARLY DIAGNOSIS","authors":"V. Kozlov, B. A. Polyakov, D. Mushnikov, E. L. Funtikova, D. L. Nedavny","doi":"10.17709/2409-2231-2019-6-2-13","DOIUrl":"https://doi.org/10.17709/2409-2231-2019-6-2-13","url":null,"abstract":"Purpose of the stydy . To study the Features of the technological component of the Ivanovo region health system policy in malignant tumors early diagnosis Materials and methods . The base of the research is the Ivanovo Regional Oncology Dispensery, Department of Health of the Ivanovo Region. Methods: sociological, expert assessment, analytical, documentary. The assessment of the technological component of oncological service policy was carried out in the three areas: a) an assessment of the quality of oncological assistance using the method of correspondence examination of completed cases of assistance with filling out expert assessment cards (600 cases of assistance); b) an assessment of patients' satisfaction with the help provided by the method of a sociological questionnaire survey (600 patients); c) an assessment of the apparent patients' dissatisfaction with the help provided based on the analysis of justified complaints (30 people). Results . The expertize of oncological medical services provided showed that there is a decrease in a number of its properties in modern conditions. The first ranking places in terms of the frequency of violations belong to the following properties of medical services quality: timeliness; adequacy; continuity; performance, availability.  In the structure of medical and organizational defects in the quality of care, according to the results of expert evaluation, the leading part of them- 70.5% — is occupied by diagnostic defects (non-compliance by the medical personnel with the oncological screening standard, non-use of instrumental and laboratory research methods). Conclusion . The policy of oncological care quality has signs of decrease (the number of diagnostic and medical-organi­zational defects averages 1.7 for each case of diagnosed cancer), which leads to advanced cases of oncopathology. The results of the study showed that the current system of oncological care in modern conditions is not sufficiently effective and requires improvement, including by increasing the doctors' level of cancer alertness, increasing the efficiency of the regional cancer pathology commissions.","PeriodicalId":119961,"journal":{"name":"Research'n Practical Medicine Journal","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122654101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A TWO-YEAR STUDY OF CANCEROGENIC POTENTIAL OF THE NEW OPIOID RECEPTOR ANTAGONIST ONDELOPRAN IN RATS","authors":"K. Kryshen, A. Muzhikyan, D. S. Gaidai, K. O. Zaikin, A. E. Katelnikova, M. Samsonov, E. Mukhametshina, G. E. Konopleva, E. Shipaeva, A. Dmitrieva, F. Shagiakhmetov, A. O. Popova, M. Makarova, V. Makarov","doi":"10.17709/2409-2231-2019-6-2-6","DOIUrl":"https://doi.org/10.17709/2409-2231-2019-6-2-6","url":null,"abstract":"Opioid receptor antagonists are widely used for the treatment of alcohol dependence. Currently, original drug Odelepran (INN: ondelopran) with a unique binding profi le to all three types of human opioid receptors (μ, κ, δ) is being developed by R-Pharm.Aim of the study. To investigate a cancerogenic poten\u0085 al of the new opioid receptor antagonist ondelopran in a twoyear study in rats Materials and methods. The study cancerogenic potencial was performed in male and female Wistar rats at the age of 8–10 weeks at the start of experiment. All animals were allocated to 8 groups. Each group consisted of 50 animals of each sex. Test item (ondelopran fi lm-coated tablets, 125 mg), was administered to the animals intragastrically as a tablets suspension in 1% starch solution daily, 5 days a week for 24 months in two doses: 10 mg/kg (equivalent therapeutic dose for humans) and 100 mg/kg. Animals of control groups were administered with placebo and vehicle (1% starch solution). Clinical observation and examination of animals were conducted weekly to detect any signs of intoxication; dynamics of the body weight and registration of animal deaths were also assessed. To assess the rate of the pathological changes, the macro- and microscopic examina\u0085 on of inner organs and neoplasms was conducted.Results. During the study the mortality rates did not diff er between the groups. Clinical signs ts.and symptoms of intoxication upon administration of the tested item and placebo were not observed. Neoplasms were found in the organs of all groups of animals. More than 30 variants of neoplasms were identifi ed upon pathomorphological examination. The identifi ed tumors are typical for rats and considered as spontaneous age-related pathology. There was no statistically signifi cant diff erences between groups in the total incidence of tumors.Conclusion. To conclude the above said, the test item of the ondelopran fi lm-coated tablets, 125 mg have no carcinogenic properties.","PeriodicalId":119961,"journal":{"name":"Research'n Practical Medicine Journal","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115661264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DIABETES INSIPIDUS: LITTLE-KNOWN FACTS","authors":"L. Morgunov","doi":"10.17709/2409-2231-2019-6-2-10","DOIUrl":"https://doi.org/10.17709/2409-2231-2019-6-2-10","url":null,"abstract":"The most common causes of diabetes insipidus are neurosurgical operations on the pituitary gland due to its defeat by benign and malignant tumors, the neoplasms themselves, lymphocytic hypophysitis. Much less is known about the development of metastatic lesions of the pituitary gland by primary tumors of the lung, breast and kidneys. Even less common is diabetes insipidus caused by leukemia, lymphoma, xanthogranulomas, germinomas, HIV infection, pituitary hemorrhage, drug-induced, combined with neurofibromatosis, as well as diabetes insipidus during pregnancy. The review describes the predictors of the development of diabetes insipidus during surgical interventions, the frequency of development and prognosis in various neurosurgical operations. The article focuses doctors of various specialties on timely diagnosis, prevention and treatment of diabetes insipidus, including its atypical forms.","PeriodicalId":119961,"journal":{"name":"Research'n Practical Medicine Journal","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123723087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMMEDIATE AND REMOTE RESULTS OF SURGICAL INTERVENTIONS ON THE BREAST","authors":"В. И. Ярема, О. Э. Фатуев, Н. Г. Степанянц, В. В. Сафронова","doi":"10.17709/2409-2231-2019-6-2-11","DOIUrl":"https://doi.org/10.17709/2409-2231-2019-6-2-11","url":null,"abstract":"Purpose of the study. To assess the women's quality of life when using in the surgical component of the treatment in reconstructive surgeries, and their effect on survival and the period of a relapse-free period. Patients and methods . Within the period 2012-2017, we analyzed the results of surgical treatment of 192 patients diagnosed with breast cancer. Stages of breast cancer were mainly I-IIB (78%). Histologically, in 89% of cases the tumor was represented by invasive non-specific cancer, in most patients the treatment was complex (84%). With it 192 radical Madden mastectomies with and without the reconstruction of the gland were performed. Results. Six months after surgery, the patients were surveyed by a psychologist, 127 (66%) patients evaluated cosmetic surgery results as good, 50 (26%) patients — as satisfactory and 15 (8%) — as unsatisfactory. The unsatisfactory results were primarily attributed to the operation after which there were various postoperative complications, in the form of suppuration of postoperative wounds, lymphorrhea, etc. the Type of surgery does not affect the frequency of comp lica tions such as infectious complications, early postoperative bleeding, lymphorrhea. Conclusion. In case of identical early postoperative complications, we obtain better cosmetic long-term results during reconstructive operations. In reconstructive breast surgery, there are several methods of restoring the lost form of the breast, while oncosurgical patients should be treated individually in each case. Technically, the use of expanders and silicone implants is easier and more convenient for the surgeon and the patient. Women with severe ptosis during the reconstructive stage of treatment with allografts are better to carry out a two-stage reconstruction. The presence of the implant does not affect the course of the postoperative period, the prognosis of survival and the period of recurrence-free period.","PeriodicalId":119961,"journal":{"name":"Research'n Practical Medicine Journal","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114609321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECT OF NATIONAL PROGRAMS IN ONCOLOGY ON SURVIVAL OF PATIENTS WITH RECTAL CANCER: A POPULATION-BASED ANALYSIS","authors":"D. Dubovichenko, M. Valkov, V. Merabishvili, A. Karpunov, L. Valkova, A. Pankratyeva","doi":"10.17709/2409-2231-2019-6-1-1","DOIUrl":"https://doi.org/10.17709/2409-2231-2019-6-1-1","url":null,"abstract":"Objective. Assessment of the impact of National Program «Health» on a rectal cancer (RC) tumor-specific survival in the Arkhangelsk region (AR), Russia over the period 2000–2017 by the data of Arkhangelsk Regional Cancer Registry (ARCR)Materials and methods. Anonymized data on all cases of RC (C19.0–C21.0) in the AR in 2000–2017 were extracted from the database of the ARCR. Over the study period, 4173 cases of the RC were selected. To assess the impact of the National Health Project in 2006 and All-national Dispensarization in 2013, the three time periods were chosen — 2000–2006, 2007–2012 and 2013–2017. Cancer-specific survival (CSS) was calculated. Separate influence of baseline factors on differences in CSS between periods was performed using Cox regression with consecutive input.Results. One- and five year CSS were 62,6% (95% confidence interval (CI) 60,03–65,05%%) and 27,8% (95% CI 25,4–30,2%) in 2000–2006, 65,1% (95% CI 62,5–67,5%) and 32% (95% CI 29,5–34,5%) in 2007–2012, 67,7% (95% CI 65,2–70,1%) and 37,4% (95% CI 33,7–41,1%) in 2013–2017, respectively.In univariate analysis the risk of death in the latest time periods was significantly lower: HR 0.86 (95% CI 0.79–0.95), p < 0.05 and 0.74 (95% CI 0.67–0.82), p<0.0001 for 2007–2012 and 2013–2017, respectively, comparing to 2000–2006. In a multivariate model only correction for treatment type has led to change of the coefficients between time periods: HR 0.94 (95% CI 0.86–1.03) and 0.84 (95% CI 0.75–0.93) for 2007–2012 and 2013–2017, respectively. The CSS was also in­dependently influenced by stage, age at diagnosis, place of residence and type of treatment.Conclusion. Population-based five-year CSS of patients with RC increased by 8% during the analyzed period. Better CSS in the latest time period is associated rather with improvement of treatment than earlier detection of RC.","PeriodicalId":119961,"journal":{"name":"Research'n Practical Medicine Journal","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122304962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MULTIPLE SURGICAL TREATMENT OF A FEMALE PATIENT WITH RECURRENT PELVIC TERATOMA","authors":"I. Moshurov, D. A. Golovkov, L. Petrov, D. V. Sukhoverkov, M. B. Bykovtsev, N. S. Ryabkov","doi":"10.17709/2409-2231-2019-6-1-12","DOIUrl":"https://doi.org/10.17709/2409-2231-2019-6-1-12","url":null,"abstract":"Teratoma is a tumor consisting of several types of tissues derived from one, two or three germ leaves, the presence of which is not peculiar to those organs and anatomical areas of the body in which the tumor develops. According to the WHO classification definition, immature teratomas are those containing embryonic tissues along with definitive, mature tissue structures. In histological WHO classification immature teratomas belong to germ cell ovarian tumors and are in­cluded into the group of teracomas. The prognosis is determined by the variant of the histological structure, the primary localization of the tumor, timely and adequate treatment.This article presents a clinical case of treatment of a young female patient with persistently recurrent pelvic teratoma.The presented observation demonstrates, on the one hand, the unpredictability of the course of the tumor process in embryonic tumors. On the other hand, there were demonstrated the possibilities of surgical treatment of another re­lapse of teratoma in a young patient with a massive tumor of the pelvic cavity in a situation where the hopes for a radical operation according to previous abdominal revisions seemed vague.","PeriodicalId":119961,"journal":{"name":"Research'n Practical Medicine Journal","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115411500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}