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iADRs: towards a web-based interactive adverse drug reaction analyzing system 基于网络的交互式药物不良反应分析系统
Pub Date : 2012-03-01 DOI: 10.1145/2180796.2180814
Wen-Yang Lin, He-Yi Li, Jhih-Wei Du, Wen-Yu Feng, Chiao-Feng Lo
Adverse Drug Reaction (ADR) is one of the most important issues on drug safety assessment. Many adverse drug reactions cannot be discovered through limited pre-marketing clinical trials; instead, they can only be recognized by a long term of post-marketing surveillance of drug usages. In this paper, we propose an interactive system platform for ADRs detection. By integrating the concept of ADRs data warehouse and innovative data mining techniques, the proposed system can not only support OLAP style of multidimensional analysis of ADRs, but also offer interactive discovery of associations between drugs and symptoms, called drug-ADR association rule, which can be further specialized by other factors interesting to users, such as demographic information. Experiments indicate that interesting and valuable drug-ADR association rules can be efficiently mined.
药品不良反应(ADR)是药品安全性评价的重要问题之一。许多药物不良反应不能通过有限的上市前临床试验发现;相反,它们只能通过对药物使用的长期上市后监测来识别。本文提出了一种用于adr检测的交互式系统平台。通过整合adr数据仓库的概念和创新的数据挖掘技术,所提出的系统不仅可以支持OLAP风格的adr多维分析,还可以提供药物与症状之间关联的交互式发现,称为药物- adr关联规则,该规则可以通过用户感兴趣的其他因素(如人口统计信息)进一步专业化。实验表明,该方法可以有效地挖掘出有趣且有价值的药物- adr关联规则。
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引用次数: 1
10 advantages of using avatars in patient-centered computer-based interventions for behavior change 在以患者为中心的基于计算机的行为改变干预中使用化身的10个优势
Pub Date : 2012-03-01 DOI: 10.1145/2180796.2180820
C. Lisetti
Recent epidemics of behavioral issues such as obesity, excessive alcohol, tobacco, and drug use, place people at risk of diseases (e.g. diabetes, cardiovascular troubles) which can often be prevented by lifestyle changes such as loosing weight with a diet and/or physical exercise. Medicine has therefore started to move toward finding ways of preventively promoting wellness rather than solely treating already established illness. Health promotion interventions aimed at helping people to change lifestyle are being deployed, but the epidemic nature of these problems calls for drastic measures to rapidly increase access to effective behavior change interventions for diverse populations. We posit that not only is automation needed, but that computer-based interventions (CBI) delivered by empathic virtual avatars also offer complementary advantages to human healthcare, listed below: 1. increase accessibility: as few as one or two short lifestyle change interventions often yield greater change than no counseling at all (Miller&Rollinick, 2002), and yet these short interventions are often unavailable. Because people accept computer-based assessment and feedback programs (Skinner, 1994; Cunningham, 1999) and because these can easily be reproduced (e.g. PC, web, mobile applications), CBIs can increase accessibility to health interventions; 2. increase confidentiality and divulgation: patients that engage in behavior that can put them at risk report more information to a computer interviewer than to its human counterpart (ServanSchreiber, 1986). Provided with sensitive information that a human would not have access to, CBIs can address issues that would otherwise be ignored; 3. tailor information: tailored communication, intended to reach one specific person’s needs vs. generic communication (e.g. a brochure), lead to better patient outcomes and are derived from individual assessment. CBIs can assess and create a user profile to deliver tailored information, and dynamically update the user profile over multiple adaptive sessions; 4. diminish variability: there exists wide variability (25%100%) in different counselor’s rates of improvement among their patients (Miller&Rollnick, 2002). When trained personnel is not available, a good CBI can eliminate variability, providing more people with motivating experiences; 5. avoid righting reflex with infinite patience: Counselors often experience the righting reflex, or the tendency to set things right by employing direct advocacy, thereby acting out patients’ ambivalence toward change. But providing extrinsic motivation is not conducive of change, and successful counselors are ones who can inhibit their righting reflex (Miller&Rollnick, 2002). Though we thrive to build humane computers, computers inherently do not have the righting reflex and can respect patients’ pace toward change (Prochaska, 1997) by demonstrating infinite patience; 6. address low literacy: most efforts to provide patients with web-based interven
最近流行的行为问题,如肥胖、过度饮酒、吸烟和吸毒,使人们面临疾病(如糖尿病、心血管疾病)的风险,而这些疾病通常可以通过改变生活方式,如通过节食和/或体育锻炼来减肥来预防。因此,医学已经开始朝着寻找预防性促进健康的方法而不是仅仅治疗已经确立的疾病的方向发展。正在采取旨在帮助人们改变生活方式的健康促进干预措施,但这些问题的普遍性要求采取严厉措施,迅速增加不同人群获得有效的行为改变干预措施的机会。我们认为,不仅需要自动化,而且由移情虚拟化身提供的基于计算机的干预(CBI)也为人类医疗保健提供了补充优势,如下所列:增加可及性:一到两次短期的生活方式改变干预往往比完全没有咨询产生更大的变化(Miller&Rollinick, 2002),然而这些短期的干预往往是不可获得的。因为人们接受基于计算机的评估和反馈程序(Skinner, 1994;Cunningham, 1999),而且由于这些可以很容易地复制(例如个人电脑、网络、移动应用程序),CBIs可以增加获得卫生干预措施的机会;2. 增加保密性和泄露:从事可能使他们处于危险中的行为的患者向计算机采访者报告的信息比向人类采访者报告的信息更多(ServanSchreiber, 1986)。cbi提供了人类无法访问的敏感信息,可以解决否则会被忽视的问题;3.量身定制的信息:量身定制的沟通,旨在满足一个特定的人的需求,而不是通用的沟通(如小册子),可以带来更好的患者结果,并且来自个人评估。cbi可以评估和创建用户配置文件,以提供量身定制的信息,并在多个自适应会话中动态更新用户配置文件;4. 减少可变性:在不同的咨询师的病人的改善率上存在很大的可变性(25% - 100%)(Miller&Rollnick, 2002)。当没有训练有素的人员时,一个好的CBI可以消除可变性,为更多的人提供激励经验;5. 以无限的耐心避免纠正反射:咨询师经常会经历纠正反射,或者倾向于通过直接的辩护来纠正事情,从而表现出患者对改变的矛盾心理。但是提供外在动机是不利于改变的,成功的咨询师是那些能够抑制他们的纠正反射的人(Miller&Rollnick, 2002)。虽然我们热衷于制造人性化的计算机,但计算机本身没有纠正反射,可以通过表现出无限的耐心来尊重患者走向变化的步伐(Prochaska, 1997);6. 解决识字率低的问题:为患者提供基于网络的干预措施的大多数努力都使用文本进行交流。美国人的平均阅读水平为8年级,20%的人的阅读水平低于5年级(Neuhauser&Kreps, 2011)。所以他们不仅不想看网页,很多人也没有能力。类似的问题也出现在技术恐惧症用户身上。具体化会话代理(eca) (Cassell, 2000)是使用合成文本到语音进行交流的虚拟角色,因此可以缩小低阅读和/或计算机读写能力人群的读写能力差距(Lisetti&Wagner, 2008);7. 减少高流失率:身体的体现和存在增加了重要性和社会便利(Zajonc, 1965)。当人们拟人化计算机角色时,他们会更加投入,进行社交互动,并尝试对话基础(Reeves&Nass, 1996;Kiesler et al., 2008)。基于化身的干预措施可以通过增加用户粘性来解决当前CBIs中存在的高流失率问题;8. 实施医患协调:种族/语言协调与医疗保健过程的质量之间有着密切的联系。然而,尽管非洲裔、西班牙裔和美洲原住民占美国人口的25%以上,但他们只占不到9%的护士、6%的医生和5%的牙医(Cooper&Power, 2004)。虽然卫生专业人员的种族多样性正在增加,但eca的种族特征已经可以与患者的种族相匹配,并立即有助于填补目前的种族一致性差距,因为eca中的人们对种族的反应与人类相同(Nass&Ibister, 2003);9. 提供工作联盟:一个强大的病人-医生工作联盟是积极的病人结果的最重要的预测因素之一。由于它们的拟人化特征,eca提供了强大的社会线索,人们可以与它们建立类似于工作联盟的个人关系(例如教练、同伴)(Cassell, 2000);10. 表达同理心:健康从业者表现出同理心的能力对成功至关重要(Miller&Rollnick, 2002)。 早期的研究表明,建立共情模型是可行的(Gratch et al., 2011),进一步的进展将使人们能够依靠与他们的网络帮助代理的长期支持关系来促进健康。
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引用次数: 18
An agenda for ultra-large-scale system research for global health informatics 全球卫生信息学的超大规模系统研究议程
Pub Date : 2012-03-01 DOI: 10.1145/2180796.2180804
J. Facelli
This extended abstract describes the characteristics of Ultra- Large-Scale Systems (ULSS) and the gaps in our understanding of these systems. We compare the characteristics of ULSS with the desired characteristics for national and global health information systems. Using the methodology proposed for the US Department of Defense and representative global health scenarios, we identify a strategy to develop a research agenda in Ultra-Large-Scale-Systems for Global Health Informatics.
这篇扩展摘要描述了超大规模系统(ULSS)的特点和我们对这些系统的理解差距。我们将ULSS的特征与国家和全球卫生信息系统的期望特征进行比较。使用为美国国防部提出的方法和具有代表性的全球健康情景,我们确定了在全球健康信息学的超大规模系统中制定研究议程的策略。
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引用次数: 3
A new paradigm for the development of future medical software systems 为未来医疗软件系统的发展提供了一个新的范例
Pub Date : 2012-03-01 DOI: 10.1145/2180796.2180812
G. Meixner, D. Zühlke
In many areas of human life, computer-based Information Technology (IT) has prevailed and become essential for the coordinated and efficient organization of workflows. Especially in the field of health care, interaction between human beings and IT is a sensitive subject. Inevitably, people working in the field of health care will have to make use of the potentials of IT in order to meet the enormous demands on e.g. patient management. When we look at the situation of current medical software systems, we can find major advances in the performance capacities of modern software systems, but must also note their rapid penetration into almost every facet of the daily hospital routine. Today medical software systems can be characterized as a vast number of (networked) software which each fulfills specific functions (e.g., hospital information system, Picture Archiving and Communication System) and which is used by different user groups (e.g., physicians, nurses, medical secretaries) with diverse user tasks [4]. Yet, for almost two decades, graphical user interfaces have dominated the interaction of medical software systems in most cases. In the future, a broader range of paradigms will emerge, allowing for multi-modal interaction. But also the growing number of heterogeneous platforms (operating systems, graphical libraries) and devices utilized complementarily (e.g., PC, Toughbook, Smartphone, PDA) demand for the development of congeneric user interfaces for a plethora of target platforms. Especially "mobile healthcare computing devices (MHCDs) are rapidly becoming an integral part of hospital information systems. Deployment of these devices is becoming an important IT strategy designed to assist in improving quality of care, enhancing patient services, increasing productivity, lowering costs, improving cash flow, as well as facilitating other critical delivery processes" [3]. For MHCDs aspects like getting the right information at the right time in the right place (context sensitivity) is important. To be able to cope with requirements like interoperability, context-sensitivity and device-independent usage a model-based approach for the development of user interfaces (MBUID) appears to be favourable [2].
在人类生活的许多领域,基于计算机的信息技术(IT)已经盛行,并成为协调和有效组织工作流程的必要条件。特别是在医疗保健领域,人与信息技术的互动是一个敏感的话题。不可避免地,在卫生保健领域工作的人们将不得不利用信息技术的潜力,以满足病人管理等方面的巨大需求。当我们观察当前医疗软件系统的情况时,我们可以发现现代软件系统在性能能力方面取得了重大进展,但也必须注意到它们迅速渗透到医院日常工作的几乎每一个方面。今天的医疗软件系统可以被描述为大量的(网络化的)软件,每个软件都实现特定的功能(例如,医院信息系统,图片存档和通信系统),由不同的用户群体(例如,医生,护士,医务秘书)使用,具有不同的用户任务[4]。然而,近二十年来,图形用户界面在大多数情况下主导了医疗软件系统的交互。在未来,将出现更广泛的范例,允许多模态交互。但是,越来越多的异构平台(操作系统,图形库)和互补使用的设备(例如,PC, Toughbook,智能手机,PDA)也需要为过多的目标平台开发相同的用户界面。特别是移动医疗计算设备(mhcd)正迅速成为医院信息系统不可或缺的一部分。这些设备的部署正在成为一项重要的IT战略,旨在帮助提高护理质量,增强患者服务,提高生产力,降低成本,改善现金流,并促进其他关键的交付流程。对于mhcd来说,在正确的时间、正确的地点获得正确的信息(上下文敏感性)等方面非常重要。为了能够处理诸如互操作性、上下文敏感性和与设备无关的使用等需求,基于模型的用户界面开发方法(MBUID)似乎是有利的。
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引用次数: 1
Statistical analysis of PET images PET图像的统计分析
Pub Date : 2012-03-01 DOI: 10.1145/2180796.2180807
P. Vizza, P. Veltri, G. Cascini
In recent decades, neuroimaging techniques have become relevant and essential supports to the diagnosis and therapy of neurological diseases. Positron Emission Tomography (PET) is a method of functional investigation that measures brain metabolism and identifies the changes that occur at cellular and molecular level, supporting physicians for studying neurological diseases, and for the definition of the diagnosis. To support image studies, there exist automatic PET images analysis algorithms; e.g., voxel-byvoxel analysis technique allows to obtain statistical measurements that can be associated to functional neurological anomalies. Research groups, both physicians as well as computer scientists, have performed statistical analysis on images dataset to identify regions of variation of the glucose in the brain [1-2]. Although these studies demonstrate that a particular group of Regions Of Interest (ROIs) identifies specific pathologies, today systems for the automatic diseases classification are still not available.
近几十年来,神经影像学技术已成为神经系统疾病诊断和治疗的重要支持手段。正电子发射断层扫描(PET)是一种功能研究方法,可以测量脑代谢并识别细胞和分子水平上发生的变化,支持医生研究神经系统疾病并定义诊断。为了支持图像研究,已有PET图像自动分析算法;例如,体素-逐体素分析技术可以获得与功能性神经异常相关的统计测量。包括医生和计算机科学家在内的研究小组已经对图像数据集进行了统计分析,以确定大脑中葡萄糖的变化区域[1-2]。尽管这些研究表明,一组特定的感兴趣区域(roi)可以识别特定的病理,但目前仍然没有用于疾病自动分类的系统。
{"title":"Statistical analysis of PET images","authors":"P. Vizza, P. Veltri, G. Cascini","doi":"10.1145/2180796.2180807","DOIUrl":"https://doi.org/10.1145/2180796.2180807","url":null,"abstract":"In recent decades, neuroimaging techniques have become relevant and essential supports to the diagnosis and therapy of neurological diseases. Positron Emission Tomography (PET) is a method of functional investigation that measures brain metabolism and identifies the changes that occur at cellular and molecular level, supporting physicians for studying neurological diseases, and for the definition of the diagnosis. To support image studies, there exist automatic PET images analysis algorithms; e.g., voxel-byvoxel analysis technique allows to obtain statistical measurements that can be associated to functional neurological anomalies. Research groups, both physicians as well as computer scientists, have performed statistical analysis on images dataset to identify regions of variation of the glucose in the brain [1-2]. Although these studies demonstrate that a particular group of Regions Of Interest (ROIs) identifies specific pathologies, today systems for the automatic diseases classification are still not available.","PeriodicalId":120498,"journal":{"name":"SIGHIT Rec.","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126827685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Effect of measuring number of steps with a digital pedometer on female student physical activity 用数字计步器测量步数对女学生身体活动的影响
Pub Date : 2012-03-01 DOI: 10.1145/2180796.2180799
M. Sugano, Rika Hirano
In recent years, various attempts have been made to improve lifestyle by means of a life log, which records behavior and patterns of life by using digital equipment. Small digital pedometers are useful for obtaining life log data since it is possible to record not only number of steps or energy consumption, but also activity time [1]. Here we assess the effect of number of steps, measured with a digital pedometer, on increasing the frequency of walking. In this study, we modified a standard pedometer so that the display was not visible and then carried out a crossover examination by dividing candidates into two groups. In addition, we issued a questionnaire to candidates to investigate their awareness of the pedometer display.
近年来,通过使用数字设备记录行为和生活模式的生活日志,人们进行了各种尝试来改善生活方式。小型数字计步器对于获取生活日志数据非常有用,因为它不仅可以记录步数或能量消耗,还可以记录活动时间[1]。在这里,我们评估步数的影响,用数字计步器测量,对增加步行频率。在这项研究中,我们修改了一个标准计步器,使其显示不可见,然后通过将候选人分为两组进行交叉检查。此外,我们向考生发放了一份问卷,调查他们对计步器显示的认识。
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引用次数: 0
Implementing a specification for exceptional data in multilevel modeling of healthcare applications 为医疗保健应用程序的多层建模中的异常数据实现规范
Pub Date : 2012-03-01 DOI: 10.1145/2180796.2180803
T. Cook, L. Cavalini
Missing information are key issues for interoperability and semantic coherence in healthcare information systems. This paper presents the implementation of the Exceptional Package in the Multilevel Healthcare Information Modeling (MLHIM) specifications, and it describes two use cases where missing information is critical for decision-making and healthcare technology assessment.
信息缺失是影响医疗信息系统互操作性和语义一致性的关键问题。本文介绍了多层医疗保健信息建模(MLHIM)规范中异常包的实现,并描述了两个用例,其中缺失的信息对决策和医疗保健技术评估至关重要。
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引用次数: 2
Sentiment analysis of speech prosody for dialogue adaptation in a diet suggestion program 某饮食建议节目对白适应的语音韵律情感分析
Pub Date : 2012-03-01 DOI: 10.1145/2180796.2180800
Scott Crouch, R. Khosla
In recent years, programs have been developed which allow robots to engage in simple dialogues with hospital and aged-care patients in order to provide information on and give healthrelated advice. To enable the robot to be persuasive and be accepted by the patient, it must not only understand their responses, but also understand their emotional state [1]. This information can then be used to modify the robot's responses. In an example dialogue, the robot asks whether the patient believes they overeat, to which the patient might respond "I don't overeat". If the patient has responded in a negative emotional tone, this may indicate a refusal to acknowledge the problem rather than the absence of it. In addition, the robot needs to learn to avoid responses which may provoke the patient. At that stage the goal of the robot is to convince the patient to acknowledge the problem before developing ways to solve it. One method of collecting data about patients' emotional state is to analyze prosodic features of their speech. Prosodic features are the patterns of frequency, energy (volume), and rate of speech. Prosodic features have been known for a long time to reflect the speaker's emotional state, as was first documented by Charles Darwin in The Descent of Man [2], which also showed that, even in other animals whose vocalizations contain no linguistic properties, feelings can be expressed. The main motivation for the development of this software is to improve upon a diet-suggestion dialogue system currently being developed and tested in aged-care homes.1 The elderly subject engages in dialogue with a health care robot, which provides suggestions to that person's diet, whilst also raising their motivation levels, and improve their perception of the robotic agent.
近年来,已经开发了一些程序,使机器人能够与医院和老年护理病人进行简单的对话,以提供有关健康的信息和建议。为了使机器人具有说服力并被患者接受,它不仅要了解患者的反应,还要了解患者的情绪状态[1]。这些信息可以用来修改机器人的反应。在一个示例对话中,机器人询问患者是否认为自己吃得过饱,患者可能会回答“我没有吃得过饱”。如果病人以消极的情绪语气回应,这可能表明他拒绝承认问题,而不是不存在问题。此外,机器人需要学会避免可能激怒患者的反应。在这个阶段,机器人的目标是在找到解决问题的方法之前说服病人承认这个问题。收集患者情绪状态数据的一种方法是分析他们说话的韵律特征。韵律特征是频率、能量(音量)和语速的模式。韵律特征反映说话人的情绪状态早已为人所知,查尔斯·达尔文(Charles Darwin)在《人类的起源》(the Descent of Man)中首次记录了这一点[2],这也表明,即使在其他发声不含语言特性的动物中,情感也是可以表达的。开发该软件的主要动机是改进目前正在养老院开发和测试的饮食建议对话系统老年人与医疗保健机器人进行对话,机器人为老年人的饮食提供建议,同时提高他们的动力水平,并改善他们对机器人代理的感知。
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引用次数: 5
Towards dynamic ontologies repository building 朝着构建动态本体存储库的方向发展
Pub Date : 2012-03-01 DOI: 10.1145/2180796.2180819
G. Diallo, M. Simonet
Biomedical researchers and healthcare professionals use ontologies to annotate data for facilitating data sharing and integration. And the wide availability of ontologies in the medical domain offers the possibility of supporting multiple knowledge based applications. In their daily activities researchers and clinical investigator may need manipulating many and hence heterogeneous ontologies. We have designed and implemented ServO (Ontology Server). ServO is a tool for a fast building of ontologies repository described in the RDF and OWL standards languages. It is available as Java API and is based on IR techniques. It supports indexing multiple heterogeneous ontologies and retrieving similar entities between them. A web client prototype is implemented to showcase some functionalities of the tool.
生物医学研究人员和医疗保健专业人员使用本体对数据进行注释,以促进数据共享和集成。医学领域本体的广泛可用性为支持多种基于知识的应用提供了可能性。在他们的日常活动中,研究人员和临床研究者可能需要操纵许多不同的本体。我们设计并实现了ServO (Ontology Server)。ServO是一个用于快速构建以RDF和OWL标准语言描述的本体存储库的工具。它可以作为Java API使用,并且基于IR技术。它支持为多个异构本体建立索引,并在它们之间检索相似的实体。实现了一个web客户端原型来展示该工具的一些功能。
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引用次数: 0
Everest: a framework for developing HL7v3 applications Everest:用于开发HL7v3应用程序的框架
Pub Date : 2012-03-01 DOI: 10.1145/2180796.2180816
Justin Fyfe, D. Bender, H. K. Edwards
Producing applications that conform to the requirements of the Health Level 7 (HL7) framework is beneficial for the accurate recordation, transmittal and sharing of medical information across organizations. Conformance to these requirements ultimately help to improve the quality of health services delivered to consumers. This paper describes Everest, a free and open source framework that allows developers to create and test HL7v3 applications.
生成符合Health Level 7 (HL7)框架要求的应用程序有助于跨组织准确地记录、传输和共享医疗信息。遵守这些要求最终有助于提高向消费者提供的保健服务的质量。本文描述了Everest,这是一个允许开发人员创建和测试HL7v3应用程序的免费开源框架。
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引用次数: 3
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SIGHIT Rec.
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