Shao-Wei Weng, Tzu-Lun Huang, Pei-Yuan Su, Pei-Yao Chang, Jia-Kang Wang
The purpose of this article is to report a case with rubeosis iridis treated by intravitreal aflibercept. A 61-year-old man had iris neovascularization and scanty vitreous hemorrhage secondary to proliferative diabetic retinopathy in the right eye. Neither neovascularization of angle nor elevation of intraocular pressure was found. Single intravitreal aflibercept 2 mg injection was performed. Rubeosis iridis disappeared on the next day. Scattered retinal laser photocoagulation was added 1 week later. There was no recurrence after 3-month follow-up. Aflibercept may serve as another anti-vascular endothelial growth factor (anti-VEGF) for treating rubeosis iridis.
{"title":"Intravitreal aflibercept for rubeosis iridis secondary to proliferative diabetic retinopathy.","authors":"Shao-Wei Weng, Tzu-Lun Huang, Pei-Yuan Su, Pei-Yao Chang, Jia-Kang Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of this article is to report a case with rubeosis iridis treated by intravitreal aflibercept. A 61-year-old man had iris neovascularization and scanty vitreous hemorrhage secondary to proliferative diabetic retinopathy in the right eye. Neither neovascularization of angle nor elevation of intraocular pressure was found. Single intravitreal aflibercept 2 mg injection was performed. Rubeosis iridis disappeared on the next day. Scattered retinal laser photocoagulation was added 1 week later. There was no recurrence after 3-month follow-up. Aflibercept may serve as another anti-vascular endothelial growth factor (anti-VEGF) for treating rubeosis iridis.</p>","PeriodicalId":12096,"journal":{"name":"Eye science","volume":"30 4","pages":"201-3"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34510888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: This study aimed to explore the best screening measure of myopia and its associated optimal referral criteria for children aged between 6 and 16.
Methods: After informed consent of cycloplegia was obtained, a total of 6,321 children aged between 6 and 16 from 53 primary or junior middle schools in Jiading District of Shanghai were included in our population-based study. Receiver operating characteristic (ROC) curve was performed to determine the best cutoff points, sensitivities and specificities of different screening tests, including uncorrected visual acuity (UCVA), noncycloplegic autorefraction (NCAR) and the combination of these two tests.
Results: There was significant difference in prevalence of myopia between boys and girls (χ2 = 6.358, P = 0.012). Compared with children of low age, the prevalence of older children was significantly higher (χ2 = 1,386.404, P < 0.001). For the combination of UCVA and NCAR, the best cutoff point was UCVA less than or equal to 0.2 logarithm of minimum angle of resolution (MAR) (20/30) and NCAR spherical equivalent refraction (SER) less than or equal to -0.75 diopters (D), with associated sensitivity and specificity of 75.0% and 85.0%, respectively, which were higher than those of UCVA and NCAR alone. After stratified by age, the best cutoff points were varied among children. The accuracy for children aged between 9 and 12 was higher than that for other ages.
Conclusions: The best screening measure of myopia was the combination of UCVA and NCAR. The optimal referral criteria of myopia for children should be age-determined.
背景:本研究旨在探讨6 - 16岁儿童近视的最佳筛查措施及其相关的最佳转诊标准。方法:在获得睫状体麻痹知情同意后，将上海市嘉定区53所中小学6 ~ 16岁的6321名儿童纳入人群研究。采用受试者工作特征(ROC)曲线确定未矫正视力(UCVA)、非睫状体麻痹性自折射(NCAR)及两项检测联合的最佳分界点、灵敏度和特异性。结果:男童、女童近视患病率差异有统计学意义(χ2 = 6.358, P = 0.012)。与低龄儿童相比，大龄儿童的患病率明显高于低龄儿童(χ2 = 1386.404, P < 0.001)。UCVA与NCAR联合应用时，最佳截断点为UCVA小于等于最小分辨角(MAR)(20/30)的0.2对数，NCAR球面等效折射(SER)小于等于-0.75屈光度(D)，相关灵敏度和特异度分别为75.0%和85.0%，高于UCVA和NCAR单独应用。在按年龄分层后，最佳分界点在儿童中有所不同。9 - 12岁儿童的准确率高于其他年龄段的儿童。结论:UCVA联合NCAR是近视的最佳筛查手段。儿童近视的最佳转诊标准应由年龄决定。
{"title":"Age-determined referral criteria of myopia for large-scale vision screening.","authors":"Hongjie Yu, Yueqin Shao, Hong Yuan, Bo Yan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to explore the best screening measure of myopia and its associated optimal referral criteria for children aged between 6 and 16.</p><p><strong>Methods: </strong>After informed consent of cycloplegia was obtained, a total of 6,321 children aged between 6 and 16 from 53 primary or junior middle schools in Jiading District of Shanghai were included in our population-based study. Receiver operating characteristic (ROC) curve was performed to determine the best cutoff points, sensitivities and specificities of different screening tests, including uncorrected visual acuity (UCVA), noncycloplegic autorefraction (NCAR) and the combination of these two tests.</p><p><strong>Results: </strong>There was significant difference in prevalence of myopia between boys and girls (χ2 = 6.358, P = 0.012). Compared with children of low age, the prevalence of older children was significantly higher (χ2 = 1,386.404, P < 0.001). For the combination of UCVA and NCAR, the best cutoff point was UCVA less than or equal to 0.2 logarithm of minimum angle of resolution (MAR) (20/30) and NCAR spherical equivalent refraction (SER) less than or equal to -0.75 diopters (D), with associated sensitivity and specificity of 75.0% and 85.0%, respectively, which were higher than those of UCVA and NCAR alone. After stratified by age, the best cutoff points were varied among children. The accuracy for children aged between 9 and 12 was higher than that for other ages.</p><p><strong>Conclusions: </strong>The best screening measure of myopia was the combination of UCVA and NCAR. The optimal referral criteria of myopia for children should be age-determined.</p>","PeriodicalId":12096,"journal":{"name":"Eye science","volume":"30 4","pages":"151-5"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34509378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jia-Kang Wang, Tzu-Lun Huang, Pei-Yuan Su, Pei-Yao Chang
Diabetic macular edema (DME) is a major sight-threatening cause in diabetic patients. We review the long-term outcome of four approved pharmacotherapy for treating DME, including intravitreal injections of corticosteroids (dexamethasone implants and fluocinolone acetonide inserts) and anti-vascular endothelial growth factor (VEGF) (ranibizumab and aflibercept). They all show superior ability to improve vision and reduce macular thickness, comparing with sham injections or macular focal/grid laser treatment. Anti-VEGF agents result in low incidence of severe ocular or systemic adverse effects, but glaucoma and cataract should be aware after intravitreal corticosteroids. Prompt treatment with these agents can lead to a better outcome
{"title":"An updated review of long-term outcomes from randomized controlled trials in approved pharmaceuticals for diabetic macular edema.","authors":"Jia-Kang Wang, Tzu-Lun Huang, Pei-Yuan Su, Pei-Yao Chang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Diabetic macular edema (DME) is a major sight-threatening cause in diabetic patients. We review the long-term outcome of four approved pharmacotherapy for treating DME, including intravitreal injections of corticosteroids (dexamethasone implants and fluocinolone acetonide inserts) and anti-vascular endothelial growth factor (VEGF) (ranibizumab and aflibercept). They all show superior ability to improve vision and reduce macular thickness, comparing with sham injections or macular focal/grid laser treatment. Anti-VEGF agents result in low incidence of severe ocular or systemic adverse effects, but glaucoma and cataract should be aware after intravitreal corticosteroids. Prompt treatment with these agents can lead to a better outcome</p>","PeriodicalId":12096,"journal":{"name":"Eye science","volume":"30 4","pages":"176-83"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34509383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-24DOI: 10.3978/J.ISSN.1000-4432.2015.11.02
Jinglin Zhang, Yong-hao Li, Xiujuan Zhao, Yu Cai, Xiling Yu, Lin Lu
BACKGROUND The purpose is to investigate the relationship between full-thickness macular hole (MH) and retinal break (RB) and/or lattice degeneration. METHODS Patients diagnosed as full-thickness MH and referred to Dr. Lin Lu from January 2009 to December 2013 were evaluated. All patients underwent general ophthalmologic examinations, fundus examination and optical coherence tomography (OCT). The RB and/or lattice degeneration were recorded. RESULTS Totally 183 eyes of 167 patients were included. The sex ratio of men to women was 1:2.88. A total of 17 eyes were pseudophakic and 166 eyes were phakic. RB and/or lattice degeneration were found in 62 eyes (33.88%). The prevalence of RB and/or lattice degeneration was similar between men and women (P = 0.344 > 0.05). There was no statistical difference between the pseudophakic eyes and phakic eyes (P = 0.138 > 0.05). All of the RB and/or lattice degeneration were located near or anterior to the equator. The inferior quadrants and the vertical meridian were affected more often than the superior quadrants and the horizontal meridian. CONCLUSIONS We identified a high incidence of RB/lattice degeneration in cases of full-thickness MH. Carefully examination of the peripheral retina and prophylactic treatment of RB and/or lattice degeneration are critical.
{"title":"Relationship between full-thickness macular hole and retinal break/lattice degeneration.","authors":"Jinglin Zhang, Yong-hao Li, Xiujuan Zhao, Yu Cai, Xiling Yu, Lin Lu","doi":"10.3978/J.ISSN.1000-4432.2015.11.02","DOIUrl":"https://doi.org/10.3978/J.ISSN.1000-4432.2015.11.02","url":null,"abstract":"BACKGROUND\u0000The purpose is to investigate the relationship between full-thickness macular hole (MH) and retinal break (RB) and/or lattice degeneration.\u0000\u0000\u0000METHODS\u0000Patients diagnosed as full-thickness MH and referred to Dr. Lin Lu from January 2009 to December 2013 were evaluated. All patients underwent general ophthalmologic examinations, fundus examination and optical coherence tomography (OCT). The RB and/or lattice degeneration were recorded.\u0000\u0000\u0000RESULTS\u0000Totally 183 eyes of 167 patients were included. The sex ratio of men to women was 1:2.88. A total of 17 eyes were pseudophakic and 166 eyes were phakic. RB and/or lattice degeneration were found in 62 eyes (33.88%). The prevalence of RB and/or lattice degeneration was similar between men and women (P = 0.344 > 0.05). There was no statistical difference between the pseudophakic eyes and phakic eyes (P = 0.138 > 0.05). All of the RB and/or lattice degeneration were located near or anterior to the equator. The inferior quadrants and the vertical meridian were affected more often than the superior quadrants and the horizontal meridian.\u0000\u0000\u0000CONCLUSIONS\u0000We identified a high incidence of RB/lattice degeneration in cases of full-thickness MH. Carefully examination of the peripheral retina and prophylactic treatment of RB and/or lattice degeneration are critical.","PeriodicalId":12096,"journal":{"name":"Eye science","volume":"115 1","pages":"156-9"},"PeriodicalIF":0.0,"publicationDate":"2015-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88212613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-09-15DOI: 10.3969/J.ISSN.1000-4432.2015.03.001
Jiakui Wang, Tzu-Lun Huang, Pei-Yuan Su, P. Chang
PURPOSE To investigate the correlation of various corneal hysteresis (CH) factors in Chinese adults. METHODS From January 2009 to November 2011, the healthy right eyes of a total of 292 adults were recruited into the study. Goldmann-correlated intraocular pressure (IOPG) and CH were measured using an ocular response analyzer (ORA). Central corneal thickness was measured using the ORA's integrated handheld ultrasonic pachymeter. The IOLMaster was used to obtain the ocular biometric measurements including axial length, anterior chamber depth, and keratometric values. The Pearson correlation coefficient was used to test correlations between CH and quantitative factors. The chi-square test was used to detect differences in categorical values. RESULTS Longer axial length (P = 0.0001), lower IOPG (P = 0.03), older age (P = 0.003), and thinner central corneal thickness (P = 0.0001) were significantly associated with lower CH. The anterior chamber depth (P = 0.34), gender (P = 0.23), and corneal curvature (P = 0.18) had no relationship to CH. CONCLUSION Various factors including axial length, intraocular pressure, age, and central corneal thickness can affect measurement of corneal biomechanical properties in Chinese adults. But the anterior chamber depth, gender, and corneal curvature were irrelevant to CH.
{"title":"Factors Affecting Corneal Hysteresis in Taiwanese Adults.","authors":"Jiakui Wang, Tzu-Lun Huang, Pei-Yuan Su, P. Chang","doi":"10.3969/J.ISSN.1000-4432.2015.03.001","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-4432.2015.03.001","url":null,"abstract":"PURPOSE\u0000To investigate the correlation of various corneal hysteresis (CH) factors in Chinese adults.\u0000\u0000\u0000METHODS\u0000From January 2009 to November 2011, the healthy right eyes of a total of 292 adults were recruited into the study. Goldmann-correlated intraocular pressure (IOPG) and CH were measured using an ocular response analyzer (ORA). Central corneal thickness was measured using the ORA's integrated handheld ultrasonic pachymeter. The IOLMaster was used to obtain the ocular biometric measurements including axial length, anterior chamber depth, and keratometric values. The Pearson correlation coefficient was used to test correlations between CH and quantitative factors. The chi-square test was used to detect differences in categorical values.\u0000\u0000\u0000RESULTS\u0000Longer axial length (P = 0.0001), lower IOPG (P = 0.03), older age (P = 0.003), and thinner central corneal thickness (P = 0.0001) were significantly associated with lower CH. The anterior chamber depth (P = 0.34), gender (P = 0.23), and corneal curvature (P = 0.18) had no relationship to CH.\u0000\u0000\u0000CONCLUSION\u0000Various factors including axial length, intraocular pressure, age, and central corneal thickness can affect measurement of corneal biomechanical properties in Chinese adults. But the anterior chamber depth, gender, and corneal curvature were irrelevant to CH.","PeriodicalId":12096,"journal":{"name":"Eye science","volume":"416 1","pages":"89-93"},"PeriodicalIF":0.0,"publicationDate":"2015-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84025975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PURPOSE To compare the education effect of video demonstrations and conventional teaching on the prevention and control of myopia. METHODS Eighty students were randomly divided into an experimental (n = 40) and a control (n = 40) group, and each group was split into two classes of 40 students. The students in the experimental group attended classes mainly based on video demonstration and those in the control group received conventional teaching. All students then undertook a test and the examination scores were statistically compared between the two groups. RESULTS The educational background, age, and gender did not differ between the two groups (all P > 0.05). The experimental group had a mean test score of 8.25 ± 1.45, which was slightly lower than the mean of 8.58 ± 1.11 in the control group, but the difference was not statistically significant (t = -1.589, P = 0.114). CONCLUSION The educational effect of video demonstrations was almost identical to that of traditional teaching. In addition, video classes reduced the training time and financial costs, indicating that they deserve widespread application.
{"title":"Comparison of the Educational Effect upon Myopia Prevention and Treatment between Video Demonstration and Traditional Teaching.","authors":"Yunkai Lu, Yangfeng Guo, Hongxing Diao, Xiaosong Liang, Jin-ping Lu, Yang-fa Zeng","doi":"10.3969/J.ISSN.1000-4432.2015.02.005","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-4432.2015.02.005","url":null,"abstract":"PURPOSE\u0000To compare the education effect of video demonstrations and conventional teaching on the prevention and control of myopia.\u0000\u0000\u0000METHODS\u0000Eighty students were randomly divided into an experimental (n = 40) and a control (n = 40) group, and each group was split into two classes of 40 students. The students in the experimental group attended classes mainly based on video demonstration and those in the control group received conventional teaching. All students then undertook a test and the examination scores were statistically compared between the two groups.\u0000\u0000\u0000RESULTS\u0000The educational background, age, and gender did not differ between the two groups (all P > 0.05). The experimental group had a mean test score of 8.25 ± 1.45, which was slightly lower than the mean of 8.58 ± 1.11 in the control group, but the difference was not statistically significant (t = -1.589, P = 0.114).\u0000\u0000\u0000CONCLUSION\u0000The educational effect of video demonstrations was almost identical to that of traditional teaching. In addition, video classes reduced the training time and financial costs, indicating that they deserve widespread application.","PeriodicalId":12096,"journal":{"name":"Eye science","volume":"46 1","pages":"67-9"},"PeriodicalIF":0.0,"publicationDate":"2015-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89471090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-06-11DOI: 10.3969/J.ISSN.1000-4432.2015.02.009
J. Zang, Guoqi Guan
Diabetic retinopathy (DR), a major microvascular complication of diabetes, has emerged as a leading cause of visual impairment and blindness among adults worldwide. However, aside from pathological damage, the traditional laser and multi-needle operation treatments required for more advanced disease can cause further damage to the visual field and increase the operation risk. Therefore, the development of new therapeutic strategies for the prevention and treatment of DR is essential. Some emerging evidence now indicates that pigment epithelium-derived factor (PEDF), a multifunctional protein, can target multiple pathways to exert neurotropic, neuropro- tective, anti-angiogenic, anti-vasopermeability, anti-inflammation, anti-thrombogenic, and anti-oxidative effects against DR. This review addresses the functions of PEDF in different pathways that could lead to potential therapeutics for the treatment of DR.
{"title":"Study of Pigment Epithelium-derived Factor in Pathogenesis of Diabetic Retinopathy.","authors":"J. Zang, Guoqi Guan","doi":"10.3969/J.ISSN.1000-4432.2015.02.009","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-4432.2015.02.009","url":null,"abstract":"Diabetic retinopathy (DR), a major microvascular complication of diabetes, has emerged as a leading cause of visual impairment and blindness among adults worldwide. However, aside from pathological damage, the traditional laser and multi-needle operation treatments required for more advanced disease can cause further damage to the visual field and increase the operation risk. Therefore, the development of new therapeutic strategies for the prevention and treatment of DR is essential. Some emerging evidence now indicates that pigment epithelium-derived factor (PEDF), a multifunctional protein, can target multiple pathways to exert neurotropic, neuropro- tective, anti-angiogenic, anti-vasopermeability, anti-inflammation, anti-thrombogenic, and anti-oxidative effects against DR. This review addresses the functions of PEDF in different pathways that could lead to potential therapeutics for the treatment of DR.","PeriodicalId":12096,"journal":{"name":"Eye science","volume":"74 1","pages":"81-8"},"PeriodicalIF":0.0,"publicationDate":"2015-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90395181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-06-11DOI: 10.3969/j.issn.1000-4432.2015.02.007
Hai-yan Wang, Liping Wang, Fang Du, Peng Zhang, Yusheng Wang
PURPOSE To present a case of frosted branch angiitis with tuberculous meningoencephalitis who was followed up for 18 months after treatment. METHODS Case report. RESULTS A 19-year-old female with tuberculous meningoencephalitis complained of bilateral blurred vision, and presented with frosted branch angiitis and macula edema in both eyes. Treatment with systemic glucocorticoid and standard anti-tuberculosis medicine totally resolved the retinal periphlebitis and macular edema, with vision improvement achieved at the 18-month follow-up. CONCLUSION Frosted branch angiitis could be secondary to tuberculous meningoencephalitis. Based on standard anti-tuberculosis medicine, systemic glucocorticoid may help in the remission of frosted branch angiitis.
{"title":"Bilateral Frosted Branch Angiitis in a Patient with Tuberculous Meningoencephalitis.","authors":"Hai-yan Wang, Liping Wang, Fang Du, Peng Zhang, Yusheng Wang","doi":"10.3969/j.issn.1000-4432.2015.02.007","DOIUrl":"https://doi.org/10.3969/j.issn.1000-4432.2015.02.007","url":null,"abstract":"PURPOSE\u0000To present a case of frosted branch angiitis with tuberculous meningoencephalitis who was followed up for 18 months after treatment.\u0000\u0000\u0000METHODS\u0000Case report.\u0000\u0000\u0000RESULTS\u0000A 19-year-old female with tuberculous meningoencephalitis complained of bilateral blurred vision, and presented with frosted branch angiitis and macula edema in both eyes. Treatment with systemic glucocorticoid and standard anti-tuberculosis medicine totally resolved the retinal periphlebitis and macular edema, with vision improvement achieved at the 18-month follow-up.\u0000\u0000\u0000CONCLUSION\u0000Frosted branch angiitis could be secondary to tuberculous meningoencephalitis. Based on standard anti-tuberculosis medicine, systemic glucocorticoid may help in the remission of frosted branch angiitis.","PeriodicalId":12096,"journal":{"name":"Eye science","volume":"47 1","pages":"75-6"},"PeriodicalIF":0.0,"publicationDate":"2015-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84199537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-06-11DOI: 10.3969/J.ISSN.1000-4432.2015.02.004
Jiakui Wang, Tzu-Lun Huang, P. Su, P. Chang, Ying-Yu Tseng
PURPOSE To investigate the short-term efficacy and safety of intravitreal aflibercept in a case series of patients from Taiwan, China, with macular edema secondary to branch retinal vein occlusion (BRVO). METHODS A total of 32 patients with macular edema associated with BRVO, without prior macular laser or other intervention, were enrolled consecutively from September 2013 to February 2015. The cases received single 2 mg injections of intravitreal aflibercept. Primary outcome measures included changes in central foveal thickness (CFT; 1 mm increments by spectral-domain optic coherence tomography) and best corrected visual acuity (BCVA), determined at 1, 2, and 3 months after the injection. Complications after injections were recorded. The changes in CFT and BCVA were compared with Wilcoxon sign-rank tests. RESULTS The CFT was significantly reduced and the BCVA was significantly improved at 1, 2, and 3 months after injection (all P < 0.05). Tomography findings revealed no recurrence within 3 months. No systemic thromboembolic events, elevated intraocular pressure, retinal detachment, or infectious endophthalmitis occurred following injection. CONCLUSION Single intravitreal aflibercept may be useful in treating macular edema associated with BRVO within 3 months. No adverse systemic or ocular effects were found in this case series.
{"title":"Intravitreal Aflibercept for Macular Edema Secondary to Branch Retinal Vein Occlusion in Chinese Patients.","authors":"Jiakui Wang, Tzu-Lun Huang, P. Su, P. Chang, Ying-Yu Tseng","doi":"10.3969/J.ISSN.1000-4432.2015.02.004","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-4432.2015.02.004","url":null,"abstract":"PURPOSE\u0000To investigate the short-term efficacy and safety of intravitreal aflibercept in a case series of patients from Taiwan, China, with macular edema secondary to branch retinal vein occlusion (BRVO).\u0000\u0000\u0000METHODS\u0000A total of 32 patients with macular edema associated with BRVO, without prior macular laser or other intervention, were enrolled consecutively from September 2013 to February 2015. The cases received single 2 mg injections of intravitreal aflibercept. Primary outcome measures included changes in central foveal thickness (CFT; 1 mm increments by spectral-domain optic coherence tomography) and best corrected visual acuity (BCVA), determined at 1, 2, and 3 months after the injection. Complications after injections were recorded. The changes in CFT and BCVA were compared with Wilcoxon sign-rank tests.\u0000\u0000\u0000RESULTS\u0000The CFT was significantly reduced and the BCVA was significantly improved at 1, 2, and 3 months after injection (all P < 0.05). Tomography findings revealed no recurrence within 3 months. No systemic thromboembolic events, elevated intraocular pressure, retinal detachment, or infectious endophthalmitis occurred following injection.\u0000\u0000\u0000CONCLUSION\u0000Single intravitreal aflibercept may be useful in treating macular edema associated with BRVO within 3 months. No adverse systemic or ocular effects were found in this case series.","PeriodicalId":12096,"journal":{"name":"Eye science","volume":"13 1","pages":"63-6, 69"},"PeriodicalIF":0.0,"publicationDate":"2015-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76898509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-06-11DOI: 10.3969/J.ISSN.1000-4432.2015.02.006
Shaofen Huang, Jiajian Liang, G. Yam, Zhihao Lu, C. Pang, H. Chen
PURPOSE Oxygen-induced retinopathy (OIR) is a robust and widely used animal model for the study of retinal neovascularization (NV). Dextran perfusion and Griffonia simplicifolia isolectin B4 (GSI-B4) staining are two common methods for examining the occurrence and extent of OIR. This study provides a quantitative comparison of the two for OIR detection. METHODS At postnatal day 7 (PN7), fifteen C57BL/6J mice were exposed to a 75% hyperoxic condition for 5 days and then returned to room air conditions. At PN17, the mice received intravitreal injection of GSI-B4 Alexa Fluor 568 conjugate. After 10 hours, they were infused with FITC-dextran conjugate via the left ventricle. Retinal flat mounts were photographed by confocal microscopy. Areas with fluorescent signals and the total retinal areas were quantified by Image J software. RESULTS Both GSI-B4 and dextran detected the peripheral neovascular area. The mean hyper fluorescence area was 0.33 ± 0.14% of whole retinal area determined by GSI-B4 staining and 0.25 ± 0.28% determined by dextran perfusion. The difference between the two measures was 0.08% (95% CI:-0.59%, 0.43%). The Pearson correlation coefficient between the two methods was 0.386,P =0.035. The mean coincidence rates were 14.3 ± 13.4% and 24.9 ± 18.5% for GSI-B4 and dextran staining, respectively. CONCLUSION Both methods can complement each other in demonstrating and quantitatively evaluating retinal NV. A poor agreement was found between the two methods; GSI-B4 isolectin was more effective than FITC-dextran perfusion in evaluating the extent of retinal NV in a mouse model of OIR.
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