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145914 one hundred and forty-five thousand nine hundred and fourteen
Q3 Medicine Pub Date : 2023-05-11 DOI: 10.24425/fmc.2023.145914
Pelvic venous disorder (PeVD) is a prevalent chronic condition characterized by the presence of varicose veins in the pelvis, leading to the development of chronic pelvic pain. Despite the growing interest in assessing quality of life in PeVD, well-designed and validated disease-specific questionnaires are missing. The objective of this study was a linguistic and clinical validation of the Symptom Questionnaire (SQ) in a cohort of Polish females with pelvic vein incompetence. The Polish version of SQ was developed using a standardized validation process that involved a back-and- forth translation protocol. A total of 58 female patients diagnosed with pelvic varicose veins, representing diverse educational back- grounds, participated in the study. Multiple issues were observed during linguistic validation, primarily originating from disparities between the Polish and British healthcare systems, as well as differing levels of sexual health education of those two populations. Cronbach α was calculated separately for each part of the questionnaire with results exceeded 0.6 for each section. Test-retest analysis indicated most Pearson correlation coefficients surpassing 0.70. The absolute agreement consistency between pretest and post-test measures, evaluated using the Intra Class Correlation (ICC), exceeded 0.8 in three sections and 0.7 in the remaining three sections. However, the clinical validation failed due to the lack of standardized score calculation proposed by the authors of the questionnaire and inaccurately assigned values in the answer key for five questions. Consequently, the practical utility of SQ in daily clinical settings remains uncertain, highlighting the urgent need for the development of a new, user-friendly questionnaire specifically tailored to assess the quality of life in individuals with PeVD.
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引用次数: 0
145911 one hundred and forty-five thousand nine hundred and eleven
Q3 Medicine Pub Date : 2023-05-11 DOI: 10.24425/fmc.2023.145911
Atopic dermatitis (AD) is a chronic, recurrent inflammatory dermatosis. The most characteristic symptoms of the disease include itch, eczematous eruptions and excessive dryness of the skin. Elderly patients with AD represent a poorly characterized population because the physiological ageing, possible comorbidity and polypharmacy modify the clinical presentation typically observed in the younger age groups. The aim of the study is to comprehensively assess the clinical characteristics of elderly patients (>60 years old) with AD. Data were collected from 26 AD patients treated in the Department of Dermatology of the University Hospital in Krakow. Late-onset AD with generalized/prurigo lesions was the most predominant phenotype. Skin biopsy was required in 15 (58%) patients in the differential diagnosis process. Allergic rhinitis, a positive family history of atopy and xerosis were associated with a higher number of hospitalizations during the year prior to the last admission (p = 0.034, p = 0.046 and p = 0.036, respectively). Xerosis was more prevalent among subjects with polypharmacy (p = 0.046) and higher serum total IgE concentration (p = 0.048). AD in elderly patients is a new phenotype of the disease that requires careful differential diagnosis. Aged patients with an individual or family history of atopy, due to the increased incidence of severe exacerbations of AD, may benefit from the introduction of proactive therapy.
{"title":"145911","authors":"","doi":"10.24425/fmc.2023.145911","DOIUrl":"https://doi.org/10.24425/fmc.2023.145911","url":null,"abstract":"Atopic dermatitis (AD) is a chronic, recurrent inflammatory dermatosis. The most characteristic symptoms of the disease include itch, eczematous eruptions and excessive dryness of the skin. Elderly patients with AD represent a poorly characterized population because the physiological ageing, possible comorbidity and polypharmacy modify the clinical presentation typically observed in the younger age groups. The aim of the study is to comprehensively assess the clinical characteristics of elderly patients (>60 years old) with AD. Data were collected from 26 AD patients treated in the Department of Dermatology of the University Hospital in Krakow. Late-onset AD with generalized/prurigo lesions was the most predominant phenotype. Skin biopsy was required in 15 (58%) patients in the differential diagnosis process. Allergic rhinitis, a positive family history of atopy and xerosis were associated with a higher number of hospitalizations during the year prior to the last admission (p = 0.034, p = 0.046 and p = 0.036, respectively). Xerosis was more prevalent among subjects with polypharmacy (p = 0.046) and higher serum total IgE concentration (p = 0.048). AD in elderly patients is a new phenotype of the disease that requires careful differential diagnosis. Aged patients with an individual or family history of atopy, due to the increased incidence of severe exacerbations of AD, may benefit from the introduction of proactive therapy.","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46141934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
145918 one hundred and forty-five thousand nine hundred and eighteen
Q3 Medicine Pub Date : 2023-05-11 DOI: 10.24425/fmc.2023.145918
QF-PCR is a widely used molecular biology method. To name just a few of its uses, it is considered to be useful in paternity tests, identification tests or prenatal diagnostics. Therefore, there is a good chance that medical faculty students would come into contact with this technology - directly or indirectly - during their professional work. The following article proposes a teaching classes scenario conducted in the problem-based learning manner, which aims to familiarize students with the QF-PCR technique. In addition, other modern methods of molecular genetics are among topics that students can learn during the problem-based learning modules. The classes are divided into three parts. In the first part, students learn about the possible usage of QF-PCR in paternity tests. The second part focuses on learning about the advantages and limitations of QF-PCR in prenatal diagnosis. Learning activities in the last part are designed to show the limitations of the diagnostic properties of the method - students analyze the case study, in which QF-PCR must be replaced by other modern methods of molecular genetics. By analyzing three independent stories, students learn about usage, advantages and limitations of QF-PCR, and additionally gain knowledge in basic, pre-clinical and clinical sciences. This course is designated as an elective course for final year medical students who have completed either: a basic genetics course, a molecular genetics course, a biochemistry course or a molecular biology course. The focus of the classes is to draw students' attention to the possible application and rapid development of molecular biology techniques, which is the base for modern therapeutic and diagnostic strategies.
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引用次数: 0
145915 145915
Q3 Medicine Pub Date : 2023-05-11 DOI: 10.24425/fmc.2023.145915
Melanoma is a highly malignant neoplasm with the most typical primary locations in the skin and eyeball and rarely reported in the other organs, including the gallbladder. More commonly metastases of melanoma of various primary sites to the gallbladder are observed. However, generally melanoma of the gallbladder is a rare entity with only 217 cases reported in the literature up to date. The paper summarizes knowledge on epidemiology, symptoms, laboratory and imaging findings, morphology, treatment options, and outcome of patients with both primary and metastatic melanoma to the gallbladder.
{"title":"145915","authors":"","doi":"10.24425/fmc.2023.145915","DOIUrl":"https://doi.org/10.24425/fmc.2023.145915","url":null,"abstract":"Melanoma is a highly malignant neoplasm with the most typical primary locations in the skin and eyeball and rarely reported in the other organs, including the gallbladder. More commonly metastases of melanoma of various primary sites to the gallbladder are observed. However, generally melanoma of the gallbladder is a rare entity with only 217 cases reported in the literature up to date. The paper summarizes knowledge on epidemiology, symptoms, laboratory and imaging findings, morphology, treatment options, and outcome of patients with both primary and metastatic melanoma to the gallbladder.","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47740089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
145916 one hundred and forty-five thousand nine hundred and sixteen
Q3 Medicine Pub Date : 2023-05-11 DOI: 10.24425/fmc.2023.145916
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引用次数: 0
The significance of masticatory muscle's relaxation in the treatment of the temporomandibular disorders - Review article. 咀嚼肌放松在颞下颌疾病治疗中的意义综述。
Q3 Medicine Pub Date : 2023-04-30 DOI: 10.24425/fmc.2023.145429
Małgorzata Pihut, Magdalena Orczykowska, Piotr Ceranowicz, Ilona Korzonek, Andrzej Gala

Temporomandibular disorder (TMD) is a disease of multifactorial etiology and a complex of symptoms, related to disorders of the masticatory muscles, temporomandibular joints and the surrounding orofacial structures. One of the main problems in the course of TMD disorders is the systematic increase in the tension of the masticatory muscles (masseter muscles, temporalis and medial and lateral pterygoid muscles), what is the cause of many damages and the development of pathological conditions in the stomatognathic system. The article discusses the differences in the structure of the masticatory and skeletal muscles, as well as the different nature and isoforms of myosin, which determines the much faster generation of contraction in the masticatory muscles and consequently easier generation of excessive, harmful tensions in the masticatory muscles. The article describes the causes of increased tension in the masticatory muscles and methods of their relaxation used in the basic and supportive treatment of temporomandibular disorders. The use of occlusal splints, physiotherapeutic procedures and TMD treatment with botulinum toxin type A were characterized. A role of psychological support and the methods used for patients with TMD were emphasized.

颞下颌关节紊乱(Temporomandibular disorder, TMD)是一种多因素病因和复杂症状的疾病,与咀嚼肌、颞下颌关节和周围口面结构的紊乱有关。TMD疾病过程中的主要问题之一是咀嚼肌(咬肌,颞肌和翼状内外侧肌)的张力系统性增加,这是导致许多损伤和口腔系统病理状况发展的原因。本文讨论了咀嚼肌和骨骼肌结构的差异,以及肌球蛋白的性质和同型的不同,这决定了咀嚼肌收缩产生得更快,从而更容易产生咀嚼肌过度的、有害的紧张。本文描述了咀嚼肌张力增加的原因和在颞下颌疾病的基础和支持治疗中使用的放松方法。使用咬合夹板,物理治疗程序和用A型肉毒杆菌毒素治疗TMD的特点。强调了心理支持在TMD患者中的作用和治疗方法。
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引用次数: 0
Relationships between quality of life and comprehensive geriatric assessment among seniors - a cross-sectional study in Krakow, Poland. 生活质量与老年人综合老年评估之间的关系——波兰克拉科夫的一项横断面研究。
Q3 Medicine Pub Date : 2023-04-30 DOI: 10.24425/fmc.2023.145426
Anna Pachołek, Eliza Siemaszko-Oniszczuk, Joanna Mierzwa, Anna Wróbel, Karolina Piotrowicz, Jerzy Gąsowski, Tomasz Tomasik

B a c k g r o u n d: Due to current increased life expectancy, the quality of life (QoL) of senior patients is gaining in importance. The aims of this study were: to estimate QoL in a group of patients, aged above 64 years, that is cared for by general practitioners (GPs) in Krakow, Poland, and to find relation- ships between elements of QoL and the results of comprehensive geriatric assessment (CGA) and other important medical and social factors. M e t h o d s: We designed a cross-sectional, questionnaire study among patients who attended GPs' surgeries from April 2018 to April 2019. To examine the patients, we used the Euro-Quality of Life Questionnaire (EQ-5D-5L) and eight scales forming CGA: the Activities of Daily Living, the Instrumental Activities of Daily Living, Mini-Mental State Examination, Geriatric Depression Scale, Timed Up and Go Test, Mini Nutritional Assessment, Clinical Frailty Scale and Athens Insomnia Scale. R e s u l t s: The lowest QoL was observed in dimensions of pain/discomfort and mobility, where 70% and 52% of patients, respectively, reported problems in these areas. Only 91 (21%) respondents had highest results in all five dimensions of QoL. The average score in the Visual Analogue Scale (VAS) of the EQ-5D-5L (representing self-rated health on a given day) was 62.36 ± 18.98 points. Statistically significant relationships were observed between QoL and age, physical activity and multimorbidity (in all cases p <0.001). The results of QoL were correlated with every aspect of CGA, while the strongest relationship was noticed between scores in the EQ-5D-5L VAS scale and scales assessing depression and frailty (p <0.001; r = -0.57 both).

由于当前预期寿命的增加,老年患者的生活质量(QoL)变得越来越重要。本研究的目的是:估计波兰克拉科夫一组64岁以上全科医生(gp)护理的患者的生活质量,并发现生活质量要素与综合老年评估(CGA)结果及其他重要的医学和社会因素之间的关系。我们在2018年4月至2019年4月期间参加全科医生手术的患者中设计了一项横断面问卷研究。我们采用欧洲生活质量问卷(EQ-5D-5L)和构成CGA的8个量表:日常生活活动、日常生活工具活动、迷你精神状态检查、老年抑郁量表、定时起床测试、迷你营养评估、临床虚弱量表和雅典失眠症量表。在疼痛/不适和活动方面观察到最低的生活质量,其中70%和52%的患者分别报告了这些领域的问题。只有91名(21%)受访者在生活质量的所有五个维度上都取得了最高的成绩。EQ-5D-5L视觉模拟量表(VAS)平均得分为62.36±18.98分。生活质量与年龄、身体活动和多病之间存在统计学意义的关系(所有病例p
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引用次数: 0
A comparison of curricula at various medical schools across the world. 世界各地不同医学院的课程比较。
Q3 Medicine Pub Date : 2023-04-30 DOI: 10.24425/fmc.2023.145435
Dorota Zawiślak, Robert Kupis, Ian Perera, Grzegorz Cebula

B a c k g r o u n d: Medical education has changed in response to scientific advances and social needs. A i m: The aim of the study was to examine curricula of medical schools around the world and to observe the trends that currently dominate in medical education. M e t h o d: We have collected information on the current curricula of various medical schools using their official websites. When necessary, we supplemented the information using published articles describing the curriculum of a given medical school. R e s u l t s: Our findings reveal that medical schools demonstrate the need for constant reforms and adaptation to changing conditions worldwide. Generally, there is a tendency to integrate basic and clinical fields, to sooner establish bedside teaching, to provide less theoretical and more practical approaches to teaching, to implement more communication skills, and provide students with research training. C o n c l u s i o n s: Medical education has evolved and will continue to change with time. Medical schools introduce modifications to their curricula and share their experiences.

医学教育随着科学的进步和社会的需要而发生了变化。A:这项研究的目的是检查世界各地医学院的课程,并观察目前在医学教育中占主导地位的趋势。他告诉记者:我们通过各医学院的官方网站收集了他们目前的课程信息。必要时,我们使用描述特定医学院课程的已发表文章来补充信息。我们的研究结果表明,医学院需要不断改革和适应世界范围内不断变化的环境。总的来说,有一种趋势是将基础和临床领域结合起来,尽快建立床边教学,提供较少的理论和更多的实践教学方法,实施更多的沟通技巧,并为学生提供研究训练。医学教育已经发展,并将继续随着时间的推移而变化。医学院对他们的课程进行修改,并分享他们的经验。
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引用次数: 0
Expanded insights into the neural component of the activity-based anorexia animal model - morphological changes in the enteric nervous system and altered pain perception. 扩展了对以活动为基础的厌食症动物模型的神经成分的见解-肠神经系统的形态学改变和疼痛感知的改变。
Q3 Medicine Pub Date : 2023-04-30 DOI: 10.24425/fmc.2023.145430
Kamil Skowron, Paulina Stach, Magdalena Kurnik-Łucka, Katarzyna Chwaleba, Mateusz Giełczyński, Wiktoria Suchy, Veronika Aleksandrovych, Michał Jurczyk, Beata Kuśnierz-Cabala, Krzysztof Gil

Anorexia nervosa (AN) is an eating disorder characterized by distinct etiopathogenetic concepts that are gradually being linked together to unravel the dominant pathophysiological pathways underlying the disease. Excessive food restrictions, often accompanied by over-exercise and undertaken to lose weight, lead to the development of numerous complications. The biological concept of neurohormonal dysfunction in AN seems incomplete without demonstrating or excluding the role of the enteric nervous system (ENS). Using an animal model of activity-based anorexia (ABA), we conducted the preliminary assessment of the ENS structure. Here we show, in preparations stained by immunohistochemistry with anti- ChAT, anti-NOS, anti-PGP 9.5, anti-c-fos, and anti-TH antibodies, a lower density of cholinergic and nitrergic nerve fibers as well as reduced neuronal activity in myenteric plexus. Such structural and functional damage to the ENS may be responsible for a number of gastrointestinal symptoms that worsen the course of the disease. In addition, we expanded the study to address the unresolved issue of mechanical and thermal pain sensitivity in AN. The Von Frey and hot plate tests revealed, that in ABA animals, the pain threshold for mechanical stimulus decreases while for thermal increases. In this way, we have significantly supplemented the background of AN with potentially observable nervous system changes which may influence the evolution of the therapeutic approach in the future.

神经性厌食症(AN)是一种以不同的发病概念为特征的饮食失调,这些概念逐渐被联系在一起,以揭示该疾病背后的主要病理生理途径。过度的饮食限制,往往伴随着过度运动和减肥,导致许多并发症的发展。如果没有证明或排除肠神经系统(ENS)的作用,神经激素功能障碍的生物学概念似乎是不完整的。采用活动性厌食症(ABA)动物模型,我们对ENS结构进行了初步评估。我们发现,在免疫组化染色的抗ChAT、抗nos、抗pgp 9.5、抗c-fos和抗th抗体的制剂中,胆碱能和氮能神经纤维密度降低,肌丛神经元活性降低。这种对ENS的结构和功能损害可能是导致许多胃肠道症状加重疾病进程的原因。此外,我们扩大了研究范围,以解决AN中尚未解决的机械和热疼痛敏感性问题。Von Frey和热板实验表明,ABA动物在机械刺激下的痛阈值降低,热刺激下的痛阈值升高。通过这种方式,我们通过潜在的可观察到的神经系统变化显著地补充了AN的背景,这些变化可能会影响未来治疗方法的发展。
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引用次数: 0
Performance of portable emergency suction devices in pre-hospital conditions: a pilot study in the fire brigade. 院前条件下便携式紧急吸引装置的性能:消防队的试点研究。
Q3 Medicine Pub Date : 2023-04-30 DOI: 10.24425/fmc.2023.145431
Łukasz Dudziński, Tomasz Kubiak, Mariusz Feltynowski, Mariusz Panczyk, Piotr Leszczyński

A i m: Assessment of the effectiveness and efficiency of three mobile (portable) rescue aspirators models in the opinion of state fire service officers. Comparison with the use of the medical simulation element.

Material and methods: The study was conducted in organizational units of the State Fire Service (24-hour officers). The research consisted in carrying out the task with the use of three models of mobile rescue aspirators (manual, hand-foot, battery). Each participating firefighter had the task of sucking up an equal amount of fluid (100 ml, respectively) with each model of an aspirator. The test fluid was water at room temperature in a homogeneous 1:1 mixture with sugar (increased viscosity and density, simulated real conditions). Immediately after three suction attempts (with measured suction time), each officer completed a questionnaire on the three models used. Descriptive statistics were used to characterize the variables. The following measures were calculated for the variables: mean (M) and standard deviation (SD), minimum, maximum. The following measures were calculated for categorical variables: number (n) and frequency (%).

Results: 184 officers (182 M and 2 F) took part in the study, including commanders 18.43%, rescuers 65.22%, drivers 16.30%. In the study area 1,609 officers serve in the combat division as at the end of 2021. The studied group accounts for 11.43%. Age of respondents M 34.04 SD 8.24 Min 21 Max 52, length of service M 8.48, SD 7.20 Min 1, Max 25. The longest mean time of completing the task was recorded for model 2 (hand-foot) and it was 6.77 sec.

Conclusions: SFS officers highly appreciated the usefulness and effectiveness of the battery-operated automatic aspirator. This assessment may contribute to the widespread introduction of such a model to rescue sets in the SFS. Time of performing the task by mode 1 was significantly longer by elderly people. People with experience with the model 1 during rescue and firefighting operations had a significantly shorter time of performing the task with the use of the model 2. According to the subjective assessment of firefighters, the most effective is model 3, which is confirmed by the suction time obtained at the work station.

A i m:评估三种移动(便携式)救援吸入器模型的有效性和效率在国家消防官员的意见。与使用医学模拟元素的比较。材料和方法:本研究在国家消防局组织单位(24小时警官)进行。该研究包括使用三种型号的移动救援吸痰器(手动,手-脚,电池)来执行任务。每位参与的消防员的任务是用每种型号的吸入器吸入等量的液体(分别为100毫升)。测试流体为室温下的水和糖的均匀1:1混合物(增加粘度和密度,模拟真实条件)。在三次吸痰尝试后(测量吸痰时间),每位警官立即填写一份关于所使用的三种模型的问卷。使用描述性统计来描述变量的特征。对变量进行如下计算:均值(M)和标准差(SD),最小值,最大值。对分类变量计算以下度量:数量(n)和频率(%)。结果:184名军官(182名M、2名F)参与了研究,其中指挥官18.43%,救援人员65.22%,驾驶员16.30%。截至2021年底,在该研究地区有1609名军官在战斗师服役。研究群体占11.43%。受访者年龄M 34.04 SD 8.24 Min 21 Max 52,服务年限M 8.48, SD 7.20 Min 1, Max 25。模型2(手-脚)平均完成任务的时间最长,为6.77秒。结论:SFS人员高度评价电池驱动的自动吸痰器的实用性和有效性。这一评估可能有助于将这种模型广泛引入SFS的救助集。老年人执行模式1任务的时间明显更长。在救援和消防行动中有模型1经验的人使用模型2执行任务的时间显着缩短。根据消防员的主观评价,最有效的是模型3,这是由在工作站上获得的吸入时间所证实的。
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引用次数: 0
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Folia medica Cracoviensia
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