Eye最新文献

Objectives: To describe a rare phenotype of birdshot chorioretinitis (BSCR) characterised by diffuse retinal depigmentation and to evaluate its relationship with disease chronicity and visual outcomes.

Methods: This observational study included patients from the CO-BIRD cohort with ultra-widefield fundus imaging. Retinal depigmentation was graded using the albinism scale by Kruijt et al. (grades 0-3). Eyes with a grade ≥ 2 in at least one image were included. Disease activity and severity were assessed using best-corrected visual acuity (BCVA), vision-related quality of life (VFQ-25), visual field testing and multimodal imaging.

Results: Among 1016 eyes (508 patients), 52 eyes (26 patients, 5.1%) had depigmentation grade ≥ 2; 22 eyes (2.2%) reached grade 3. Fifteen years after symptom onset, BCVA worse than 0.7 logMAR occurred in 42.1% of grade 3 versus 5.0% of grade 2 eyes (p = 0.014). VFQ-25 scores were similarly reduced in both groups. Grade 3 was associated with a lower risk of optic disc oedema (HR = 0.38; p = 0.028) and a non-significant reduction in macular oedema risk. Choroidal neovascularisation occurred only in grade 3 (40.9%). Grade 3 was linked to worse BCVA (p = 0.012), higher pattern standard deviation (p = 0.011), and a history of active disease. Compared with previously published CO-BIRD data, grade 3 showed faster BCVA decline (p = 0.044) and greater cumulative loss (p = 0.001).

Conclusion: Diffuse retinal depigmentation resembling albinism is an uncommon but severe expression of BSCR, indicative of chronic disease and associated with poorer visual outcomes.

Purpose: This study aimed to investigate age-related trends and associations of biometric parameters in the Korean population.

Methods: We retrospectively reviewed the patients who underwent IOLMaster 700 scanning between November 2022 and December 2024. We investigated the correlations between age and ocular biometric parameters-axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), corneal power (K), white-to-white distance (WTW), and vitreous chamber depth (VCD).

Results: 2223 eyes (mean age: 71.46 ± 11.12 years) were included. Pearson's correlation analysis showed that AL, ACD, and VCD were moderately negatively correlated with age (p < 0.001), whereas LT was strongly positively correlated with age (p < 0.001). However, multiple linear regression analysis revealed that age was positively associated with LT and ACD (p < 0.001 and p = 0.038, respectively), whereas it was negatively associated with VCD, CCT, K, and WTW (all p < 0.001). AL was not independently associated with age in this model (p = 0.185).

Conclusion: Age was independently associated with an increase in LT and ACD and a decrease in VCD, CCT, K, and WTW in the Korean population, whereas AL was not independently associated with age. These findings enhance our understanding of ocular aging and associated biometric patterns.

Purpose: Conjunctival myxoma is a rare benign mesenchymal tumour frequently misdiagnosed as conjunctival cysts, lymphangiomas, or other similar lesions. This study aims to characterise the clinical profile and treatment outcomes of conjunctival myxoma at a single tertiary centre.

Methods: We retrospectively reviewed records of patients with histopathologically confirmed conjunctival myxoma treated at Zhongshan Ophthalmic Center between January 2021 and December 2024. Data collected included primary symptoms, tumour location (temporal, nasal, superior, inferior), anatomical involvement (eyelid, conjunctiva, orbit), size, shape, and colour. Ultrasound biomicroscopy and MRI were performed when indicated. All patients underwent complete local excision. Follow-up data were obtained from clinic visits and telephone interviews as of March 4, 2025.

Results: The eyes of 13 patients were identified. Mean age was 41.6 ± 3.9 years; nine patients (69.2%) were female. Median follow-up was 32.8 months (range, 1-84). All presented with painless, slow-growing, mobile conjunctival masses. Most lesions were dome-shaped, yellowish-pink, cystic-translucent, with well-defined margins. Primary symptoms included ocular redness (5/13), pain (2/13), and pruritus (1/13). All cases were unilateral, predominantly affecting the nasal conjunctiva (7/13). Twelve lesions involved the bulbar conjunctiva; two extended into the orbit, and one involved the inner canthus. No recurrences were observed.

Conclusion: Conjunctival myxoma is a benign tumour typically affecting the bulbar conjunctiva, more common in females, and usually unilateral. Imaging aids differential diagnosis, while pathology remains essential for confirmation. Microsurgical excision yields excellent outcomes with low recurrence.