Introduction: Beyond impacting the quality of life, unpleasant stretch marks, skin aging, the dermal scars secondary to acne and chickenpox, and wrinkles expose those harboring these skin defects to psychiatric problems like anxiety, depression, ADHD, and insomnia more often than one might suspect. Remodeling skin scarring and supporting the deteriorated networks of dermal elastic fibers also have medical value. The moisturizing properties and skin-protective scavenger action against free radicals rapidly developed by non-cross-linked hyaluronic acid offer a powerful rationale to help with those problems. Methods: The study focused on a survey questionnaire administered by the investigators to a prospective cohort of 45 subjects of both genders with stretch marks, dermal scars, and skin aging. Before the survey, all individuals had undergone a three-session treatment cycle with a Class-III CE-marked medical device containing 40 mg of non-cross-linked HA in 2-mL prefilled disposable syringes with 30G½ needles (IALEST®, Mastelli Srl, Sanremo, Italy). The primary observational efficacy assessment tool was the six-score Wrinkle Severity Rating Scale (WSRS); the secondary efficacy assessment tool was the five-score Global Aesthetic Improvement Scale (GAIS). Timing of WSRS and GAIS assessments: at baseline (T0), before the first intradermal treatment session, and three to four weeks after T2 (end of the treatment cycle). Results: The mean WSRS scores for skin quality significantly improved between the T0 baseline visit (2.8 ± 1.17) and the T2 final follow-up visit (1.6 ± 1.09; –42.9%, p <0.001). The cohort distribution of the GAIS skin quality descriptors assessed by the investigators improved by one severity level in 66.7% of surveyed subjects, two severity levels in 20.0%, and four levels in 2.2%. Only a tiny cohort minority (2 individuals out of 45, 4.4%) reported no subjective improvement in skin quality. Among surveyed participants, 95.6% reported a clinically meaningful skin quality improvement. The device safety was high. Conclusions: The real-world survey, performed within the framework of a long-term program to monitor the device’s clinical performance and safety over time, demonstrated that the HA-based medical device retains its long-standing record of efficient performance and excellent safety with no variations over time.
导读:除了影响生活质量外，令人不快的妊娠纹、皮肤老化、痤疮和水痘引发的皮肤疤痕以及皱纹还会让那些有这些皮肤缺陷的人更容易出现精神问题，比如焦虑、抑郁、注意力缺陷多动症和失眠，这种情况比人们想象的要频繁得多。重塑皮肤瘢痕和支持老化的真皮弹性纤维网络也具有医学价值。非交联透明质酸迅速发展的保湿特性和皮肤保护清除自由基的作用为帮助解决这些问题提供了强有力的理论依据。方法:研究人员对45名有妊娠纹、皮肤疤痕和皮肤老化的男女受试者进行问卷调查。在调查之前，所有患者都接受了三个疗程的治疗周期，使用带有iii类ce标志的医疗器械，其中含有40mg非交联HA，用2ml预填充一次性注射器使用30G½针头(IALEST®，Mastelli Srl，圣雷莫，意大利)。主要观察性疗效评估工具为六分皱纹严重性评定量表(WSRS);二级疗效评估工具为五分制全球审美改善量表(GAIS)。WSRS和GAIS评估的时间:基线(T0)，第一次皮内治疗前，T2(治疗周期结束)后3至4周。结果:在T0基线随访(2.8±1.17)和T2最终随访(1.6±1.09)之间，wrs皮肤质量平均评分显著提高;-42.9%， p <0.001)。研究人员评估的GAIS皮肤质量描述符的队列分布在66.7%的调查对象中改善了一个严重级别，20.0%的调查对象改善了两个严重级别，2.2%的调查对象改善了四个严重级别。只有一小部分人(45人中2人，4.4%)报告皮肤质量没有主观改善。在接受调查的参与者中，95.6%的人报告有临床意义的皮肤质量改善。设备安全性高。结论:在长期监测设备临床性能和安全性的计划框架内进行的真实世界调查表明，基于ha的医疗设备保持了其高效性能和出色安全性的长期记录，没有随时间变化。
{"title":"Acne Scars, Stretch Marks, and Similar Skin Defects Qualify as Medical Problems. A Real-World Survey on a Hyaluronic Acid Medical Device","authors":"Lucia Cimarra","doi":"10.33425/2689-1093.1052","DOIUrl":"https://doi.org/10.33425/2689-1093.1052","url":null,"abstract":"Introduction: Beyond impacting the quality of life, unpleasant stretch marks, skin aging, the dermal scars secondary to acne and chickenpox, and wrinkles expose those harboring these skin defects to psychiatric problems like anxiety, depression, ADHD, and insomnia more often than one might suspect. Remodeling skin scarring and supporting the deteriorated networks of dermal elastic fibers also have medical value. The moisturizing properties and skin-protective scavenger action against free radicals rapidly developed by non-cross-linked hyaluronic acid offer a powerful rationale to help with those problems. Methods: The study focused on a survey questionnaire administered by the investigators to a prospective cohort of 45 subjects of both genders with stretch marks, dermal scars, and skin aging. Before the survey, all individuals had undergone a three-session treatment cycle with a Class-III CE-marked medical device containing 40 mg of non-cross-linked HA in 2-mL prefilled disposable syringes with 30G½ needles (IALEST®, Mastelli Srl, Sanremo, Italy). The primary observational efficacy assessment tool was the six-score Wrinkle Severity Rating Scale (WSRS); the secondary efficacy assessment tool was the five-score Global Aesthetic Improvement Scale (GAIS). Timing of WSRS and GAIS assessments: at baseline (T0), before the first intradermal treatment session, and three to four weeks after T2 (end of the treatment cycle). Results: The mean WSRS scores for skin quality significantly improved between the T0 baseline visit (2.8 ± 1.17) and the T2 final follow-up visit (1.6 ± 1.09; –42.9%, p <0.001). The cohort distribution of the GAIS skin quality descriptors assessed by the investigators improved by one severity level in 66.7% of surveyed subjects, two severity levels in 20.0%, and four levels in 2.2%. Only a tiny cohort minority (2 individuals out of 45, 4.4%) reported no subjective improvement in skin quality. Among surveyed participants, 95.6% reported a clinically meaningful skin quality improvement. The device safety was high. Conclusions: The real-world survey, performed within the framework of a long-term program to monitor the device’s clinical performance and safety over time, demonstrated that the HA-based medical device retains its long-standing record of efficient performance and excellent safety with no variations over time.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135802907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rex Friday Ogoronte Alderton Ijah, Linda U Iroegbu-Emeruem, Mary Obidiya Okuku, Nwizor Monday Nkadam, Victoria Amagboruju
Background: The newly developed Nigerian addition to the universal health coverage has surgery, obstetrics, anesthesia, and nursing as components of the plan. This study evaluated the challenges in the nursing care of the surgical patient in two public Teaching Hospitals in Port Harcourt, Nigeria. Materials and Methods: A cross sectional descriptive study was conducted among total population of consenting Nurses and Medical Doctors at the Surgery Departments two public Teaching Hospitals, using semi-structured selfadministered questionnaire. Data obtained was entered into Microsoft Excel Spreadsheet / Statistical Package for the Social Sciences, and formed into tables. Results: There were 67(26.1%) male and 190 (73.9%) female respondents. The mean age of respondents was 37.63 ± 10.22 years. The mean years in practice was 11.05 ± 9.26 years. One hundred and forty-nine (58.0%) of the respondents were nurses. Most challenging nursing issues were giving intravenous fluids according to schedule (75 = 29.2%), wound dressing (73 = 28.4%), inadequate equipment and manpower (51 = 19.8%), administration and charting of intravenous fluids (26 = 10.1%), and drug administration (26 = 10.1%). The most challenging surgeon / doctor-related issues was poor staff interpersonal relationship (103 = 40.1%) followed by poor supervision of the surgical team (97 = 37.7%). Conclusion: The challenges of nursing the surgical patient in our setting are of multiple origin. Administrative issues of inadequate employment of manpower and its multiplier effects are reported along with patient-related and health professional issues.
{"title":"The Surgical Patient and Nursing Care in a Low-Income Setting: Challenges and Way Forward","authors":"Rex Friday Ogoronte Alderton Ijah, Linda U Iroegbu-Emeruem, Mary Obidiya Okuku, Nwizor Monday Nkadam, Victoria Amagboruju","doi":"10.33425/2689-1093.1054","DOIUrl":"https://doi.org/10.33425/2689-1093.1054","url":null,"abstract":"Background: The newly developed Nigerian addition to the universal health coverage has surgery, obstetrics, anesthesia, and nursing as components of the plan. This study evaluated the challenges in the nursing care of the surgical patient in two public Teaching Hospitals in Port Harcourt, Nigeria. Materials and Methods: A cross sectional descriptive study was conducted among total population of consenting Nurses and Medical Doctors at the Surgery Departments two public Teaching Hospitals, using semi-structured selfadministered questionnaire. Data obtained was entered into Microsoft Excel Spreadsheet / Statistical Package for the Social Sciences, and formed into tables. Results: There were 67(26.1%) male and 190 (73.9%) female respondents. The mean age of respondents was 37.63 ± 10.22 years. The mean years in practice was 11.05 ± 9.26 years. One hundred and forty-nine (58.0%) of the respondents were nurses. Most challenging nursing issues were giving intravenous fluids according to schedule (75 = 29.2%), wound dressing (73 = 28.4%), inadequate equipment and manpower (51 = 19.8%), administration and charting of intravenous fluids (26 = 10.1%), and drug administration (26 = 10.1%). The most challenging surgeon / doctor-related issues was poor staff interpersonal relationship (103 = 40.1%) followed by poor supervision of the surgical team (97 = 37.7%). Conclusion: The challenges of nursing the surgical patient in our setting are of multiple origin. Administrative issues of inadequate employment of manpower and its multiplier effects are reported along with patient-related and health professional issues.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"427 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135802908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ibrahim Acir, Haci Ali Erdogan, Mert Gobel, Vildan Yayla
Background: Decompressive craniectomy reduces mortality and morbidity in ischemic stroke patients with malignant cerebral edema. Prognostic markers such as red cell distribution width, neutrophil lymphocyte ratio, and platelet count are needed to predict the timing of decompressive surgery in ischemic stroke patients. Sodium, a parameter that changes before and after decompression surgery, may also be a factor to consider when assessing the patient's prognosis and deciding whether to proceed with surgery. In this study, we aimed to examine the changes in laboratory parameters in stroke patients according to the time of decompression surgery. Material and Method: At our stroke center, 52 patients were diagnosed with stroke and underwent decompressive craniectomy. The patients were divided into four groups based on their decompression time (the first 24 hours, 24-48 hours, 48-72 hours, and after 72 hours). The width of the red cell distribution, platelet count, neutrophillymphocyte ratios, and sodium levels were calculated and compared between groups and National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) scores are all listed. Results: The patients had a mean age of 62 ± 11 years, with 31 males and 21 females. The patients' admission, 24th hour, and post-operative sodium levels were not significantly different. The patients' admission, 24th hour, and post-op RDW did not differ statistically significantly. The 24th hour NLR levels of the groups differed significantly (p=0.049). Conclusion: There is a need for laboratory measurements that can estimate the time required for decompression surgery. Nevertheless, no significant difference between groups was observed in our study, which investigated at RDW, NLR, platelet count, and sodium levels.
{"title":"Evaluation of Laboratory Parameters in Stroke Patients Based on Decompressive Craniectomy Timing","authors":"Ibrahim Acir, Haci Ali Erdogan, Mert Gobel, Vildan Yayla","doi":"10.33425/2689-1093.1051","DOIUrl":"https://doi.org/10.33425/2689-1093.1051","url":null,"abstract":"Background: Decompressive craniectomy reduces mortality and morbidity in ischemic stroke patients with malignant cerebral edema. Prognostic markers such as red cell distribution width, neutrophil lymphocyte ratio, and platelet count are needed to predict the timing of decompressive surgery in ischemic stroke patients. Sodium, a parameter that changes before and after decompression surgery, may also be a factor to consider when assessing the patient's prognosis and deciding whether to proceed with surgery. In this study, we aimed to examine the changes in laboratory parameters in stroke patients according to the time of decompression surgery. Material and Method: At our stroke center, 52 patients were diagnosed with stroke and underwent decompressive craniectomy. The patients were divided into four groups based on their decompression time (the first 24 hours, 24-48 hours, 48-72 hours, and after 72 hours). The width of the red cell distribution, platelet count, neutrophillymphocyte ratios, and sodium levels were calculated and compared between groups and National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) scores are all listed. Results: The patients had a mean age of 62 ± 11 years, with 31 males and 21 females. The patients' admission, 24th hour, and post-operative sodium levels were not significantly different. The patients' admission, 24th hour, and post-op RDW did not differ statistically significantly. The 24th hour NLR levels of the groups differed significantly (p=0.049). Conclusion: There is a need for laboratory measurements that can estimate the time required for decompression surgery. Nevertheless, no significant difference between groups was observed in our study, which investigated at RDW, NLR, platelet count, and sodium levels.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135827918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cyril Kamadjou, Divine Enoru Eyongeta, Annie Kameni, Jerry Kuitche, Lamine Niang, Khaled Atallah, Mohammed Lezrek, Herve Moby Mpah
Background and Aim: We present in this paper the technique and results of percutaneous nephrolithotomy as a minimally invasive treatment for large renal and pyeloureteric junction stones at the Centre medico-chirugical d’urologie in Douala, Cameroon. Methods: This was a retrospective study carried out from January 2019 to July 2022. We included 25 patients with calculi in the renal pelvis and pyeloureteric junction treated through percutaneous nephrolithotomy. Results: We included a total of 25 patients (18 men and 7 women) with a median age of 44 [36-48] years. Of the 25 patients, 23(88%) had a single calculus and 3(22%) presented with a Staghorn calculus. The median size of the calculi was 23.5 [20.25–27.75] mm and in 60% of cases; the stone was on the right side of the body. In all cases, the definitive diagnosis was made using abdominal CT scans and in 20 (80%) patients, the diagnosis was made incidentally during a CT scan for other reasons. All patients were treated through percutaneous nephrolithotomy, performed in the prone position in 21(84%) patients. Three patients who had a positive urine culture prior to the procedure benefited from a preoperative double J stent placement and all patients had post-surgery percutaneous drain placement which was left in place for 24 hours. The median surgery duration was 135 [120–165] minutes. Seventeen patients (68%) were stone free after the procedure. Conclusion: Percutaneous nephrolithotomy is an effective mini-invasive technique in the treatment of voluminous kidney and pyeloureteric junction stones. It is reliable, reproducible and has fewer complications and, therefore, proves to be an excellent choice in Sub-Saharan Africa.
{"title":"Percutaneous Nephrolithotomy: A Mini Invasive Approach for Renal and Pelvic Stones. Initial Experience from a Resource-Limited Setting in Douala Cameroon","authors":"Cyril Kamadjou, Divine Enoru Eyongeta, Annie Kameni, Jerry Kuitche, Lamine Niang, Khaled Atallah, Mohammed Lezrek, Herve Moby Mpah","doi":"10.33425/2689-1093.1049","DOIUrl":"https://doi.org/10.33425/2689-1093.1049","url":null,"abstract":"Background and Aim: We present in this paper the technique and results of percutaneous nephrolithotomy as a minimally invasive treatment for large renal and pyeloureteric junction stones at the Centre medico-chirugical d’urologie in Douala, Cameroon. Methods: This was a retrospective study carried out from January 2019 to July 2022. We included 25 patients with calculi in the renal pelvis and pyeloureteric junction treated through percutaneous nephrolithotomy. Results: We included a total of 25 patients (18 men and 7 women) with a median age of 44 [36-48] years. Of the 25 patients, 23(88%) had a single calculus and 3(22%) presented with a Staghorn calculus. The median size of the calculi was 23.5 [20.25–27.75] mm and in 60% of cases; the stone was on the right side of the body. In all cases, the definitive diagnosis was made using abdominal CT scans and in 20 (80%) patients, the diagnosis was made incidentally during a CT scan for other reasons. All patients were treated through percutaneous nephrolithotomy, performed in the prone position in 21(84%) patients. Three patients who had a positive urine culture prior to the procedure benefited from a preoperative double J stent placement and all patients had post-surgery percutaneous drain placement which was left in place for 24 hours. The median surgery duration was 135 [120–165] minutes. Seventeen patients (68%) were stone free after the procedure. Conclusion: Percutaneous nephrolithotomy is an effective mini-invasive technique in the treatment of voluminous kidney and pyeloureteric junction stones. It is reliable, reproducible and has fewer complications and, therefore, proves to be an excellent choice in Sub-Saharan Africa.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135827917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma (IPT-like FDC sarcomas, also known as FDC/FRC sarcoma) is a subgroup of follicular dendritic cell sarcoma (FDC), a rare neoplasm that often occurs in the spleen [1]. FDC/FRC sarcomas can affect other organs including the liver, colon, and the peripancreatic region [2-4]. The tumor has a predilection for young to middle-aged adults and may present with subset of symptoms including fever, abdominal pain, sweats, fatigue, and commonly a splenic solitary mass formation [5]. FDC/FRC sarcoma comprises of neoplastic spindle cells, typically with a follicular dendritic cell differentiation and over 90% of the cases are associated with EBV infection [6]. Here we present the a case of a IPT-like FDC sarcoma in a 49- year old female treated with splenectomy and a review of the literature.
{"title":"Inflammatory Pseudotumor-Like Follicular/Fibroblastic Dendritic Cell Sarcoma: Focus on Surgical Treatment Approach","authors":"Zarrin Hossein-zadeh, Katherine Rivero-Soto, Roberto Rivero-Soto","doi":"10.33425/2689-1093.1050","DOIUrl":"https://doi.org/10.33425/2689-1093.1050","url":null,"abstract":"Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma (IPT-like FDC sarcomas, also known as FDC/FRC sarcoma) is a subgroup of follicular dendritic cell sarcoma (FDC), a rare neoplasm that often occurs in the spleen [1]. FDC/FRC sarcomas can affect other organs including the liver, colon, and the peripancreatic region [2-4]. The tumor has a predilection for young to middle-aged adults and may present with subset of symptoms including fever, abdominal pain, sweats, fatigue, and commonly a splenic solitary mass formation [5]. FDC/FRC sarcoma comprises of neoplastic spindle cells, typically with a follicular dendritic cell differentiation and over 90% of the cases are associated with EBV infection [6]. Here we present the a case of a IPT-like FDC sarcoma in a 49- year old female treated with splenectomy and a review of the literature.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"655 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135827916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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