Pub Date : 2024-04-08DOI: 10.1080/17425247.2024.2340653
Denzel Ryan D. Cruz, Avery Zheng, Tilahun Debele, Peter Larson, Gregory R. Dion, Yoonjee C. Park
Endotracheal intubation is a common procedure to maintain an open airway with risks for traumatic injury. Pathological changes resulting from intubation can cause upper airway complications, includ...
{"title":"Drug delivery systems for wound healing treatment of upper airway injury","authors":"Denzel Ryan D. Cruz, Avery Zheng, Tilahun Debele, Peter Larson, Gregory R. Dion, Yoonjee C. Park","doi":"10.1080/17425247.2024.2340653","DOIUrl":"https://doi.org/10.1080/17425247.2024.2340653","url":null,"abstract":"Endotracheal intubation is a common procedure to maintain an open airway with risks for traumatic injury. Pathological changes resulting from intubation can cause upper airway complications, includ...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":"10 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-08DOI: 10.1080/17425247.2024.2341184
Sandra Aulia Mardikasari, Gábor Katona, Bence Sipos, Ildikó Csóka
Intranasal antibiotic products are gaining popularity as a promising method of administering antibiotics, which provide numerous benefits, e.g. enhancing drug bioavailability, reducing adverse effe...
{"title":"Essential considerations toward development of effective nasal antibiotic formulation: features, strategies, and future directions","authors":"Sandra Aulia Mardikasari, Gábor Katona, Bence Sipos, Ildikó Csóka","doi":"10.1080/17425247.2024.2341184","DOIUrl":"https://doi.org/10.1080/17425247.2024.2341184","url":null,"abstract":"Intranasal antibiotic products are gaining popularity as a promising method of administering antibiotics, which provide numerous benefits, e.g. enhancing drug bioavailability, reducing adverse effe...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":"100 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-03DOI: 10.1080/17425247.2024.2336494
John Chen, Warren H. Finlay, Reinhard Vehring, Andrew R. Martin
The nose has been receiving increased attention as a route for drug delivery. As the site of deposition constitutes the first point of contact of the body with the drug, characterization of the reg...
{"title":"Characterizing regional drug delivery within the nasal airways","authors":"John Chen, Warren H. Finlay, Reinhard Vehring, Andrew R. Martin","doi":"10.1080/17425247.2024.2336494","DOIUrl":"https://doi.org/10.1080/17425247.2024.2336494","url":null,"abstract":"The nose has been receiving increased attention as a route for drug delivery. As the site of deposition constitutes the first point of contact of the body with the drug, characterization of the reg...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":"70 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-20DOI: 10.1080/17425247.2024.2308073
Vineet Kumar Jain, Keerti Jain, Harvinder Popli
Amphotericin B (AmB), a promising antifungal and antileishmanial drug, acts on the membrane of microorganisms. The clinical use of AmB is limited due to issues associated with its delivery includin...
{"title":"Conjugates of amphotericin B to resolve challenges associated with its delivery","authors":"Vineet Kumar Jain, Keerti Jain, Harvinder Popli","doi":"10.1080/17425247.2024.2308073","DOIUrl":"https://doi.org/10.1080/17425247.2024.2308073","url":null,"abstract":"Amphotericin B (AmB), a promising antifungal and antileishmanial drug, acts on the membrane of microorganisms. The clinical use of AmB is limited due to issues associated with its delivery includin...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":"18 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139507395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-13DOI: 10.1080/17425247.2024.2306138
Patrick T. Ronaldson, Thomas P. Davis
Successful neuropharmacology requires optimization of CNS drug delivery and, by extension, free drug concentrations at brain molecular targets. Detailed assessment of blood-brain barrier (BBB) phys...
{"title":"Blood-brain barrier transporters: a translational consideration for CNS delivery of neurotherapeutics","authors":"Patrick T. Ronaldson, Thomas P. Davis","doi":"10.1080/17425247.2024.2306138","DOIUrl":"https://doi.org/10.1080/17425247.2024.2306138","url":null,"abstract":"Successful neuropharmacology requires optimization of CNS drug delivery and, by extension, free drug concentrations at brain molecular targets. Detailed assessment of blood-brain barrier (BBB) phys...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":"38 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139463668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-20DOI: 10.1080/17425247.2023.2297937
Huali Chen, Qianyu Zhang
Due to the concerns raised by the extensive application of PEGylation, polypeptides have stood out as excellent candidates with adequate biocompatibility and biodegradability with tunable hydrophil...
{"title":"Polypeptides as alternatives to PEGylation of therapeutic agents","authors":"Huali Chen, Qianyu Zhang","doi":"10.1080/17425247.2023.2297937","DOIUrl":"https://doi.org/10.1080/17425247.2023.2297937","url":null,"abstract":"Due to the concerns raised by the extensive application of PEGylation, polypeptides have stood out as excellent candidates with adequate biocompatibility and biodegradability with tunable hydrophil...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":"123 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138816456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.1080/17425247.2023.2295940
Snigdha Singh, Mukta Agrawal, Rajat Vashist, Rohit K Patel, Sanchita Dhanchandra Sangave, Amit Alexander
The efficiency of brain therapeutics is greatly hindered by the blood-brain barrier (BBB). BBB’s protective function, selective permeability, and dynamic functionality maintain the harmony between ...
{"title":"Recent advancements on in vitro blood-brain barrier model: a reliable and efficient screening approach for preclinical and clinical investigation","authors":"Snigdha Singh, Mukta Agrawal, Rajat Vashist, Rohit K Patel, Sanchita Dhanchandra Sangave, Amit Alexander","doi":"10.1080/17425247.2023.2295940","DOIUrl":"https://doi.org/10.1080/17425247.2023.2295940","url":null,"abstract":"The efficiency of brain therapeutics is greatly hindered by the blood-brain barrier (BBB). BBB’s protective function, selective permeability, and dynamic functionality maintain the harmony between ...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":"52 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138689163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-13DOI: 10.1080/17425247.2023.2294884
Marco Uboldi, Arianna Chiappa, Margherita Rossi, Francesco Briatico-Vangosa, Alice Melocchi, Lucia Zema
Efficacy and compliance of type II diabetes treatment would greatly benefit from dosage forms providing controlled release of metformin in the upper gastrointestinal tract. In this respect, the fea...
在上消化道控制释放二甲双胍的剂型对 II 型糖尿病治疗的有效性和依从性大有裨益。在这方面，二甲双胍的...
{"title":"Development of a multi-component gastroretentive expandable drug delivery system (GREDDS) for personalized administration of metformin","authors":"Marco Uboldi, Arianna Chiappa, Margherita Rossi, Francesco Briatico-Vangosa, Alice Melocchi, Lucia Zema","doi":"10.1080/17425247.2023.2294884","DOIUrl":"https://doi.org/10.1080/17425247.2023.2294884","url":null,"abstract":"Efficacy and compliance of type II diabetes treatment would greatly benefit from dosage forms providing controlled release of metformin in the upper gastrointestinal tract. In this respect, the fea...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":"2 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138689502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-11DOI: 10.1080/17425247.2023.2292692
Monika Wojtyłko, Dimitrios A. Lamprou, Anna Froelich, Wiesław Kuczko, Radosław Wichniarek, Tomasz Osmałek
3D printing (3DP) applications in medicine are intensively investigated, creating an opportunity to provide patient-tailored therapy by delivering a drug with an accurate dose and release profile. ...
{"title":"3D-printed solid oral dosage forms for mental and neurological disorders: recent advances and future perspectives","authors":"Monika Wojtyłko, Dimitrios A. Lamprou, Anna Froelich, Wiesław Kuczko, Radosław Wichniarek, Tomasz Osmałek","doi":"10.1080/17425247.2023.2292692","DOIUrl":"https://doi.org/10.1080/17425247.2023.2292692","url":null,"abstract":"3D printing (3DP) applications in medicine are intensively investigated, creating an opportunity to provide patient-tailored therapy by delivering a drug with an accurate dose and release profile. ...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":"19 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138574885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01Epub Date: 2023-08-08DOI: 10.1080/17425247.2023.2244413
Yanjun Zhou, Luan Jia, Guangshuai Zhang, Gang Chen, Di Zhou, Xianbao Shi, Qiang Fu, Ning Li
Objectives: The dissolvable microneedles loaded with cedrol based on flexible backing were developed to deliver cedrol directly and continuously to the dermis, where the drug concentration in the hair follicle can be increased locally.
Methods: The tip-layer matrix solution was prepared by mixing cedrol and polyvinylpyrrolidone K25 (PVP K25), and the pedestal matrix solution was prepared with aqueous hyaluronic acid. The cedrol-loaded dissolvable microneedles (cedrol-DMNs) were prepared under vacuum conditions. The mechanical properties, pig skin penetration efficiency, in vitro cutaneous permeation test, and the amount of drug in the skin and receptor chamber were evaluated. Pharmacodynamical studies were performed with C57BL/6 mice.
Results: The mechanical properties of cedrol-DMNs were good. In vitro cutaneous permeation tests and pharmacodynamical studies demonstrated that cedrol-DMN could efficiently deliver the drug to the deep dermis and effectively promote hair growth.
Conclusions: The cedrol-DMNs offer a promising strategy for treating patients suffering from hair loss.
{"title":"Cedrol-loaded dissolvable microneedles based on flexible backing for promoting hair growth.","authors":"Yanjun Zhou, Luan Jia, Guangshuai Zhang, Gang Chen, Di Zhou, Xianbao Shi, Qiang Fu, Ning Li","doi":"10.1080/17425247.2023.2244413","DOIUrl":"10.1080/17425247.2023.2244413","url":null,"abstract":"<p><strong>Objectives: </strong>The dissolvable microneedles loaded with cedrol based on flexible backing were developed to deliver cedrol directly and continuously to the dermis, where the drug concentration in the hair follicle can be increased locally.</p><p><strong>Methods: </strong>The tip-layer matrix solution was prepared by mixing cedrol and polyvinylpyrrolidone K25 (PVP K25), and the pedestal matrix solution was prepared with aqueous hyaluronic acid. The cedrol-loaded dissolvable microneedles (cedrol-DMNs) were prepared under vacuum conditions. The mechanical properties, pig skin penetration efficiency, in vitro cutaneous permeation test, and the amount of drug in the skin and receptor chamber were evaluated. Pharmacodynamical studies were performed with C57BL/6 mice.</p><p><strong>Results: </strong>The mechanical properties of cedrol-DMNs were good. In vitro cutaneous permeation tests and pharmacodynamical studies demonstrated that cedrol-DMN could efficiently deliver the drug to the deep dermis and effectively promote hair growth.</p><p><strong>Conclusions: </strong>The cedrol-DMNs offer a promising strategy for treating patients suffering from hair loss.</p>","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":" ","pages":"1267-1276"},"PeriodicalIF":6.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10316608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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