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2017 International Conference on Intelligent Informatics and Biomedical Sciences (ICIIBMS)最新文献

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Development of quantitative index evaluating anticancer or carcinogenic potential of diet: The Anti-Cancer Food Scoring System (ACFS) 1.0 评价饮食抗癌或致癌潜力的定量指标的发展:抗癌食品评分系统(ACFS) 1.0
C. H. Rim
Cancer is a global health burden, and one-third of the cancer was estimated to be related with diet. The most reliable report about diet and cancer prevention is the expert report of the World Cancer Research Fund & American Institute of Cancer Research (WCRF & AICR). In a recent study, cancer mortality has been reduced by 60% in the population adhered the guidelines of the report. However, most of the studies including WCRF & AICR report, have written with academic terms in nutritional and medical aspects, and most of them are in English. The aim of this study is to create a model, named Anti-Cancer Food Scoring System (ACFS), that can provide a simple index of the anticancer or carcinogenic potential of food. This index will help the people without expertise can assess the anticancer potential of their daily meals.
癌症是一个全球性的健康负担,据估计,三分之一的癌症与饮食有关。关于饮食和癌症预防最可靠的报告是世界癌症研究基金会和美国癌症研究所(WCRF & AICR)的专家报告。在最近的一项研究中,遵循报告指导方针的人群中,癌症死亡率降低了60%。然而,包括WCRF和AICR报告在内的大多数研究都使用了营养和医学方面的学术术语,而且大多数都是英文的。这项研究的目的是建立一个模型,称为抗癌食品评分系统(ACFS),可以提供一个简单的指数,抗癌或致癌的食品潜力。该指标将帮助没有专业知识的人评估日常饮食的抗癌潜力。
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引用次数: 0
Ins and outs of dendritic integration in awake mice 清醒小鼠树突整合的来龙去脉
Christopher J. Roome, B. Kuhn
Neurons are frequently viewed as discrete input-output computers; decoding synaptic inputs to their dendrites to generate correct outputs from their soma, through ‘dendritic integration’. Yet fundamental properties, such as spatio-temporal patterns of synaptic inputs, and the number of inputs required to generate an output in awake animals, remain unknown. We combined simultaneous voltage and calcium imaging from spiny dendrites, with somatic electrical recording from cerebellar Purkinje neurons to investigate dendritic integration in awake mice. Here we show spatio-temporal patterns of dendritic signaling and their non-linear relationship with somatic output and provide an estimate for the number of synaptic inputs required to generate a somatic output. Sub-millisecond two-photon imaging detected rapid and localized sub- and supra-threshold dendritic signaling and revealed how high frequency electrical dendritic inputs concurrently regulate somatic output and permit isolated dendritic computations with millisecond precision. These findings explore the complexity of dendritic signaling and support the hypothesis that dendritic processes behave as fundamental computational units.
神经元通常被视为离散的输入输出计算机;解码突触输入到树突,通过“树突整合”从它们的躯体中产生正确的输出。然而,基本特性,如突触输入的时空模式,以及在清醒的动物中产生输出所需的输入数量,仍然是未知的。我们结合了来自棘树突的同时电压和钙成像,以及来自小脑浦肯野神经元的体电记录来研究清醒小鼠的树突整合。在这里,我们展示了树突信号的时空模式及其与躯体输出的非线性关系,并提供了产生躯体输出所需的突触输入数量的估计。亚毫秒双光子成像检测到快速和局部的亚阈值和超阈值树突信号,揭示了高频树突电输入如何同时调节体细胞输出,并允许毫秒精度的孤立树突计算。这些发现探索了树突信号的复杂性,并支持树突过程作为基本计算单元的假设。
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引用次数: 0
Autonomous flight drone for infrastructure (transmission line) inspection (3) 用于基础设施(输电线路)巡检的自主飞行无人机(3)
M. Morita, Hironobu Kinjo, Shido Sato
Drones are currently being used for a wide range of applications, such as for the i-Construction initiative and public surveys [1] conducted by the Ministry of Land, Infrastructure, Transport and Tourism, and for surveillance and for crop-dusting operations [2]. For these purposes, drones are controlled either by a pilot through an FPV, or drones fly autonomously by estimating self-position using GPS. GPS data, however, can become faulty under bridges, inside tunnels, or near high-voltage power lines [3], which could lead to drone flight errors. To address this issue, we are developing a system for conducting infrastructure inspections using drones that basically use GPS for autonomous flight control, but can also estimate self-position through image processing when GPS cannot be used under situations such as those mentioned above.
无人机目前被用于广泛的应用,例如由土地、基础设施、交通和旅游部进行的i-Construction倡议和公共调查b[1],以及用于监视和作物喷粉作业b[1]。出于这些目的,无人机要么由飞行员通过FPV控制,要么通过GPS估计自身位置来自主飞行。然而,GPS数据在桥梁下、隧道内或高压电线附近可能会出现故障,这可能导致无人机飞行错误。为了解决这个问题,我们正在开发一种使用无人机进行基础设施检查的系统,该系统基本上使用GPS进行自主飞行控制,但在上述情况下无法使用GPS时,也可以通过图像处理来估计自我位置。
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引用次数: 12
Artificial neural network based nuclei segmentation on cytology pleural effusion images 基于人工神经网络的胸膜积液细胞学图像核分割
Khin Yadanar Win, S. Choomchuay, K. Hamamoto, Manasanan Raveesunthornkiat
Automated segmentation of cell nuclei is the crucial step towards computer-aided diagnosis system because the morphological features of the cell nuclei are highly associated with the cell abnormality and disease. This paper contributes four main stages required for automatic segmentation of the cell nuclei on cytology pleural effusion images. Initially, the image is preprocessed to enhance the image quality by applying contrast limited adaptive histogram equalization (CLAHE). The segmentation process is relied on a supervised Artificial Neural network (ANN) based pixel classification. Then, the boundaries of the extracted cell nuclei regions are refined by utilizing the morphological operation. Finally, the overlapped or touched nuclei are identified and split by using the marker-controlled watershed method. The proposed method is evaluated with the local dataset containing 35 cytology pleural effusion images. It achieves the performance of 0.95%, 0.86 %, 0.90% and 92% in precision, recall, F-measure and Dice Similarity Coefficient respectively. The average computational time for the entire algorithm took 15 mins per image. To our knowledge, this is the first attempt that utilizes ANN as the segmentation on cytology pleural effusion images.
细胞核的自动分割是计算机辅助诊断系统的关键一步,因为细胞核的形态特征与细胞异常和疾病高度相关。本文提出了细胞学胸膜积液图像中细胞核自动分割的四个主要步骤。首先,通过应用对比度有限的自适应直方图均衡化(CLAHE)对图像进行预处理以提高图像质量。分割过程依赖于基于监督人工神经网络(ANN)的像素分类。然后,利用形态学运算细化提取的细胞核区域的边界。最后,利用标记控制分水岭法对重叠或接触的细胞核进行识别和分离。用包含35张细胞学胸膜积液图像的局部数据集对该方法进行了评估。在查全率、查全率、f测度和骰子相似系数上分别达到0.95%、0.86%、0.90%和92%。整个算法的平均计算时间为每张图像15分钟。据我们所知,这是第一次尝试利用人工神经网络对细胞学胸膜积液图像进行分割。
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引用次数: 8
Emergence of robust cooperative states by iterative internalizations of opponents' personalized values in minority game 少数博弈中对手个性化价值的迭代内化产生稳健合作状态
Takashi Sato
Adolescence is a period in which individuals begin facing some challenging choices. Through these choices, and social interactions with peers, adolescent individuals develop their “personalized values” that are the foundations of their actions. It is known that the adolescent brains have high plasticity, and that the adolescent brains change dynamically, other than that of an adult brains. This study discusses the type of behavior that emerges from adolescents, as well as adult individuals with elevated plasticities. To realize this, we adopt the minority game (MG), which is one of the task concerning the choice described above. We implement Elman-nets with different learning rates that express different degrees of the plasticity as the player models in the MG. Our simulation results showed that it is a possibility that robust cooperative states emerge by iteratively internalizing the opponent players' personalized values among players that have a network of reference relationship, irrespective of their varying degrees of plasticity.
青春期是个人开始面临一些具有挑战性的选择的时期。通过这些选择,以及与同龄人的社会互动,青少年发展了他们的“个性化价值观”,这是他们行动的基础。众所周知,青少年的大脑具有很高的可塑性,与成年人的大脑不同,青少年的大脑是动态变化的。这项研究讨论了青少年以及具有较高可塑性的成年人的行为类型。为了实现这一点,我们采用了小众博弈(MG),它是上述选择的任务之一。我们使用不同学习率的Elman-nets来表达不同程度的可塑性,就像MG中的玩家模型一样。仿真结果表明,在具有参考关系网络的玩家中,不管他们的可塑性程度如何,通过迭代地内化对手的个性化价值观,都有可能出现稳健的合作状态。
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引用次数: 3
2-P imaging of mouse visual cortex layer 6 corticothalamic feedback during different behavior states 不同行为状态下小鼠视觉皮层第6层皮质丘脑反馈的二维成像
S. Augustinaite, B. Kuhn
Layer 6 (L6), the deepest lamina of cerebral cortex, is one of the key structures regulating behavior state related information processing within the cortex and various subcortical areas. However, very little is known about the functional significance of different L6 circuits in vivo. L6 experiments in the behaving animals still remain challenging due to hard access of the recording / imaging site, complexity of neuronal circuits and heterogeneity in neuron morphology. Here, we focus on primary visual cortex L6 feedback projections to visual thalamus (lateral geniculate nucleus) which regulate visual signal transmission from retina to cortex. We developed a method to “dissect” and study these L6 corticothalamic feedback projections in vivo with 2P microscopy. With this method, we can reliably image retrogradely labeled corticothalamic and other excitatory L6 neurons throughout full layer, down to about 850 μm below dura in a head-fixed mouse. Up to a few hundred individual neurons can be recorded simultaneously for several hours and/or repeatedly recorded during different days, while monitoring mouse behavior state. This allows us to study the cortical feedback to the primary visual thalamus during different behavior states, ranging from full alertness to sleep.
第6层(Layer 6, L6)是大脑皮层最深处的层,是皮层及皮层下各区域内调节行为状态相关信息加工的关键结构之一。然而,我们对体内不同L6回路的功能意义知之甚少。由于难以进入记录/成像部位,神经元回路的复杂性和神经元形态的异质性,在行为动物中进行L6实验仍然具有挑战性。在这里,我们主要关注初级视觉皮层L6反馈投射到视觉丘脑(外侧膝状核),它调节视觉信号从视网膜到皮层的传递。我们开发了一种方法来“解剖”和研究这些L6皮质丘脑反馈投影在体内用2P显微镜。利用这种方法,我们可以可靠地成像逆行标记的皮质丘脑和其他兴奋性L6神经元,覆盖整个层,直至硬脑膜下约850 μm。在监测小鼠行为状态的同时,可以同时记录数百个神经元,并在数小时内和/或在不同天内重复记录。这使我们能够研究从完全清醒到睡眠等不同行为状态下皮层对初级视觉丘脑的反馈。
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引用次数: 0
Classification of P300 in EEG signals for disable subjects using singular spectrum analysis 残障受试者脑电信号P300的奇异谱分类
H. Tjandrasa, S. Djanali, F. X. Arunanto
Brain-computer interfaces have been enabled severely disabled users to communicate with their environments. One method is to use a controlled stimulus to elicit the P300 event-related potential. EEG signals during the repeated stimuli were recorded from four disabled subjects and processed with a Butterworth bandpass filter and Singular Spectrum Analysis, normalized, separated into 2 groups of the target and non-target trial data, and averaged for every 5 trials for each group before classified using a neural network. The purpose of averaging every five target and non-target trials was to emerge the P300 component of even-related potentials so that the target trials could be differentiated from the non-target trials. Further processing by selecting 1 of every 5 processed non-target trials increased the value of sensitivity by 10.9%, it showed that the number of false negatives of target trials was reduced. The results of the classification gave the maximum accuracy of 92.5%. The average values of sensitivity, specificity, and accuracy were 70.8%, 89,8%, and 84.6% respectively.
脑机接口已经使严重残疾的用户能够与他们的环境进行交流。一种方法是使用受控刺激诱发P300事件相关电位。记录4名残疾受试者在重复刺激过程中的脑电信号,经Butterworth带通滤波和奇异谱分析处理后归一化,将目标和非目标试验数据分为2组,每组5次试验取平均值,然后利用神经网络进行分类。对每5个靶和非靶试验取平均值的目的是得到偶相关电位的P300分量,以便将靶试验与非靶试验区分开来。进一步处理后,每处理5个非靶试验中选择1个,敏感性值提高10.9%,表明靶试验的假阴性数量减少。分类结果给出的最高准确率为92.5%。敏感性、特异性和准确性的平均值分别为70.8%、89、8%和84.6%。
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引用次数: 2
Development of endoscopic system based on fluorescence imaging for detection of colon cancer 基于荧光成像的结肠癌内镜检测系统的研制
Kiri Lee, Jiseop Kim, Byungjun Park, H. Bang, Byungyeon Kim, Youngjae Won, Seungrag Lee
Molecular endoscopic fluorescence imaging can improve noninvasive detection of lesions in the colon. We developed fluorescence endoscopic imaging system. We obtained fluorescence image of ex vivo mouse colon tissue from designed image acquisition system.
分子内窥镜荧光成像可以改善结肠病变的无创检测。我们开发了荧光内窥镜成像系统。利用设计的图像采集系统获得小鼠离体结肠组织的荧光图像。
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引用次数: 0
A medical training system using augmented reality 使用增强现实技术的医疗培训系统
Ryosuke Umeda, Mohamed Atef Seif, H. Higa, Yukio Kuniyoshi
This paper presents a medical training system using augmented reality, AR. Recognizing an AR marker through a Web camera, computer generated images appear on a real space. We prepared 3D (three-dimensional) anatomical objects to show, and evaluated our system using AR platform. From the experimental result, we found that our system could overlay the digital information on the operator's surrounding real world appropriately.
本文介绍了一种利用增强现实技术(AR)的医疗培训系统,通过网络摄像头识别AR标记,计算机生成的图像出现在真实空间中。我们准备了3D(三维)解剖对象来展示,并使用AR平台对我们的系统进行了评估。从实验结果来看,我们的系统可以将数字信息适当地覆盖在操作员周围的真实世界上。
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引用次数: 11
Behavior analysis of a small animal using IoT sensor system 利用物联网传感器系统对小动物进行行为分析
Asuka Noda, O. Fukuda, H. Okumura, K. Arai
The purpose of this paper is to monitor and analyze the behavior of small animals, which has been still poorly by many research. By using IoT sensors and a monitoring camera, the user can observe the behavior of small animals. The system can inform the user of IoT sensor events through Twitter and e-mail service. Also, their states are recorded on a Google spreadsheet. Then, we can analyze the behavior based on the records. The experiments were conducted to verify validity of the system with a djungarian hamster. The experimental results revealed that the behavior of small animals were changed depending on environment around them. By using the Bayesian network, the environment and time period were successfully estimated only based on the IoT sensor data.
本文的目的是监测和分析小动物的行为,这方面的研究仍然很少。通过使用物联网传感器和监控摄像头,用户可以观察小动物的行为。该系统可以通过Twitter和电子邮件服务向用户通报物联网传感器事件。此外,他们的状态记录在谷歌电子表格上。然后,我们可以根据记录分析行为。以一只保加利亚仓鼠为实验对象,验证了该系统的有效性。实验结果表明,小动物的行为会随着周围环境的变化而改变。通过使用贝叶斯网络,仅基于物联网传感器数据就成功估计了环境和时间段。
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引用次数: 6
期刊
2017 International Conference on Intelligent Informatics and Biomedical Sciences (ICIIBMS)
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