Aim: This study aimed to evaluate the performance of three large language models (LLMs)-ChatGPT-4.0, Claude 3.5 Sonnet, and DeepSeek R1-in answering multiple-choice questions (MCQs) related to pediatric dentistry. Accuracy and justification quality were analyzed using Bloom's taxonomy.
目的:本研究旨在评估三种大型语言模型(llm)-ChatGPT-4.0, Claude 3.5 Sonnet和DeepSeek r1 -在回答与儿科牙科相关的多项选择题(mcq)中的性能。使用Bloom分类法分析准确性和证明质量。
{"title":"Evaluation of large language models in pediatric dentistry: a Bloom's taxonomy-based analysis.","authors":"Atanu Mukhopadhyay, Santanu Mukhopadhyay, Raju Biswas","doi":"10.3897/folmed.67.e154338","DOIUrl":"https://doi.org/10.3897/folmed.67.e154338","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to evaluate the performance of three large language models (LLMs)-ChatGPT-4.0, Claude 3.5 Sonnet, and DeepSeek R1-in answering multiple-choice questions (MCQs) related to pediatric dentistry. Accuracy and justification quality were analyzed using Bloom's taxonomy.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this paper, we describe how we successfully debulked a large juvenile nasopharyngeal angiofibroma (JNA) in a 15-year-old boy using the coblation technique. The child had been complaining about recurrent epistaxis and persistent nasal obstruction for several months. JNA is a rare benign tumor that predominantly affects adolescent and young adult males. JNAs exhibit gradual progression, local expansion, high vascularity, and a notable tendency for persistence and recurrence. Due to their high vascularity, JNAs require surgical removal, and treatment commonly includes preoperative embolization and endoscopic methods. Complete tumor resection is the gold standard treatment. Tumor manipulation can lead to substantial bleeding due to its rich blood supply and lack of surface muscle fibers. Using the coblation technique for tumor debulking offers distinct advantages, including better control of blood loss, reduced thermal damage, improved visibility of the surrounding area, better postoperative recovery, and less resection of vital anatomical structures.
{"title":"The use of coblation technique for the debulking of juvenile angiofibroma.","authors":"Evangelos Giotakis, Vasileios Ragos, Aris Giotakis, Aris Papapetropoulos, Panagiotis Chadoulos, Aikaterini D Lianou","doi":"10.3897/folmed.67.e142588","DOIUrl":"https://doi.org/10.3897/folmed.67.e142588","url":null,"abstract":"<p><p>In this paper, we describe how we successfully debulked a large juvenile nasopharyngeal angiofibroma (JNA) in a 15-year-old boy using the coblation technique. The child had been complaining about recurrent epistaxis and persistent nasal obstruction for several months. JNA is a rare benign tumor that predominantly affects adolescent and young adult males. JNAs exhibit gradual progression, local expansion, high vascularity, and a notable tendency for persistence and recurrence. Due to their high vascularity, JNAs require surgical removal, and treatment commonly includes preoperative embolization and endoscopic methods. Complete tumor resection is the gold standard treatment. Tumor manipulation can lead to substantial bleeding due to its rich blood supply and lack of surface muscle fibers. Using the coblation technique for tumor debulking offers distinct advantages, including better control of blood loss, reduced thermal damage, improved visibility of the surrounding area, better postoperative recovery, and less resection of vital anatomical structures.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-14DOI: 10.3897/folmed.67.e143525
Georgi V Lazarov
Aim: This study investigated the relationship between erectile dysfunction and the estradiol-to-testosterone ratio in men aged 35 to 45.
目的:探讨35 ~ 45岁男性勃起功能障碍与雌二醇/睾酮比值的关系。
{"title":"Estradiol-to-testosterone ratio and erectile dysfunction in men aged 35-45.","authors":"Georgi V Lazarov","doi":"10.3897/folmed.67.e143525","DOIUrl":"https://doi.org/10.3897/folmed.67.e143525","url":null,"abstract":"<p><strong>Aim: </strong>This study investigated the relationship between erectile dysfunction and the estradiol-to-testosterone ratio in men aged 35 to 45.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cholesteatomas are benign tumors composed of skin-related substances. They can extensively infiltrate the ear and compromise surrounding structures, requiring surgical removal. Computed tomography can assist with surgical planning by illustrating the position and impact of the cholesteatoma. Recent advancements in magnetic resonance imaging have demonstrated enhanced visualization of cholesteatomas. Whereas additional surgical intervention was formerly necessary to identify cholesteatoma recurrence, magnetic resonance imaging can now often serve as an alternative. This paper reviews the current evidence on diagnosing, managing, and following up with patients with cholesteatoma. It also presents an interesting case that highlights the value of diffusion-weighted imaging (DWI), even in cases of initial diagnosis.
{"title":"Cholesteatoma: diagnosis, management and follow-up, and an interesting case report.","authors":"Aikaterini Lianou, Magdalini Bizoglou, Dimitra Simou, Georgios Psychogios","doi":"10.3897/folmed.67.e140847","DOIUrl":"https://doi.org/10.3897/folmed.67.e140847","url":null,"abstract":"<p><p>Cholesteatomas are benign tumors composed of skin-related substances. They can extensively infiltrate the ear and compromise surrounding structures, requiring surgical removal. Computed tomography can assist with surgical planning by illustrating the position and impact of the cholesteatoma. Recent advancements in magnetic resonance imaging have demonstrated enhanced visualization of cholesteatomas. Whereas additional surgical intervention was formerly necessary to identify cholesteatoma recurrence, magnetic resonance imaging can now often serve as an alternative. This paper reviews the current evidence on diagnosing, managing, and following up with patients with cholesteatoma. It also presents an interesting case that highlights the value of diffusion-weighted imaging (DWI), even in cases of initial diagnosis.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-14DOI: 10.3897/folmed.67.e153005
Alyea Al-Harthy, Mohammad Arafa
Introduction: An endometrial polyp (EP) is an abnormal growth of the endometrium inside the uterine cavity. Histologically, the polyp contains glandular, stromal, vascular (thick-walled vessels), and connective tissue elements (fibrous stroma). The most common symptoms of patients with endometrial polyps are abnormal bleeding and infertility.
{"title":"Clinicopathological study of endometrial polyps: experience from a tertiary care center.","authors":"Alyea Al-Harthy, Mohammad Arafa","doi":"10.3897/folmed.67.e153005","DOIUrl":"10.3897/folmed.67.e153005","url":null,"abstract":"<p><strong>Introduction: </strong>An endometrial polyp (EP) is an abnormal growth of the endometrium inside the uterine cavity. Histologically, the polyp contains glandular, stromal, vascular (thick-walled vessels), and connective tissue elements (fibrous stroma). The most common symptoms of patients with endometrial polyps are abnormal bleeding and infertility.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Root canal system decontamination is recognized as one of the main pillars of successful endodontic treatment, although variations in the efficacy of current disinfection methods have been reported. In light of this, the present study investigated the activation of 5.25% sodium hypochlorite (NaOCl) using a 980 nm diode laser (laser-activated irrigation) as an adjunct to conventional decontamination, with the addition of photobiomodulation therapy. The objectives were to achieve optimal clinical outcomes over long-term follow-up, to alleviate post-endodontic pain, and to propose effective decontamination treatment protocols.
{"title":"Management of perio-endo interface complex case with NaOCl photoactivated with 980 nm to optimize root canal system decontamination with 12-month follow-up.","authors":"Reem Hanna, Ioana Cristina Miron, Stefano Benedicenti","doi":"10.3897/folmed.67.e143587","DOIUrl":"https://doi.org/10.3897/folmed.67.e143587","url":null,"abstract":"<p><p>Root canal system decontamination is recognized as one of the main pillars of successful endodontic treatment, although variations in the efficacy of current disinfection methods have been reported. In light of this, the present study investigated the activation of 5.25% sodium hypochlorite (NaOCl) using a 980 nm diode laser (laser-activated irrigation) as an adjunct to conventional decontamination, with the addition of photobiomodulation therapy. The objectives were to achieve optimal clinical outcomes over long-term follow-up, to alleviate post-endodontic pain, and to propose effective decontamination treatment protocols.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Anastomotic leak (AL) in colorectal surgery remains a source of concern, as it jeopardizes patient recovery and increases morbidity, particularly if not detected early. The CRP in the drain fluid has barely been investigated as a new predictive marker of AL that would improve treatment outcomes.
{"title":"Diagnostic accuracy of CRP in the drainage fluid for early detection of anastomotic leakage in colorectal surgery - a pilot study.","authors":"Ilektra Kyrochristou, Georgios Anagnostopoulos, Konstantina Psalla, Panagiotis Giannakakis, Athanasios Rogdakis","doi":"10.3897/folmed.67.e154087","DOIUrl":"https://doi.org/10.3897/folmed.67.e154087","url":null,"abstract":"<p><strong>Introduction: </strong>Anastomotic leak (AL) in colorectal surgery remains a source of concern, as it jeopardizes patient recovery and increases morbidity, particularly if not detected early. The CRP in the drain fluid has barely been investigated as a new predictive marker of AL that would improve treatment outcomes.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-14DOI: 10.3897/folmed.67.e152506
Ravishtaashini Vanitha, Franziska Abelein, Kalina P Stoyanova
Introduction: Malaria is a significant global health problem, predominantly affecting the tropical regions.
疟疾是一个重大的全球健康问题,主要影响热带地区。
{"title":"Imported and non-travel related cases of malaria in Europe - a ten-year analytic retrospective review.","authors":"Ravishtaashini Vanitha, Franziska Abelein, Kalina P Stoyanova","doi":"10.3897/folmed.67.e152506","DOIUrl":"https://doi.org/10.3897/folmed.67.e152506","url":null,"abstract":"<p><strong>Introduction: </strong>Malaria is a significant global health problem, predominantly affecting the tropical regions.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-14DOI: 10.3897/folmed.67.e152985
Georgi Stoitsev, Denitsa Gavrilova, Vassil Gegouskov
Tumors of the heart and blood vessels are relatively rare. Primary cardiac hemangiomas, in particular, are very rare benign tumors of the heart, occurring at a frequency of 2.8%. To date, just over 200 cases have been documented in scientific literature. Most have been discovered incidentally during autopsies or clinical procedures for unrelated conditions. Most reports present cardiac hemangiomas as isolated cases. According to scientific data, they can appear at any age, and their clinical presentation varies depending on their location and size. Here, we present the case of an asymptomatic cardiac tumor that was discovered incidentally in a 66-year-old male patient during treatment for infective endocarditis of the mitral valve. Despite extensive cardiac imaging, the tumor could not be diagnosed before surgical intervention. Ultimately, the tumor was found on the epicardium of the right ventricle, close to the right coronary artery. It was completely resected. Histological analysis verified it as a cardiac cavernous hemangioma.
{"title":"Small-sized cardiac cavernous hemangioma in patient with endocarditis - an incidental finding.","authors":"Georgi Stoitsev, Denitsa Gavrilova, Vassil Gegouskov","doi":"10.3897/folmed.67.e152985","DOIUrl":"https://doi.org/10.3897/folmed.67.e152985","url":null,"abstract":"<p><p>Tumors of the heart and blood vessels are relatively rare. Primary cardiac hemangiomas, in particular, are very rare benign tumors of the heart, occurring at a frequency of 2.8%. To date, just over 200 cases have been documented in scientific literature. Most have been discovered incidentally during autopsies or clinical procedures for unrelated conditions. Most reports present cardiac hemangiomas as isolated cases. According to scientific data, they can appear at any age, and their clinical presentation varies depending on their location and size. Here, we present the case of an asymptomatic cardiac tumor that was discovered incidentally in a 66-year-old male patient during treatment for infective endocarditis of the mitral valve. Despite extensive cardiac imaging, the tumor could not be diagnosed before surgical intervention. Ultimately, the tumor was found on the epicardium of the right ventricle, close to the right coronary artery. It was completely resected. Histological analysis verified it as a cardiac cavernous hemangioma.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-16DOI: 10.3897/folmed.67.e139995
Atalay Kutlu, Akif Erbin, Turan Ozdemir, Ahmet Eren Sagir, Begum Calim Gurbuz, Halil Lutfi Canat
Xanthogranulomatous pyelonephritis (XGP) is a rare and severe chronic inflammatory condition of the kidney. XGP's exact etiology remains unclear, although it is frequently associated with chronic urinary obstruction and infections within the urinary tract. Superinfections such as Escherichiacoli, Proteusmirabilis, and occasionally Pseudomonas species typically cause XGP. Documented cases of Raoultellaornithinolytica (R.ornithinolytica) infections in humans, particularly within the urinary tract, are limited. However, advancements in diagnostic techniques are expected to increase the detection of such rare pathogens. To the best of our knowledge, currently, there is no evidence in the literature indicating that this pathogen is responsible for XGP. We present a case of XGP in which we isolated R.ornithinolytica and discuss its treatment in the current literature.
{"title":"Xanthogranulomatous pyelonephritis caused by an unusual pathogen <i>Raoultella ornithinolytica</i>: a case report.","authors":"Atalay Kutlu, Akif Erbin, Turan Ozdemir, Ahmet Eren Sagir, Begum Calim Gurbuz, Halil Lutfi Canat","doi":"10.3897/folmed.67.e139995","DOIUrl":"10.3897/folmed.67.e139995","url":null,"abstract":"<p><p>Xanthogranulomatous pyelonephritis (XGP) is a rare and severe chronic inflammatory condition of the kidney. XGP's exact etiology remains unclear, although it is frequently associated with chronic urinary obstruction and infections within the urinary tract. Superinfections such as Escherichiacoli, Proteusmirabilis, and occasionally Pseudomonas species typically cause XGP. Documented cases of Raoultellaornithinolytica (R.ornithinolytica) infections in humans, particularly within the urinary tract, are limited. However, advancements in diagnostic techniques are expected to increase the detection of such rare pathogens. To the best of our knowledge, currently, there is no evidence in the literature indicating that this pathogen is responsible for XGP. We present a case of XGP in which we isolated R.ornithinolytica and discuss its treatment in the current literature.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}