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Editorial: Global excellence in oral health: Europe. 社论:全球口腔健康卓越:欧洲。
Pub Date : 2023-01-01 DOI: 10.3389/froh.2023.1219999
V Pavlic, L J Kesic
COPYRIGHT © 2023 Pavlic and Kesic. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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引用次数: 0
Editorial: Inflammasome, purinergic signaling, and immunometabolism in oral health and disease. 社论:口腔健康和疾病中的炎性体、嘌呤能信号和免疫代谢。
Pub Date : 2023-01-01 DOI: 10.3389/froh.2023.1236507
Ana Carolina Morandini, Luiz Eduardo Baggio Savio
COPYRIGHT © 2023 Morandini and Savio. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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引用次数: 0
Psychologically informed oral health interventions in pregnancy and type 2 diabetes: A scoping review. 妊娠期和 2 型糖尿病患者的口腔健康心理干预:范围综述。
Pub Date : 2022-12-21 eCollection Date: 2022-01-01 DOI: 10.3389/froh.2022.1068905
Camilla Böhme Kristensen, Mark Ide, Angus Forbes, Koula Asimakopoulou

Introduction: Oral health is a critical aspect of gestational diabetes management. Gestational diabetes is high blood glucose levels during pregnancy and is managed like type 2 diabetes with diet and physical activity interventions. This scoping review sets out to discuss why oral health support should also become part of gestational diabetes management.

Objectives: The primary objective was to synthesise the existing psychologically informed oral health interventions for pregnant women and individuals with type 2 diabetes, and the extent to which these interventions map on to the COM-B Model. No literature exists on oral health interventions in gestational diabetes, why studies with type 2 diabetes populations were selected instead. The secondary objective was to identify the precise outcomes targeted in the interventions.

Methodology: The Joanna Briggs Institute's Methodology for Scoping Reviews was used to conduct this review. The populations of interest were pregnant women and individuals with type 2 diabetes, and eligible concepts were psychologically informed oral health interventions. Quasi-experimental and experimental designs were considered. The Ovid Interface including Embase, Medline, Global Health, APA PsychInfo, Health Management Information, Maternity, Infant Care Database, the Cochrane Library, and CINAHL was used as information sources. The study selection followed the PRISMA guidelines. The first search was conducted on the week commencing the 25th of July 2022, with a follow-up search conducted on the 10th of October 2022.

Results: 28 records were included for synthesis. The most frequently assessed psychological outcome was oral health knowledge and the most frequently assessed oral clinical outcome was Plaque Index. All studies used an educational intervention approach, while psychological capability in the COM-B Model was targeted in all interventions by increasing oral health knowledge among the participants. The Health Belief Model was the most frequently used theory in the interventions.

Conclusion: The results demonstrate that oral health is a recognised aspect of pregnancy and type 2 diabetes. The findings from this review and a qualitative interview study which is under development will inform the first oral health intervention for women with gestational diabetes in the United Kingdom.

引言口腔健康是妊娠糖尿病管理的一个重要方面。妊娠糖尿病是指妊娠期间血糖水平过高,与 2 型糖尿病一样,需要通过饮食和体育锻炼进行干预。本范围综述旨在讨论为什么口腔健康支持也应成为妊娠糖尿病管理的一部分:主要目的是综合现有的针对孕妇和 2 型糖尿病患者的心理干预措施,以及这些干预措施与 COM-B 模型的对应程度。目前还没有关于妊娠期糖尿病患者口腔健康干预措施的文献,因此选择了针对 2 型糖尿病患者的研究。次要目标是确定干预措施所针对的确切结果:本综述采用乔安娜-布里格斯研究所(Joanna Briggs Institute)的 "范围综述方法"(Methodology for Scoping Reviews)。研究对象为孕妇和 2 型糖尿病患者,符合条件的概念为心理干预。研究考虑了准实验和实验设计。Ovid 界面包括 Embase、Medline、Global Health、APA PsychInfo、Health Management Information、Maternity、Infant Care Database、Cochrane Library 和 CINAHL 作为信息来源。研究选择遵循 PRISMA 指南。首次检索于 2022 年 7 月 25 日开始的一周内进行,后续检索于 2022 年 10 月 10 日进行。最常评估的心理结果是口腔健康知识,最常评估的口腔临床结果是牙菌斑指数。所有研究都采用了教育干预方法,而 COM-B 模型中的心理能力在所有干预中都以增加参与者的口腔健康知识为目标。健康信念模式是干预中最常用的理论:结果表明,口腔健康是妊娠和 2 型糖尿病的一个公认方面。本综述和正在进行的定性访谈研究的结果将为英国首次针对妊娠糖尿病妇女的口腔健康干预提供参考。
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引用次数: 0
Paycheck Protection Program (PPP) COVID-19 relief funding for veteran-, minority-, and women- owned dental businesses: A cross-sectional study. 薪酬保护计划 (PPP) COVID-19 为退伍军人、少数民族和妇女拥有的牙科企业提供救济资金:一项横断面研究。
Pub Date : 2022-12-15 eCollection Date: 2022-01-01 DOI: 10.3389/froh.2022.1041415
Elizabeth Alpert, Sean G Boynes, Amber Shaver, Annaliese Cothron

Background: The Covid-19 pandemic exacerbated dental staffing shortages, which impact care delivery and ultimately oral health equity. Federal funding efforts like the Paycheck Protection Program (PPP) sought to aid traditionally underserved businesses including those owned by veterans, minority racial and ethnic groups, and women.

Objectives: (1) To examine differences in PPP funding between veteran- and nonveteran-owned dental care delivery businesses and organizations and (2) to analyze other relevant factors associated with variation in PPP funding levels for dental businesses.

Methods: Using publicly available PPP data, we ran unadjusted bivariable and adjusted multivariable linear regression models to estimate associations between loan approval amount and forgiveness amount, veteran status, and relevant covariates.

Results: Minority racial and ethnic groups and women received less PPP funding and less loan forgiveness, on average, compared with non-minority groups. In the adjusted model with no missing self-reported demographic observations at p < 0.10, veterans received more PPP funding and loan forgiveness, on average, compared to non-veterans.

Conclusion: To our knowledge, this is the first comprehensive analysis of all dental recipients of PPP funding throughout the United States. Despite PPP program intentions and strategies, traditionally underserved dental businesses did not receive increased funding to support employment.

背景:Covid-19 大流行加剧了牙科人员的短缺,这影响了医疗服务的提供,并最终影响了口腔健康的公平性。目标:(1)研究退伍军人和非退伍军人所有的牙科医疗服务企业和组织在 PPP 资助方面的差异;(2)分析与牙科企业 PPP 资助水平差异相关的其他因素:利用公开的 PPP 数据,我们运行了未经调整的双变量和经调整的多变量线性回归模型,以估计贷款批准额和豁免额、退伍军人身份以及相关协变量之间的关联:与非少数族裔群体相比,少数族裔群体和妇女获得的购买力平价资助和贷款豁免平均较少。在没有缺失自我报告人口学观察数据的调整模型中,P 结论为:少数种族和族裔群体及女性获得的 PPP 资金和贷款豁免平均少于非少数种族和族裔群体:据我们所知,这是对全美所有接受 PPP 资助的牙科患者进行的首次全面分析。尽管有 PPP 项目的意图和策略,但传统上服务不足的牙科企业并没有获得更多的资金来支持就业。
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引用次数: 0
Systematic review on dental caries preventive and managing strategies among type 2 diabetic patients. 2型糖尿病患者龋齿防治策略的系统综述。
Pub Date : 2022-11-18 eCollection Date: 2022-01-01 DOI: 10.3389/froh.2022.998171
Haoran Chen, Robert Hill, Aylin Baysan

Purpose: The purpose of this systematic review was to evaluate current evidence to prevent and manage dental caries in patients with type 2 diabetes mellitus (T2DM).

Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the Participants, Intervention, Comparison, Outcomes and Study Design (PICOS) strategy was used to formulate a structured search: systematic search of PubMed, Cochrane Library, MEDLINE via Ovid, EMBASE, Scopus, Web of Science, and Lilacs without any date limit and/or language restrictions. Two independent reviewers performed data extraction and risk of bias assessments in the included studies. Data homogeneity was assessed according to interventions for treating dental caries in T2DM. Statistical analyses were performed with JMP®.

Results: Two studies out of 909 were included in the systematic review. Only quantitative studies involving topical applications for management of dental caries in patients with T2DM were included. One study assessed the effect of intensive oral hygiene care program including toothbrushing and interdental cleaning using interproximal brushes and/or dental floss and supragingival debridement by dental hygienist with educational brochures in T2DM, while another investigated the immunologically active salivary substitutes with using Oral Hygiene Instructions (OHI), mouthwash, and moisturizing gel for 6 months. Intensive oral hygiene care program or immunologically active salivary substitutes with using OHI, mouthwash, and moisturizing gel for 6 months were reported to reverse/arrest dental caries in patients with T2DM.

Conclusion: The current randomized controlled clinical trials demonstrated that regular extensive oral health education using interdental cleaning aids, mouthwash, moistening gel, and saliva substitutes including lactoperoxidase, lysozyme, glucose oxidase, and lactoferrin could control oral inflammation and contribute to the management of dental caries in patients with T2DM.

Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020197507, identifier: CRD42020197507.

目的:本系统综述的目的是评估2型糖尿病(T2DM)患者预防和治疗龋齿的现有证据。方法:遵循系统评价和荟萃分析的首选报告项目(PRISMA)指南,采用参与者、干预、比较、结果和研究设计(PICOS)策略制定结构化搜索:通过Ovid、EMBASE、Scopus、Web of Science和Lilacs系统搜索PubMed、Cochrane Library、MEDLINE,没有任何日期限制和/或语言限制。两名独立审稿人对纳入的研究进行了数据提取和偏倚风险评估。根据治疗2型糖尿病患者龋齿的干预措施评估数据的同质性。采用JMP®进行统计学分析。结果:909项研究中有2项纳入系统评价。仅纳入了涉及局部应用于T2DM患者龋齿管理的定量研究。一项研究评估了强化口腔卫生保健计划的效果,包括刷牙和使用近端牙刷和/或牙线进行牙间清洁,以及由牙科保健师使用T2DM教育手册进行龈上清创术,而另一项研究则使用口腔卫生指南(OHI)、漱口水和保湿凝胶进行了为期6个月的免疫活性唾液替代品调查。强化口腔卫生保健计划或免疫活性唾液替代品,使用OHI、漱口水和保湿凝胶6个月,据报道可以逆转/阻止T2DM患者的龋齿。结论:目前的随机对照临床试验表明,定期进行广泛的口腔健康教育,使用牙间清洁辅助工具、漱口水、保湿凝胶和唾液替代品(包括乳酸过氧化物酶、溶菌酶、葡萄糖氧化酶和乳铁蛋白)可以控制口腔炎症,有助于T2DM患者龋齿的管理。系统评价注册:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020197507,标识符:CRD42020197507。
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引用次数: 0
Editorial: The interplay between the oral Microbiota and rheumatoid arthritis. 社论:口腔微生物群与类风湿关节炎的相互作用。
Pub Date : 2022-11-08 eCollection Date: 2022-01-01 DOI: 10.3389/froh.2022.1055482
Daniel Manoil, Nagihan Bostanci, Axel Finckh
COPYRIGHT © 2022 Manoil, Bostanci and Finckh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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引用次数: 0
Mapping of dental graduates' career paths in Hong Kong, Japan and mainland China. 香港、日本及中国内地牙科专业毕业生的职业发展路径图。
Pub Date : 2022-11-03 eCollection Date: 2022-01-01 DOI: 10.3389/froh.2022.994613
Chloe Meng Jiang, Takashi Nishioka, Guang Hong, Hao Yu, Chang-Yuan Zhang, Chun Hung Chu

Dental graduates have a variety of career-path choices. After graduation, they may join private dental practice, government- or hospital-based dental care services, research groups, academia, business or industry. With globalization and frequent international exchange, dental graduates nowadays can explore careers outside their home country. However, dental education systems and job opportunities vary widely across different regions and countries. Diversity of accreditation in dental education, different licensure requirements, and lack of global competencies in dental care often limit the globalization, operation and survival of dental practice and education worldwide. The requirements for professional education and practice can be quite diverse, and these differences will be barriers to dental graduates seeking career development outside their home home country. Fresh dental graduates have minimal experience in job hunting. More specifically, they are unfamiliar with potential career paths. This paper was based on the 4th trilateral symposium 2022 organized by The University of Hong Kong, Tohoku University, and Fujian Medical University, which offered a lecture to discuss career paths for dental graduates in Hong Kong, Japan, and mainland China. The aim of this paper was to provide dentists, particularly fresh graduated dental students, with practical insight into different career paths in Hong Kong (Special Administrative Region of China, SAR), Japan and mainland China, and factors that may influence their career options. It assists dental students in exploring possibilities in dentistry and preparing for their career development after graduation from dental school.

牙科毕业生有各种各样的职业道路选择。毕业后,他们可以加入私人牙科诊所、政府或医院牙科护理服务、研究团体、学术界、商业或工业。随着全球化和频繁的国际交流,如今的牙科毕业生可以在国外探索职业。然而,不同地区和国家的牙科教育系统和就业机会差别很大。牙科教育认证的多样性、不同的执照要求以及缺乏全球牙科保健能力往往限制了全球牙科实践和教育的全球化、运作和生存。对专业教育和实践的要求可能是多种多样的,这些差异将成为牙科毕业生在本国以外寻求职业发展的障碍。刚毕业的牙科毕业生找工作的经验很少。更具体地说,他们不熟悉潜在的职业道路。本文基于由香港大学、东北大学和福建医科大学主办的2022年第四次三方研讨会,该研讨会为香港、日本和中国大陆的牙科毕业生提供了一个讲座,讨论他们的职业道路。本文的目的是让牙医,特别是刚毕业的牙科专业学生,了解香港(中国特别行政区)、日本和中国大陆不同的职业发展道路,以及可能影响他们职业选择的因素。它帮助牙科学生探索牙科的可能性,为他们从牙科学校毕业后的职业发展做准备。
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引用次数: 0
Dental caries and associated factors among diabetic and nondiabetic adult patients attending Bichena Primary Hospital's Outpatient Department. 比奇纳初级医院门诊部糖尿病和非糖尿病成年患者的龋齿及其相关因素
Pub Date : 2022-11-02 eCollection Date: 2022-01-01 DOI: 10.3389/froh.2022.938405
Anley Shiferaw, Girma Alem, Mekonnen Tsehay, Getiye Dejenu Kibret

Purpose: Dental caries is a significant public health issue affecting both the diabetic and nondiabetic populations. However, the problem and associated factors of dental caries among diabetics and nondiabetics patients are not well-known in Ethiopia. This study aims to compare the prevalence of dental caries and associated factors among diabetic and nondiabetic patients at the Outpatient Department of Bichena Primary Hospital in Northwest, Ethiopia.

Methods: Institutional based, comparative cross-sectional study was conducted from October 7 to December 6, 2019, among 200 diabetes and 400 nondiabetic adult patients. A consecutive sampling technique was implemented to recruit study participants. Data were collected by a pretested structured questionnaire and analysis was performed in Statistical Package for Social Science version 20. Bivariable and multivariable logistic regressions were employed and variables with a p-value < 0.05 were declared statistically significant.

Results: A total of 582 patients were involved in the study with a response rate of 97.0%. The prevalence of dental caries was 67.9% [95% confidence interval (CI): 63.2%-72.8%] and 79.6% (95% CI: 74.0%-85.70%) in nondiabetic and diabetic group, respectively. Females gender [adjusted odds ratio (AOR) = 1.79, 95% CI: 1.15-2.77], poor oral hygiene (AOR = 2.95, 95% CI: 1.71-5.11), lack of regular teeth cleaning habits (AOR = 3.26, 95% CI: 2.13-4.97), feeling dry mouth (AOR = 2.31, 95% CI: 1.11-4.81), sugared tea drinking (AOR = 2.00, 95% CI: 1.18-3.38), inadequate oral health knowledge (AOR = 3.51, 95% CI: 2.19-5.62), and khat chewing (AOR = 2.14, 95% CI: 1.24-3.71) were significantly associated factors with high prevalence of dental caries.

Conclusion: The prevalence of caries was significantly higher among diabetics than nondiabetics. Oral health education with preventive measures such as improving teeth cleaning practice, reducing sugary foods and drinks intake, and improving oral hygiene practice of patients should be mainstreamed along with diabetic follow-up care.

目的:龋齿是影响糖尿病和非糖尿病人群的重要公共卫生问题。然而,糖尿病和非糖尿病患者的龋齿问题及其相关因素在埃塞俄比亚并不为人所知。本研究旨在比较埃塞俄比亚西北部比切纳初级医院门诊部糖尿病和非糖尿病患者的龋齿患病率及其相关因素。方法:2019年10月7日至12月6日,对200名糖尿病和400名非糖尿病成人患者进行了基于机构的比较横断面研究。采用连续抽样技术招募研究参与者。数据收集采用预测试的结构化问卷,分析采用Statistical Package for Social Science第20版。采用双变量和多变量logistic回归,变量p值为p值。结果:共纳入582例患者,有效率为97.0%。非糖尿病组和糖尿病组龋齿患病率分别为67.9%[95%可信区间(CI): 63.2% ~ 72.8%]和79.6% (95% CI: 74.0% ~ 85.70%)。女性[调整优势比(AOR) = 1.79, 95% CI: 1.15-2.77]、口腔卫生差(AOR = 2.95, 95% CI: 1.71-5.11)、缺乏规律的牙齿清洁习惯(AOR = 3.26, 95% CI: 2.13-4.97)、口干(AOR = 2.31, 95% CI: 1.11-4.81)、喝糖茶(AOR = 2.00, 95% CI: 1.18-3.38)、口腔卫生知识不足(AOR = 3.51, 95% CI: 2.19-5.62)、咀嚼阿拉伯茶(AOR = 2.14, 95% CI: 1.24-3.71)是导致龋齿高发的显著相关因素。结论:糖尿病患者的龋患病率明显高于非糖尿病患者。应将改善清洁牙齿习惯、减少含糖食物和饮料摄入、改善患者口腔卫生习惯等预防措施的口腔健康教育与糖尿病患者的随访护理一起纳入主流。
{"title":"Dental caries and associated factors among diabetic and nondiabetic adult patients attending Bichena Primary Hospital's Outpatient Department.","authors":"Anley Shiferaw,&nbsp;Girma Alem,&nbsp;Mekonnen Tsehay,&nbsp;Getiye Dejenu Kibret","doi":"10.3389/froh.2022.938405","DOIUrl":"https://doi.org/10.3389/froh.2022.938405","url":null,"abstract":"<p><strong>Purpose: </strong>Dental caries is a significant public health issue affecting both the diabetic and nondiabetic populations. However, the problem and associated factors of dental caries among diabetics and nondiabetics patients are not well-known in Ethiopia. This study aims to compare the prevalence of dental caries and associated factors among diabetic and nondiabetic patients at the Outpatient Department of Bichena Primary Hospital in Northwest, Ethiopia.</p><p><strong>Methods: </strong>Institutional based, comparative cross-sectional study was conducted from October 7 to December 6, 2019, among 200 diabetes and 400 nondiabetic adult patients. A consecutive sampling technique was implemented to recruit study participants. Data were collected by a pretested structured questionnaire and analysis was performed in Statistical Package for Social Science version 20. Bivariable and multivariable logistic regressions were employed and variables with a <i>p</i>-value < 0.05 were declared statistically significant.</p><p><strong>Results: </strong>A total of 582 patients were involved in the study with a response rate of 97.0%. The prevalence of dental caries was 67.9% [95% confidence interval (CI): 63.2%-72.8%] and 79.6% (95% CI: 74.0%-85.70%) in nondiabetic and diabetic group, respectively. Females gender [adjusted odds ratio (AOR) = 1.79, 95% CI: 1.15-2.77], poor oral hygiene (AOR = 2.95, 95% CI: 1.71-5.11), lack of regular teeth cleaning habits (AOR = 3.26, 95% CI: 2.13-4.97), feeling dry mouth (AOR = 2.31, 95% CI: 1.11-4.81), sugared tea drinking (AOR = 2.00, 95% CI: 1.18-3.38), inadequate oral health knowledge (AOR = 3.51, 95% CI: 2.19-5.62), and khat chewing (AOR = 2.14, 95% CI: 1.24-3.71) were significantly associated factors with high prevalence of dental caries.</p><p><strong>Conclusion: </strong>The prevalence of caries was significantly higher among diabetics than nondiabetics. Oral health education with preventive measures such as improving teeth cleaning practice, reducing sugary foods and drinks intake, and improving oral hygiene practice of patients should be mainstreamed along with diabetic follow-up care.</p>","PeriodicalId":12463,"journal":{"name":"Frontiers in Oral Health","volume":" ","pages":"938405"},"PeriodicalIF":0.0,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40717645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Editorial: Highlights in oral infections and microbes 2021/2. 社论:口腔感染和微生物的重点研究2012 /2。
Pub Date : 2022-11-02 eCollection Date: 2022-01-01 DOI: 10.3389/froh.2022.1040789
Georgios N Belibasakis, Oleh Andrukhov, Robert P Allaker
COPYRIGHT © 2022 Belibasakis, Andrukhov and Allaker. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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引用次数: 1
Evaluating clinical utility of subgingival and salivary endotoxin activity levels as periodontal biomarkers. 评估龈下和唾液内毒素活性水平作为牙周生物标志物的临床应用。
Pub Date : 2022-11-01 eCollection Date: 2022-01-01 DOI: 10.3389/froh.2022.1029806
Svetislav Zaric, Alexander Strachan, Yuko Kurushima, Anbo Dong, Clare McIlwaine, Zoe Harrington, Luigi Nibali, Andrew Foey, Mark Ide
Objectives The use of periodontal biomarkers for identification and monitoring of unique patient populations could foster better stratification of at-risk groups, increase access to treatment for those most in need, facilitate preventive measures and improve personalised care plans. The aim of this study was to examine the diagnostic and prognostic utility of oral lipopolysaccharides as bacterially-derived periodontal biomarkers. Methods Periodontal parameters were recorded, and saliva and subgingival plaque samples were collected at the beginning of the study from periodontally healthy volunteers and periodontitis patients, and three months after completion of conventional periodontal treatment in the periodontitis group. Endotoxin activity in the samples was measured using the recombinant factor C assay. Associations between clinical periodontal parameters and subgingival and salivary endotoxin activities were analysed using a multivariate regression model, while the ROC curve was applied to estimate the sensitivity, specificity and c-statistics for salivary and subgingival endotoxin activities as diagnostic biomarkers for periodontitis. Results Significant correlations were found between subgingival endotoxin activities, probing pocket depth and periodontal diagnosis, which were independent from patients' age, gender and smoking status. In addition, subgingival endotoxin levels had high specificity and sensitivity in detecting periodontal health and disease (0.91 and 0.85 respectively). Salivary endotoxin activity was positively associated with periodontal diagnosis, mean probing pocket depth, percentages of sites over 4 mm and full mouth bleeding score. However, it was inferior in discriminating patients with stable periodontium from those with periodontitis (sensitivity = 0.69, specificity = 0.61) compared to subgingival endotoxin activity. Conclusions Subgingival endotoxin activity has good diagnostic and prognostic values as a site-specific periodontal biomarker and is not influenced by the patient's age, gender or smoking status. In contrast, salivary endotoxin activity, as a patient-level biomarker, is dependent on patient's age, has poorer diagnostic and prognostic capability, but shows good correlations with disease susceptibility and both its extent and severity.
目的:使用牙周生物标志物来识别和监测独特的患者群体,可以促进风险群体的更好分层,增加最需要的人获得治疗的机会,促进预防措施和改进个性化护理计划。本研究的目的是检查口腔脂多糖作为细菌来源的牙周生物标志物的诊断和预后效用。方法:记录牙周参数,收集牙周健康志愿者、牙周炎患者在研究开始时、牙周炎组常规牙周治疗完成3个月后的唾液和龈下菌斑样本。用重组因子C法测定样品的内毒素活性。使用多元回归模型分析临床牙周参数与龈下和唾液内毒素活性之间的关系,并应用ROC曲线估计唾液和牙龈下内毒素活性作为牙周炎诊断生物标志物的敏感性、特异性和c统计量。结果:龈下内毒素活性、探诊袋深度与牙周诊断有显著相关性,与患者年龄、性别、吸烟状况无关。此外,龈下内毒素水平在检测牙周健康和疾病方面具有很高的特异性和敏感性(分别为0.91和0.85)。唾液内毒素活性与牙周诊断、平均探诊袋深度、超过4mm的部位百分比和全口出血评分呈正相关。然而,与龈下内毒素活性相比,它在鉴别牙周组织稳定和牙周炎患者方面较差(敏感性= 0.69,特异性= 0.61)。结论:龈下内毒素活性作为一种部位特异性牙周生物标志物具有良好的诊断和预后价值,且不受患者年龄、性别或吸烟状况的影响。相比之下,唾液内毒素活性作为患者水平的生物标志物,依赖于患者的年龄,诊断和预后能力较差,但与疾病易感性及其程度和严重程度具有良好的相关性。
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引用次数: 0
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Frontiers in Oral Health
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