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Beckenbodeneingriffe: höchstes Risiko nach Vaginalgeburt 骨盆底干预:阴道分娩后风险最高
IF 2.7 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-11-30 DOI: 10.1055/a-2175-5313
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引用次数: 0
Induction of Labour with a Double Balloon Catheter - Comparison of Effectiveness of Six Versus Twelve Hours Insertion Time: a Prospective Case Control Study. 双气囊导尿管引产- 6小时与12小时插入时间的有效性比较:一项前瞻性病例对照研究。
IF 2.7 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-11-30 eCollection Date: 2023-12-01 DOI: 10.1055/a-2177-0290
Lena Strößner, Yvonne Heimann, Ekkehard Schleußner, Anna Kolterer

Introduction: Induction of labour is a common obstetric procedure to initiate or augment contractions when labour is delayed or uncertain. The double balloon catheter is a safe and effective mechanical method for cervical ripening during induction of labour. This study evaluates the effectiveness of reducing double balloon catheter insertion time from 12 to 6 hours.

Methods: 248 women undergoing induction with a double balloon catheter at term were divided into two groups: catheter placed for 12 hours at 8 pm in the first half of 2021 (P12) and catheter placed for 6 hours at 7 am in the second half of 2021 (P6). T-tests, chi-squared tests, and Wilcoxon signed rank test were used for statistical analysis. Primary and secondary endpoints included induction to delivery interval, prostaglandin to delivery interval, mode of delivery, and maternal and neonatal outcomes.

Results: The P6 group had a significantly reduced induction to delivery interval of 558 min (P6: 1348 min, P12: 1906 min, p < 0.01, 95% CI: 376-710) within demographically comparable groups. Multiparous women also showed a significant reduction in prostaglandin to delivery interval of 260 min (P6: 590 min, P12: 850 min, p = 0.038, 95% CI: 9-299). There were no significant differences in mode of delivery, maternal blood loss, or neonatal outcome.

Conclusion: Reducing double balloon catheter placement time from 12 to 6 hours resulted in almost 9 hours less induction to delivery interval without adverse effects on maternal and neonatal outcome.

导言:引产是一种常见的产科程序,用于在分娩延迟或不确定时启动或增强宫缩。双气囊导尿管是引产过程中宫颈成熟的一种安全有效的机械方法。本研究评估将双球囊导管插入时间从12小时减少到6小时的有效性。方法:248例足月行双球囊导尿管诱导的妇女分为两组:2021年上半年晚上8点放置导尿管12小时(P12), 2021年下半年早上7点放置导尿管6小时(P6)。采用t检验、卡方检验和Wilcoxon符号秩检验进行统计分析。主要和次要终点包括诱导分娩间隔、前列腺素至分娩间隔、分娩方式以及产妇和新生儿结局。结果:P6组诱导分娩间隔时间明显缩短558 min (P6: 1348 min, P12: 1906 min, p)。结论:双球囊置管时间由12小时缩短至6小时,诱导分娩间隔时间缩短近9小时,对产妇及新生儿预后无不良影响。
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引用次数: 0
Präeklampsie: Ist das Absetzen von ASS bei unauffälligem Doppler vertretbar? 子痫前期:如果多普勒正常,是否有理由停用 ASA?
IF 2.7 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-11-30 DOI: 10.1055/a-2175-5439
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引用次数: 0
Vaginale Hysteropexie vs. Hysterektomie mit apikaler Suspension 阴道子宫切除术与带顶端悬吊术的子宫切除术
IF 2.7 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-11-30 DOI: 10.1055/a-2175-5467
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引用次数: 0
Genetische Diagnostik in der Reproduktionsmedizin 生殖医学中的基因诊断
IF 2.7 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-11-30 DOI: 10.1055/a-2175-5341
Überschüssiges Probenmaterial darf anonymisiert für weitere Zwecke (z. B. wissenschaftliche Fragestellungen, Lehre, allgemeine Qualitätssicherung) ohne zeitliche Befristung aufbewahrt werden. Ich bin damit einverstanden, dass im Hinblick auf die o.g. Erkrankung / Störung / Diagnose eine genetische Untersuchung bei mir, meinem Kind oder der von mir betreuten Person durchgeführt wird. Über die Aussagemöglichkeiten und -grenzen der genetischen Diagnostik sowie mein Recht auf Nichtwissen der Untersuchungsergebnisse bin ich aufgeklärt worden. Untersuchungsmaterial Heparin-Vollblut DNA ____________________ Abnahmedatum: Genetische Diagnostik in der Reproduktionsmedizin
多余的样本材料可匿名保存,以用于进一步的目的(如科学问题、教学、一般质量保 证),没有任何时间限制。我同意对我、我的子女或我所照顾的人进行与上述疾病/失调/诊断有关的基因检测。我已被告知基因诊断的可能性和局限性以及我不知道检测结果的权利。检测材料 肝素全血 DNA ____________________ 采集日期: 生殖医学基因诊断
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引用次数: 0
Teilnahme-Aufruf – Favorisierte Arbeitszeitmodelle in der Gynäkologie – FARBEN-Studie der Jungen Foren DGGG, OEGGG und SGGG 征集参与 - 妇科最受欢迎的工作时间模式 - DGGG、OEGGG 和 SGGG 青年论坛开展的 FARBEN 研究
IF 2.7 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-11-30 DOI: 10.1055/a-2173-1434
Amanda Klee, N. Amann, C. Becker, P. Fößleitner, N. Krawczyk, Rama Kiblawi, Solveig Simowitsch, Nikolas Tauber, N. Taumberger, Maggie Banys-Paluchowski
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引用次数: 0
Diagnose und Therapie ektoper Schwangerschaften außerhalb der Tube 输卵管外异位妊娠的诊断和治疗
IF 2.7 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-11-30 DOI: 10.1055/a-2175-5355
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引用次数: 0
Perinatale Mortalität bei pränatal diagnostizierten Vasa praevia 产前诊断为前庭大腺畸形的围产期死亡率
IF 2.7 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-11-30 DOI: 10.1055/a-2175-5453
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引用次数: 0
Multiple Gestation as a Risk Factor for SARS-CoV-2-Associated Adverse Maternal Outcome: Data From the COVID-19 Related Obstetric and Neonatal Outcome Study (CRONOS). 多胎妊娠是sars - cov -2相关不良孕产妇结局的危险因素:来自COVID-19相关产科和新生儿结局研究(CRONOS)的数据
IF 2.4 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-11-30 eCollection Date: 2023-12-01 DOI: 10.1055/a-2196-6224
Marina Sourouni, Ariane Germeyer, Manuel Feißt, Alexandra Balzer, Helen Köster, Annemarie Minte, Dörthe Brüggmann, Celine Kohll, Kristin Reinhardt, Michaela Möginger, Anja Leonhardt, Constanze Banz-Jansen, Michael Bohlmann, Christiane Fröhlich, Clara Backes, Dietrich Hager, Lisa Kaup, Elsa Hollatz-Galuschki, Charlotte Engelbrecht, Filiz Markfeld-Erol, Carsten Hagenbeck, Hening Schäffler, Jennifer Winkler, Johannes Stubert, Katharina Rathberger, Laura Lüber, Linda Hertlein, Antonia Machill, Manuela Richter, Martin Berghäuser, Michael Weigel, Mirjam Morgen, Nora Horn, Peter Jakubowski, Bastian Riebe, Babett Ramsauer, Robert Sczesny, Ute Margaretha Schäfer-Graf, Susanne Schrey, Sven Kehl, Julia Lastinger, Sven Seeger, Olaf Parchmann, Antonella Iannaccone, Jens Rohne, Luise Gattung, Christine A Morfeld, Michael Abou-Dakn, Markus Schmidt, Michaela Glöckner, Anja Jebens, Kathleen Marie Sondern, Ulrich Pecks, Ralf Schmitz, Mareike Möllers

Introduction: Studies have shown that pregnant women with COVID-19 have a higher risk of intensive care unit admission and invasive mechanical ventilation support than non-pregnant women. Pregnancy-associated physiological changes in respiratory function may contribute to the elevated risk. Alteration in lung volumes and capacities are attributed to the mechanical impediment caused by the growing fetus. Multiple pregnancies may therefore compromise functional lung capacity earlier than singleton pregnancies and contribute to severe respiratory symptoms of COVID-19.

Materials and methods: A total of 5514 women with a symptomatic SARS-CoV-2 infection during pregnancy registered in the COVID-19 Related Obstetric and Neonatal Outcome Study were included. The COVID-19-related adverse maternal outcomes were compared in 165 multiple versus 5349 singleton pregnancies. Combined adverse maternal outcome was defined as presence of COVID-19-related hospitalization and/or pneumonia and/or oxygen administration and/or transfer to ICU and/or death. Multivariate logistic regression was used to estimate the odds ratios and 95% confidence intervals were calculated.

Results: The frequency of dyspnea, likelihood of developing dyspnea in a defined pregnancy week and duration of the symptomatic phase of the COVID-19 infection did not differ between the two groups. On average, COVID-19-related combined adverse outcome occurred earlier during pregnancy in women expecting more than one child than in singleton pregnancies. The overall incidence of singular and combined COVID-19-associated adverse maternal outcomes was not significantly different between groups. However, regression analysis revealed that multiple gestation, preconceptional BMI > 30 kg/m 2 and gestational age correlated significantly with an increased risk of combined adverse maternal outcome. Conversely, maternal age and medically assisted reproduction were not significant risk factors for combined adverse maternal outcome.

Conclusion: Our data show that multiple gestation alone is a risk factor for COVID-19-associated combined adverse maternal outcome. Moreover, severe courses of COVID-19 in women expecting more than one child are observed earlier in pregnancy than in singleton pregnancies.

研究表明,与非孕妇相比,感染COVID-19的孕妇入住重症监护病房和有创机械通气支持的风险更高。妊娠相关的呼吸功能生理变化可能导致风险升高。肺容量和肺活量的改变可归因于胎儿生长所引起的机械障碍。因此,多胎妊娠可能比单胎妊娠更早损害肺功能,并导致COVID-19的严重呼吸道症状。材料和方法:纳入在COVID-19相关产科和新生儿结局研究中登记的5514名有症状的妊娠期SARS-CoV-2感染的妇女。比较了165例多胎妊娠和5349例单胎妊娠中与covid -19相关的不良孕产妇结局。综合不良产妇结局定义为出现与covid -19相关的住院和/或肺炎和/或给氧和/或转至ICU和/或死亡。采用多变量logistic回归估计比值比,并计算95%置信区间。结果:两组患者在妊娠周内发生呼吸困难的频率、发生呼吸困难的可能性以及COVID-19感染症状期的持续时间均无差异。平均而言,与单胎妊娠相比,多胎妊娠期间与covid -19相关的综合不良后果发生得更早。与covid -19相关的单一和联合不良孕产妇结局的总体发生率在组间无显著差异。然而,回归分析显示,多胎妊娠、孕前BMI > 30 kg/ m2和胎龄与合并不良产妇结局的风险增加显著相关。相反,产妇年龄和医疗辅助生殖不是综合不良产妇结局的重要危险因素。结论:我们的数据显示,单胎妊娠是covid -19相关联合不良孕产妇结局的危险因素。此外,与单胎妊娠相比,多胎妊娠妇女出现COVID-19严重病程的时间更早。
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引用次数: 0
RANK and RANKL Expression in Tumors of Patients with Early Breast Cancer. 早期乳腺癌患者肿瘤中的 RANK 和 RANKL 表达。
IF 2.7 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-11-22 eCollection Date: 2024-01-01 DOI: 10.1055/a-2192-2998
Annika Behrens, Lena Wurmthaler, Felix Heindl, Paul Gass, Lothar Häberle, Bernhard Volz, Carolin C Hack, Julius Emons, Ramona Erber, Arndt Hartmann, Matthias W Beckmann, Matthias Ruebner, William C Dougall, Michael F Press, Peter A Fasching, Hanna Huebner

Introduction: The receptor activator of nuclear factor-κB (RANK) pathway was associated with the pathogenesis of breast cancer. Several studies attempted to link the RANK/RANKL pathway to prognosis; however, with inconsistent outcomes. We aimed to further contribute to the knowledge about RANK/RANKL as prognostic factors in breast cancer. Within this study, protein expression of RANK and its ligand, RANKL, in the tumor tissue was analyzed in association with disease-free survival (DFS) and overall survival (OS) in a study cohort of patients with early breast cancer.

Patients and methods: 607 samples of female primary and early breast cancer patients from the Bavarian Breast Cancer Cases and Controls Study were analyzed to correlate the RANK and RANKL expression with DFS and OS. Therefore, expression was quantified using immunohistochemical staining of a tissue microarray. H-scores were determined with the cut-off value of 8.5 for RANK and 0 for RANKL expression, respectively.

Results: RANK and RANKL immunohistochemistry were assessed by H-score. Both biomarkers did not correlate (ρ = -0.04). According to molecular subtypes, triple-negative tumors and HER2-positive tumors showed a higher number of RANK-positive tumors (H-score ≥ 8.5), however, no subtype-specific expression of RANKL could be detected. Higher RANKL expression tended to correlate with a better prognosis. However, RANK and RANKL expression could not be identified as statistically significant prognostic factors within the study cohort.

Conclusions: Tumor-specific RANK and RANKL expressions are not applicable as prognostic factors for DFS and OS, but might be associated with subtype-specific breast cancer progression.

导言核因子κB受体激活剂(RANK)通路与乳腺癌的发病机制有关。一些研究试图将 RANK/RANKL 通路与预后联系起来,但结果并不一致。我们的目的是进一步加深对作为乳腺癌预后因素的 RANK/RANKL 的了解。在这项研究中,我们分析了早期乳腺癌患者研究队列中肿瘤组织中 RANK 及其配体 RANKL 蛋白表达与无病生存期(DFS)和总生存期(OS)的关系。因此,通过组织芯片的免疫组化染色对表达进行了量化。RANK和RANKL表达的临界值分别为8.5和0:结果:RANK和RANKL免疫组化是通过H-评分来评估的。这两种生物标志物没有相关性(ρ = -0.04)。根据分子亚型,三阴性肿瘤和HER2阳性肿瘤的RANK阳性肿瘤数量较多(H-score ≥ 8.5),但未检测到亚型特异性的RANKL表达。RANKL表达越高,预后越好。然而,在研究队列中,RANK和RANKL的表达不能被确定为具有统计学意义的预后因素:肿瘤特异性RANK和RANKL表达不能作为DFS和OS的预后因素,但可能与亚型特异性乳腺癌进展有关。
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