{"title":"Stellungnahme zur Kritik des Patientenbeauftragten – Individuelle Gesundheitsleistungen (IGeL) in der Frauenheilkunde","authors":"","doi":"10.1055/a-2316-6434","DOIUrl":"https://doi.org/10.1055/a-2316-6434","url":null,"abstract":"","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141395030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vaginale Hysterektomie: Hat der Verzicht auf die Adnexektomie Nachteile?","authors":"","doi":"10.1055/a-2286-4465","DOIUrl":"https://doi.org/10.1055/a-2286-4465","url":null,"abstract":"","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141413891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Schützt die Wassergeburt vor Analsphinkterverletzungen?","authors":"","doi":"10.1055/a-2286-4451","DOIUrl":"https://doi.org/10.1055/a-2286-4451","url":null,"abstract":"","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141395006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Joseph Hermann Schmidt (1804–1852): vom Kreisphysikus zum Vortragenden Rath im preußischen Ministerium der geistlichen, Unterrichts- und Medicinalangelegenheiten","authors":"M. David, Andreas D. Ebert","doi":"10.1055/a-2286-4597","DOIUrl":"https://doi.org/10.1055/a-2286-4597","url":null,"abstract":"","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141394249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Würdigung – Nachruf auf Professor Adolf Eduard Schindler","authors":"","doi":"10.1055/a-2316-1873","DOIUrl":"https://doi.org/10.1055/a-2316-1873","url":null,"abstract":"","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141396717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beeinträchtigt eine Adenomyosis uteri den Erfolg der In-vitro-Fertilisation?","authors":"","doi":"10.1055/a-2286-4507","DOIUrl":"https://doi.org/10.1055/a-2286-4507","url":null,"abstract":"","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141413760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-29eCollection Date: 2024-05-01DOI: 10.1055/a-2263-5152
Michael Untch, Nina Ditsch, Peter A Fasching, Steffi Busch, Johannes Ettl, Renate Haidinger, Nadia Harbeck, Christian Jackisch, Diana Lüftner, Lothar Müller, Eugen Ruckhäberle, Eva Schumacher-Wulf, Christoph Thomssen, Rachel Wuerstlein, Volkmar Müller
The rationale behind the "International Consensus Conference for Advanced Breast Cancer" (ABC) is to standardize the treatment of patients with advanced or metastatic breast cancer worldwide using an evidence-based approach. The aim is also to ensure that patients in all countries receive adequate treatment based on current treatment recommendations and standards. The 7th International Consensus Conference on Advanced Breast Cancer (ABC7) took place from November 9 to 12, 2023 in Lisbon/Portugal. ABC7 focused on metastatic disease as well as on locally advanced and inflammatory breast cancer. Special topics included the treatment of oligometastatic patients, leptomeningeal disease, treatment of brain metastases, and pregnant women with ABC. As in previous years, patient advocates from all over the world participated in the consensus conference and were involved in decision making.
{"title":"Discussion of ABC7 Consensus and German Recommendations.","authors":"Michael Untch, Nina Ditsch, Peter A Fasching, Steffi Busch, Johannes Ettl, Renate Haidinger, Nadia Harbeck, Christian Jackisch, Diana Lüftner, Lothar Müller, Eugen Ruckhäberle, Eva Schumacher-Wulf, Christoph Thomssen, Rachel Wuerstlein, Volkmar Müller","doi":"10.1055/a-2263-5152","DOIUrl":"10.1055/a-2263-5152","url":null,"abstract":"<p><p>The rationale behind the \"International Consensus Conference for Advanced Breast Cancer\" (ABC) is to standardize the treatment of patients with advanced or metastatic breast cancer worldwide using an evidence-based approach. The aim is also to ensure that patients in all countries receive adequate treatment based on current treatment recommendations and standards. The 7th International Consensus Conference on Advanced Breast Cancer (ABC7) took place from November 9 to 12, 2023 in Lisbon/Portugal. ABC7 focused on metastatic disease as well as on locally advanced and inflammatory breast cancer. Special topics included the treatment of oligometastatic patients, leptomeningeal disease, treatment of brain metastases, and pregnant women with ABC. As in previous years, patient advocates from all over the world participated in the consensus conference and were involved in decision making.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-29eCollection Date: 2024-05-01DOI: 10.1055/a-2286-6066
Andreas Schneeweiss, Sara Y Brucker, Hanna Huebner, Lea L Volmer, Carolin C Hack, Katharina Seitz, Matthias Ruebner, Sabine Heublein, Verena Thewes, Diana Lüftner, Michael P Lux, Ingolf Jurhasz-Böss, Florin-Andrei Taran, Pauline Wimberger, Daniel Anetsberger, Milena Beierlein, Marcus Schmidt, Julia Radosa, Volkmar Müller, Wolfgang Janni, Brigitte Rack, Erik Belleville, Michael Untch, Marc Thill, Nina Ditsch, Bahriye Aktas, Ivonne Nel, Hans-Christian Kolberg, Tobias Engerle, Hans Tesch, Christian Roos, Christina Budden, Hans Neubauer, Andreas D Hartkopf, Tanja N Fehm, Peter A Fasching
In recent years, new targeted therapies have been developed to treat patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer. Some of these therapies have not just become the new therapy standard but also led to significantly longer overall survival rates. The cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) have become the therapeutic standard for first-line therapy. Around 70 - 80% of patients are treated with a CDK4/6i. In recent years, a number of biomarkers associated with progression, clonal selection or evolution have been reported for CDK4/6i and their endocrine combination partners. Understanding the mechanisms behind treatment efficacy and resistance is important. A better understanding could contribute to planning the most effective therapeutic sequences and utilizing basic molecular information to overcome endocrine resistance. One study with large numbers of patients which aims to elucidate these mechanisms is the Comprehensive Analysis of sPatial, TempORal and molecular patterns of ribociclib efficacy and resistance in advanced Breast Cancer patients (CAPTOR BC) trial. This overview summarizes the latest clinical research on resistance to endocrine therapies, focusing on CDK4/6 inhibitors and discussing current study concepts.
{"title":"CDK4/6 Inhibition - Therapy Sequences and the Quest to Find the Best Biomarkers - an Overview of Current Programs.","authors":"Andreas Schneeweiss, Sara Y Brucker, Hanna Huebner, Lea L Volmer, Carolin C Hack, Katharina Seitz, Matthias Ruebner, Sabine Heublein, Verena Thewes, Diana Lüftner, Michael P Lux, Ingolf Jurhasz-Böss, Florin-Andrei Taran, Pauline Wimberger, Daniel Anetsberger, Milena Beierlein, Marcus Schmidt, Julia Radosa, Volkmar Müller, Wolfgang Janni, Brigitte Rack, Erik Belleville, Michael Untch, Marc Thill, Nina Ditsch, Bahriye Aktas, Ivonne Nel, Hans-Christian Kolberg, Tobias Engerle, Hans Tesch, Christian Roos, Christina Budden, Hans Neubauer, Andreas D Hartkopf, Tanja N Fehm, Peter A Fasching","doi":"10.1055/a-2286-6066","DOIUrl":"10.1055/a-2286-6066","url":null,"abstract":"<p><p>In recent years, new targeted therapies have been developed to treat patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer. Some of these therapies have not just become the new therapy standard but also led to significantly longer overall survival rates. The cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) have become the therapeutic standard for first-line therapy. Around 70 - 80% of patients are treated with a CDK4/6i. In recent years, a number of biomarkers associated with progression, clonal selection or evolution have been reported for CDK4/6i and their endocrine combination partners. Understanding the mechanisms behind treatment efficacy and resistance is important. A better understanding could contribute to planning the most effective therapeutic sequences and utilizing basic molecular information to overcome endocrine resistance. One study with large numbers of patients which aims to elucidate these mechanisms is the Comprehensive Analysis of sPatial, TempORal and molecular patterns of ribociclib efficacy and resistance in advanced Breast Cancer patients (CAPTOR BC) trial. This overview summarizes the latest clinical research on resistance to endocrine therapies, focusing on CDK4/6 inhibitors and discussing current study concepts.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-29eCollection Date: 2024-05-01DOI: 10.1055/a-2280-5530
Cihan Kaya, Murat Yassa, Koray Gorkem Sacinti, Fatih Aktoz, Ali Can Gunes
{"title":"The Greener Choice: Vaginal Hysterectomy's Environmental Edge Over Laparoscopic Techniques.","authors":"Cihan Kaya, Murat Yassa, Koray Gorkem Sacinti, Fatih Aktoz, Ali Can Gunes","doi":"10.1055/a-2280-5530","DOIUrl":"10.1055/a-2280-5530","url":null,"abstract":"","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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