Minori Mezaki, Chika Manabe, Junichiro Nagumo, T. Yoshimura, T. Nagahama, H. Itagaki, A. Takaoka
{"title":"A trial to predict skin irritancy of cosmetic products using cytotoxicity tests","authors":"Minori Mezaki, Chika Manabe, Junichiro Nagumo, T. Yoshimura, T. Nagahama, H. Itagaki, A. Takaoka","doi":"10.2131/fts.10.113","DOIUrl":"https://doi.org/10.2131/fts.10.113","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77150742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Sultana, K. Fukamachi, Jiegou Xu, H. Tsuda, M. Suzui
{"title":"mRNA expression profile of cytokines in rat primary alveolar macrophages treated with multiwalled carbon nanotube (MWCNT)","authors":"N. Sultana, K. Fukamachi, Jiegou Xu, H. Tsuda, M. Suzui","doi":"10.2131/fts.10.27","DOIUrl":"https://doi.org/10.2131/fts.10.27","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78002709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Takayasu Moroki, Fumika Akizawa, Satoshi Kondo, Sakura Fujiwara, T. Yoshikawa, Y. Inoue
{"title":"Toxicological effects of repeated subcutaneous administration of corn oil for 4 weeks in rats","authors":"Takayasu Moroki, Fumika Akizawa, Satoshi Kondo, Sakura Fujiwara, T. Yoshikawa, Y. Inoue","doi":"10.2131/fts.10.169","DOIUrl":"https://doi.org/10.2131/fts.10.169","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83117441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of continuous thiamine intake on onset and progression of type 2 diabetes in leptin-receptor deficient mice","authors":"Y. Kohda","doi":"10.2131/fts.10.83","DOIUrl":"https://doi.org/10.2131/fts.10.83","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89768607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mayuu Tokudome, Asuka Kaizaki-Miitsumoto, S. Numazawa
{"title":"Effect of blood collection tubes containing separation gels on the measurement of drug concentrations in clinical toxicology","authors":"Mayuu Tokudome, Asuka Kaizaki-Miitsumoto, S. Numazawa","doi":"10.2131/fts.10.179","DOIUrl":"https://doi.org/10.2131/fts.10.179","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84412011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"DNA damage mediated by 4,4'-methylenebis(2-chloroaniline) cannot be detected via the DNA damage marker γH2AX: A case study","authors":"Saho Kobayashi, H. Kashiwagi","doi":"10.2131/fts.10.21","DOIUrl":"https://doi.org/10.2131/fts.10.21","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86460108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Proliferating cells, such as tumor cells, require nucleotides for DNA replication. Mammalian cells are equipped with de novo purine and pyrimidine nucleotide biosynthesis pathways, and a salvage pathway that recycles purine bases, to supply nucleotides for the same. To avoid imbalance in intracellular nucleotide levels, de novo nucleotide biosynthesis pathway is regulated by feedback mechanisms, such as synthase inhibition by nucleotide products. Recently, we reported that the aldehyde dehydrogenase 1 family member L1 (ALDH1L1) consumes 10-formyltetrahydrofolate (10-fTHF), which is utilized by the de novo purine nucleotide synthesis, and results in the accumulation of 5-aminoimidazole-4-carboxamide ribonucleotide (ZMP) during purine biosynthesis. Given that ZMP inhibits pyrimidine nucleotide synthesis, in the present study, we examined the effects of ZMP using brequinar, a dihydroorotate dehydrogenase inhibitor. ALDH1L1-mediated ZMP accumulation was unaffected by brequinar, and no effect was observed when brequinar was combined with 5-aminoimidazole-4-carboxamide riboside (AICAr), a nucleoside of ZMP. Furthermore, we examined involvement in the salvage pathway, because attenuation of de novo purine nucleotide synthesis may require a supply of purine nucleotides from the salvage pathway. The guanine analog, 6-thioguanine, and the 2'-deoxycytidine analog, cytarabine, were used in the assessment of dependency on the salvage pathway. We found that neither ALDH1L1-mediated ZMP accumulation nor the presence of AICAr affected the salvage pathway. Collectively, these results suggest that these purine and pyrimidine analogs can be useful for the treatment of tumor cells, regardless of ALDH1L1 expression.
{"title":"Effects of expression of the 10-formyltetrahydrofolate metabolizing enzyme ALDH1L1 on pyrimidine nucleotide synthesis and the salvage pathway","authors":"Masato Sasaki, Fumie Itoh, Nobuyuki Shibata","doi":"10.2131/fts.10.241","DOIUrl":"https://doi.org/10.2131/fts.10.241","url":null,"abstract":"Proliferating cells, such as tumor cells, require nucleotides for DNA replication. Mammalian cells are equipped with de novo purine and pyrimidine nucleotide biosynthesis pathways, and a salvage pathway that recycles purine bases, to supply nucleotides for the same. To avoid imbalance in intracellular nucleotide levels, de novo nucleotide biosynthesis pathway is regulated by feedback mechanisms, such as synthase inhibition by nucleotide products. Recently, we reported that the aldehyde dehydrogenase 1 family member L1 (ALDH1L1) consumes 10-formyltetrahydrofolate (10-fTHF), which is utilized by the de novo purine nucleotide synthesis, and results in the accumulation of 5-aminoimidazole-4-carboxamide ribonucleotide (ZMP) during purine biosynthesis. Given that ZMP inhibits pyrimidine nucleotide synthesis, in the present study, we examined the effects of ZMP using brequinar, a dihydroorotate dehydrogenase inhibitor. ALDH1L1-mediated ZMP accumulation was unaffected by brequinar, and no effect was observed when brequinar was combined with 5-aminoimidazole-4-carboxamide riboside (AICAr), a nucleoside of ZMP. Furthermore, we examined involvement in the salvage pathway, because attenuation of de novo purine nucleotide synthesis may require a supply of purine nucleotides from the salvage pathway. The guanine analog, 6-thioguanine, and the 2'-deoxycytidine analog, cytarabine, were used in the assessment of dependency on the salvage pathway. We found that neither ALDH1L1-mediated ZMP accumulation nor the presence of AICAr affected the salvage pathway. Collectively, these results suggest that these purine and pyrimidine analogs can be useful for the treatment of tumor cells, regardless of ALDH1L1 expression.","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135158355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akira Kawashima, Kaoru Inoue, K. Ushida, K. Kai, Hiroshi Suzuki, Lucia Satiko Yoshida-Yamashita, A. Hirose, K. Masumura
{"title":"Derivation of human health hazard assessment values of 1,2-dichloroethane under the Japan Chemical Substances Control Law","authors":"Akira Kawashima, Kaoru Inoue, K. Ushida, K. Kai, Hiroshi Suzuki, Lucia Satiko Yoshida-Yamashita, A. Hirose, K. Masumura","doi":"10.2131/fts.10.91","DOIUrl":"https://doi.org/10.2131/fts.10.91","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84590926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"K16ApoE inhibits the activity of acetylcholinesterase but is not the primary toxicological mechanism in mice","authors":"Linlin Shao, T. Michelena","doi":"10.2131/fts.10.125","DOIUrl":"https://doi.org/10.2131/fts.10.125","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88240798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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