M. Fujii, Miko Imai, Hiroki Kuwabara, Minori Awano, K. Hashizaki, H. Taguchi
{"title":"Influence of skin condition on the skin penetration of dextran 4000 and ovalbumin","authors":"M. Fujii, Miko Imai, Hiroki Kuwabara, Minori Awano, K. Hashizaki, H. Taguchi","doi":"10.2131/fts.7.281","DOIUrl":"https://doi.org/10.2131/fts.7.281","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"15 1","pages":"281-286"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85156772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dong-pan Wu, Tsuyoshi Nakano, Y. Tsuneoka, Tsutomu Takahashi, Y. Shinoda, T. Kaji, Y. Fujiwara
{"title":"Arsenite inhibits gene expression of perlecan, syndecan-1, -2, -3 and biglycan in cultured vascular endothelial cells","authors":"Dong-pan Wu, Tsuyoshi Nakano, Y. Tsuneoka, Tsutomu Takahashi, Y. Shinoda, T. Kaji, Y. Fujiwara","doi":"10.2131/fts.7.77","DOIUrl":"https://doi.org/10.2131/fts.7.77","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"26 1","pages":"77-83"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77937297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Koki Sugimoto, Eito Shimizu, Nozomi Hagihara, Ryota Hosomi, K. Fukunaga, Munehiro Yoshida, T. Yoshioka, Koretarō Takahashi
{"title":"Repeated 28-day and 13-week dose toxicity studies of oils prepared from the internal organs of the Japanese giant scallop (Patinopecten yessoensis) in rats","authors":"Koki Sugimoto, Eito Shimizu, Nozomi Hagihara, Ryota Hosomi, K. Fukunaga, Munehiro Yoshida, T. Yoshioka, Koretarō Takahashi","doi":"10.2131/fts.7.177","DOIUrl":"https://doi.org/10.2131/fts.7.177","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"51 1","pages":"177-188"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72617617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Kikuchi, Kaori Harata, C. Kawai, H. Madhyastha, A. Yamauchi, F. Kuribayashi
{"title":"Retinoic acid dramatically enhances cytotoxicity of equol against human monoblastic U937 cells, but not against human peripheral neutrophils","authors":"H. Kikuchi, Kaori Harata, C. Kawai, H. Madhyastha, A. Yamauchi, F. Kuribayashi","doi":"10.2131/fts.7.201","DOIUrl":"https://doi.org/10.2131/fts.7.201","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"1 1","pages":"201-206"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88782987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Kawashima, Kaoru Inoue, Y. Yoshizaki, K. Ushida, K. Kai, Hiroshi Suzuki, M. Takano, S. Fujii, Kaoru Yabe, M. Matsumoto, Takashi Yamada, A. Hirose
ABSTRACT — 3-Methylpentane, isooctane, and isononane are acyclic branched saturated hydrocarbons with carbon numbers C6, C8, and C9, respectively. To assess human risk, we conducted a combined repeated-dose and reproductive/developmental oral toxicity studies in rats. [Organization for Economic Co-operation and Development (OECD) Test Guideline 422]. Each hydrocarbon was administered by gavage to rats at three doses (plus a control group). All three chemicals targeted the liver and kidney. An increase in liver weight without hepatic injury was observed as the adaptive response to the chemical treatments. Males treated by each chemical showed α2u-globulin nephropathy, which is a rat-specific finding that bears no human relevance. Reproduction/developmental toxicity parameters showed no treatment-related effects in parents or offspring at any dose for the three chemicals, except for the retardation of offspring bodyweight development which may be a secondary effect of a maternal systemic condition or direct effect on offspring in isononane. No observed adverse effect levels (NOAELs) of repeated toxicity in either sex were determined to be 300 mg/kg/day for 3-methylpentane, 100 mg/kg/day for isooctane, and 250 mg/kg/day for isononane. NOAELs of reproductive/developmental toxicity in parents and offspring were determined to be 1000 mg/kg/day for 3-methylpentane, and 300 mg/kg/day for isooctane. For isononane, NOAELs were determined to be 1000 mg/kg/day for reproduction, and 250 mg/kg/day for offspring development. These results provide new toxicological information and support the category assessment of published reports that evaluate the acyclic branched saturated hydrocarbons as low-toxicity substances.
{"title":"Combined repeated-dose and reproductive/developmental oral toxicity of 3-methylpentane, isooctane, and isononane in rats","authors":"A. Kawashima, Kaoru Inoue, Y. Yoshizaki, K. Ushida, K. Kai, Hiroshi Suzuki, M. Takano, S. Fujii, Kaoru Yabe, M. Matsumoto, Takashi Yamada, A. Hirose","doi":"10.2131/fts.7.259","DOIUrl":"https://doi.org/10.2131/fts.7.259","url":null,"abstract":"ABSTRACT — 3-Methylpentane, isooctane, and isononane are acyclic branched saturated hydrocarbons with carbon numbers C6, C8, and C9, respectively. To assess human risk, we conducted a combined repeated-dose and reproductive/developmental oral toxicity studies in rats. [Organization for Economic Co-operation and Development (OECD) Test Guideline 422]. Each hydrocarbon was administered by gavage to rats at three doses (plus a control group). All three chemicals targeted the liver and kidney. An increase in liver weight without hepatic injury was observed as the adaptive response to the chemical treatments. Males treated by each chemical showed α2u-globulin nephropathy, which is a rat-specific finding that bears no human relevance. Reproduction/developmental toxicity parameters showed no treatment-related effects in parents or offspring at any dose for the three chemicals, except for the retardation of offspring bodyweight development which may be a secondary effect of a maternal systemic condition or direct effect on offspring in isononane. No observed adverse effect levels (NOAELs) of repeated toxicity in either sex were determined to be 300 mg/kg/day for 3-methylpentane, 100 mg/kg/day for isooctane, and 250 mg/kg/day for isononane. NOAELs of reproductive/developmental toxicity in parents and offspring were determined to be 1000 mg/kg/day for 3-methylpentane, and 300 mg/kg/day for isooctane. For isononane, NOAELs were determined to be 1000 mg/kg/day for reproduction, and 250 mg/kg/day for offspring development. These results provide new toxicological information and support the category assessment of published reports that evaluate the acyclic branched saturated hydrocarbons as low-toxicity substances.","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"13 1","pages":"259-279"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83619975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yasunori Masubuchi, Satomi Kikuchi, Hiromu Okano, Yasunori Takahashi, K. Takashima, Ryota Ojiro, Qian Tang, Toshinori Yoshida, Mihoko Koyanagi, R. Maronpot, S. Hayashi, M. Shibutani
{"title":"Lack of combined effect of continuous exposure to α-glycosyl isoquercitrin from fetal stages to adulthood and voluntary exercise or environmental enrichment on learning and behaviors in rats","authors":"Yasunori Masubuchi, Satomi Kikuchi, Hiromu Okano, Yasunori Takahashi, K. Takashima, Ryota Ojiro, Qian Tang, Toshinori Yoshida, Mihoko Koyanagi, R. Maronpot, S. Hayashi, M. Shibutani","doi":"10.2131/fts.7.241","DOIUrl":"https://doi.org/10.2131/fts.7.241","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"96 1","pages":"241-248"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80220786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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