N. Sultana, K. Fukamachi, D. Roy, Jiegou Xu, H. Tsuda, M. Suzui
{"title":"mRNA expression levels of CCL4, IL6, and CXCL2 in multiwalled carbon nanotube induced lung tumors in rats","authors":"N. Sultana, K. Fukamachi, D. Roy, Jiegou Xu, H. Tsuda, M. Suzui","doi":"10.2131/fts.10.137","DOIUrl":"https://doi.org/10.2131/fts.10.137","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"203 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88566221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jin-Yong Lee, M. Tokumoto, Gi-Wook Hwang, M. Satoh
{"title":"Effect of cadmium on expression of BIRC family genes in HeLa cells","authors":"Jin-Yong Lee, M. Tokumoto, Gi-Wook Hwang, M. Satoh","doi":"10.2131/fts.10.133","DOIUrl":"https://doi.org/10.2131/fts.10.133","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79154579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fernanda Martins, Tamara C. Lopes de Castro, S. Saad, Rose C. G. Trevisane, Ricardo P. Moreira, Edite Taninaga, M. L. Queiroz, C. O. Torello
{"title":"Chlorella improves inflammatory profiles and quality of life of prediabetes and diabetes patients","authors":"Fernanda Martins, Tamara C. Lopes de Castro, S. Saad, Rose C. G. Trevisane, Ricardo P. Moreira, Edite Taninaga, M. L. Queiroz, C. O. Torello","doi":"10.2131/fts.10.31","DOIUrl":"https://doi.org/10.2131/fts.10.31","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80611886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Various nanomaterials are used as food additives, medicines, and cosmetics; however, their biological effects are not completely understood. Since the cell membrane is the first point of contact between nanomaterials and cells, we investigated whether amorphous silica particles and titanium dioxide nanoparticles (nTiO2) interact with the transporters present in the cell membrane. In this study, we prepared an adriamycin (ADM) resistant variant of the mouse lymphocytic leukemia cell line L1210 (L1210/ADM). Since our L1210/ADM cells were confirmed to excrete ADM in a P-glycoprotein (P-gp)-dependent manner, we investigated whether nano- and micro-sized amorphous silica particles (nSP and mSP) and nTiO2 inhibited ADM excretion from L1210/ADM cells. Both nSP and nTiO2 inhibited ADM efflux in a dose-dependent manner; however, mSP did not inhibit ADM efflux even at the highest dose (0.25 mg/mL). These results suggest that nSP and nTiO2 interfere with P-gp, which is involved in ADM transport, and L1210/ADM cells are suitable for safety screening tests of nanomaterials.
{"title":"Titanium dioxide and silica nanoparticles inhibit the efflux of adriamycin in multi-drug resistant L1210/ADM cells","authors":"Daisaku Miura, Teppei Koreeda, Naohiko Anzai, Ken-ichi Kiyomiya","doi":"10.2131/fts.10.259","DOIUrl":"https://doi.org/10.2131/fts.10.259","url":null,"abstract":"Various nanomaterials are used as food additives, medicines, and cosmetics; however, their biological effects are not completely understood. Since the cell membrane is the first point of contact between nanomaterials and cells, we investigated whether amorphous silica particles and titanium dioxide nanoparticles (nTiO2) interact with the transporters present in the cell membrane. In this study, we prepared an adriamycin (ADM) resistant variant of the mouse lymphocytic leukemia cell line L1210 (L1210/ADM). Since our L1210/ADM cells were confirmed to excrete ADM in a P-glycoprotein (P-gp)-dependent manner, we investigated whether nano- and micro-sized amorphous silica particles (nSP and mSP) and nTiO2 inhibited ADM excretion from L1210/ADM cells. Both nSP and nTiO2 inhibited ADM efflux in a dose-dependent manner; however, mSP did not inhibit ADM efflux even at the highest dose (0.25 mg/mL). These results suggest that nSP and nTiO2 interfere with P-gp, which is involved in ADM transport, and L1210/ADM cells are suitable for safety screening tests of nanomaterials.","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"153 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135158348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alzahraa Fergany, Frederick Adams Ekuban, Cai Zong, Gaku Ichihara
Recent studies demonstrated that upregulation of proinflammatory cytokines were associated with neurotoxicity of acrylamide, which is used widely in industries and generated in food cooked at high temperature. The interleukin-1 (IL-1) is one of cytokines that play an important role in immune response. Anakinra is an IL-1 receptor antagonist used as anti-inflammatory medicine against inflammatory diseases such as juvenile idiopathic arthritis. In this study, ten-week old wild type male mice were allocated into 6 groups. Group 1 to 3 daily received subcutaneous injection with vehicle and oral exposure to ACR in drinking water at 0, 150 or 300 ppm for 28 days, and group 4-6 daily received injection with Anakinra and oral exposure to ACR in drinking water at 0, 150 or 300 ppm for 28 days. The landing foot spread (LFS) test was carried out to assess the motor function, and immunohistochemistry was carried out for quantification of noradrenergic axons and microglia activation. The results of LFS did not show significant effect of Anakinra treatment on ACR-induced increase in landing foot spread in mice. The body weight was dose-dependently decreased by ACR exposure only in the groups treated with Anakinra. The IHC staining for microglia and noradrenergic axon density does not show any significant effect of treatment with Anakinra or exposure to ACR. The study demonstrated that daily treatment with Anakinra at 25 mg/kg body weight does not ameliorate ACR-induced neurotoxicity in mice, while potentiates ACR-induced loss of body weight.
{"title":"Effect of Anakinra (Kineret<sup>®</sup>) treatment on acrylamide-induced neurotoxicity in mice","authors":"Alzahraa Fergany, Frederick Adams Ekuban, Cai Zong, Gaku Ichihara","doi":"10.2131/fts.10.221","DOIUrl":"https://doi.org/10.2131/fts.10.221","url":null,"abstract":"Recent studies demonstrated that upregulation of proinflammatory cytokines were associated with neurotoxicity of acrylamide, which is used widely in industries and generated in food cooked at high temperature. The interleukin-1 (IL-1) is one of cytokines that play an important role in immune response. Anakinra is an IL-1 receptor antagonist used as anti-inflammatory medicine against inflammatory diseases such as juvenile idiopathic arthritis. In this study, ten-week old wild type male mice were allocated into 6 groups. Group 1 to 3 daily received subcutaneous injection with vehicle and oral exposure to ACR in drinking water at 0, 150 or 300 ppm for 28 days, and group 4-6 daily received injection with Anakinra and oral exposure to ACR in drinking water at 0, 150 or 300 ppm for 28 days. The landing foot spread (LFS) test was carried out to assess the motor function, and immunohistochemistry was carried out for quantification of noradrenergic axons and microglia activation. The results of LFS did not show significant effect of Anakinra treatment on ACR-induced increase in landing foot spread in mice. The body weight was dose-dependently decreased by ACR exposure only in the groups treated with Anakinra. The IHC staining for microglia and noradrenergic axon density does not show any significant effect of treatment with Anakinra or exposure to ACR. The study demonstrated that daily treatment with Anakinra at 25 mg/kg body weight does not ameliorate ACR-induced neurotoxicity in mice, while potentiates ACR-induced loss of body weight.","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"128 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135955405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monascus Color Y-001, a natural food pigment produced from Monascus purpureus Y-001 fermentation, was administered orally by gavage to 4 Beagle dogs/sex/group for 90 days at doses of 0 (vehicle: 0.1% Tween 80, 10 mL/kg bw), 1, 5 and 25 mg/kg bw/day. In the clinical observations, vomiting/vomitus (dark red watery substance or undigested feed) was observed for males and females in the 25, but not 5 or 1 mg/kg bw/day group at a relatively high frequency. In addition, loose stools were observed for males in this group on a single occasion. These signs were considered to be effects of the test article on the digestive tract. No treatment-related effects were noted in the detailed observations for symptoms, body weights, food consumptions, ophthalmology, hematology, clinical chemistry, urinalysis, gross pathology, organ weights or histopathology. Thus, the no-observed-adverse-effect level (NOAEL) was judged to be 5 mg/kg bw/day in both sexes of the dogs.
{"title":"Subchronic oral toxicity study of Monascus Color in beagle dogs","authors":"Akihiro Hagiwara, Yunagi Murase, Shuuhei Kubo, Haruko Koizumi, Mikio Nakamura, Shoji Fukushima","doi":"10.2131/fts.10.209","DOIUrl":"https://doi.org/10.2131/fts.10.209","url":null,"abstract":"Monascus Color Y-001, a natural food pigment produced from Monascus purpureus Y-001 fermentation, was administered orally by gavage to 4 Beagle dogs/sex/group for 90 days at doses of 0 (vehicle: 0.1% Tween 80, 10 mL/kg bw), 1, 5 and 25 mg/kg bw/day. In the clinical observations, vomiting/vomitus (dark red watery substance or undigested feed) was observed for males and females in the 25, but not 5 or 1 mg/kg bw/day group at a relatively high frequency. In addition, loose stools were observed for males in this group on a single occasion. These signs were considered to be effects of the test article on the digestive tract. No treatment-related effects were noted in the detailed observations for symptoms, body weights, food consumptions, ophthalmology, hematology, clinical chemistry, urinalysis, gross pathology, organ weights or histopathology. Thus, the no-observed-adverse-effect level (NOAEL) was judged to be 5 mg/kg bw/day in both sexes of the dogs.","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135700963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fernanda Martins, Tamara C. Lopes de Castro, Andrey Santos, D. Guadagnini, Rose C. G. Trevisane, Ricardo P. Moreira, Edite Taninaga, M. Saad, M. L. Queiroz, C. O. Torello
{"title":"Chlorella modulation of gut microbiota dysbiosis in patients with type-2 diabetes","authors":"Fernanda Martins, Tamara C. Lopes de Castro, Andrey Santos, D. Guadagnini, Rose C. G. Trevisane, Ricardo P. Moreira, Edite Taninaga, M. Saad, M. L. Queiroz, C. O. Torello","doi":"10.2131/fts.10.45","DOIUrl":"https://doi.org/10.2131/fts.10.45","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79886065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Survey of toxicity study packages and designs of intravitreal drugs approved in Japan","authors":"Kotaro Yamada, Yoshinori Yamagiwa, Yu Haranosono","doi":"10.2131/fts.10.249","DOIUrl":"https://doi.org/10.2131/fts.10.249","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"306 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134980229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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