Seiko Hashiguchi, A. Miyauchi, Keiji Komemoto, Tomoyuki Ueda, Kenji Tokuda, A. Hirose, H. Yoshida, T. Akashi, M. Kurokawa, W. Watanabe
{"title":"Effects of intranasal administration of multi-walled carbon nanotube (MWCNT) suspension on respiratory syncytial virus (RSV) infection in mice","authors":"Seiko Hashiguchi, A. Miyauchi, Keiji Komemoto, Tomoyuki Ueda, Kenji Tokuda, A. Hirose, H. Yoshida, T. Akashi, M. Kurokawa, W. Watanabe","doi":"10.2131/fts.8.215","DOIUrl":"https://doi.org/10.2131/fts.8.215","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85220753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Miyajima, T. Kawakami, K. Komoriya, Reiko Kato, M. Usami, K. Isama
{"title":"Potency shift in immunomodulatory activities of zinc oxide (ZnO) nanoparticles in THP-1 cells is associated with cytotoxicity","authors":"A. Miyajima, T. Kawakami, K. Komoriya, Reiko Kato, M. Usami, K. Isama","doi":"10.2131/fts.8.205","DOIUrl":"https://doi.org/10.2131/fts.8.205","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84213813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Misuzu Tanaka, Akane Kanasaki, Noriko Hayashi, T. Iida, K. Murao
{"title":"The influence of long-term ingestion of D-allulose in hypercholesterolemia patients under statin therapy","authors":"Misuzu Tanaka, Akane Kanasaki, Noriko Hayashi, T. Iida, K. Murao","doi":"10.2131/FTS.8.23","DOIUrl":"https://doi.org/10.2131/FTS.8.23","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"58 1","pages":"23-31"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83948584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Fujino, Kouta Sugizaki, Saki Ohkawa, S. Fujikawa, Toshiyuki Oshima, M. Hayakawa
{"title":"Ouabagenin, an aglycone of cardiotonic steroid ouabain, functions as LXR ligand but avoids the increase in the SREBP-1 by inducing Krüppel-like factor 15","authors":"T. Fujino, Kouta Sugizaki, Saki Ohkawa, S. Fujikawa, Toshiyuki Oshima, M. Hayakawa","doi":"10.2131/FTS.8.17","DOIUrl":"https://doi.org/10.2131/FTS.8.17","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"8 1","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87671052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Taquahashi, Hirokatsu Saito, M. Kuwagata, S. Kitajima
{"title":"Development of an inhalation exposure system of a pressurized metered-dose inhaler (pMDI) formulation for small experimental animals","authors":"Y. Taquahashi, Hirokatsu Saito, M. Kuwagata, S. Kitajima","doi":"10.2131/fts.8.169","DOIUrl":"https://doi.org/10.2131/fts.8.169","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78668221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shuso Takeda, Masayo Hirao-Suzuki, Y. Yamagishi, Takahiro Sugihara, Masataka Kaneko, G. Sakai, Tetsuya Nakamura, Yuhzo Hieda, M. Takiguchi, Masahiro Okada, N. Sugihara
{"title":"Effects of the ethanol extract of Neopyropia yezoensis, cultivated in the Seto Inland Sea (Setonaikai), on the viability of 10 human cancer cells including endocrine therapy-resistant breast cancer cells","authors":"Shuso Takeda, Masayo Hirao-Suzuki, Y. Yamagishi, Takahiro Sugihara, Masataka Kaneko, G. Sakai, Tetsuya Nakamura, Yuhzo Hieda, M. Takiguchi, Masahiro Okada, N. Sugihara","doi":"10.2131/fts.8.75","DOIUrl":"https://doi.org/10.2131/fts.8.75","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89946550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuki Nishiyama, Masaya Uchida, Akinori Terada, S. Kono, H. Ishibashi, K. Arizono, N. Tominaga
The evaluation of developmental toxicity requires new methods that provide an alternative to animal use. In this study, we evaluated the effects of thalidomide exposure [upon nanosecond pulsed electric field (nsPEF) treatment] on the embryonic development of, teratogenic effects in, and gene expression levels in medaka embryos, to determine whether the adverse effects of thalidomide can be detected using medaka. Incorporation of thalidomide into medaka embryos led to malformations in individuals. The results obtained by microinjecting thalidomide into zebrafish embryos could be reproduced by medaka embryo electroporation. Furthermore, the teratogenic mechanism of thalidomide was confirmed at the genetic level. Medaka eggs, in addition to zebrafish, can be used to assess the effects of thalidomide. As the nsPEF method can efficiently incorporate of test chemicals into medaka eggs, it is suggested to have great potential for use as a high-throughput animal alternative evaluation system.
{"title":"Electroporation of thalidomide to medaka (Oryzias latipes) embryo for evaluation of developmental toxicity","authors":"Yuki Nishiyama, Masaya Uchida, Akinori Terada, S. Kono, H. Ishibashi, K. Arizono, N. Tominaga","doi":"10.2131/fts.8.189","DOIUrl":"https://doi.org/10.2131/fts.8.189","url":null,"abstract":"The evaluation of developmental toxicity requires new methods that provide an alternative to animal use. In this study, we evaluated the effects of thalidomide exposure [upon nanosecond pulsed electric field (nsPEF) treatment] on the embryonic development of, teratogenic effects in, and gene expression levels in medaka embryos, to determine whether the adverse effects of thalidomide can be detected using medaka. Incorporation of thalidomide into medaka embryos led to malformations in individuals. The results obtained by microinjecting thalidomide into zebrafish embryos could be reproduced by medaka embryo electroporation. Furthermore, the teratogenic mechanism of thalidomide was confirmed at the genetic level. Medaka eggs, in addition to zebrafish, can be used to assess the effects of thalidomide. As the nsPEF method can efficiently incorporate of test chemicals into medaka eggs, it is suggested to have great potential for use as a high-throughput animal alternative evaluation system.","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72701224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Sugita, Junpei Yamamoto, Kimika Kaneshima, Chika Kitaoka-Saito, M. Sekimoto, O. Endo, Y. Takagi, Y. Kato-Yoshinaga
{"title":"Acrylamide in dog food","authors":"K. Sugita, Junpei Yamamoto, Kimika Kaneshima, Chika Kitaoka-Saito, M. Sekimoto, O. Endo, Y. Takagi, Y. Kato-Yoshinaga","doi":"10.2131/FTS.8.49","DOIUrl":"https://doi.org/10.2131/FTS.8.49","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"40 3","pages":"49-52"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72573790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Takashi Yamada, T. Kawamura, Taeko Maruyama, Masayuki Kurimoto, Hiroshi Yamamoto, N. Katsutani, A. Hirose
{"title":"Quantitative structure-activity relationship and a category approach to support algal toxicity assessment of human pharmaceuticals","authors":"Takashi Yamada, T. Kawamura, Taeko Maruyama, Masayuki Kurimoto, Hiroshi Yamamoto, N. Katsutani, A. Hirose","doi":"10.2131/fts.8.195","DOIUrl":"https://doi.org/10.2131/fts.8.195","url":null,"abstract":"","PeriodicalId":12489,"journal":{"name":"Fundamental Toxicological Sciences","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78820622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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