Pub Date : 2023-04-01DOI: 10.23946/2500-0764-2023-8-1-143-149
G. Zoloev, A. A. Kosovskikh, O. Rudenkova, Zh. V. Pikelgaupt, V. V. Manzhos, K. V. Cherevatenko
Severe COVID-19 is not restricted to the lungs but also affects other organs and tissues, making the choice of the therapeutic regimen challenging, in particular with patients having comorbid conditions. Here we present the case of successful treatment of COVID-19 in patient with Hodgkin lymphoma and brain injury, focusing on the signs, symptoms, and differential diagnosis.
{"title":"A clinical case of COVID-19 in a patient with Hodgkin lymphoma and brain damage","authors":"G. Zoloev, A. A. Kosovskikh, O. Rudenkova, Zh. V. Pikelgaupt, V. V. Manzhos, K. V. Cherevatenko","doi":"10.23946/2500-0764-2023-8-1-143-149","DOIUrl":"https://doi.org/10.23946/2500-0764-2023-8-1-143-149","url":null,"abstract":"Severe COVID-19 is not restricted to the lungs but also affects other organs and tissues, making the choice of the therapeutic regimen challenging, in particular with patients having comorbid conditions. Here we present the case of successful treatment of COVID-19 in patient with Hodgkin lymphoma and brain injury, focusing on the signs, symptoms, and differential diagnosis.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82868545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.23946/2500-0764-2023-8-1-109-118
K. V. Marochko, Y. Parfenova, N. Artymuk, O. Novikova, D. Beglov
Annually, about 15 million of infants are born prematurely, and preterm birth is associated with an increased risk of neonatal morbidity and mortality. Further, the risk of repeated premature birth is relatively high, as 25% of pregnancies following those interrupted at 23-28 weeks of gestation also result in a preterm birth within the similar time frame. Among the major risk factors of preterm birth is cervical insufficiency, and cervical length measurement is recommended for all pregnant women at 18−21 weeks of gestation. For patients at high risk of late miscarriage and preterm birth, cervical length measurement should be performed weekly from 15 to 24 weeks of gestation. The use of pessary, which reduces amniotic sac pressure on the internal os, has been suggested as an appropriate option to correct cervical insufficiency as it does not require surgery, has low risk of complications and is easy to use. Relevant papers published hitherto report contradictory results, which require further research.
{"title":"Use of pessary for cervical insufficiency: a discussion","authors":"K. V. Marochko, Y. Parfenova, N. Artymuk, O. Novikova, D. Beglov","doi":"10.23946/2500-0764-2023-8-1-109-118","DOIUrl":"https://doi.org/10.23946/2500-0764-2023-8-1-109-118","url":null,"abstract":"Annually, about 15 million of infants are born prematurely, and preterm birth is associated with an increased risk of neonatal morbidity and mortality. Further, the risk of repeated premature birth is relatively high, as 25% of pregnancies following those interrupted at 23-28 weeks of gestation also result in a preterm birth within the similar time frame. Among the major risk factors of preterm birth is cervical insufficiency, and cervical length measurement is recommended for all pregnant women at 18−21 weeks of gestation. For patients at high risk of late miscarriage and preterm birth, cervical length measurement should be performed weekly from 15 to 24 weeks of gestation. The use of pessary, which reduces amniotic sac pressure on the internal os, has been suggested as an appropriate option to correct cervical insufficiency as it does not require surgery, has low risk of complications and is easy to use. Relevant papers published hitherto report contradictory results, which require further research.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89745038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.23946/2500-0764-2023-8-1-93-100
Vitaliy B. Tskhay, Gulnar T. Mikailly, I. I. Tskhay, Krasnoyarsk Partizana Zheleznyaka Street
Aim. To study the short- and long-term results of organ-sparing surgery in patients with severe diffuse adenomyosis who are in the perimenopausal age.Materials and Methods. The study included 18 patients with severe diffuse adenomyosis who underwent fertility-sparing excision of diffuse adenomyosis by means of Osada procedure. Efficiency of surgical treatment and subsequent drug therapy was evaluated at 12 and 24 months of follow-up by pelvic ultrasound examination. The frequency of adenomyosis symptoms and quality of life were assessed using the standard SF-36 questionnaire.Results. Recovery of the menstrual cycle, freedom from pain and anemia, and improved quality of life were documented in all cases (18/18), whereas onset of menopause occurred in half of the cases (9/18). In particular, all scales of the Physical Component Summary from SF-36 questionnaire were significantly improved at both follow-up time points.Conclusion. Organ-sparing excision of diffuse adenomyosis using Osada procedure is the option of choice and might represent an alternative to hysterectomy in women with perimenopausal age, in addition to those of earlier reproductive age.
{"title":"Short- and long-term results of organ-sparing surgery in patients with severe diffuse adenomyosis at perimenopausal transition","authors":"Vitaliy B. Tskhay, Gulnar T. Mikailly, I. I. Tskhay, Krasnoyarsk Partizana Zheleznyaka Street","doi":"10.23946/2500-0764-2023-8-1-93-100","DOIUrl":"https://doi.org/10.23946/2500-0764-2023-8-1-93-100","url":null,"abstract":"Aim. To study the short- and long-term results of organ-sparing surgery in patients with severe diffuse adenomyosis who are in the perimenopausal age.Materials and Methods. The study included 18 patients with severe diffuse adenomyosis who underwent fertility-sparing excision of diffuse adenomyosis by means of Osada procedure. Efficiency of surgical treatment and subsequent drug therapy was evaluated at 12 and 24 months of follow-up by pelvic ultrasound examination. The frequency of adenomyosis symptoms and quality of life were assessed using the standard SF-36 questionnaire.Results. Recovery of the menstrual cycle, freedom from pain and anemia, and improved quality of life were documented in all cases (18/18), whereas onset of menopause occurred in half of the cases (9/18). In particular, all scales of the Physical Component Summary from SF-36 questionnaire were significantly improved at both follow-up time points.Conclusion. Organ-sparing excision of diffuse adenomyosis using Osada procedure is the option of choice and might represent an alternative to hysterectomy in women with perimenopausal age, in addition to those of earlier reproductive age.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90308010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.23946/2500-0764-2023-8-1-32-42
T. Belokrinitskaya, N. Frolova, K. A. Kargina, E. A. Shametova, M. I. Chuprova, K. Rodionova
Aim. To identify confounders and clinical symptoms of COVID-19 in low-risk pregnant women during the pandemics from 2020 to 2022.Materials and Methods. The study included pregnant women with COVID-19: 1) those who have been admitted in October-December 2020 (n = 163); 2) those who have been admitted in May-August 2021 (n = 158); 3) those who have been admitted in January-February 2022 (n = 160). Patients in all groups were in the 3st trimester of gestation and were comparable in age (18–35 years), socioeconomic status, parity, body mass index, and had no established risk factors for COVID-19.Results. Iron deficiency anemia, tobacco smoking, and belonging to the East Asian ethnic group were recognized as reliable confounders for COVID-19 in pregnant women. In the 1st year of the pandemic, the most common symptoms were: loss of smell/taste (87.7%), somnolence (68,7%), and shortness of breath (68.1%). In the 2nd pandemic year, SARS-CoV-2 Delta variant more frequently resulted in fever above 38°C (19.6% vs 7.4%), pneumonia (61.4% vs 21.4%), respiratory failure (17.7% vs 4.9%), admission to intensive care unit (11.4% vs 6.4%), and invasive mechanical ventilation (1.89% vs 0). Symptoms of COVID-19 in the 3rd year of the pandemic were similar to those observed in seasonal acute respiratory viral infections: runny nose (66.7%) and cough (54.4%), whereas the cases of pneumonia were rare (3.8%).Conclusion. Among the most reliable confounders of COVID-19 in pregnant women without any risk factors in the 3rd trimester of gestation are iron deficiency anemia, tobacco smoking, and belonging to the East Asian ethnic group. Each SARS-CoV-2 variant provoked vastly different symptoms.
{"title":"COVID-19 pandemic in low-risk pregnant women in 2020-2022: disease confounders and clinical characteristics","authors":"T. Belokrinitskaya, N. Frolova, K. A. Kargina, E. A. Shametova, M. I. Chuprova, K. Rodionova","doi":"10.23946/2500-0764-2023-8-1-32-42","DOIUrl":"https://doi.org/10.23946/2500-0764-2023-8-1-32-42","url":null,"abstract":"Aim. To identify confounders and clinical symptoms of COVID-19 in low-risk pregnant women during the pandemics from 2020 to 2022.Materials and Methods. The study included pregnant women with COVID-19: 1) those who have been admitted in October-December 2020 (n = 163); 2) those who have been admitted in May-August 2021 (n = 158); 3) those who have been admitted in January-February 2022 (n = 160). Patients in all groups were in the 3st trimester of gestation and were comparable in age (18–35 years), socioeconomic status, parity, body mass index, and had no established risk factors for COVID-19.Results. Iron deficiency anemia, tobacco smoking, and belonging to the East Asian ethnic group were recognized as reliable confounders for COVID-19 in pregnant women. In the 1st year of the pandemic, the most common symptoms were: loss of smell/taste (87.7%), somnolence (68,7%), and shortness of breath (68.1%). In the 2nd pandemic year, SARS-CoV-2 Delta variant more frequently resulted in fever above 38°C (19.6% vs 7.4%), pneumonia (61.4% vs 21.4%), respiratory failure (17.7% vs 4.9%), admission to intensive care unit (11.4% vs 6.4%), and invasive mechanical ventilation (1.89% vs 0). Symptoms of COVID-19 in the 3rd year of the pandemic were similar to those observed in seasonal acute respiratory viral infections: runny nose (66.7%) and cough (54.4%), whereas the cases of pneumonia were rare (3.8%).Conclusion. Among the most reliable confounders of COVID-19 in pregnant women without any risk factors in the 3rd trimester of gestation are iron deficiency anemia, tobacco smoking, and belonging to the East Asian ethnic group. Each SARS-CoV-2 variant provoked vastly different symptoms.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85786986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.23946/2500-0764-2023-8-1-132-142
O. Barbarash, V. Kashtalap, L. Barbarash
Here we provide a brief overview of current consensus documents and clinical guidelines concerning the management of the patients with acute coronary syndrome (ACS) without ST segment elevation, which have been released in 2021-2022. Further, we consider statistics on ACS in the Russian Federation and discuss an expert analysis of the effects of COVID-19 pandemic on ACS-associated healthcare in Russian Federation, as well as the pathological effects of SARS-CoV-2 on the circulatory system. The fourth universal definition of myocardial infarction (2018) is also clarified according to the recent updates.
{"title":"Non-ST segment elevation myocardial infarction: results of 2021−2022","authors":"O. Barbarash, V. Kashtalap, L. Barbarash","doi":"10.23946/2500-0764-2023-8-1-132-142","DOIUrl":"https://doi.org/10.23946/2500-0764-2023-8-1-132-142","url":null,"abstract":"Here we provide a brief overview of current consensus documents and clinical guidelines concerning the management of the patients with acute coronary syndrome (ACS) without ST segment elevation, which have been released in 2021-2022. Further, we consider statistics on ACS in the Russian Federation and discuss an expert analysis of the effects of COVID-19 pandemic on ACS-associated healthcare in Russian Federation, as well as the pathological effects of SARS-CoV-2 on the circulatory system. The fourth universal definition of myocardial infarction (2018) is also clarified according to the recent updates.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75210414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.23946/2500-0764-2023-8-1-119-131
Zhanna V. Gudinova, Lidia V. Demakova
Here we describe the most common and informative procedures for the primary statistical analysis of medical data. We emphasize the importance of using histogram, normality tests, median, percentiles, confidence intervals, ranking procedures, and as analytical tools. The material is illustrated with step-by-step graphical explanation of applying commercially available software for fulfilling these tasks. The lecture is designed for biomedical students and clinicians.
{"title":"Statistical analysis of medical data: descriptive statistics and group comparison","authors":"Zhanna V. Gudinova, Lidia V. Demakova","doi":"10.23946/2500-0764-2023-8-1-119-131","DOIUrl":"https://doi.org/10.23946/2500-0764-2023-8-1-119-131","url":null,"abstract":"Here we describe the most common and informative procedures for the primary statistical analysis of medical data. We emphasize the importance of using histogram, normality tests, median, percentiles, confidence intervals, ranking procedures, and as analytical tools. The material is illustrated with step-by-step graphical explanation of applying commercially available software for fulfilling these tasks. The lecture is designed for biomedical students and clinicians.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89476797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.23946/2500-0764-2023-8-1-63-70
S. Rudakova, O. E. Teslova, N. E. Mutalinova, Yulia F. Kuzmenko, S. V. Strek, N. Penyevskaya, N. Rudakov
Aim. To improve emergency diagnostic measures and preventive antimicrobial therapy in patients with ixodid tick bites using molecular genetic techniques for identification of Вorrelia spp.Materials and Methods. Borrelia strains were isolated by inoculation of tick suspension on the BSK-H medium. Molecular genetic screening of Вorrelia spp. was performed by real-time polymerase chain reaction (PCR) and sequencing. In total, we examined 4,276 patients including 272 bitten by Ixodes persulcatus and 3,108 bitten by Dermacentor reticulatus. In addition, we investigated blood of 896 patients for molecular signatures of Borrelia spp.Results. Borrelia spp. was detected by PCR in 30.1% of Ixodes persulcatus and 3.2% of Dermacentor reticulatus suspensions. However, detection of Borrelia spp. in blood was rare, reaching only 1.1% in those bitten by Ixodes persulcatus and two cases of Dermacentor reticulatus bites. Genotyping of Borrelia spp. in 8 tick suspensions showed the presence of Borrelia garinii in 1 sample, Borrelia afzelii in 5 samples, Borrelia bavariensis in 1 sample, and Borrelia miyamotoi in 1 sample.Conclusion. Molecular genetic screening showed the significant proportion of Ixodid ticks bearing Borrelia spp., indicating the need in specific antimicrobial therapy.
{"title":"Molecular genetic surveillance based on the identification of borrelia in ixodid ticks","authors":"S. Rudakova, O. E. Teslova, N. E. Mutalinova, Yulia F. Kuzmenko, S. V. Strek, N. Penyevskaya, N. Rudakov","doi":"10.23946/2500-0764-2023-8-1-63-70","DOIUrl":"https://doi.org/10.23946/2500-0764-2023-8-1-63-70","url":null,"abstract":"Aim. To improve emergency diagnostic measures and preventive antimicrobial therapy in patients with ixodid tick bites using molecular genetic techniques for identification of Вorrelia spp.Materials and Methods. Borrelia strains were isolated by inoculation of tick suspension on the BSK-H medium. Molecular genetic screening of Вorrelia spp. was performed by real-time polymerase chain reaction (PCR) and sequencing. In total, we examined 4,276 patients including 272 bitten by Ixodes persulcatus and 3,108 bitten by Dermacentor reticulatus. In addition, we investigated blood of 896 patients for molecular signatures of Borrelia spp.Results. Borrelia spp. was detected by PCR in 30.1% of Ixodes persulcatus and 3.2% of Dermacentor reticulatus suspensions. However, detection of Borrelia spp. in blood was rare, reaching only 1.1% in those bitten by Ixodes persulcatus and two cases of Dermacentor reticulatus bites. Genotyping of Borrelia spp. in 8 tick suspensions showed the presence of Borrelia garinii in 1 sample, Borrelia afzelii in 5 samples, Borrelia bavariensis in 1 sample, and Borrelia miyamotoi in 1 sample.Conclusion. Molecular genetic screening showed the significant proportion of Ixodid ticks bearing Borrelia spp., indicating the need in specific antimicrobial therapy.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"119 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77934089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.23946/2500-0764-2023-8-1-101-108
During the COVID-19 pandemic, the incidence of acute mesenteric ischemia (AMI) increased to 10.9 per 100 000 population. Here we discuss causes, symptoms, current diagnosis and treatment of AMI.Frequently, such patients suffer from stenosis or occlusion of superior mesenteric artery accompanied by coronary artery disease, chronic heart failure, or chronic brain ischaemia. The main clinical symptom is constant abdominal pain which is sharp in case of mesenteric artery thrombosis or dull if thrombosis is restricted to the branch of superior or inferior mesenteric veins. Conventionally, the diagnosis of AMI is verified by multislice computed tomography angiography and contrast-enhanced multislice computed tomography. Timely diagnosis with emergency surgery reduces mortality from 90% to 30-50%. The best treatment outcomes are observed after early revascularizations and minimally invasive endovascular interventions.
{"title":"Acute mesenterial ischaemia: a contemporary view","authors":"","doi":"10.23946/2500-0764-2023-8-1-101-108","DOIUrl":"https://doi.org/10.23946/2500-0764-2023-8-1-101-108","url":null,"abstract":"During the COVID-19 pandemic, the incidence of acute mesenteric ischemia (AMI) increased to 10.9 per 100 000 population. Here we discuss causes, symptoms, current diagnosis and treatment of AMI.Frequently, such patients suffer from stenosis or occlusion of superior mesenteric artery accompanied by coronary artery disease, chronic heart failure, or chronic brain ischaemia. The main clinical symptom is constant abdominal pain which is sharp in case of mesenteric artery thrombosis or dull if thrombosis is restricted to the branch of superior or inferior mesenteric veins. Conventionally, the diagnosis of AMI is verified by multislice computed tomography angiography and contrast-enhanced multislice computed tomography. Timely diagnosis with emergency surgery reduces mortality from 90% to 30-50%. The best treatment outcomes are observed after early revascularizations and minimally invasive endovascular interventions.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91245803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.23946/2500-0764-2023-8-1-8-20
Aim. To establish cut-off values for the concentrations of complement C3 and ceruloplasmin, diagnostic markers of reduced antral follicle count (AFC) and anti-Müllerian hormone (AMH) which both indicate diminished ovarian reserve, in women of reproductive age.Materials and Methods. Here we enrolled 864 women (18-40 years of age, average age 31.70 ± 5.14 years) who underwent an annual medical examination in 2017–2019 in the Irkutsk Region and the Republic of Buryatia. Reduced AFC was defined as ≤ 5 antral follicles in each ovary at pelvic ultrasound examination whilst reduced AMH was defined as < 1.2 ng/mL. In total, 112 women had reduced ovarian reserve and 752 were included into the control group. In addition to AMH, we also measured serum prolactin, gonadotropins, inhibin B, estradiol, complement C3, and ceruloplasmin using enzyme-linked immunosorbent assay. The cut-off values were determined by plotting a receiver operating characteristic (ROC) curve and calculating the area under the curve (AUC).Results. The cut-off level of complement C3 was 894 (867; 1355.5) mg/mL [AUC: 0.769 (0.635; 0.904)] in women with reduced AFC (≤ 5) and 981.5 (916.5; 1467.5) mg/mL [AUC: 0.62 (0.493; 0.746)] in women with reduced AMH (< 1.2 ng/mL). The cut-off level of ceruloplasmin was 1.745 (1.625; 1.975) mg/mL [AUC: 0.859 (0.759; 0.96)] in women with reduced AFC (≤ 5) and 1.975 (1.665; 2.15) mg/mL, [AUC: 0.662 (0.542; 0.782)] in women with reduced AMH (< 1.2 ng/mL).Conclusion. We have established the cut-off values for the serum complement C3 and ceruloplasmin in women with reduced AFC and AMH, indicators defining diminished ovarian reserve in women of reproductive age.
{"title":"Ceruloplasmin and complement C3 are markers of diminished ovarian reserve in premenopausal women","authors":"","doi":"10.23946/2500-0764-2023-8-1-8-20","DOIUrl":"https://doi.org/10.23946/2500-0764-2023-8-1-8-20","url":null,"abstract":"Aim. To establish cut-off values for the concentrations of complement C3 and ceruloplasmin, diagnostic markers of reduced antral follicle count (AFC) and anti-Müllerian hormone (AMH) which both indicate diminished ovarian reserve, in women of reproductive age.Materials and Methods. Here we enrolled 864 women (18-40 years of age, average age 31.70 ± 5.14 years) who underwent an annual medical examination in 2017–2019 in the Irkutsk Region and the Republic of Buryatia. Reduced AFC was defined as ≤ 5 antral follicles in each ovary at pelvic ultrasound examination whilst reduced AMH was defined as < 1.2 ng/mL. In total, 112 women had reduced ovarian reserve and 752 were included into the control group. In addition to AMH, we also measured serum prolactin, gonadotropins, inhibin B, estradiol, complement C3, and ceruloplasmin using enzyme-linked immunosorbent assay. The cut-off values were determined by plotting a receiver operating characteristic (ROC) curve and calculating the area under the curve (AUC).Results. The cut-off level of complement C3 was 894 (867; 1355.5) mg/mL [AUC: 0.769 (0.635; 0.904)] in women with reduced AFC (≤ 5) and 981.5 (916.5; 1467.5) mg/mL [AUC: 0.62 (0.493; 0.746)] in women with reduced AMH (< 1.2 ng/mL). The cut-off level of ceruloplasmin was 1.745 (1.625; 1.975) mg/mL [AUC: 0.859 (0.759; 0.96)] in women with reduced AFC (≤ 5) and 1.975 (1.665; 2.15) mg/mL, [AUC: 0.662 (0.542; 0.782)] in women with reduced AMH (< 1.2 ng/mL).Conclusion. We have established the cut-off values for the serum complement C3 and ceruloplasmin in women with reduced AFC and AMH, indicators defining diminished ovarian reserve in women of reproductive age.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91058798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.23946/2500-0764-2023-8-1-21-31
A. Sosnina, I. Tarasova, I. Syrova, O. Maleva, O. Trubnikova, O. Barbarash
Aim. To study long-term changes (5 to 7 years after coronary artery bypass graft (CABG) surgery) in cognitive status of patients with type 2 diabetes.Materials and Methods. The study included 47 male patients admitted to the Research Institute for Complex Issues of Cardiovascular Diseases for the CABG surgery. Criteria of inclusion were signed informed consent, age from 40 to 75 years, male gender, planned on-pump CABG surgery, and right-handedness. Criteria of exclusion were brain pathology at multislice computed tomography, chronic cerebral ischemia grade II-IV, Beck Depression Inventory score > 16 points, the Mini-Mental State Examination (MMSE) score < 24 points and the Frontal Assessment Battery score < 11 points, arrhythmia, class IIB-IV chronic heart failure stage IIB, chronic obstructive pulmonary disease, cancer, and past medical history of brain injury or stroke. Pre-operative examination of patients classified them into two groups: with (n = 21) and without (n = 26) type 2 diabetes mellitus (DM).Results. 5-7 years after CABG surgery, patients with type 2 DM had a cognitive decline according to MMSE scale as compared to the preoperative level (28,0 [27,0; 29,0] and 27,0 [26,0; 28,0], p = 0.04). In keeping with these findings, odds ratio (OR) of mild cognitive impairment (MCI) in patients with type 2 DM was 1.92 (95% CI = 1.09- 3.37, p = 0.02). Psychomotor and executive functions were reduced in patients with type 2 DM both at baseline and in particular 5-7 years after CABG (p ≤ 0.05). The correlation between glycated hemoglobin (HbA1c) and cognitive parameters were found only in patients with type 2 DM. Higher HbA1c level was also associated with deteriorated executive functions and short-term memory.Conclusion. 5−7 years after CABG surgery, patients with type 2 DM suffer from a cognitive decline and reduced psychomotor and executive functions.
的目标。研究2型糖尿病患者认知状态的长期变化(冠状动脉搭桥术后5 ~ 7年)。材料与方法。这项研究包括47名在心血管疾病复杂问题研究所接受冠状动脉搭桥手术的男性患者。入选标准为签署知情同意书，年龄40 - 75岁，男性，计划进行无泵搭桥手术，惯用右手。排除标准为多层计算机断层扫描脑病理，慢性脑缺血II-IV级，贝克抑郁量表评分> 16分，迷你精神状态检查(MMSE)评分< 24分，额叶评估电池评分< 11分，心律失常，IIB- iv级慢性心力衰竭IIB期，慢性阻塞性肺疾病，癌症，既往脑损伤或脑卒中病史。术前检查将患者分为2型糖尿病组(n = 21)和非2型糖尿病组(n = 26)。CABG术后5-7年，2型DM患者的MMSE量表认知能力较术前水平下降(28,0;29,0]和27,0 [26,0;28.0]， p = 0.04)。与这些发现一致，2型糖尿病患者轻度认知障碍(MCI)的优势比(OR)为1.92 (95% CI = 1.09- 3.37, p = 0.02)。2型糖尿病患者的精神运动和执行功能在基线时，特别是CABG后5-7年均有所下降(p≤0.05)。糖化血红蛋白(HbA1c)与认知参数的相关性仅在2型糖尿病患者中发现，较高的HbA1c水平也与执行功能和短期记忆的恶化有关。CABG术后5 - 7年，2型糖尿病患者认知能力下降，精神运动和执行功能下降。
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