Pub Date : 2025-01-01DOI: 10.1016/j.genhosppsych.2024.12.011
Pao-Huan Chen , Cheng-Yi Hsiao , Jiunn-Kae Wang , Hsiao-Lun Ku , Kuo-Hsuan Chung , Shang-Ying Tsai
Objective
Allostatic load refers to the pathophysiological consequences of uncompensated adaptation to chronic stress. Few studies have investigated the effect of allostatic load on cardiac health in patients with serious mental disorders (SMDs), a population at high risk of cardiac mortality. Herein we evaluated associations between allostatic load and cardiac structure and function in young adults with SMDs.
Method
A total of 106 participants aged younger than 45 years underwent echocardiographic study, blood biochemistry examination, and blood cell count analysis. Echocardiographic imaging was conducted in accordance with recommendations of the American Society of Echocardiography and European Association of Cardiovascular Imaging. Allostatic load index was calculated using 15 measures representing cardiovascular, metabolic, and inflammatory or oxidative stress markers.
Results
The SMD group exhibited a significantly higher allostatic load index than did control (Cohen's d = 0.59). Additionally, they exhibited a greater left ventricular relative wall thickness (LVRWT, Cohen's d = 0.39) and a less favorable mitral valve E/A ratio (Cohen's d = 0.31), left ventricular ejection fraction (Cohen's d = 0.51), and global longitudinal strain (Cohen's d = 0.71). After demographic and clinical characteristics were adjusted for, multiple linear regression revealed that allostatic load index was positively associated with LVRWT (β = 0.255) and negatively associated with mitral valve E/A ratio (β = −0.247) in the SMD group.
Conclusions
This is the first study to suggest that allostatic load may play a critical role in accelerated adverse cardiac remodeling among young patients with SMDs. Future studies should elucidate the underlying mechanisms.
目的：适应负荷是指无补偿适应慢性应激的病理生理后果。很少有研究调查适应负荷对严重精神障碍（SMDs）患者心脏健康的影响，这是一个心脏死亡率高的人群。在此，我们评估了年轻成年smd患者的适应负荷与心脏结构和功能之间的关系。方法：对106名年龄小于45岁的参与者进行超声心动图检查、血液生化检查和血细胞计数分析。超声心动图成像是按照美国超声心动图学会和欧洲心血管成像协会的建议进行的。采用代表心血管、代谢和炎症或氧化应激标志物的15项指标计算适应负荷指数。结果：SMD组的适应负荷指数明显高于对照组（Cohen’s d = 0.59）。此外，他们表现出更大的左心室相对壁厚（LVRWT, Cohen's d = 0.39）和更不利的二尖瓣E/ a比（Cohen's d = 0.31），左心室射血分数（Cohen's d = 0.51）和整体纵向应变（Cohen's d = 0.71）。在调整了人口统计学和临床特征后，多元线性回归显示，SMD组的适应负荷指数与LVRWT呈正相关（β = 0.255），与二尖瓣E/A比负相关（β = -0.247）。结论：这是第一个表明适应负荷可能在加速年轻smd患者不良心脏重构中起关键作用的研究。未来的研究应阐明潜在的机制。
{"title":"Association between allostatic load and cardiac structural and functional abnormalities in young adults with serious mental disorders","authors":"Pao-Huan Chen , Cheng-Yi Hsiao , Jiunn-Kae Wang , Hsiao-Lun Ku , Kuo-Hsuan Chung , Shang-Ying Tsai","doi":"10.1016/j.genhosppsych.2024.12.011","DOIUrl":"10.1016/j.genhosppsych.2024.12.011","url":null,"abstract":"<div><h3>Objective</h3><div>Allostatic load refers to the pathophysiological consequences of uncompensated adaptation to chronic stress. Few studies have investigated the effect of allostatic load on cardiac health in patients with serious mental disorders (SMDs), a population at high risk of cardiac mortality. Herein we evaluated associations between allostatic load and cardiac structure and function in young adults with SMDs.</div></div><div><h3>Method</h3><div>A total of 106 participants aged younger than 45 years underwent echocardiographic study, blood biochemistry examination, and blood cell count analysis. Echocardiographic imaging was conducted in accordance with recommendations of the American Society of Echocardiography and European Association of Cardiovascular Imaging. Allostatic load index was calculated using 15 measures representing cardiovascular, metabolic, and inflammatory or oxidative stress markers.</div></div><div><h3>Results</h3><div>The SMD group exhibited a significantly higher allostatic load index than did control (Cohen's <em>d</em> = 0.59). Additionally, they exhibited a greater left ventricular relative wall thickness (LVRWT, Cohen's <em>d</em> = 0.39) and a less favorable mitral valve E/A ratio (Cohen's <em>d</em> = 0.31), left ventricular ejection fraction (Cohen's <em>d</em> = 0.51), and global longitudinal strain (Cohen's <em>d</em> = 0.71). After demographic and clinical characteristics were adjusted for, multiple linear regression revealed that allostatic load index was positively associated with LVRWT (<em>β</em> = 0.255) and negatively associated with mitral valve E/A ratio (<em>β</em> = −0.247) in the SMD group.</div></div><div><h3>Conclusions</h3><div>This is the first study to suggest that allostatic load may play a critical role in accelerated adverse cardiac remodeling among young patients with SMDs. Future studies should elucidate the underlying mechanisms.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"92 ","pages":"Pages 40-45"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.genhosppsych.2024.12.001
Runtang Meng , Nongnong Yang , Yi Luo , Ciarán O'Driscoll , Haiyan Ma , Alice M. Gregory , Joseph M. Dzierzewski
Objective
The RU_SATED scale is increasingly used across the globe to measure sleep health. However, there is a lack of consensus around its psychometric and diagnostic performance. We conducted an empirical investigation into the psychometrics of the Chinese version of the RU_SATED (RU_SATED-C) scale, with a focus on structural validity and diagnostic performance.
Methods
1171 adults were enrolled from three communities in Hangzhou, China in July 2022. The dataset was spilt in half, and we ran a bootstrapped exploratory graph analysis (bootEGA) in one half and a confirmatory factor analysis (CFA) in the other half to assess structural validity. Correlations with insomnia, wellness, anxiety, and depression symptoms were examined in order to assess concurrent validity; and Cronbach's α and McDonald's ω were calculated to assess internal consistency. Additionally, a Receiver Operating Characteristic (ROC) analysis established and externally validated the optimal score for identifying insomnia symptoms.
Results
A one-dimensional structure, as identified by bootEGA, was corroborated in the CFA [comparative fit index = 0.934, root mean square error of approximation = 0.088, standardized root mean square residual = 0.051]. A moderate correlation was shown with insomnia symptoms, while weak correlations were observed with wellness, anxiety, and depression symptoms. The RU_SATED-C scale displayed sub-optimal internal consistency where coefficients dropped if any item was removed. A recommended cutoff score of ≤13 was derived for probable insomnia with a satisfactory diagnostic performance.
Conclusion
The RU_SATED-C scale displayed a one-dimensional model, along with adequate concurrent validity, internal consistency, and diagnostic performance. Further work necessitates multi-scenario testing and additional validation using objective sleep assessments.
{"title":"Detecting psychometric and diagnostic performance of the RU_SATED v2.0 multidimensional sleep health scale in community-dwelling adults combining exploratory graph analysis and ROC analysis","authors":"Runtang Meng , Nongnong Yang , Yi Luo , Ciarán O'Driscoll , Haiyan Ma , Alice M. Gregory , Joseph M. Dzierzewski","doi":"10.1016/j.genhosppsych.2024.12.001","DOIUrl":"10.1016/j.genhosppsych.2024.12.001","url":null,"abstract":"<div><h3>Objective</h3><div>The RU_SATED scale is increasingly used across the globe to measure sleep health. However, there is a lack of consensus around its psychometric and diagnostic performance. We conducted an empirical investigation into the psychometrics of the Chinese version of the RU_SATED (RU_SATED-C) scale, with a focus on structural validity and diagnostic performance.</div></div><div><h3>Methods</h3><div>1171 adults were enrolled from three communities in Hangzhou, China in July 2022. The dataset was spilt in half, and we ran a bootstrapped exploratory graph analysis (bootEGA) in one half and a confirmatory factor analysis (CFA) in the other half to assess structural validity. Correlations with insomnia, wellness, anxiety, and depression symptoms were examined in order to assess concurrent validity; and Cronbach's α and McDonald's ω were calculated to assess internal consistency. Additionally, a Receiver Operating Characteristic (ROC) analysis established and externally validated the optimal score for identifying insomnia symptoms.</div></div><div><h3>Results</h3><div>A one-dimensional structure, as identified by bootEGA, was corroborated in the CFA [comparative fit index = 0.934, root mean square error of approximation = 0.088, standardized root mean square residual = 0.051]. A moderate correlation was shown with insomnia symptoms, while weak correlations were observed with wellness, anxiety, and depression symptoms. The RU_SATED-C scale displayed sub-optimal internal consistency where coefficients dropped if any item was removed. A recommended cutoff score of ≤13 was derived for probable insomnia with a satisfactory diagnostic performance.</div></div><div><h3>Conclusion</h3><div>The RU_SATED-C scale displayed a one-dimensional model, along with adequate concurrent validity, internal consistency, and diagnostic performance. Further work necessitates multi-scenario testing and additional validation using objective sleep assessments.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"92 ","pages":"Pages 75-83"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-27DOI: 10.1016/j.genhosppsych.2024.12.021
Robin M. Masheb , Adam Batten , Sarah E. Siegel , Joy Huggins , Alison Marsh , Jennifer L. Snow , Lindsay F. Munro , Dawne Vogt , Marney A. White , Shira Maguen
Objective
To develop a Diagnostic and Statistical Manual of Mental Disorders (DSM-5) eating disorder screener.
Method
Veterans enrolled in VA healthcare (N = 344) completed a survey of screening items and established measures. A validation subset (n = 166) participated in diagnostic interviews to confirm an eating disorder diagnosis. Items most predictive of diagnosis were included or adapted for a confirmatory national survey (N = 405).
Results
Item selection models using machine learning techniques resulted in a five-item screen with good sensitivity, specificity and area under the curve (0.75, 0.87, and 0.83). Items included: (1) Do you do things to rid your body or stomach of calories or food (vomiting, excessive exercise, laxative or diuretic use, or something else)? (2) Do you ever eat an extremely large amount of food without thinking? (3) Are you or other people in your life concerned about a recent change in your weight? (4) Is your weight or shape one of the main ways you judge yourself? (5) Do you need to eat in order to get back to sleep when you wake up at night?
Conclusion
The 5-item BRief Eating Disorder Screener (BREDS) is the first screen developed and validated for a broad range of DSM-5 eating disorder diagnoses.
{"title":"Development and validation of the BRief Eating Disorder Screener (BREDS) for US veterans in healthcare and community settings","authors":"Robin M. Masheb , Adam Batten , Sarah E. Siegel , Joy Huggins , Alison Marsh , Jennifer L. Snow , Lindsay F. Munro , Dawne Vogt , Marney A. White , Shira Maguen","doi":"10.1016/j.genhosppsych.2024.12.021","DOIUrl":"10.1016/j.genhosppsych.2024.12.021","url":null,"abstract":"<div><h3>Objective</h3><div>To develop a Diagnostic and Statistical Manual of Mental Disorders (DSM-5) eating disorder screener.</div></div><div><h3>Method</h3><div>Veterans enrolled in VA healthcare (<em>N</em> = 344) completed a survey of screening items and established measures. A validation subset (<em>n</em> = 166) participated in diagnostic interviews to confirm an eating disorder diagnosis. Items most predictive of diagnosis were included or adapted for a confirmatory national survey (<em>N</em> = 405).</div></div><div><h3>Results</h3><div>Item selection models using machine learning techniques resulted in a five-item screen with good sensitivity, specificity and area under the curve (0.75, 0.87, and 0.83). Items included: (1) Do you do things to rid your body or stomach of calories or food (vomiting, excessive exercise, laxative or diuretic use, or something else)? (2) Do you ever eat an extremely large amount of food without thinking? (3) Are you or other people in your life concerned about a recent change in your weight? (4) Is your weight or shape one of the main ways you judge yourself? (5) Do you need to eat in order to get back to sleep when you wake up at night?</div></div><div><h3>Conclusion</h3><div>The 5-item BRief Eating Disorder Screener (BREDS) is the first screen developed and validated for a broad range of DSM-5 eating disorder diagnoses.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"93 ","pages":"Pages 1-8"},"PeriodicalIF":4.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-25DOI: 10.1016/j.genhosppsych.2024.12.022
Yufei Qiu , Man Wu , Jiali Liu , Chaoyang Li , Yiqing Yu , Lijuan Zeng , Fen Yang , Xiaohong Zhang , Gang Chen
Background
Depression and anxiety are prevalent among older adults. However, most older adults have poor access to age-specific mental health services. While Information technology-based Cognitive Behavioral Therapy (ICBT) has shown promise as an accessible alternative to face-to-face interventions, its effectiveness specifically within the older adults warrants further investigation.
Objective
To evaluate the effectiveness of ICBT on depression and anxiety symptoms among older adults.
Methods
Research articles retrieved from PubMed, EMBASE, the Cochrane Library, Web of Science, PsycINFO, and MEDLINE from inception to April 10, 2024, were reviewed. The search was designed to identify Randomized Controlled Trials (RCTs) that examined the efficacy of ICBT in reducing self-reported depression or anxiety symptoms in older adults. The quality of included studies was assessed using the Cochrane risk-of-bias tool for randomized trials, version 2.0. Posttreatment means and standard deviations (SDs) were compared between intervention and control groups, and pooled effect sizes (Hedges' g) were calculated.
Results
A total of 11 RCTs were eligible for inclusion in this review. Compared to control groups, ICBT yielded small to medium post-treatment pooled effect sizes regarding depressive symptoms (Hedges' g = −0.65, 95 % CI −0.95 to −0.35; P < 0.001) and anxiety symptoms (Hedges' g = −0.47, 95 % CI −0.74 to −0.19; P < 0.001). Subgroup analyses showed that: (1) interventions lasting ≥8 weeks (Hedges' g = −0.88, 95 % CI −1.37 to −0.39; P < 0.001) were more effective than <8 weeks for depressive symptoms; however, <8 weeks (Hedges' g = −0.52, 95 % CI −0.93 to −0.10; P = 0.014) was more effective for anxiety symptoms; (2) ICBT delivered through slideshows was more effective than through other digital platforms for both depressive (Hedges' g = −1.36, 95 % CI −2.40 to −0.31; P = 0.011) and anxiety symptoms (Hedges' g = −1.00, 95 % CI −1.30 to −0.70; P< 0.001); and (3) non-tailored ICBT was more effective than tailored versions for both depressive (Hedges' g = −1.06, 95 % CI −2.03 to −0.09; P = 0.032) and anxiety symptoms (Hedges' g = −0.70, 95 % CI −1.14 to −0.27; P = 0.001).
Conclusions
This meta-analysis reinforces the effectiveness of ICBT in relieving depression and anxiety symptoms among older adults. Future research should identify the most effective components of ICBT to optimize their development.
{"title":"Effectiveness of information technology-based cognitive behavioral therapy on depression and anxiety symptoms among older adults: Systematic review and meta-analysis","authors":"Yufei Qiu , Man Wu , Jiali Liu , Chaoyang Li , Yiqing Yu , Lijuan Zeng , Fen Yang , Xiaohong Zhang , Gang Chen","doi":"10.1016/j.genhosppsych.2024.12.022","DOIUrl":"10.1016/j.genhosppsych.2024.12.022","url":null,"abstract":"<div><h3>Background</h3><div>Depression and anxiety are prevalent among older adults. However, most older adults have poor access to age-specific mental health services. While Information technology-based Cognitive Behavioral Therapy (ICBT) has shown promise as an accessible alternative to face-to-face interventions, its effectiveness specifically within the older adults warrants further investigation.</div></div><div><h3>Objective</h3><div>To evaluate the effectiveness of ICBT on depression and anxiety symptoms among older adults.</div></div><div><h3>Methods</h3><div>Research articles retrieved from PubMed, EMBASE, the Cochrane Library, Web of Science, PsycINFO, and MEDLINE from inception to April 10, 2024, were reviewed. The search was designed to identify Randomized Controlled Trials (RCTs) that examined the efficacy of ICBT in reducing self-reported depression or anxiety symptoms in older adults. The quality of included studies was assessed using the Cochrane risk-of-bias tool for randomized trials, version 2.0. Posttreatment means and standard deviations (SDs) were compared between intervention and control groups, and pooled effect sizes (Hedges' g) were calculated.</div></div><div><h3>Results</h3><div>A total of 11 RCTs were eligible for inclusion in this review. Compared to control groups, ICBT yielded small to medium post-treatment pooled effect sizes regarding depressive symptoms (Hedges' g = −0.65, 95 % CI −0.95 to −0.35; <em>P</em> < 0.001) and anxiety symptoms (Hedges' g = −0.47, 95 % CI −0.74 to −0.19; <em>P</em> < 0.001). Subgroup analyses showed that: (1) interventions lasting ≥8 weeks (Hedges' g = −0.88, 95 % CI −1.37 to −0.39; <em>P</em> < 0.001) were more effective than <8 weeks for depressive symptoms; however, <8 weeks (Hedges' g = −0.52, 95 % CI −0.93 to −0.10; <em>P =</em> 0.014) was more effective for anxiety symptoms; (2) ICBT delivered through slideshows was more effective than through other digital platforms for both depressive (Hedges' g = −1.36, 95 % CI −2.40 to −0.31; <em>P</em> = 0.011) and anxiety symptoms (Hedges' g = −1.00, 95 % CI −1.30 to −0.70; <em>P</em> <em><</em> 0.001); and (3) non-tailored ICBT was more effective than tailored versions for both depressive (Hedges' g = −1.06, 95 % CI −2.03 to −0.09; <em>P =</em> 0.032) and anxiety symptoms (Hedges' g = −0.70, 95 % CI −1.14 to −0.27; <em>P</em> = 0.001).</div></div><div><h3>Conclusions</h3><div>This meta-analysis reinforces the effectiveness of ICBT in relieving depression and anxiety symptoms among older adults. Future research should identify the most effective components of ICBT to optimize their development.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"93 ","pages":"Pages 9-19"},"PeriodicalIF":4.1,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143181437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-26DOI: 10.1016/j.genhosppsych.2024.11.012
Meng-Yi Chen , Gabor S. Ungvari , Yu-Tao Xiang
{"title":"Response to the comments on “Global prevalence of poor sleep quality in cancer patients: A systematic review and meta-analysis”","authors":"Meng-Yi Chen , Gabor S. Ungvari , Yu-Tao Xiang","doi":"10.1016/j.genhosppsych.2024.11.012","DOIUrl":"10.1016/j.genhosppsych.2024.11.012","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"92 ","pages":"Page 1"},"PeriodicalIF":4.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.genhosppsych.2024.11.006
Seong-Uk Baek , Jin-Ha Yoon
Objective
Promoting preventive healthcare service utilization is essential for disease prevention. This study explored the association between depressive symptoms and participation in influenza vaccinations and health checkups.
Methods
This cross-sectional study included a nationwide sample consisting of 26,692 Korean adults. Depressive symptoms were assessed using the Patient Health Questionnaire–9 and categorized as none, mild, and moderate-to-severe. Participation in influenza vaccination during the past year and routine health checkups during the past two years were assessed. Logistic regression analysis was used to determine the association between depressive symptoms and participation in influenza vaccination and health checkups, with odds ratios (ORs) and 95 % confidence intervals (CIs).
Results
The prevalence of non-, mild, and moderate-to-severe depressive symptoms was 80.7 %, 14.1 %, and 5.3 %, respectively. A total of 38.5 % and 66.9 % of the individuals participated in influenza vaccination and health checkups, respectively. In the adjusted model, the ORs (95 % CIs) of the association between depressive symptoms and vaccination uptake were 0.93 (0.84–1.02) for mild and 0.78 (0.67–0.90) for moderate-to-severe depressive symptoms, compared with those for non-depressive symptoms. Additionally, the adjusted ORs (95 % CIs) of the association between depressive symptoms and health checkup participation were 0.87 (0.79–0.96) for mild and 0.76 (0.65–0.87) for moderate-to-severe depressive symptoms, compared with those for non-depressive symptoms.
Conclusion
Our findings suggest that depressive symptoms are associated with the underuse of preventive healthcare services. This study underscores the need for targeted policy interventions to increase preventive healthcare utilization among individuals with depressive symptoms.
{"title":"Association between depressive symptoms and participation in influenza vaccination and health checkups: Findings from the Korea National Health and Nutrition Examination Survey","authors":"Seong-Uk Baek , Jin-Ha Yoon","doi":"10.1016/j.genhosppsych.2024.11.006","DOIUrl":"10.1016/j.genhosppsych.2024.11.006","url":null,"abstract":"<div><h3>Objective</h3><div>Promoting preventive healthcare service utilization is essential for disease prevention. This study explored the association between depressive symptoms and participation in influenza vaccinations and health checkups.</div></div><div><h3>Methods</h3><div>This cross-sectional study included a nationwide sample consisting of 26,692 Korean adults. Depressive symptoms were assessed using the Patient Health Questionnaire–9 and categorized as none, mild, and moderate-to-severe. Participation in influenza vaccination during the past year and routine health checkups during the past two years were assessed. Logistic regression analysis was used to determine the association between depressive symptoms and participation in influenza vaccination and health checkups, with odds ratios (ORs) and 95 % confidence intervals (CIs).</div></div><div><h3>Results</h3><div>The prevalence of non-, mild, and moderate-to-severe depressive symptoms was 80.7 %, 14.1 %, and 5.3 %, respectively. A total of 38.5 % and 66.9 % of the individuals participated in influenza vaccination and health checkups, respectively. In the adjusted model, the ORs (95 % CIs) of the association between depressive symptoms and vaccination uptake were 0.93 (0.84–1.02) for mild and 0.78 (0.67–0.90) for moderate-to-severe depressive symptoms, compared with those for non-depressive symptoms. Additionally, the adjusted ORs (95 % CIs) of the association between depressive symptoms and health checkup participation were 0.87 (0.79–0.96) for mild and 0.76 (0.65–0.87) for moderate-to-severe depressive symptoms, compared with those for non-depressive symptoms.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that depressive symptoms are associated with the underuse of preventive healthcare services. This study underscores the need for targeted policy interventions to increase preventive healthcare utilization among individuals with depressive symptoms.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"91 ","pages":"Pages 180-185"},"PeriodicalIF":4.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.genhosppsych.2024.08.004
Kevin G. Saulnier , Julia Browne , Stephanie Merrill , Anna L. Philibert , Peter P. Grau , Benjamin R. Szymanski , Nicholas W. Bowersox
{"title":"Rapid transition to virtual care during the COVID-19 pandemic for VHA patients with serious mental illness","authors":"Kevin G. Saulnier , Julia Browne , Stephanie Merrill , Anna L. Philibert , Peter P. Grau , Benjamin R. Szymanski , Nicholas W. Bowersox","doi":"10.1016/j.genhosppsych.2024.08.004","DOIUrl":"10.1016/j.genhosppsych.2024.08.004","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"91 ","pages":"Pages 240-242"},"PeriodicalIF":4.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.genhosppsych.2024.09.010
Gerald Scott Winder , Victoria Gill , Shivali Patel , Haila Asefa , Jessica L. Mellinger
{"title":"Expert and patient cognitive interviews in the development of a novel alcohol insight scale for use in hepatology and liver transplantation","authors":"Gerald Scott Winder , Victoria Gill , Shivali Patel , Haila Asefa , Jessica L. Mellinger","doi":"10.1016/j.genhosppsych.2024.09.010","DOIUrl":"10.1016/j.genhosppsych.2024.09.010","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"91 ","pages":"Pages 256-258"},"PeriodicalIF":4.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.genhosppsych.2024.10.016
Fangbo Lin , Yanyao Deng , Jie Li , Chao Liu , Le Xiao
Background
The relationship between dietary antioxidant intake and depression remains controversial. This study aimed to explore the intermediary role of oxidative stress and inflammatory markers in linking dietary antioxidant intake to depression among middle-aged and older adults.
Methods
This is a cross-sectional study from the 2003–2014 National Health and Nutrition Examination Survey (NHANES), depressive symptoms were identified using a score of 10 or above on the Patient Health Questionnaire-9 (PHQ-9). Dietary antioxidant intake was measured via the Composite Dietary Antioxidant Index (CDAI). We utilized multivariable logistic regression to assess the link between CDAI and depression risk, followed by mediation analysis to explore the potential mediating effects of oxidative stress and inflammatory markers.
Results
In the multivariate analysis, a robust inverse relationship was noted between the Composite Dietary Antioxidant Index (CDAI) and depression risk, with participants in the upper CDAI tertile demonstrating a 36 % reduced risk compared to those in the lower tertile (OR: 0.64, 95 % CI: 0.53–0.79; P < 0.001). The relationship was nearly linear, as indicated by restricted cubic splines. Furthermore, higher CDAI scores were linked to lower depression scores (β = −0.03, 95 % CI: −0.05 to −0.01; P < 0.001). Mediation analysis indicated that GGT, albumin, and the systemic immune-inflammation index (SII) accounted for 4.6 %, 6.3 %, and 6.1 % of the CDAI-depression association, respectively, with a total mediated effect of 11.4 % (all P < 0.001).
Conclusion
The CDAI exhibits a significant negative association with depression, potentially mediated by oxidative stress and inflammation among middle-aged and older adults.
{"title":"Oxidative stress and inflammatory factors mediate the association between dietary antioxidant intake and depressive symptoms in middle and old-aged individuals: A cross-sectional study from NHANES","authors":"Fangbo Lin , Yanyao Deng , Jie Li , Chao Liu , Le Xiao","doi":"10.1016/j.genhosppsych.2024.10.016","DOIUrl":"10.1016/j.genhosppsych.2024.10.016","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between dietary antioxidant intake and depression remains controversial. This study aimed to explore the intermediary role of oxidative stress and inflammatory markers in linking dietary antioxidant intake to depression among middle-aged and older adults.</div></div><div><h3>Methods</h3><div>This is a cross-sectional study from the 2003–2014 National Health and Nutrition Examination Survey (NHANES), depressive symptoms were identified using a score of 10 or above on the Patient Health Questionnaire-9 (PHQ-9). Dietary antioxidant intake was measured via the Composite Dietary Antioxidant Index (CDAI). We utilized multivariable logistic regression to assess the link between CDAI and depression risk, followed by mediation analysis to explore the potential mediating effects of oxidative stress and inflammatory markers.</div></div><div><h3>Results</h3><div>In the multivariate analysis, a robust inverse relationship was noted between the Composite Dietary Antioxidant Index (CDAI) and depression risk, with participants in the upper CDAI tertile demonstrating a 36 % reduced risk compared to those in the lower tertile (OR: 0.64, 95 % CI: 0.53–0.79; <em>P</em> < 0.001). The relationship was nearly linear, as indicated by restricted cubic splines. Furthermore, higher CDAI scores were linked to lower depression scores (β = −0.03, 95 % CI: −0.05 to −0.01; <em>P</em> < 0.001). Mediation analysis indicated that GGT, albumin, and the systemic immune-inflammation index (SII) accounted for 4.6 %, 6.3 %, and 6.1 % of the CDAI-depression association, respectively, with a total mediated effect of 11.4 % (all <em>P</em> < 0.001).</div></div><div><h3>Conclusion</h3><div>The CDAI exhibits a significant negative association with depression, potentially mediated by oxidative stress and inflammation among middle-aged and older adults.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"91 ","pages":"Pages 160-166"},"PeriodicalIF":4.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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