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Utilizing Proximity for Increasing Student Knowledge Retention: A Near-Peer Tutoring Program Needs Study 利用邻近性提高学生知识保留率:一个需要研究的近同伴辅导项目
IF 0.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-09-01 DOI: 10.21802/gmj.2022.3.2
Johnathon S. Lueck, Thomas Varkey, Daniel Ramirez
The purpose of this study was to demonstrate the desire and need for peer-to-peer tutoring programs at Division 1 Dell Medical School at the University of Texas. Materials and Methods. Two sets of surveys were created and sent to students at the Dell Medical School, University of Texas, USA. One survey asking about the need or desire to engage with a peer tutor was sent to first-year students, and another one asking about the desire to provide these services to underclassmen as a potential leadership course option was sent to third-year students. Results. For the first-year student survey, 52.9% of respondents disagreed or strongly disagreed of being aware of near-peer tutoring and 70.5% of respondents either agreed or strongly agreed that it would be an option utilized by students. For the third-year student survey, 75% of students either disagreed or felt neutral in being aware of near-peer tutoring as an option to serve underclassmen, whereas 65% of upperclassmen either agreed or strongly agreed that if near-peer tutoring had been offered, they would have chosen this leadership course option in the effort to teach their underclassmen peers. Conclusions. Numerous studies have demonstrated peer-to-peer tutorial options to be of high utility to students in the medical education space. This particular paper obtained results demonstrating students’ desire to engage in peer tutoring voluntarily for their own course success goals and upperclassmen’s desire to participate as near-peer tutors for the benefit of underclassmen.
这项研究的目的是证明德克萨斯大学戴尔医学院第一分院对对等辅导项目的渴望和需求。材料和方法。创建了两组调查,并发送给了美国得克萨斯大学戴尔医学院的学生。一组调查询问了与同伴导师合作的必要性或愿望,另一组调查则询问了作为潜在领导力课程选项向三年级学生提供这些服务的愿望。后果在一年级学生调查中,52.9%的受访者不同意或强烈不同意意识到近同伴辅导,70.5%的受访者同意或强烈同意这将是学生使用的一种选择。在第三年的学生调查中,75%的学生不同意或感觉中立,认为近同伴辅导是为低年级学生服务的一种选择,而65%的高年级学生同意或强烈同意,如果提供近同伴辅导,他们会选择这一领导力课程来教低年级学生。结论。大量研究表明,在医学教育领域,对等辅导选项对学生具有很高的实用性。这篇特别的论文获得的结果表明,学生们为了自己的课程成功目标而自愿参与同伴辅导的愿望,以及高年级学生为了低年级学生的利益而作为近同伴导师参与的愿望。
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引用次数: 0
Antibacterial Polyacrylamide and Dextran-Graft-Polyacrylamide Hydrogels for the Treatment of Open Wounds 抗菌聚丙烯酰胺和右旋糖酐接枝聚丙烯酰胺水凝胶治疗开放性伤口
IF 0.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-09-01 DOI: 10.21802/gmj.2022.3.5
P. Virych, O. Nadtoka, N. Kutsevol, B. Krysa, V. Krysa
Background. Open wound treatment requires a use of bandage material to prevent the development of pathogenic microflora and to provide the necessary conditions for tissue regeneration. The aim of the study was to compare the effectiveness of polyacrylamide (PAA) and dextran-graft-polyacrylamide (D-PAA) hydrogels loaded with silver nanoparticles (AgNPs), antibiotics, and photosensitizers for the treatment of bacterial infection of open wounds. Materials and Methods. PAA and D-PAA hydrogels with AgNPs, methylene blue (0.001%) without (MB) and with red light irradiation (660 nm) (MB+L), chlorhexidine (0.05%) and cefuroxime (0.1%) were used. There were tested in vitro and in vivo (a rat model) antibacterial activities against wild-type Staphylococcus aureus, Escherichia coli, antibiotic-resistant Escherichia coli and Klebsiella pneumoniae strains obtained from the wound. Clinical investigations were performed in patients with chronic venous ulcers of the lower extremities with no response to traditional treatments. Results. S. aureus, E. coli, and K. pneumoniae strains were sensitive to PAA and D-PAA hydrogels with AgNPs, chlorhexidine, and cefuroxime. Antibiotic-resistant E. coli was not inhibited by the hydrogels with cefuroxime. This strain was less sensitive to chlorhexidine and MB+L. There were no differences between unloaded PAA and D-PAA hydrogels; the antibacterial properties of the dressing were determined by an antibacterial component loaded into the hydrogel. The use of unloaded D-PAA hydrogels in vivo helped reduce the size of the wound by 28.6% and 42.8% three and five days after wound modeling, respectively. Similar results were obtained for D-PAA hydrogels loaded with cefuroxime, chlorhexidine, and MB+L. D-PAA hydrogel with AgNPs reduced wound size by 50% and 62.5% three and five days after wound induction, respectively, demonstrated greater antibacterial activity and was selected for clinical investigations. In a patient, 14 days after bandage application, the fibrin membrane disappeared, the ulcers were covered with pink granulations, marginal epithelialization appeared. Conclusions. PAA and D-PAA hydrogels can be loaded with the antibacterial compounds of various types. The type of polymer does not affect the antibacterial properties of the final hydrogels. The hydrogels with chlorhexidine and MB+L can be potentially used to treat bacterial contamination of wounds and ulcers. Nevertheless, their disadvantage is the inability to absorb or precipitate tissue breakdown products that interfere with normal regeneration and inflammation. D-PAA/AgNPs are the best option for treating ulcers due to the ability to control the properties of the hydrogels and nanoparticles, as well as multiple mechanisms of antibacterial action.
背景。开放性伤口治疗需要使用绷带材料,以防止致病性微生物群的发展,并为组织再生提供必要的条件。本研究的目的是比较聚丙烯酰胺(PAA)和葡聚糖-接枝聚丙烯酰胺(D-PAA)水凝胶载银纳米颗粒(AgNPs)、抗生素和光敏剂治疗开放性伤口细菌感染的效果。材料与方法。采用含AgNPs的PAA和D-PAA水凝胶,不含(MB)的亚甲基蓝(0.001%),红光照射(660 nm) (MB+L),氯己定(0.05%)和头孢呋辛(0.1%)。体外和体内(大鼠模型)对创面获得的野生型金黄色葡萄球菌、大肠杆菌、耐药大肠杆菌和肺炎克雷伯菌进行抑菌活性测试。对传统治疗无效的下肢慢性静脉溃疡患者进行临床调查。结果。金黄色葡萄球菌、大肠杆菌和肺炎克雷伯菌对含AgNPs、氯己定和头孢呋辛的PAA和D-PAA水凝胶敏感。头孢呋辛水凝胶对耐药大肠杆菌无抑制作用。该菌株对氯己定和MB+L不敏感。空载PAA和D-PAA水凝胶之间没有差异;敷料的抗菌性能是通过在水凝胶中加入抗菌成分来确定的。在体内使用无负载的D-PAA水凝胶,创面建模后3天和5天,创面大小分别减少28.6%和42.8%。对于负载头孢呋辛、氯己定和MB+L的D-PAA水凝胶,也得到了类似的结果。含有AgNPs的D-PAA水凝胶在伤口诱导后3天和5天分别减少了50%和62.5%的伤口大小,表现出更强的抗菌活性,并被选中用于临床研究。1例患者使用绷带14天后,纤维蛋白膜消失,溃疡被粉红色肉芽覆盖,出现边缘上皮化。结论。PAA和D-PAA水凝胶可以装载各种类型的抗菌化合物。聚合物的类型不影响最终水凝胶的抗菌性能。含有氯己定和MB+L的水凝胶可以潜在地用于治疗伤口和溃疡的细菌污染。然而,它们的缺点是不能吸收或沉淀组织分解产物,干扰正常的再生和炎症。由于能够控制水凝胶和纳米颗粒的特性,以及多种抗菌作用机制,D-PAA/AgNPs是治疗溃疡的最佳选择。
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引用次数: 0
Hyperostosis Frontalis Interna and Temporalis Interna: A Rare Case Report 额内、颞内肌肥厚1例报告
IF 0.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-09-01 DOI: 10.21802/gmj.2022.3.8
M. V. Ravishankar, V. Srikantaiah, N. Pushpa, Sapna Patel
Hyperostosis is a slow-growing benign bone tumour often seen in the bones of the cranial vault, more commonly found in elderly females. It is an incidental finding noted during radiological examination. The clinical manifestation of such tumour depends on its location inside the cranial cavity: the proximity to the paranasal sinuses, brain tissue, nerves, or blood vessels, etc. Its clinical findings may range from mild obstruction of the paranasal sinuses or blood vessels to severe compression of the surrounding cranial nerves. Here a rare case of hyperostosis of the frontal and temporal bones found during a routine cadaveric dissection in the Department of Anatomy is presented. Causes of the formation of such unusually enlarged bone masses inside the cranial cavity and their clinical presentation are discussed.
骨质增生是一种生长缓慢的良性骨肿瘤,常见于颅顶骨,多见于老年女性。这是放射学检查时偶然发现的。这种肿瘤的临床表现取决于其在颅腔内的位置:靠近鼻窦、脑组织、神经或血管等。其临床表现可从鼻窦或血管的轻度阻塞到周围脑神经的严重压迫。这里是一个罕见的病例,额骨和颞骨肥大发现在常规尸体解剖在解剖部门提出。本文讨论了颅腔内异常增大的骨团形成的原因及其临床表现。
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引用次数: 0
Awareness of and Attitudes Towards Domestic Violence in Turkish Society 土耳其社会对家庭暴力的认识和态度
IF 0.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-09-01 DOI: 10.21802/gmj.2022.3.4
Havva Gezgİn Yazici, Makbule Batmaz, Cigdem Okten
The objective of this study was to identify domestic violence awareness and attitudes towards violence among adult individuals in Turkish society. Materials and Methods. This descriptive and cross-sectional study was conducted online between September 15, 2021 and November 15, 2021 and included 353 individuals. The data were collected using the snowball sampling method, the Google Forms, the Socio-Demographic Descriptive Information Form, the Domestic Violence Awareness Scale, and the Attitudes Towards Domestic Violence (ADV) Scale. For data analysis, the number, percentage, mean, standard deviation, Student’s t-test, one-way analysis of variance (ANOVA), post hoc (Tukey, LSD) analyses, Cohen’s d and Eta squared (η 2) coefficients, and correlation analysis were used. Results. Most research participants were females (79.0%), with the average age of 30.53 ± 13.11 years. Of all the participants, 56.9% stated that they witnessed domestic violence, 22.7% stated that they experienced violence against women, 8.2% stated that they used violence. While the mean Domestic Violence Awareness Scale score was calculated as 41.09 ± 3.98, the mean score of the ADV Scale was calculated as 20.18 ± 7.82. The scores of domestic violence awareness differed significantly depending on education level (p=0.042; η 2=0.018). The scores of women’s attitude towards domestic violence (19.10) were lower than those in men (24.26) (p=0.05; d=0.684; η2=0.072). Participants’ attitudes towards domestic violence varied significantly by family type (p=0.006; η2=0.029), education level (p=0.007; η2=0.028), and occupation (p=0.007; η2=0.040). There was a significant positive relationship between awareness of and attitudes towards domestic violence (r=0.226). Conclusions. Study participants had a high sense of awareness towards domestic violence and a negative attitude towards violence. Their awareness of domestic violence was affected by education level, while their attitudes towards domestic violence was affected by gender, type of family, education level, and occupation.  
本研究的目的是确定土耳其社会成年个体对家庭暴力的认识和态度。材料和方法。这项描述性和横断面研究于2021年9月15日至2021年11月15日在网上进行,共有353人参与。数据采用滚雪球抽样法、谷歌表格、社会人口描述信息表、家庭暴力意识量表和对家庭暴力的态度量表收集。在数据分析中,使用了数字、百分比、平均值、标准差、Student t检验、单因素方差分析(ANOVA)、事后分析(Tukey,LSD)、Cohen’s d和Eta平方(η2)系数以及相关分析。后果大多数研究参与者是女性(79.0%),平均年龄为30.53±13.11岁。在所有参与者中,56.9%的人表示目睹了家庭暴力,22.7%的人表示经历过对妇女的暴力,8.2%的人表示使用过暴力。家庭暴力意识量表的平均得分为41.09±3.98,ADV量表的得分为20.18±7.82。家庭暴力意识得分随教育水平的不同而有显著差异(p=0.042;η2=0.018)。女性对家庭暴力的态度得分(19.10)低于男性(24.26)(p=0.05;d=0.684;η2=0.072)。参与者对家庭暴力态度因家庭类型(p=0.006;η2=0.029)、教育水平(p=0.007;η2=0.02 8),和职业(p=0.007;η2=0.040)。对家庭暴力的认识和态度之间存在显著的正相关关系(r=0.226)。结论。研究参与者对家庭暴力有高度的认识,对暴力持消极态度。他们对家庭暴力的认识受到教育水平的影响,而他们对家庭虐待的态度受到性别、家庭类型、教育水平和职业的影响。
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引用次数: 0
A Different Approach to Breast Self-Examination Training: Family Training 乳腺自检训练的另一种方法:家庭训练
IF 0.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-09-01 DOI: 10.21802/gmj.2022.3.6
Gulsun Ayran, G. Gundogdu, Ece Yaman, Sema Kutluata
Background. Breast self-examination (BSE) is an effective, cost-free, early diagnosis method that enables women to take responsibility for their own health in the early diagnosis of breast cancer, which is the most common cause of death in women. The objective of the study was to determine the effect of BSE training given by female nursing students to their mothers and sisters on their BSE behavior and self-esteem. Materials and Methods. This study is of one-group pretest-posttest quasi-experimental design. It was carried out at the Faculty of Health Sciences of Erzincan University in Turkey between December 2019 and May 2020. The universe of the study consisted of 140 third- and fourth-year female students over the age of 18 enrolled in the Department of Nursing, Faculty of Health Sciences, Erzincan University, Turkey. The total number of mothers and sisters in the study sample was 126. The data were collected in two stages, before and one month after family training. IBM SPSS Statistics 22 software package was used for statistical data analysis. The percentage, mean, standard deviation, and Student’s t-test were used for statistical processing. The p-value of 0.05 was considered statistically significant for all tests. Results. The knowledge level of study participants about breast cancer and BSE was analyzed, and the source of their knowledge was assessed. Applying family training approach showed a significant increase in BSE knowledge level of participants one month after training. It was accompanied by increasing BSE skills and self-esteem levels (according to the mean values of the Rosenberg Self-Esteem Scale). Conclusions. Training for family members is an effective method to increase women' s knowledge and skills in BSE. In addition, BSE training enabled female students and their families to participate in BSE practice.
背景乳腺自查(BSE)是一种有效、无成本的早期诊断方法,使女性能够在乳腺癌症的早期诊断中对自己的健康负责,乳腺癌是女性最常见的死亡原因。本研究的目的是确定女护理学生对其母亲和姐妹进行疯牛病培训对其疯牛病行为和自尊的影响。材料和方法。本研究为一组前测后测准实验设计。这项研究于2019年12月至2020年5月在土耳其埃尔津坎大学健康科学学院进行。这项研究的范围包括140名18岁以上的三年级和四年级女生,她们就读于土耳其埃尔津坎大学健康科学学院护理系。研究样本中的母亲和姐妹总数为126人。数据分两个阶段收集,分别是家庭培训前和家庭培训后一个月。使用IBM SPSS Statistics 22软件包进行统计数据分析。百分比、平均值、标准差和Student t检验用于统计处理。0.05的p值被认为对所有测试具有统计学意义。后果分析研究参与者对癌症和疯牛病的知识水平,并评估他们的知识来源。应用家庭培训方法显示,培训一个月后,参与者的疯牛病知识水平显著提高。伴随着BSE技能和自尊水平的提高(根据Rosenberg自尊量表的平均值)。结论。对家庭成员进行培训是提高妇女疯牛病知识和技能的有效方法。此外,疯牛病培训使女学生及其家人能够参与疯牛病实践。
{"title":"A Different Approach to Breast Self-Examination Training: Family Training","authors":"Gulsun Ayran, G. Gundogdu, Ece Yaman, Sema Kutluata","doi":"10.21802/gmj.2022.3.6","DOIUrl":"https://doi.org/10.21802/gmj.2022.3.6","url":null,"abstract":"Background. Breast self-examination (BSE) is an effective, cost-free, early diagnosis method that enables women to take responsibility for their own health in the early diagnosis of breast cancer, which is the most common cause of death in women. \u0000The objective of the study was to determine the effect of BSE training given by female nursing students to their mothers and sisters on their BSE behavior and self-esteem. \u0000Materials and Methods. This study is of one-group pretest-posttest quasi-experimental design. It was carried out at the Faculty of Health Sciences of Erzincan University in Turkey between December 2019 and May 2020. The universe of the study consisted of 140 third- and fourth-year female students over the age of 18 enrolled in the Department of Nursing, Faculty of Health Sciences, Erzincan University, Turkey. The total number of mothers and sisters in the study sample was 126. The data were collected in two stages, before and one month after family training. IBM SPSS Statistics 22 software package was used for statistical data analysis. The percentage, mean, standard deviation, and Student’s t-test were used for statistical processing. The p-value of 0.05 was considered statistically significant for all tests. \u0000Results. The knowledge level of study participants about breast cancer and BSE was analyzed, and the source of their knowledge was assessed. Applying family training approach showed a significant increase in BSE knowledge level of participants one month after training. It was accompanied by increasing BSE skills and self-esteem levels (according to the mean values of the Rosenberg Self-Esteem Scale). \u0000Conclusions. Training for family members is an effective method to increase women' s knowledge and skills in BSE. In addition, BSE training enabled female students and their families to participate in BSE practice.","PeriodicalId":12537,"journal":{"name":"Galician Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48488043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perceived Stress and Quality of Life in Healthcare Workers of Non-COVID-19-Designated Hospitals During the COVID-19 Pandemic in Ukraine 乌克兰新冠肺炎大流行期间非COVID-19-指定医院医护人员的压力和生活质量
IF 0.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-09-01 DOI: 10.21802/gmj.2022.3.3
Oksana Mats, Zoriana Karpik, D. Boiko, Vadym Rud, L. Zhyvotovska
Introduction. Healthcare workers are more vulnerable to negative influences of the Covid-19 pandemic than cross-border travelers as they experience greater occupational stress, exacerbated by the possibility of self-contamination or contamination of their relatives through direct contact with patients, reduced social communication, deterioration in self-care and quality of life due to lack of energy and time. The aim of the study was to assess the level of stress and quality of life in healthcare workers of non-COVID-19-designated hospitals in Ukraine during the COVID-19 pandemic. Materials and Methods. There was carried out a case-control study that included 150 respondents divided into three groups: experimental groups (EG) 1 and 2 comprised 50 physicians and 50 nurses of non-COVID-19-designated hospitals, respectively; the control group (CG) included 50 healthy individuals not working in the healthcare field. The data were collected using paper questionnaires involving sociodemographic questions, the Perceived Stress Scale, and the 36-Item Short Form Health Survey. Results. EG 1 and EG 2 had significantly increased stress levels as compared to the CG. Physical functioning criterion in EG 2 was significantly lower than those in EG 1 and the CG. Vitality and social functioning indicators were significantly lower in EG 1 and EG 2 as compared to the CG. Quality of mental health was worse in EG 1 than in the CG. Conclusions. During the COVID-19 pandemic, healthcare workers of non-COVID-19-designated hospitals experienced a significant reorganization of their work environment, which required them to adjust rapidly to new conditions and psychological difficulties. The medical staff was found to have an increased level of perceived stress and decreased quality of life, which could affect the quality of medical care. Our findings suggest that the COVID-19 pandemic necessitates the development and implementation of stress coping measures to improve mental and physical health of healthcare workers, which can be used to achieve proper work and rest routines, create a microclimate within the team, and restore the work-life balance.
介绍。与跨境旅行者相比,卫生保健工作者更容易受到新冠肺炎大流行的负面影响,因为他们面临更大的职业压力,而且由于与患者直接接触可能导致自我污染或亲属污染,社会沟通减少,缺乏精力和时间导致自我保健和生活质量下降,从而加剧了压力。该研究的目的是评估2019冠状病毒病大流行期间乌克兰非COVID-19指定医院医护人员的压力水平和生活质量。材料与方法。开展病例对照研究,150名被调查者分为三组:实验组(EG) 1和2分别由非冠状病毒定点医院的50名医生和50名护士组成;对照组(CG)包括50名不在医疗保健领域工作的健康个体。数据是通过包括社会人口学问题、感知压力量表和36项简短健康调查在内的纸质问卷收集的。结果。与CG相比,EG 1和EG 2的应激水平显著升高。EG 2的生理功能指标明显低于EG 1和CG。EG 1和EG 2的活力和社会功能指标明显低于CG。EG 1组的心理健康质量较CG组差。结论。新冠肺炎疫情期间,非疫情定点医院医护人员的工作环境经历了重大重组,需要他们迅速适应新的条件和心理困难。研究发现,医务人员感受到的压力增加,生活质量下降,这可能影响医疗服务的质量。我们的研究结果表明,新冠肺炎疫情需要制定和实施压力应对措施,以改善医护人员的身心健康,从而实现合理的作息习惯,营造团队内的小气候,恢复工作与生活的平衡。
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引用次数: 2
The Effect of Preoperative Anxiety on Postoperative Symptoms in Patients Without a History of Anxiety Scheduled for Coronary Artery Bypass Grafting 无冠状动脉搭桥术焦虑史患者术前焦虑对术后症状的影响
IF 0.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-09-01 DOI: 10.21802/gmj.2022.3.7
Nurten Arslan Isik, I. Emir
The aim of this study was to measure the level of preoperative anxiety in patients scheduled for coronary artery bypass grafting (CABG) to assess the relationship between anxiety and postoperative symptoms. Materials and Methods. This descriptive study was conducted at a single university hospital from February to November 2021. Seventy-four CABG patients who completed the Anxiety Specific to Surgery Questionnaire, the Visual Analogue Scale, the Modified Borg Scale, the Rhodes Index of Nausea, Vomiting and Retching were included in the study. The data were analyzed by the mean, standard deviation, frequency distribution, Mann-Whitney U Test, and Spearman’s correlation analysis. Results. The average age of participants was 65.55 ± 8.35; 66.2% of them were males. The ASSQ total scores of female participants were significantly higher as compared to male participants (p < 0.05). There was a statistically significant positive relationship between the levels of anxiety in patients before CABG and the levels of postoperative pain and dyspnea severity (p < 0.05). Conclusions. Patients were found to experience predominantly moderate to severe anxiety before CABG, and increased dyspnea complaints and pain in the postoperative period. A coordinated, multidisciplinary approach to preoperative training of healthcare professionals may offer a promising way to provide more efficient and productive services.
本研究的目的是测量冠状动脉旁路移植术(CABG)患者的术前焦虑水平,以评估焦虑与术后症状的关系。材料与方法。本描述性研究于2021年2月至11月在一家大学医院进行。74例CABG患者完成了手术特异性焦虑问卷、视觉模拟量表、改良Borg量表、恶心、呕吐和干呕的Rhodes指数。采用均值、标准差、频率分布、Mann-Whitney U检验和Spearman相关分析对数据进行分析。结果。参与者平均年龄65.55±8.35岁;66.2%为男性。女性受试者的ASSQ总分显著高于男性受试者(p < 0.05)。CABG术前患者焦虑水平与术后疼痛、呼吸困难严重程度呈显著正相关(p < 0.05)。结论。发现患者在冠脉搭桥前主要经历中度至重度焦虑,术后呼吸困难主诉和疼痛增加。一个协调的,多学科的方法来术前培训的卫生保健专业人员可能提供一个有希望的方式,以提供更有效和更有成效的服务。
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引用次数: 2
Immunohistochemical Expression of IMP3 in Cutaneous Basal Cell Carcinoma 皮肤基底细胞癌中IMP3的免疫组织化学表达
IF 0.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-09-01 DOI: 10.21802/gmj.2022.3.1
V. Bartoš
Background. Insulin-like growth factor-II mRNA-binding protein 3 (IMP3) is an oncofetal protein upregulated in tumor cells during carcinogenesis. It has been linked to adverse clinical outcome in many malignancies. This study was aimed to evaluate an immunohistochemical expression status of IMP3 in cutaneous basal cell carcinoma (BCC) and to correlate it with the Ki-67 index values. Methods. Biopsy specimens from 32 cases of BCC were enrolled into this analysis. All samples were immunohistochemically stained for IMP3 (Clone 69.1) and Ki-67 antigen (Clone MIB-1). Results. IMP3 showed a weak expression in 11 (34.4%) cases, a moderate expression in 11 (34.4%) cases, a strong expression in 5 (15.6%) cases, and negative staining in 5 (15.6%) cases. Among seven BCCs exhibiting aggressive-growth features, all but one showed weak reactivity. In contrast, all five BCCs manifesting strong IMP3 positivity consisted of the indolent-growth histologic subtypes. BCCs with infiltrative histomorphology did not appear to have a tendency towards more striking production of IMP3. There was no significant relationship between the IMP3 expression status and the proliferation status (Ki-67 ≤ 50% vs. Ki-67 > 50%) of the tumor tissue (p > 0.05). Conclusions. The vast majority of cutaneous BCCs express IMP3, suggesting this oncoprotein is implicated in BCC carcinogenesis. However, more pronounced expression does not seem to be associated with aggressive-growth phenotype of BCC or higher proliferative activity of neoplastic cells.
背景胰岛素样生长因子II mRNA结合蛋白3(IMP3)是一种在肿瘤细胞癌变过程中上调的癌胚蛋白。它与许多恶性肿瘤的不良临床结果有关。本研究旨在评估IMP3在皮肤基底细胞癌(BCC)中的免疫组织化学表达状态,并将其与Ki-67指标值相关联。方法。本分析纳入了32例基底细胞癌的活检标本。对所有样品进行IMP3(克隆69.1)和Ki-67抗原(克隆MIB-1)的免疫组化染色。后果IMP3弱表达11例(34.4%),中度表达11例,强表达5例(15.6%),阴性染色5例(15.2%)。在表现出侵袭性生长特征的7个BCC中,除1个外,其余均表现出弱反应性。相反,所有五个表现出强IMP3阳性的基底细胞癌均由惰性生长组织学亚型组成。具有浸润性组织形态学的基底细胞癌似乎没有产生更显著IMP3的趋势。IMP3的表达状态与肿瘤组织的增殖状态(Ki-67≤50%,Ki-67>50%)无显著关系(p>0.05)。绝大多数皮肤基底细胞癌表达IMP3,这表明这种癌蛋白与基底细胞癌的致癌作用有关。然而,更显著的表达似乎与BCC的侵袭性生长表型或肿瘤细胞的更高增殖活性无关。
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引用次数: 0
Artificial Intelligence Approach in Prostate Cancer Diagnosis: Bibliometric Analysis 人工智能在前列腺癌症诊断中的应用:文献计量分析
IF 0.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-06-01 DOI: 10.21802/gmj.2022.2.5
A. Denysenko, T. Savchenko, A. Dovbysh, A. Romaniuk, R. Moskalenko
Background. Prostate cancer is one of the most common male malignancies worldwide that ranks second in cancer-related mortality. Artificial intelligence can reduce subjectivity and improve the efficiency of prostate cancer diagnosis using fewer resources as compared to standard diagnostic scheme. This review aims to highlight the main concepts of prostate cancer diagnosis and artificial intelligence application and to determine achievements, current trends, and potential research directions in this field, using bibliometric analysis. Materials and Methods.The studies on the application of artificial intelligence in the morphological diagnosis of prostate cancer for the past 35 years were searched for in the Scopus database using “artificial intelligence” and “prostate cancer” keywords. The selected studies were systematized using Scopus bibliometric tools and the VOSviewer software. Results. The number of publications in this research field has drastically increased since 2016, with most research carried out in the United States, Canada, and the United Kingdom. They can be divided into three thematic clusters and three qualitative stages in the development of this research field in timeline aspect. Conclusions. Artificial intelligence algorithms are now being actively developed, playing a huge role in the diagnosis of prostate cancer. Further development and improvement of artificial intelligence algorithms have the potential to automate and standardize the diagnosis of prostate cancer.
背景。前列腺癌是世界上最常见的男性恶性肿瘤之一,在癌症相关死亡率中排名第二。与标准诊断方案相比,人工智能可以减少主观性,使用更少的资源提高前列腺癌诊断效率。本文综述了前列腺癌诊断和人工智能应用的主要概念,并运用文献计量学分析方法对人工智能在该领域的研究成果、发展趋势和潜在的研究方向进行了总结。材料与方法。在Scopus数据库中以“人工智能”和“前列腺癌”为关键词检索近35年来人工智能在前列腺癌形态学诊断中的应用研究。使用Scopus文献计量工具和VOSviewer软件对所选研究进行系统化。结果。自2016年以来,这一研究领域的出版物数量急剧增加,其中大多数研究在美国、加拿大和英国进行。从时间上看,这一研究领域的发展可分为三个主题群和三个定性阶段。结论。人工智能算法目前正在积极发展,在前列腺癌的诊断中发挥着巨大的作用。人工智能算法的进一步发展和改进有可能使前列腺癌的诊断自动化和标准化。
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引用次数: 0
Validity and Reliability of the Turkish Version of the COVID-19-Impact on Quality of Life Scale 土耳其版COVID-19对生活质量影响量表的有效性和可靠性
IF 0.1 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-06-01 DOI: 10.21802/gmj.2022.2.4
Çiğdem Ökten, Havva Gezgİn Yazici
The objective of this study was to adapt the COVID-19-Impact on Quality of Life (COV19-QoL) scale for Turkish individuals and to determine its validity and reliability. Materials and Methods. This methodological study was conducted between December 25, 2020 and January 10, 2021. The research was conducted online and included 485 participants who completed a socio-demographic questionnaire, the COV19-QoL scale and the Duke Health Profile (DUKE) on Google Forms. Back translation was used for the Turkish version of the COV19-QoL scale. Language and content validity of the scale were found to be acceptable. Results. Ten experts were consulted regarding content validity of the scale. The results, item content validity of 0.95 and scale content validity of 0.95, indicated excellent content validity. Explanatory factor analysis found one principal structure with a total variance of 59.449%. The Cronbach’s alpha internal consistency coefficient was 0.86 for the scale. A statistically significant moderate negative correlation was found between the participants’ COV19-QoL scale score and their general health score on the DUKE (r = − 0.384; p < 0.01). Conclusions. This study found that the Turkish version of the COV19-QoL scale is a valid and reliable instrument for assessing the effects of the COVID-19 pandemic on the Turkish population’s quality of life.
本研究的目的是将COV19-QoL量表应用于土耳其个体,并确定其有效性和可靠性。材料和方法。该方法研究于2020年12月25日至2021年1月10日期间进行。这项研究是在网上进行的,包括485名参与者,他们在谷歌表格上完成了社会人口学问卷、COV19生活质量量表和杜克大学健康档案(Duke)。COV19 QoL量表的土耳其语版本使用了反向翻译。量表的语言和内容有效性是可以接受的。后果就量表的内容有效性咨询了十位专家。项目内容有效性0.95,量表内容有效性0.95,表明内容有效性良好。解释因子分析发现一个主结构的总方差为59.449%。该量表的Cronbachα内部一致性系数为0.86。参与者的COV19生活质量量表评分与他们在DUKE上的总体健康评分之间存在统计学上显著的中度负相关(r=-0.384;p<0.01)。结论。这项研究发现,土耳其版的COV19-QoL量表是评估新冠肺炎大流行对土耳其人口生活质量影响的有效和可靠的工具。
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引用次数: 0
期刊
Galician Medical Journal
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