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Endoscopic devices and techniques for the management of gastric varices (with videos) 治疗胃静脉曲张的内窥镜设备和技术(附视频)。
IF 6.7 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/j.gie.2024.06.038
ASGE Technology Committee, Guru Trikudanathan MD, FASGE , Erik F. Rahimi MD, FASGE , Amit Bhatt MD , Juan Carlos Bucobo MD, FASGE , Vinay Chandrasekhara MD, FASGE , Andrew P. Copland MD , Samuel Han MD, MS , Allon Kahn MD , Kumar Krishnan MD, FASGE , Nikhil A. Kumta MD, MS , David R. Lichtenstein MD, FASGE , Jorge V. Obando MD , Rahul Pannala MD, MPH, FASGE , Mansour A. Parsi MD, MPH, MBA, FASGE , Monica Saumoy MD, MS , Arvind J. Trindade MD, FASGE , Julie Yang MD, FASGE , Ryan J. Law DO , ASGE Technology Committee Chair

Background and Aims

Gastric variceal bleeding occurs less commonly than bleeding from esophageal varices (EVs), although it is associated with higher morbidity and mortality. Bleeding from gastroesophageal varices type 1 (GOV1) is treated like EVs. In contrast, other forms of gastric variceal bleeding, including gastroesophageal varices type 2 (GOV2) and isolated gastric varices types 1 (IGV1) and 2 (IGV2), are treated with varying endoscopic approaches. Nonendoscopic methods include transjugular intrahepatic portosystemic shunt (TIPS) or balloon-occluded retrograde transvenous obliteration (BRTO). This technology report focuses on endoscopic management of gastric varices (GVs).

Methods

The MEDLINE database was searched through August 2022 for relevant articles by using key words such as gastric varices, glue, cyanoacrylate, thrombin, sclerosing agents, band ligation, topical hemostatic spray, coils, EUS, TIPS, and BRTO. The article was drafted, reviewed, and edited by the American Society for Gastrointestinal Endoscopy (ASGE) Technology Committee and approved by the Governing Board of the ASGE.

Results

Endoscopic injection with cyanoacrylate (CYA) glue has been the primary endoscopic method to treat GVs. EUS-guided angiotherapy with CYA glue and coil embolization has emerged as an alternative method enabling improved detection of GVs with a high technical success for targeting and obliterating GVs. Combining CYA glue with coil therapy allows the coil to act as a scaffold for the glue, reducing the risk of glue embolization and improving outcomes. Alternative injectates or topical treatments have been described but remain poorly studied.

Conclusions

The mainstay paradigm for the endoscopic management of gastric variceal bleeding is the injection of CYA glue. The published success of EUS-guided angiotherapy using CYA glue with or without embolization coils has increased our treatment armamentarium.
背景和目的:胃静脉曲张出血的发生率低于食管静脉曲张(EV)出血,但其发病率和死亡率较高。1型胃食管静脉曲张(GOV1)出血的治疗方法与食管静脉曲张相同。相比之下,其他形式的胃静脉曲张出血,包括胃食管静脉曲张 2 型(GOV2)和孤立胃静脉曲张 1 型(IGV1)和 2 型(IGV2),则采用不同的内镜方法进行治疗。非内镜方法包括经颈静脉肝内门体分流术(TIPS)或球囊闭塞逆行经静脉阻塞术(BRTO)。本技术报告侧重于胃静脉曲张(GVs)的内镜治疗:方法:通过使用胃静脉曲张、胶水、氰基丙烯酸酯、凝血酶、硬化剂、带状结扎、局部止血喷雾剂、线圈、EUS、TIPS 和 BRTO 等关键词,在 MEDLINE 数据库中搜索截至 2022 年 8 月的相关文章。文章由美国消化内镜学会(American Society for Gastrointestinal Endoscopy,ASGE)技术委员会起草、审核和编辑,并经ASGE理事会批准:内镜下注射氰基丙烯酸酯(CYA)胶水一直是治疗龙胆紫的主要内镜方法。在 EUS 引导下使用 CYA 胶水和线圈栓塞进行血管治疗已成为一种替代方法,这种方法能更好地检测 GV,在靶向和阻塞 GV 方面具有很高的技术成功率。将 CYA 胶水与线圈疗法相结合可使线圈成为胶水的支架,从而降低胶水栓塞的风险并改善治疗效果。其他注射剂或局部治疗方法也有描述,但研究尚少:结论:内镜治疗胃静脉曲张出血的主流模式是注射 CYA 胶水。已发表的在 EUS 引导下使用 CYA 胶和或不使用栓塞线圈进行血管治疗的成功案例增加了我们的治疗手段。
{"title":"Endoscopic devices and techniques for the management of gastric varices (with videos)","authors":"ASGE Technology Committee,&nbsp;Guru Trikudanathan MD, FASGE ,&nbsp;Erik F. Rahimi MD, FASGE ,&nbsp;Amit Bhatt MD ,&nbsp;Juan Carlos Bucobo MD, FASGE ,&nbsp;Vinay Chandrasekhara MD, FASGE ,&nbsp;Andrew P. Copland MD ,&nbsp;Samuel Han MD, MS ,&nbsp;Allon Kahn MD ,&nbsp;Kumar Krishnan MD, FASGE ,&nbsp;Nikhil A. Kumta MD, MS ,&nbsp;David R. Lichtenstein MD, FASGE ,&nbsp;Jorge V. Obando MD ,&nbsp;Rahul Pannala MD, MPH, FASGE ,&nbsp;Mansour A. Parsi MD, MPH, MBA, FASGE ,&nbsp;Monica Saumoy MD, MS ,&nbsp;Arvind J. Trindade MD, FASGE ,&nbsp;Julie Yang MD, FASGE ,&nbsp;Ryan J. Law DO ,&nbsp;ASGE Technology Committee Chair","doi":"10.1016/j.gie.2024.06.038","DOIUrl":"10.1016/j.gie.2024.06.038","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Gastric variceal bleeding occurs less commonly than bleeding from esophageal varices (EVs), although it is associated with higher morbidity and mortality. Bleeding from gastroesophageal varices type 1 (GOV1) is treated like EVs. In contrast, other forms of gastric variceal bleeding, including gastroesophageal varices type 2 (GOV2) and isolated gastric varices types 1 (IGV1) and 2 (IGV2), are treated with varying endoscopic approaches. Nonendoscopic methods include transjugular intrahepatic portosystemic shunt (TIPS) or balloon-occluded retrograde transvenous obliteration (BRTO). This technology report focuses on endoscopic management of gastric varices (GVs).</div></div><div><h3>Methods</h3><div>The MEDLINE database was searched through August 2022 for relevant articles by using key words such as gastric varices, glue, cyanoacrylate, thrombin, sclerosing agents, band ligation, topical hemostatic spray, coils, EUS, TIPS, and BRTO. The article was drafted, reviewed, and edited by the American Society for Gastrointestinal Endoscopy (ASGE) Technology Committee and approved by the Governing Board of the ASGE.</div></div><div><h3>Results</h3><div>Endoscopic injection with cyanoacrylate (CYA) glue has been the primary endoscopic method to treat GVs. EUS-guided angiotherapy with CYA glue and coil embolization has emerged as an alternative method enabling improved detection of GVs with a high technical success for targeting and obliterating GVs. Combining CYA glue with coil therapy allows the coil to act as a scaffold for the glue, reducing the risk of glue embolization and improving outcomes. Alternative injectates or topical treatments have been described but remain poorly studied.</div></div><div><h3>Conclusions</h3><div>The mainstay paradigm for the endoscopic management of gastric variceal bleeding is the injection of CYA glue. The published success of EUS-guided angiotherapy using CYA glue with or without embolization coils has increased our treatment armamentarium.</div></div>","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":"101 3","pages":"Pages 496-510"},"PeriodicalIF":6.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reproducibility of EUS-guided shear wave elastography for assessment of hepatic fibrosis: a prospective pilot cohort study 一项前瞻性试点队列研究:EUS 引导的剪切波弹性成像评估肝纤维化的再现性。
IF 6.7 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/j.gie.2024.10.064
David L. Diehl MD , Vikas Sangwan MD , Sandeep Khurana MD , Harshit S. Khara MD , Jianying Zhang MD, MPH, MSc , Bradley D. Confer DO

Background and Aims

Noninvasive assessment of liver fibrosis is important in the management of liver disease. EUS-guided shear wave elastography (EUS-SWE) is a newer technology that can measure liver stiffness, thereby estimating hepatic fibrosis. There are limited data comparing EUS-SWE to vibration-controlled transient elastography (VCTE) using liver biopsy as the reference standard, and the reproducibility of EUS-SWE measurements is not known.

Methods

In total, 52 patients referred for EUS-guided liver biopsy (EUS-LB) were prospectively enrolled. Patients first underwent VCTE, then 2 consecutive EUS-SWE measurements done first in the left and then another 2 in the right. Bilobar EUS-LB was then done. Receiver operating characteristic curves were developed to compare EUS-SWE to VCTE and correlate to histology. Analysis was performed to determine EUS-SWE variability in paired measurements for each lobe and between right and left liver lobes.

Results

The most common indication for EUS-LB was non-alcoholic steatohepatitis fibrosis staging in 46% of patients. Right lobe SWE had a strong correlation with fibrosis stage ρ = 0.571 (P < .0001) whereas left lobe EUS-SWE had a moderate correlation ρ = 0.368 (P < .0079). Both EUS-SWE and VCTE were similar for discrimination of all stages of fibrosis based on empiric receiver operating characteristic curves. However, the variance between paired consecutive EUS-SWE measurements was 3.5 times higher in the left lobe compared to the right lobe (P < .0001).

Conclusion

EUS-SWE provides an assessment of hepatic fibrosis comparable to VCTE. EUS-SWE in the left lobe has 3.5 times higher variance between consecutive measurements compared to the right.
背景和目的:肝纤维化的无创评估在肝病的治疗中很重要。eus引导横波弹性成像(EUS-SWE)是一种较新的技术,可以测量肝脏硬度,从而估计肝纤维化。将EUS-SWE与以肝活检为金标准的振动控制瞬态弹性成像(VCTE)进行比较的数据有限,而且EUS-SWE测量结果的可重复性尚不清楚。方法:前瞻性纳入52例行eus引导肝活检(EUS-LB)的患者。患者首先接受VCTE,然后连续两次EUS-SWE测量,一次在左侧,另一次在右侧。然后进行双叶EUS-LB。绘制受试者工作特征曲线,将EUS-SWE与VCTE进行比较,并与组织学相关联。分析确定每个肝叶和左右肝叶之间成对测量的EUS-SWE变异性。结果:在46%的患者中,EUS-LB最常见的适应症是非酒精性脂肪性肝炎纤维化分期。右肺叶SWE与纤维化分期有很强的相关性,ρ = 0.571 (P < 0.0001),而左肺叶EUS-SWE有中等相关性,ρ = 0.368 (P < 0.0079)。根据经验ROC曲线,EUS-SWE和VCTE对纤维化各阶段的区分相似。然而,配对连续EUS-SWE测量之间的方差在左叶比右叶高3.5倍(P < 0.0001)。结论:EUS-SWE提供了与VCTE相当的肝纤维化评估。左叶的EUS-SWE在连续测量之间的方差是右叶的3.5倍。
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引用次数: 0
Prognostic value of preoperative intragastric meal distribution in gastric emptying scintigraphy for long-term success of gastric peroral endoscopic myotomy in gastroparesis 胃排空闪烁成像中的术前胃内进食分布对胃瘫胃口周围内镜肌切开术长期成功的预后价值
IF 6.7 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/j.gie.2024.05.011
Antoine Debourdeau MD , Véronique Vitton MD, PhD , Sandra Gonzalez MD, PhD , Henri Collet MD , Yassine Al Tabaa MD , Marc Barthet MD, PhD , Jean-Michel Gonzalez MD, PhD

Background and Aims

Gastric emptying scintigraphy (GES) is the criterion standard for the diagnosis of gastroparesis. However, data are lacking regarding the prognostic value of preoperative intragastric meal distribution during GES in patients undergoing gastric peroral endoscopic myotomy (G-POEM) for gastroparesis. This study investigated the association of GES morphologic parameters and the long-term clinical success of G-POEM.

Methods

This retrospective study included patients who underwent G-POEM for refractory gastroparesis in a tertiary center with preoperative GES data. Intragastric meal distribution was measured using the proximal to distal count ratio (PDCR) at 0, 1, 2 and 4 hours, and the retention index was calculated. Clinical success was defined as a decrease of at least 50% in the Gastroparesis Cardinal Symptom Index total score after G-POEM.

Results

In total, 77 patients were included with a mean follow-up of 40.14 months. Clinical success was observed in 54.55% of patients. The retention index was not associated with clinical success. Only PDCR at 0 hours (PDCR0) was associated with clinical success. In univariate analysis, the median PDCR0 was 6.0 (interquartile range, 5.59) in patients with clinical success and 4.29 (interquartile range, 4.51) in patients with clinical failure (P = .019). In multivariate analysis, PDCR0 >5.25 was associated with clinical success (odds ratio, 4.36; 95% confidence interval, 1.55-12.26; P = .00524).

Conclusions

This study suggests that in patients with gastroparesis, a high PDCR0 value (suggestive for a preferential fundic meal distribution) during preoperative GES is associated with long-term clinical response to G-POEM.
背景和目的:胃排空闪烁成像(GES)是诊断胃瘫的金标准。然而,对于因胃瘫而接受胃口周围内镜下肌切开术(GPOEM)的患者,目前还缺乏有关 GES 术前胃内膳食分布预后价值的数据。本研究调查了 GES 形态学参数与 G-POEM 长期临床成功率的关系:这项回顾性研究纳入了在一家三级中心接受G-POEM治疗难治性胃瘫并提供术前GES数据的患者。使用近端与远端计数比(PDCR)测量0、1、2和4小时(h)的胃内膳食分布,并计算潴留指数(RI)。临床成功的定义是,G-POEM 术后胃痉挛卡迪纳尔症状指数(GCSI)总分下降至少 50%:共有 77 名患者接受了治疗,平均随访时间为 40.14 个月。54.55%的患者获得了临床成功。RI与临床成功率无关。只有 0h 时的 PDCR(PDCR0)与临床成功率相关。在单变量分析中,临床成功患者的中位 PDCR0 为 6.0(IQR 5.59),临床失败患者的中位 PDCR0 为 4.29(IQR 4.51)(P=0.019)。在多变量分析中,PDCR0>5.25与临床成功相关(HR=4.36 [1.55;12.26],P=0.00524):本研究表明,对于胃瘫患者,术前胃肠造影时的高 PDCR0 值(提示胃底膳食优先分布)与 G-POEM 的长期临床反应相关。
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引用次数: 0
Evaluating no fixation, endoscopic suture fixation, and an over-the-scope clip for anchoring fully covered self-expandable metal stents in benign upper GI conditions: a comparative multicenter international study (with video) 评估在良性上消化道疾病中固定全覆盖自膨胀金属支架的无固定、内窥镜缝合固定和镜外夹:一项多中心国际比较研究(附视频)。
IF 6.7 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/j.gie.2024.08.015
Amit Mehta MD , Ashraf Ashhab MD , Apurva Shrigiriwar MD , Redeat Assefa MD , Andrew Canakis DO , Michael Frohlinger MD , Christopher A. Bouvette MD , Gregus Matus MD , Paul Punkenhofer MD , Francesco Vito Mandarino MD , Francesco Azzolini MD , Jamil S. Samaan MD , Rashmi Advani MD , Shivani K. Desai MD , Bradley Confer DO , Vikas K. Sangwan MD , Jonh J. Pineda-Bonilla MD , David P. Lee MD , Kinnari Modi MD , Chiemeziem Eke MD , Mouen A. Khashab MD

Background and Aims

Fully covered self-expandable metal stents (FCSEMSs) are widely used in benign upper GI conditions, but stent migration remains a limitation. An over-the-scope clip (OTSC) device (Stentfix {SF], Ovesco Endoscopy) for stent anchoring has recently been developed. The aim of this study was to evaluate the effect of OTSC fixation on FCSEMS migration rate.

Methods

In this retrospective review of consecutive patients who underwent FCSEMS placement for benign upper GI conditions from January 2011 to October 2022 at 16 centers, the primary outcome was rate of stent migration. The secondary outcomes were clinical success and adverse events.

Results

A total of 311 (no fixation [NF] 122, SF 94, endoscopic suturing [ES] 95) patients underwent 316 stenting procedures. Compared with the NF group (n = 49, 39%), the rates of stent migration were significantly lower in the SF (n = 16, 17%, P = .001) and ES (n = 23, 24%, P = .01) groups. The rates of stent migration were not different between the SF and ES groups (P = .2). On multivariate analysis, SF (odds ratio [OR], 0.34, 95% CI, 0.17-0.70, P < .01) and ES (OR, 0.46, 95% CI, 0.23-0.91; P = .02) were independently associated with decreased risk of stent migration. Compared with the NF group (n = 64; 52%), there were higher rates of clinical success in the SF (n = 64; 68%; P = .03) and ES (n = 66; 69%; P = .02) groups. There was no significant difference in the rates of adverse events among the 3 groups.

Conclusion

Stent fixation using OTSCs is safe and effective at preventing stent migration and may also result in improved clinical response.
背景和目的:全覆盖自膨胀金属支架(FCSEMS)广泛应用于良性上消化道疾病,但支架移位仍是一个限制因素。最近开发了一种用于支架固定的镜外夹(OTSC)装置(Ovesco Endoscopy)。本研究旨在评估 OTSC 固定对 SEMS 移位率的影响:方法:对 2011 年 1 月 1 日至 2022 年 10 月 10 日期间在 16 个中心因良性上消化道疾病接受 FCSEMS 置入术的连续患者进行回顾性研究。主要结果是支架移位率。次要结果为临床成功率和不良事件:共有 311 例(无固定 122 例、OTSC 94 例、内镜缝合 95 例)患者接受了 316 例支架植入手术。与无固定(NF)组(n=49,39%)相比,OTSC(SF)组(n=16,17%,p=0.001)和内镜缝合(ES)组(n=23,24%,p=0.01)的支架移位率显著降低。SF 组和 ES 组的支架移位率没有差异(P=0.2)。多变量分析显示,SF 组(OR 0.34,CI 0.17-0.70,P=0.01)和 ES 组(N=23,24,P=0.01)的支架移位率没有差异(P=0.2):使用 OTSC 进行支架固定既安全又能有效防止支架移位,还能改善临床反应。
{"title":"Evaluating no fixation, endoscopic suture fixation, and an over-the-scope clip for anchoring fully covered self-expandable metal stents in benign upper GI conditions: a comparative multicenter international study (with video)","authors":"Amit Mehta MD ,&nbsp;Ashraf Ashhab MD ,&nbsp;Apurva Shrigiriwar MD ,&nbsp;Redeat Assefa MD ,&nbsp;Andrew Canakis DO ,&nbsp;Michael Frohlinger MD ,&nbsp;Christopher A. Bouvette MD ,&nbsp;Gregus Matus MD ,&nbsp;Paul Punkenhofer MD ,&nbsp;Francesco Vito Mandarino MD ,&nbsp;Francesco Azzolini MD ,&nbsp;Jamil S. Samaan MD ,&nbsp;Rashmi Advani MD ,&nbsp;Shivani K. Desai MD ,&nbsp;Bradley Confer DO ,&nbsp;Vikas K. Sangwan MD ,&nbsp;Jonh J. Pineda-Bonilla MD ,&nbsp;David P. Lee MD ,&nbsp;Kinnari Modi MD ,&nbsp;Chiemeziem Eke MD ,&nbsp;Mouen A. Khashab MD","doi":"10.1016/j.gie.2024.08.015","DOIUrl":"10.1016/j.gie.2024.08.015","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Fully covered self-expandable metal stents (FCSEMSs) are widely used in benign upper GI conditions, but stent migration remains a limitation. An over-the-scope clip (OTSC) device (Stentfix {SF], Ovesco Endoscopy) for stent anchoring has recently been developed. The aim of this study was to evaluate the effect of OTSC fixation on FCSEMS migration rate.</div></div><div><h3>Methods</h3><div>In this retrospective review of consecutive patients who underwent FCSEMS placement for benign upper GI conditions from January 2011 to October 2022 at 16 centers, the primary outcome was rate of stent migration. The secondary outcomes were clinical success and adverse events.</div></div><div><h3>Results</h3><div>A total of 311 (no fixation [NF] 122, SF 94, endoscopic suturing [ES] 95) patients underwent 316 stenting procedures. Compared with the NF group (n = 49, 39%), the rates of stent migration were significantly lower in the SF (n = 16, 17%, <em>P</em> = .001) and ES (n = 23, 24%, <em>P</em> = .01) groups. The rates of stent migration were not different between the SF and ES groups (<em>P</em> = .2). On multivariate analysis, SF (odds ratio [OR], 0.34, 95% CI, 0.17-0.70, <em>P</em> &lt; .01) and ES (OR, 0.46, 95% CI, 0.23-0.91; <em>P</em> = .02) were independently associated with decreased risk of stent migration. Compared with the NF group (n = 64; 52%), there were higher rates of clinical success in the SF (n = 64; 68%; <em>P</em> = .03) and ES (n = 66; 69%; <em>P</em> = .02) groups. There was no significant difference in the rates of adverse events among the 3 groups.</div></div><div><h3>Conclusion</h3><div>Stent fixation using OTSCs is safe and effective at preventing stent migration and may also result in improved clinical response.</div></div>","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":"101 3","pages":"Pages 589-597"},"PeriodicalIF":6.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EUS-guided gastroenterostomy for malignant gastric outlet obstruction: impact of clinical and demographic factors on outcomes 内镜超声引导下胃肠造口术治疗恶性胃出口梗阻:临床和人口学因素对结果的影响。
IF 6.7 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/j.gie.2024.10.053
Ravi Teja Pasam MBBS, MPH , Thomas Mathews MD , Kimberly F. Schuster BA , Daniel Szvarca MD , Trent Walradt MD , Pichamol Jirapinyo MD, MPH , Christopher C. Thompson MD, MSc

Background and Aims

EUS-guided gastroenterostomy (EUS-GE) has emerged as an alternative to surgical gastrojejunostomy and endoluminal stenting for malignant gastric outlet obstruction (MGOO). Studies regarding factors associated with the EUS-GE outcomes are limited.

Methods

A retrospective observational study was conducted with consecutive patients who underwent EUS-GE for MGOO from January 2016 to November 2023. Primary outcomes were technical success (establishing EUS-GE) and clinical success (low-residue diet tolerance without re-intervention at 90-day follow-up). Secondary outcomes were adverse events (AEs), reinterventions, and full regular diet tolerance.

Results

Technical success and clinical success rates were 92.70% (127 of 137) and 88.00%, respectively, with 42.86% of the patients tolerating a regular diet. Patients with peritoneal carcinomatosis had lower odds of technical success (odds ratio [OR], .19; 95% confidence interval [CI], .04-.93). Obstruction at the level of stomach, compared with duodenum, had lower odds of clinical success (OR, .06; 95% CI, .006-.56). AE and reintervention rates were 14.17% and 8.66%. Nasogastric tube decompression before EUS-GE was associated with lower AE rates in multivariable analysis (OR, .32; 95% CI, .11-.95). Prior GI surgery was associated with reintervention in multivariable analysis (OR, 4.09; 95% CI, 1.02-16.45; P = .047).

Conclusions

EUS-GE has high technical and clinical success rates, with many patients tolerating a regular diet. Routine nasogastric tube decompression should be considered to minimize AEs. MGOO at the level of the stomach is associated with lower clinical success rates. Extra care should be taken while performing EUS-GE in patients with peritoneal carcinomatosis. Prior GI surgery is a likely risk factor for reintervention.
背景和目的:内镜超声引导下胃肠造口术(EUS-GE)已成为手术胃空肠造口术和腔内支架治疗恶性胃出口梗阻(MGOO)的替代方法。有关 EUS-GE 效果相关因素的研究十分有限:本中心对2016年1月至2023年11月期间接受EUS-GE治疗恶性胃出口梗阻的连续患者进行了回顾性观察研究。主要结果为技术成功(建立 EUS-GE)和临床成功(90 天随访时可耐受低残留饮食,无需再次干预)。次要结果为不良事件(AE)、再次干预和完全耐受常规饮食:技术成功率和临床成功率分别为92.70%(127/137)和88.00%,42.86%的患者可以耐受常规饮食。腹膜癌患者的技术成功率较低(OR:0.19,95% CI:0.04-0.93)。与十二指肠阻塞相比,胃部阻塞的临床成功几率较低(OR:0.06,95% CI:0.006-0.56)。AE和再介入率分别为14.17%和8.66%。在多变量分析中,在 EUS-GE 之前进行 NGT 减压与较低的 AE 发生率相关(OR:0.32,95% CI:0.11-0.95)。在多变量分析中,之前的胃肠道手术与再介入相关(OR:4.09;95% CI:1.02-16.45,P值:0.047):EUS-GE的技术和临床成功率都很高,许多患者都能接受常规饮食。应考虑对 NGT 进行常规减压,以尽量减少 AEs。胃水平的 MGOO 与较低的临床成功率有关。对腹膜癌患者进行 EUS-GE 时应格外小心。之前的胃肠道手术很可能是再次介入的风险因素。
{"title":"EUS-guided gastroenterostomy for malignant gastric outlet obstruction: impact of clinical and demographic factors on outcomes","authors":"Ravi Teja Pasam MBBS, MPH ,&nbsp;Thomas Mathews MD ,&nbsp;Kimberly F. Schuster BA ,&nbsp;Daniel Szvarca MD ,&nbsp;Trent Walradt MD ,&nbsp;Pichamol Jirapinyo MD, MPH ,&nbsp;Christopher C. Thompson MD, MSc","doi":"10.1016/j.gie.2024.10.053","DOIUrl":"10.1016/j.gie.2024.10.053","url":null,"abstract":"<div><h3>Background and Aims</h3><div>EUS-guided gastroenterostomy (EUS-GE) has emerged as an alternative to surgical gastrojejunostomy and endoluminal stenting for malignant gastric outlet obstruction (MGOO). Studies regarding factors associated with the EUS-GE outcomes are limited.</div></div><div><h3>Methods</h3><div>A retrospective observational study was conducted with consecutive patients who underwent EUS-GE for MGOO from January 2016 to November 2023. Primary outcomes were technical success (establishing EUS-GE) and clinical success (low-residue diet tolerance without re-intervention at 90-day follow-up). Secondary outcomes were adverse events (AEs), reinterventions, and full regular diet tolerance.</div></div><div><h3>Results</h3><div>Technical success and clinical success rates were 92.70% (127 of 137) and 88.00%, respectively, with 42.86% of the patients tolerating a regular diet. Patients with peritoneal carcinomatosis had lower odds of technical success (odds ratio [OR], .19; 95% confidence interval [CI], .04-.93). Obstruction at the level of stomach, compared with duodenum, had lower odds of clinical success (OR, .06; 95% CI, .006-.56). AE and reintervention rates were 14.17% and 8.66%. Nasogastric tube decompression before EUS-GE was associated with lower AE rates in multivariable analysis (OR, .32; 95% CI, .11-.95). Prior GI surgery was associated with reintervention in multivariable analysis (OR, 4.09; 95% CI, 1.02-16.45; <em>P</em> = .047).</div></div><div><h3>Conclusions</h3><div>EUS-GE has high technical and clinical success rates, with many patients tolerating a regular diet. Routine nasogastric tube decompression should be considered to minimize AEs. MGOO at the level of the stomach is associated with lower clinical success rates. Extra care should be taken while performing EUS-GE in patients with peritoneal carcinomatosis. Prior GI surgery is a likely risk factor for reintervention.</div></div>","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":"101 3","pages":"Pages 580-588.e1"},"PeriodicalIF":6.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of endoscopy in pregnancy: a review 妊娠期内窥镜检查的作用:综述。
IF 6.7 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/j.gie.2024.10.058
Hadie Razjouyan MD, MPH, Jennifer L. Maranki MD, MSc, FASGE
{"title":"Role of endoscopy in pregnancy: a review","authors":"Hadie Razjouyan MD, MPH,&nbsp;Jennifer L. Maranki MD, MSc, FASGE","doi":"10.1016/j.gie.2024.10.058","DOIUrl":"10.1016/j.gie.2024.10.058","url":null,"abstract":"","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":"101 3","pages":"Pages 520-526"},"PeriodicalIF":6.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Information for readers
IF 6.7 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/S0016-5107(25)00019-7
{"title":"Information for readers","authors":"","doi":"10.1016/S0016-5107(25)00019-7","DOIUrl":"10.1016/S0016-5107(25)00019-7","url":null,"abstract":"","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":"101 3","pages":"Page A16"},"PeriodicalIF":6.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare cause of recurrent pancreatitis: intraductal papillary mucinous neoplasm in the duct of Santorini (with video) 复发性胰腺炎的罕见病因:圣托里尼导管内乳头状粘液瘤
IF 6.7 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/j.gie.2024.10.050
Peijing Bao MB, Guangchao Li MD, Ning Zhong MD, Yanqing Li MD, Peng Wang MD
{"title":"A rare cause of recurrent pancreatitis: intraductal papillary mucinous neoplasm in the duct of Santorini (with video)","authors":"Peijing Bao MB,&nbsp;Guangchao Li MD,&nbsp;Ning Zhong MD,&nbsp;Yanqing Li MD,&nbsp;Peng Wang MD","doi":"10.1016/j.gie.2024.10.050","DOIUrl":"10.1016/j.gie.2024.10.050","url":null,"abstract":"","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":"101 3","pages":"Pages 679-680"},"PeriodicalIF":6.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic scoring of immune-mediated colitis disease activity 免疫介导性结肠炎疾病活动的内窥镜评分
IF 6.7 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/j.gie.2024.10.007
Viktoria Bergqvist MD, PhD, Peter Gedeon MD, PhD, Erik Hertervig MD, PhD, Jan Marsal MD, PhD
{"title":"Endoscopic scoring of immune-mediated colitis disease activity","authors":"Viktoria Bergqvist MD, PhD,&nbsp;Peter Gedeon MD, PhD,&nbsp;Erik Hertervig MD, PhD,&nbsp;Jan Marsal MD, PhD","doi":"10.1016/j.gie.2024.10.007","DOIUrl":"10.1016/j.gie.2024.10.007","url":null,"abstract":"","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":"101 3","pages":"Pages 695-696"},"PeriodicalIF":6.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use patterns, technical challenges, and patient selection associated with single-use duodenoscopes and duodenoscopes with single-use endcaps in the United States and Canada 美国和加拿大一次性使用十二指肠镜和一次性使用带盖十二指肠镜的使用模式、技术挑战和患者选择。
IF 6.7 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/j.gie.2024.09.043
Monique T. Barakat MD, PhD , Kelita Singh MD , Mike Wei MD, Shai Friedland MD, Subhas Banerjee MD

Background and Aims

The extent of adoption, patient selection, and use patterns of single-use duodenoscopes and duodenoscopes with single-use endcaps have not yet been characterized, and large-scale assessments of endoscopist-reported function and challenges have not been reported.

Methods

An anonymous 6-minute electronic survey assessing use and experience with single-use duodenoscopes and duodenoscopes with novel design features was distributed to U.S. and Canadian endoscopy centers, and responses were analyzed using descriptive statistics.

Results

The survey was notable for a 70.2% response rate, with representation from academic (68.9%), community (18%), and veterans affairs (8.2%) centers. Most institutions used standard reprocessable duodenoscopes and duodenoscopes with single-use endcaps (34.4%) or a mix of standard reprocessable duodenoscopes, duodenoscopes with single-use endcaps, and single-use duodenoscopes (29.5%). No center used only single-use duodenoscopes. Some institutions (10.3%) planned to transition to duodenoscopes with a single-use endcap, 10.3% to a mix of single-use duodenoscopes and duodenoscopes with a single-use endcap, and 1.7% to single-use duodenoscopes alone. Challenges were reported with each type of novel duodenoscope, and selection patterns for use were characterized.

Conclusions

This first of its kind, large-scale survey of use patterns and functionality of newly introduced duodenoscopes is notable for the fairly widespread use of duodenoscopes with single-use endcaps and more limited use of single-use duodenoscopes. Both novel duodenoscope designs are associated with mechanical limitations that respondents indicate represent challenges to successful completion of ERCPs.
背景和目的:一次性使用的十二指肠镜和带有一次性使用内盖的十二指肠镜的采用程度、患者选择和使用模式尚未定性,对内镜医师报告的功能和挑战的大规模评估也是如此:向美国和加拿大的内镜中心分发了一份 6 分钟的匿名电子调查表,评估一次性使用十二指肠镜和具有新颖设计特点的十二指肠镜的使用情况和经验,并使用描述性统计对回复进行分析:该调查的回复率为 70.2%,其中包括学术中心(68.9%)、社区中心(18%)和退伍军人事务中心(8.2%)。大多数机构使用标准可再处理十二指肠镜和带一次性使用端盖的十二指肠镜(34.4%),或混合使用标准可再处理十二指肠镜、带一次性使用端盖的十二指肠镜和一次性使用十二指肠镜(29.5%)。没有一家中心只使用一次性十二指肠镜(0%)。10.3%的中心计划过渡到使用带一次性内盖的十二指肠镜,10.3%的中心计划过渡到混合使用一次性十二指肠镜和带一次性内盖的十二指肠镜,1.7%的中心计划过渡到仅使用一次性十二指肠镜。报告了每种新型十二指肠镜面临的挑战,并描述了使用时的选择模式:这项首次对新引进的十二指肠镜的使用模式和功能进行的大规模调查显示,带有一次性使用内盖的十二指肠镜的使用相当广泛,而一次性使用十二指肠镜的使用则较为有限。这两种新型十二指肠镜的设计都存在机械限制,受访者表示这对成功完成ERCP手术构成了挑战。
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引用次数: 0
期刊
Gastrointestinal endoscopy
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