Pub Date : 2026-01-19DOI: 10.1016/j.gie.2025.11.001
Douglas G. Adler MD, FACG, AGAF, FASGE
{"title":"A note from the Editor-in-Chief","authors":"Douglas G. Adler MD, FACG, AGAF, FASGE","doi":"10.1016/j.gie.2025.11.001","DOIUrl":"10.1016/j.gie.2025.11.001","url":null,"abstract":"","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":"103 2","pages":"Page 209"},"PeriodicalIF":7.5,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-19DOI: 10.1016/j.gie.2025.08.029
Luis F. Lara MD
{"title":"Sometimes less is less: endoscopic submucosal resection with band ligation of rectal neuroendocrine tumors with and without submucosal injection","authors":"Luis F. Lara MD","doi":"10.1016/j.gie.2025.08.029","DOIUrl":"10.1016/j.gie.2025.08.029","url":null,"abstract":"","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":"103 2","pages":"Pages 343-344"},"PeriodicalIF":7.5,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-19DOI: 10.1016/j.gie.2025.07.015
Alberto Murino MD
{"title":"Melius abundare quam deficere! Adding base ablation to margin ablation may further reduce the risk of residual or recurrence adenoma","authors":"Alberto Murino MD","doi":"10.1016/j.gie.2025.07.015","DOIUrl":"10.1016/j.gie.2025.07.015","url":null,"abstract":"","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":"103 2","pages":"Pages 293-294"},"PeriodicalIF":7.5,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-17DOI: 10.1016/j.gie.2025.12.291
Cary C. Cotton, Swathi Eluri, Vivek Kaul, Neil R. Sharma, Stuart R. Gordon, Toufic Kachaamy, George Smallfield, Jason Samarasena, Arvind Trindade, Field F. Willingham, Eugene Zolotarevsky, Jeremy Barber, Shivangi Kothari, Kenneth J. Chang, Petros Benias, Matthew J. McKinley, Arjun K. Juneja, Nicholas J. Shaheen
BACKGROUND AND AIMSPalliation of dysphagia associated with advanced esophageal cancer is challenging. Previous studies suggest liquid-nitrogen spray cryotherapy (LNSC) is effective to palliate obstructive esophageal cancer. We sought to prospectively examine the utility, safety, and efficacy of serial applications of repeated palliative LNSC in this population.METHODSWe performed a prospective cohort trial of LNSC for persistent esophageal cancer without the possibility of resection for palliation of obstructive symptoms. We used repeated measures and competing risks analyses to study the course of patients treated over two years. Efficacy of treatment was assessed using quality-of-life scores 14 days after treatment, using general cancer (QLQ-C30) and esophageal cancer-specific (QLQ-OES18) quality-of-life questionnaires, as well as ordinal dysphagia scores. Complications were assessed using structured interviews and classified according to Common Terminology Criteria.RESULTSOn repeated treatments, each participant (N = 49) improved their QLQ-C30 score by a mean 1.7 (95% confidence interval (CI) 0.1 - 3.3) and improved their QLQ-OES18 score by a mean 1.8 (95% CI 0.4-3.3). For each subsequent round of treatment, the effect improved 0.1 (95% CI 0.3-0.4) for the QLQ-C30 score and worsened -0.2 (95% CI -0.5 - 0.2) for QLQ-OES18 score. There was no signifcant improvement in the ordinal dysphagia score. 19 (39.6%) of 48 participants with a feedng tube at baseline required a feeding tube or stent at a mean of 8 months. While unrelated serious adverse events were common (38.8%), only two patients had events possibly related to LNSC (4.1%, melena and dysphagia).CONCLUSIONSSpray cryotherapy had a durable and repeatable benefit for palliation of obstructive symptoms of esophageal cancer and quality of life in the majority of patients, without the need for feeding tube or esophageal stent placement. Treatments were generally well-tolerated.
背景和目的晚期食管癌相关的吞咽困难的治疗具有挑战性。既往研究表明液氮喷雾冷冻治疗（LNSC）对缓解梗阻性食管癌是有效的。我们试图前瞻性地研究在这一人群中重复姑息性LNSC系列应用的实用性、安全性和有效性。方法：我们进行了一项前瞻性队列试验，采用LNSC治疗无法切除的持续性食管癌，以缓解梗阻性症状。我们使用重复测量和竞争风险分析来研究两年以上患者的治疗过程。采用治疗后14天的生活质量评分、一般癌症（QLQ-C30）和食管癌特异性（QLQ-OES18）生活质量问卷以及顺序吞咽困难评分来评估治疗效果。采用结构化访谈对并发症进行评估，并根据通用术语标准进行分类。结果在重复治疗中，每个参与者（N = 49）的QLQ-C30评分平均提高了1.7分（95%置信区间（CI） 0.1 ~ 3.3）， QLQ-OES18评分平均提高了1.8分（95% CI 0.4 ~ 3.3）。在随后的每一轮治疗中，QLQ-C30评分的效果提高了0.1 (95% CI 0.3-0.4)， QLQ-OES18评分的效果恶化了0.2 （95% CI -0.5 -0.2）。正常吞咽困难评分无明显改善。48名基线时使用饲管的患者中有19名（39.6%）在平均8个月时需要使用饲管或支架。虽然不相关的严重不良事件很常见（38.8%），但只有2例患者发生可能与LNSC相关的事件（4.1%，黑黑和吞咽困难）。结论喷雾冷冻治疗对于缓解食管癌梗阻性症状和改善大多数患者的生活质量具有持久和可重复的益处，无需置管或食管支架。治疗总体耐受良好。
{"title":"Prospective cohort study of palliative treatment of esophageal cancer with liquid nitrogen spray cryotherapy","authors":"Cary C. Cotton, Swathi Eluri, Vivek Kaul, Neil R. Sharma, Stuart R. Gordon, Toufic Kachaamy, George Smallfield, Jason Samarasena, Arvind Trindade, Field F. Willingham, Eugene Zolotarevsky, Jeremy Barber, Shivangi Kothari, Kenneth J. Chang, Petros Benias, Matthew J. McKinley, Arjun K. Juneja, Nicholas J. Shaheen","doi":"10.1016/j.gie.2025.12.291","DOIUrl":"https://doi.org/10.1016/j.gie.2025.12.291","url":null,"abstract":"BACKGROUND AND AIMSPalliation of dysphagia associated with advanced esophageal cancer is challenging. Previous studies suggest liquid-nitrogen spray cryotherapy (LNSC) is effective to palliate obstructive esophageal cancer. We sought to prospectively examine the utility, safety, and efficacy of serial applications of repeated palliative LNSC in this population.METHODSWe performed a prospective cohort trial of LNSC for persistent esophageal cancer without the possibility of resection for palliation of obstructive symptoms. We used repeated measures and competing risks analyses to study the course of patients treated over two years. Efficacy of treatment was assessed using quality-of-life scores 14 days after treatment, using general cancer (QLQ-C30) and esophageal cancer-specific (QLQ-OES18) quality-of-life questionnaires, as well as ordinal dysphagia scores. Complications were assessed using structured interviews and classified according to Common Terminology Criteria.RESULTSOn repeated treatments, each participant (N = 49) improved their QLQ-C30 score by a mean 1.7 (95% confidence interval (CI) 0.1 - 3.3) and improved their QLQ-OES18 score by a mean 1.8 (95% CI 0.4-3.3). For each subsequent round of treatment, the effect improved 0.1 (95% CI 0.3-0.4) for the QLQ-C30 score and worsened -0.2 (95% CI -0.5 - 0.2) for QLQ-OES18 score. There was no signifcant improvement in the ordinal dysphagia score. 19 (39.6%) of 48 participants with a feedng tube at baseline required a feeding tube or stent at a mean of 8 months. While unrelated serious adverse events were common (38.8%), only two patients had events possibly related to LNSC (4.1%, melena and dysphagia).CONCLUSIONSSpray cryotherapy had a durable and repeatable benefit for palliation of obstructive symptoms of esophageal cancer and quality of life in the majority of patients, without the need for feeding tube or esophageal stent placement. Treatments were generally well-tolerated.","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":"16 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145995276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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