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Dynamics of following and leading: association of movement synchrony and depression severity 跟随和引领的动态:运动同步性与抑郁严重程度的关联
IF 4.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-09-18 DOI: 10.3389/fpsyt.2024.1459082
Simone Jennissen, Anna Sandmeir, Desiree Schoenherr, Uwe Altmann, Christoph Nikendei, Henning Schauenburg, Hans-Christoph Friederich, Ulrike Dinger
ObjectiveDepression negatively affects interpersonal functioning and influences nonverbal behavior. Interpersonal theories of depression suggest that depressed individuals engage in behaviors that initially provoke others’ support and reassurance, but eventually lead to rejection that may also be expressed nonverbally.MethodsThis study investigated movement synchrony as a nonverbal indicator of support and rejection and its association with depression severity in a sample of depressed and healthy individuals. Semi-standardized diagnostic interview segments with N = 114 dyads were video recorded. Body movement was analyzed using Motion Energy Analysis, synchrony intervals were identified by computing windowed cross-lagged correlation and a peak-picking-algorithm. Depression severity was assessed via both self-rating (BDI-II) and clinician rating (HAMD).ResultsBoth self-rated and clinician-rated depression severity were negatively correlated with patient-led, but not clinician-led movement synchrony measures. The more depressed patients were, the less they initiated movement synchrony with their clinicians. These correlations remained significant after controlling for gender, age, gross body movement, and psychopharmacological medication.ConclusionFindings suggest that depression may negatively affect patients’ active initiative in interaction situations. Automatized methods as used in this study can add valuable information in the diagnosis of depression and the assessment of associated social impairments.
抑郁症会对人际功能产生负面影响,并影响非言语行为。抑郁症的人际关系理论认为,抑郁症患者的行为最初会激起他人的支持和安慰,但最终会导致拒绝,这种拒绝也可能通过非言语方式表达出来。本研究调查了抑郁症和健康人样本中作为支持和拒绝的非言语指标的动作同步性及其与抑郁症严重程度的关系。对 N = 114 个二人组的半标准化诊断访谈片段进行了录像。使用运动能量分析法对身体运动进行分析,并通过计算窗口交叉滞后相关性和峰值采样算法确定同步间隔。抑郁严重程度通过自我评分(BDI-II)和临床医生评分(HAMD)进行评估。结果自我评分和临床医生评分的抑郁严重程度与患者主导的运动同步性测量呈负相关,但与临床医生主导的运动同步性测量不相关。抑郁程度越高的患者越少主动与临床医生进行运动同步。结论研究结果表明,抑郁症可能会对患者在互动情境中的主动性产生负面影响。本研究中使用的自动化方法可以为抑郁症的诊断和相关社交障碍的评估提供有价值的信息。
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引用次数: 0
Predictors of the length of stay in psychiatric inpatient units: a retrospective study for the Paris Psychiatry Hospital Group 精神病住院病人住院时间的预测因素:巴黎精神病医院集团的回顾性研究
IF 4.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-09-18 DOI: 10.3389/fpsyt.2024.1463415
David Barruel, Anne Perozziello, Hassina Lefèvre, Annie Msellati, Corine Launay, Valérie Dauriac-Le Masson
ObjectiveShortening the length of hospital stay (LOS) has become a major challenge for psychiatric hospitals in reducing unnecessary costs and improving the patient healthcare experience. We investigated the key factors associated with a long psychiatric hospitalization.MethodThis was a retrospective study of 8,870 full-time psychiatric hospital stays (6,216 patients) in the Paris Psychiatry Hospital Group, with a discharge in 2022. We used machine learning tools and univariate and multivariate methods to explore the impact of demographic, pathway-related, and clinical variables on the LOS.ResultsLOS &gt;30 days was associated with age &gt;55 years {odds ratio [OR] =2 [95% confidence interval 1.7–2.3]}, admission from outside the sectorization zone [OR=1.2 (1.1–1.3)], admission via a psychiatric emergency unit [OR, 1.2 (1.1–1.4)], and some clinical severity markers, such as psychotic disorder diagnosis [OR, 1.5 (1.3–1.7)], mandatory care [request of a third party, OR, 2.5 (2.1–2.9); case of imminent danger, OR, 2.3 (1.9–2.7)], the presence of seclusion and mechanical restraint measures (highlighting the positive effect of restraint duration), the somatic comorbidity for female sex [OR, 1.4 (1.2–1.7)], and treatment resistance [OR, 1.4 (1.2–1.6)]. Conversely, LOS ≤30 days was associated with being in a relationship [OR, 0.6 (0.5–0.8)], admission during a travel-related psychiatric episode [OR, 0.5 (0.3–0.6)], and personality and behavior disorders [OR, 0.7 (0.6–0.9)]. We found no significant association for features such as sex and a lack of treatment compliance.ConclusionTo our knowledge, this is the first recent study to investigate and highlight the impact of factors related to various illness severity markers, medication adherence, and patient journeys on the length of psychiatric hospital stay. A better understanding of long-stay risk factors might be helpful for optimizing the allocation of medical resources and anticipating tailored therapeutic programs.
目的缩短住院时间(LOS)已成为精神病医院减少不必要费用和改善患者医疗体验的一大挑战。方法这是一项回顾性研究,研究对象是巴黎精神病医院集团的 8870 名全日制精神病住院患者(6216 名患者),出院时间为 2022 年。我们使用机器学习工具以及单变量和多变量方法探讨了人口统计学、路径相关变量和临床变量对住院时间的影响。结果住院时间30天与年龄55岁{多态比[OR] =2 [95%置信区间1.7-2.3]}、从分区以外地区入院[OR=1.2 (1.1-1.3)]、通过精神科急诊入院[OR, 1.2 (1.1-1. 4)]以及一定的临床严重程度有关。4)],以及一些临床严重性指标,如精神病性障碍诊断[OR,1.5(1.3-1.7)],强制护理[第三方要求,OR,2.5(2.1-2.9);迫在眉睫的危险情况,OR,2.3(1.9-2.7)]、隔离和机械约束措施的存在(强调约束持续时间的积极影响)、女性的躯体合并症[OR,1.4(1.2-1.7)]和治疗阻力[OR,1.4(1.2-1.6)]。相反,LOS ≤30 天与恋爱关系[OR,0.6 (0.5-0.8)]、旅行相关精神病发作期间入院[OR,0.5 (0.3-0.6)]以及人格和行为障碍[OR,0.7 (0.6-0.9)]有关。据我们所知,这是近期第一项调查并强调与各种疾病严重程度指标、用药依从性和患者旅程相关的因素对精神科住院时间影响的研究。更好地了解长期住院的风险因素可能有助于优化医疗资源的分配,并预测量身定制的治疗方案。
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引用次数: 0
Differential item functioning in the autism behavior checklist in children with autism spectrum disorder based on a machine learning approach.
IF 3.2 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-09-16 eCollection Date: 2024-01-01 DOI: 10.3389/fpsyt.2024.1447080
Kanglong Peng, Meng Chen, Libing Zhou, Xiaofang Weng

Aim: Our study utilized the Rasch analysis to examine the psychometric properties of the Autism Behavior Checklist (ABC) in children with autism spectrum disorder (ASD).

Methods: A total of 3,319 children (44.77 ± 23.52 months) were included. The Rasch model (RM) was utilized to test the reliability and validity of the ABC. The GPCMlasso model was used to test the differential item functioning (DIF).

Result: The response pattern of this sample showed acceptable fitness to the RM. The analysis supported the unidimensionality assumption of the ABC. Disordered category functions and DIF were found in all items in the ABC. The participants responded to the ABC items differently depending not only on autistic traits but also on age groups, gender, and symptom classifications.

Conclusion: The Rasch analysis produces reliable evidence to support that the ABC can precisely depict clinical ASD symptoms. Differences in population characteristics may cause unnecessary assessment bias and lead to overestimated or underestimated symptom severity. Hence, special consideration for population characteristics is needed in making an ASD diagnosis.

目的:我们的研究采用 Rasch 分析方法,对自闭症谱系障碍(ASD)儿童的自闭症行为核对表(ABC)的心理测量特性进行了研究:共纳入 3,319 名儿童(44.77 ± 23.52 个月)。采用 Rasch 模型(RM)检验 ABC 的信度和效度。结果:结果:该样本的反应模式显示与 RM 的匹配性可以接受。分析结果支持 ABC 的单维假设。在 ABC 的所有项目中都发现了类别功能紊乱和 DIF。受试者对 ABC 项目的反应不仅因自闭症特征而异,还因年龄组、性别和症状分类而异:Rasch分析提供了可靠的证据,证明ABC能准确描述自闭症临床症状。人群特征的差异可能会造成不必要的评估偏差,导致症状严重程度被高估或低估。因此,在进行 ASD 诊断时需要特别考虑人群特征。
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引用次数: 0
Effect of community attitudes on suicide mortality in South Korea: a nationwide ecological study.
IF 3.2 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-09-16 eCollection Date: 2024-01-01 DOI: 10.3389/fpsyt.2024.1423609
Minseok Hong, Hyesoo Kim, C Hyung Keun Park, Hyunju Lee, Sang Jin Rhee, Sooyeon Min, Min Ji Kim, Jeong Hun Yang, Yoojin Song, Kyunghoon Son, Yong Min Ahn

Background: Attitudes toward suicide are essential in suicide prevention, as suicide is socio-culturally nuanced. Although the relationship between individual attitudes and suicidal behavior has been extensively studied, the effect of community attitudes-aggregated by region-on suicide mortality remains ambiguous. This study explored the association between community attitudes and real-world suicide mortality.

Methods: Data on attitudes toward suicide from the 2018 Korea National Suicide Survey (N = 1500) and individual mortality data from the MicroData Integrated System were obtained. Confirmatory factor analysis supported a factor structure with three factors: "Permissiveness," "Unjustified behavior," and "Readiness to help/Preventability." Thirty regional units in South Korea aggregated the data for ecological analysis. We used negative binomial models to examine the association at the regional level, and stratified analysis by gender and age group was conducted.

Results: "Permissiveness" was associated with reduced suicide rates in a univariate model (P < 0.001). Adjusting for gender, age, and additional sociodemographics did not alter the association. Additionally, this relationship was observed in males and individuals under 60 years of age after stratification. However, "Unjustified Behavior" and "Readiness to help/Preventability" exhibited no significant association with suicide in any model or stratum.

Conclusion: The observed inverse association between permissive community attitudes and suicide contradicts the findings of previous research that links permissive individual attitudes to increased suicidal behavior. Our findings suggest that attitudes may operate differently at the individual and group levels. Although the cross-sectional design and single-country focus of this study warrant further investigation, our findings indicate that attitudes are significant contextual factors in the process of suicide, which could lead to novel approaches in suicide prevention.

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引用次数: 0
Social media addiction and personality dimensions among Tunisian medical students. 突尼斯医科学生的社交媒体成瘾与人格维度。
IF 3.2 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-09-16 eCollection Date: 2024-01-01 DOI: 10.3389/fpsyt.2024.1471425
Fatma Guermazi, Wissal Abid, Imen Baati, Farah Cherif, Emna Mziou, Dorra Mnif, Ines Feki, Rim Masmoudi, Jawaher Masmoudi

Purpose: Social media (SM) has become a common activity for today's young people. It is sometimes overused and potentially results in SM addiction. This study aims to assess SM addiction and its associated factors in medical students and to examine its relationship with dimensions of personality global self-esteem, and social self-esteem.

Materials and methods: We carried out a cross-sectional study among a sample of medical students in the region of Sfax in Tunisia. Social Media Addiction Scale-Student Form (SMAS-SF), Big Five Inventory, Rosenberg Self-Esteem Scale, and Social Self-Esteem Inventory were used to collect data.

Results: Overall, 116 medical students were included in the survey. The median age of the participants was 26 years, and 91 students (78.4%) were female. Almost half of them (55.20%) were enrolled in the third cycle. The most widely used SM was Facebook (98.3%). Students with the highest SMAS-SF scores had a significantly younger age of first use (p=0.011, r=-0.235), spent more time on their favorite SM (p=0.005, r=0.260), and performed more activities on SM, namely: making comments (p=0.005), browsing SM profiles (p=0.018), and posting videos (p=0.007) or pictures (p=0.002). The need to establish an identity was significantly associated with higher SMAS-SF scores (p=0.011). We also found that neuroticism and a low level of conscientiousness were linked to high SMAS-SF scores (p=0.006, r=0.252 and p=0.050, r=-0.183, respectively). Moreover, high SMAS-SF scores were significantly related to lower global and social self-esteem scores (p=0.015, r=-0.226 and p=0.032, r=-0.199, respectively).

Conclusion: Our results highlight the critical need to take into consideration the evaluation and intervention of self-esteem and personality dimensional issues to target interventions for SM addiction among medical students.

目的:社交媒体(SM)已成为当今年轻人的一种常见活动。有时过度使用社交媒体可能会导致社交媒体成瘾。本研究旨在评估医学生的社交媒体成瘾及其相关因素,并研究其与人格、全球自尊和社会自尊的关系:我们对突尼斯斯法克斯地区的医学生样本进行了横断面研究。研究使用了社交媒体成瘾量表-学生表(SMAS-SF)、大五量表、罗森伯格自尊量表和社交自尊量表来收集数据:共有 116 名医学生参与了调查。参与者的年龄中位数为 26 岁,91 名学生(78.4%)为女性。其中近一半(55.20%)的学生就读于第三周期。使用最多的 SM 是 Facebook(98.3%)。SMAS-SF 分数最高的学生首次使用 SM 的年龄明显较小(p=0.011,r=-0.235),在他们最喜欢的 SM 上花费的时间较多(p=0.005,r=0.260),在 SM 上进行的活动较多,即:发表评论(p=0.005)、浏览 SM 资料(p=0.018)、发布视频(p=0.007)或图片(p=0.002)。建立身份的需要与较高的 SMAS-SF 分数显著相关(p=0.011)。我们还发现,神经质和低水平的自觉性与 SMAS-SF 高分有关(分别为 p=0.006,r=0.252 和 p=0.050,r=-0.183)。此外,SMAS-SF 的高分与较低的全面自尊和社会自尊得分显著相关(分别为 p=0.015,r=-0.226 和 p=0.032,r=-0.199):我们的研究结果突出表明,亟需考虑自尊和人格维度问题的评估和干预,以便有针对性地干预医学生的SM成瘾问题。
{"title":"Social media addiction and personality dimensions among Tunisian medical students.","authors":"Fatma Guermazi, Wissal Abid, Imen Baati, Farah Cherif, Emna Mziou, Dorra Mnif, Ines Feki, Rim Masmoudi, Jawaher Masmoudi","doi":"10.3389/fpsyt.2024.1471425","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1471425","url":null,"abstract":"<p><strong>Purpose: </strong>Social media (SM) has become a common activity for today's young people. It is sometimes overused and potentially results in SM addiction. This study aims to assess SM addiction and its associated factors in medical students and to examine its relationship with dimensions of personality global self-esteem, and social self-esteem.</p><p><strong>Materials and methods: </strong>We carried out a cross-sectional study among a sample of medical students in the region of Sfax in Tunisia. <i>Social Media Addiction Scale-Student Form (SMAS-SF)</i>, <i>Big Five Inventory</i>, <i>Rosenberg Self-Esteem Scale</i>, and <i>Social Self-Esteem Inventory</i> were used to collect data.</p><p><strong>Results: </strong>Overall, 116 medical students were included in the survey. The median age of the participants was 26 years, and 91 students (78.4%) were female. Almost half of them (55.20%) were enrolled in the third cycle. The most widely used SM was Facebook (98.3%). Students with the highest <i>SMAS-SF</i> scores had a significantly younger age of first use (p=0.011, r=-0.235), spent more time on their favorite SM (p=0.005, r=0.260), and performed more activities on SM, namely: making comments (p=0.005), browsing SM profiles (p=0.018), and posting videos (p=0.007) or pictures (p=0.002). The need to establish an identity was significantly associated with higher <i>SMAS-SF</i> scores (p=0.011). We also found that neuroticism and a low level of conscientiousness were linked to high <i>SMAS-SF</i> scores (p=0.006, r=0.252 and p=0.050, r=-0.183, respectively). Moreover, high <i>SMAS-SF</i> scores were significantly related to lower <i>global</i> and <i>social self-esteem</i> scores (p=0.015, r=-0.226 and p=0.032, r=-0.199, respectively).</p><p><strong>Conclusion: </strong>Our results highlight the critical need to take into consideration the evaluation and intervention of self-esteem and personality dimensional issues to target interventions for SM addiction among medical students.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How much risk does delirium represent for the development of dementia?: Retrospective cohort study from over 260,000 patients record in a solitary institution 谵妄导致痴呆症的风险有多大?对一家医疗机构记录的 26 万多名患者进行的回顾性队列研究
IF 4.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-09-13 DOI: 10.3389/fpsyt.2024.1387615
Hironari Minami, Katsunori Toyoda, Takeo Hata, Masami Nishihara, Masashi Neo, Keiichiro Nishida, Tetsufumi Kanazawa
BackgroundDelirium frequently affects the consciousness of the elderly, particularly those in hospitals. Evidence increasingly associates linking delirium history to an increased risk of dementia. However, most studies are limited in scope, focusing mainly on postoperative or intensive care units with small patient samples, which affects the broader applicability of their findings.AimsTo elucidate the precise incidence of delirium and the subsequent onset of dementia within whole inpatients. Additionally, we aimed to explore the correlation between the emergence of delirium during hospitalization and the subsequent manifestation of dementia.Design, setting, and participantsWe conducted a retrospective cohort analysis employing a decade-long electronic medical record dataset consisted of 261,123 patients in Osaka Medical and Pharmaceutical University Hospital. Key analyses were performed October 2022 to January 2023.Main outcomes and measuresThe primary outcome, dementia onset, was determined by prescriptions for the anti-dementia drugs donepezil, galantamine, memantine, or rivastigmine, which are approved for use in Japan.Results10,781 patients met the inclusion criteria. The median interval between the onset of dementia was 972.5 days for individuals without a history of delirium, whereas for those with a history of delirium, it was notably shorter at 592.5 days. This disparity culminated in a hazard ratio of 5.29 (95% confidence interval: 1.35-20.75) for subsequent dementia onset.Conclusions and relevanceThis investigation underscores the imperative significance of directing attention toward preventive measures against delirium during hospitalization, alongside the necessity of diligent monitoring and intervention for cognitive decline in patients who encounter delirium.
背景谵妄经常影响老年人的意识,尤其是医院中的老年人。越来越多的证据表明,谵妄病史与痴呆症风险增加有关。然而,大多数研究范围有限,主要集中在术后或重症监护病房,患者样本较少,这影响了研究结果的广泛适用性。此外,我们还旨在探讨住院期间出现的谵妄与随后出现的痴呆症之间的相关性。设计、环境和参与者我们利用大阪医科药科大学医院的 261123 名患者的十年电子病历数据集进行了一项回顾性队列分析。主要结果和测量指标主要结果(痴呆症发病)由抗痴呆药物多奈哌齐、加兰他敏、美金刚或利巴斯的明的处方决定,这些药物已在日本获批使用。无谵妄病史者的痴呆症发病间隔中位数为 972.5 天,而有谵妄病史者的发病间隔中位数明显较短,为 592.5 天。这一差异最终导致随后痴呆症发病的危险比为 5.29(95% 置信区间:1.35-20.75)。结论和相关性这项调查强调了在住院期间采取预防谵妄措施的重要意义,以及对出现谵妄的患者的认知能力下降进行严格监测和干预的必要性。
{"title":"How much risk does delirium represent for the development of dementia?: Retrospective cohort study from over 260,000 patients record in a solitary institution","authors":"Hironari Minami, Katsunori Toyoda, Takeo Hata, Masami Nishihara, Masashi Neo, Keiichiro Nishida, Tetsufumi Kanazawa","doi":"10.3389/fpsyt.2024.1387615","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1387615","url":null,"abstract":"BackgroundDelirium frequently affects the consciousness of the elderly, particularly those in hospitals. Evidence increasingly associates linking delirium history to an increased risk of dementia. However, most studies are limited in scope, focusing mainly on postoperative or intensive care units with small patient samples, which affects the broader applicability of their findings.AimsTo elucidate the precise incidence of delirium and the subsequent onset of dementia within whole inpatients. Additionally, we aimed to explore the correlation between the emergence of delirium during hospitalization and the subsequent manifestation of dementia.Design, setting, and participantsWe conducted a retrospective cohort analysis employing a decade-long electronic medical record dataset consisted of 261,123 patients in Osaka Medical and Pharmaceutical University Hospital. Key analyses were performed October 2022 to January 2023.Main outcomes and measuresThe primary outcome, dementia onset, was determined by prescriptions for the anti-dementia drugs donepezil, galantamine, memantine, or rivastigmine, which are approved for use in Japan.Results10,781 patients met the inclusion criteria. The median interval between the onset of dementia was 972.5 days for individuals without a history of delirium, whereas for those with a history of delirium, it was notably shorter at 592.5 days. This disparity culminated in a hazard ratio of 5.29 (95% confidence interval: 1.35-20.75) for subsequent dementia onset.Conclusions and relevanceThis investigation underscores the imperative significance of directing attention toward preventive measures against delirium during hospitalization, alongside the necessity of diligent monitoring and intervention for cognitive decline in patients who encounter delirium.","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142252809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Individualized multi-modal MRI biomarkers predict 1-year clinical outcome in first-episode drug-naïve schizophrenia patients 个性化多模态核磁共振成像生物标志物可预测初次发病、未接受过药物治疗的精神分裂症患者的 1 年临床疗效
IF 4.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-09-13 DOI: 10.3389/fpsyt.2024.1448145
Aoxiang Zhang, Chenyang Yao, Qian Zhang, Ziyuan Zhao, Jiao Qu, Su Lui, Youjin Zhao, Qiyong Gong
BackgroundAntipsychotic medications offer limited long-term benefit to about 30% of patients with schizophrenia. We aimed to explore the individual-specific imaging markers to predict 1-year treatment response of schizophrenia.MethodsStructural morphology and functional topological features related to treatment response were identified using an individualized parcellation analysis in conjunction with machine learning (ML). We performed dimensionality reductions using the Pearson correlation coefficient and three feature selection analyses and classifications using 10 ML classifiers. The results were assessed through a 5-fold cross-validation (training and validation cohorts, n = 51) and validated using the external test cohort (n = 17).ResultsML algorithms based on individual-specific brain network proved more effective than those based on group-level brain network in predicting outcomes. The most predictive features based on individual-specific parcellation involved the GMV of the default network and the degree of the control, limbic, and default networks. The AUCs for the training, validation, and test cohorts were 0.947, 0.939, and 0.883, respectively. Additionally, the prediction performance of the models constructed by the different feature selection methods and classifiers showed no significant differences.ConclusionOur study highlighted the potential of individual-specific network parcellation in treatment resistant schizophrenia prediction and underscored the crucial role of feature attributes in predictive model accuracy.
背景抗精神病药物对约30%的精神分裂症患者的长期治疗效果有限。我们的目的是探索个体特异性成像标记物,以预测精神分裂症患者1年的治疗反应。方法通过个体化解析分析与机器学习(ML)相结合,确定了与治疗反应相关的结构形态学和功能拓扑学特征。我们使用皮尔逊相关系数和三种特征选择分析进行了降维,并使用 10 个 ML 分类器进行了分类。结果基于个体特异性脑网络的 ML 算法在预测结果方面比基于群体水平脑网络的算法更有效。基于个体特异性解析的最具预测性的特征包括默认网络的 GMV 以及控制网络、边缘网络和默认网络的程度。训练组、验证组和测试组的AUC分别为0.947、0.939和0.883。此外,不同特征选择方法和分类器构建的模型的预测性能没有明显差异。 结论:我们的研究强调了个体特异性网络解析在耐药精神分裂症预测中的潜力,并强调了特征属性在预测模型准确性中的关键作用。
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引用次数: 0
Validation of the personal suicide stigma questionnaire among adolescents with suicide attempts in mainland China 在中国大陆自杀未遂青少年中验证个人自杀耻辱感问卷
IF 4.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-09-13 DOI: 10.3389/fpsyt.2024.1445247
Xiaoning Wang, Qunfang Miao, Jiannv Wang, Lingjing Qiu, Jinsheng Zhang, Peiqing Li, Yaoyao Huang
ObjectivesThe study aimed to translate and culturally adapt the personal suicide stigma questionnaire (PSSQ) into simplified Chinese and evaluate its psychometric properties among adolescents who have attempted suicide in mainland China.MethodsFollowing Brislin’s translation model and using purposive sampling, we surveyed 440 adolescents who had attempted suicide at Hangzhou Seventh People’s Hospital in Zhejiang Province, China. Content validity was determined by a panel of experts, and the construct validity of the scale was assessed using exploratory factor analysis (EFA), confirmatory factor analysis (CFA), convergent validity, and discriminant validity. Reliability analysis was evaluated using Cronbach’s α coefficient, test–retest reliability, and half-split reliability.ResultsThe Chinese version of the PSSQ consists of three dimensions and 14 items. After two rounds of expert consultation, the item-content validity index for all items exceeded 0.70, and the scale-content validity index exceeded 0.90. EFA extracted three factors and retained all 14 items. The CFA indicators demonstrated a good fit. The Cronbach’s α coefficient of the scale was 0.880, the half-split reliability was 0.681, and the test–retest reliability was 0.862. It is evident that the PSSQ and its subscales demonstrate stable structural validity and good internal consistency in measuring self-stigma among individuals with suicidal tendencies, indicating that the PSSQ is a reliable tool for assessing the degree of personal stigma in Chinese adolescents who have attempted suicide.ConclusionThis study ensured the linguistic and cultural appropriateness of the Chinese version of the PSSQ through cross-cultural adaptation and validation of its reliability and validity, thereby enhancing the accuracy and reliability of assessing personal stigma among Chinese adolescents who have attempted suicide. The validation of the Chinese version of the scale not only enriches the research tools available for studying personal stigma related to suicide in mainland China, but also provides a reliable quantitative tool for future research on the psychological states of individuals who have attempted suicide, the impact of stigma, and the effectiveness of interventions.
目的 本研究旨在将个人自杀耻辱感问卷(PSSQ)翻译成简体中文,并对其进行文化适应性调整,同时评估其在中国大陆自杀未遂青少年中的心理测量学特性。方法 按照布里斯林的翻译模型,我们采用目的性抽样法,对浙江省杭州市第七人民医院的440名自杀未遂青少年进行了调查。内容效度由专家小组确定,量表的建构效度采用探索性因素分析(EFA)、确认性因素分析(CFA)、收敛效度和区分效度进行评估。信度分析采用 Cronbach's α 系数、重测信度和半分信度进行评估。经过两轮专家咨询,所有项目的项目-内容效度指数均超过 0.70,量表-内容效度指数超过 0.90。EFA 提取了三个因子,保留了全部 14 个项目。CFA 指标显示了良好的拟合效果。量表的 Cronbach's α 系数为 0.880,半分信度为 0.681,重测信度为 0.862。由此可见,PSSQ及其分量表在测量有自杀倾向者的自我污名时表现出稳定的结构效度和良好的内部一致性,表明PSSQ是评估中国自杀未遂青少年个人污名程度的可靠工具。结论本研究通过对 PSSQ 中文版进行跨文化改编和信度、效度验证,确保了 PSSQ 中文版在语言和文化上的适宜性,从而提高了评估中国自杀未遂青少年个人污名的准确性和可靠性。中文版量表的验证不仅丰富了研究中国大陆自杀相关个人污名的研究工具,也为今后研究自杀未遂者的心理状态、污名的影响以及干预措施的有效性提供了可靠的量化工具。
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引用次数: 0
Unraveling the spectrum: overlap, distinctions, and nuances of ADHD and ASD in children 揭开谱系:儿童多动症和自闭症的重叠、区别和细微差别
IF 4.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-09-13 DOI: 10.3389/fpsyt.2024.1387179
Sabrina Martinez, Kalin Stoyanov, Luis Carcache
This review explores the clinical presentation of similarities and differences in Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD). This paper investigates the deficits in executive function, social function, and emotional intelligence that are seen in both conditions and how the presence of both conditions can exacerbate these deficiencies. Understanding the clinical presentations in these domains is critical to refine diagnostic methods and treatments and improve outcomes for those affected by these neurodevelopmental disorders. The similarities in clinical presentation between ADHD and ASD present a significant diagnostic challenge, with individuals often exhibiting similar behaviors and difficulty navigating the complexities that encompass reacting to their environment. Further research is paramount in gaining more knowledge of the disorders and challenges faced by these individuals, especially those with the presence of both conditions.
本综述探讨了注意力缺陷/多动障碍(ADHD)和自闭症谱系障碍(ASD)在临床表现上的异同。本文探讨了这两种疾病在执行功能、社会功能和情商方面的缺陷,以及这两种疾病如何会加剧这些缺陷。了解这些领域的临床表现对于完善诊断方法和治疗方法以及改善这些神经发育障碍患者的治疗效果至关重要。多动症和自闭症在临床表现上的相似性给诊断带来了巨大的挑战,患者往往表现出相似的行为,难以驾驭复杂的环境反应。进一步的研究对于进一步了解这些患者,尤其是同时患有这两种疾病的患者所面临的障碍和挑战至关重要。
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引用次数: 0
Drug overdose deaths during prison riots and mental states of prisoners: a case study 监狱骚乱期间吸毒过量致死与囚犯的精神状态:案例研究
IF 4.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-09-13 DOI: 10.3389/fpsyt.2024.1377995
Luca Tomassini, Gianni Giuli, Edoardo Bottoni, Maria Chiara David, Roberto Scendoni
Prison riots, though often sensationalized in the media, have profound consequences, with a significant death toll. Prison populations, historically plagued by psychiatric disorders, witness high rates of suicide, particularly linked to turbulent events like riots. This study examines three drug overdose deaths resulting from a prison riot during the initial wave of the SARS-CoV-2 pandemic in Italy. To ascertain the nature of these deaths, a comprehensive toxicological analysis was conducted. Immunochemical screening and gas chromatography-mass spectrometry were employed to detect a spectrum of drugs, including MDMA, methadone, morphine, cannabis derivatives, benzodiazepines, and others. The toxicological findings revealed high concentrations of various substances in the biological fluids of the deceased inmates. Tramadol and mirtazapine were implicated in one case, while methadone was a common factor in the deaths of two inmates, one of whom also ingested diazepam. The synergistic effects of substances were explored, with methadone identified as a leading cause of death in two cases. Prison riots exacerbate drug abuse issues within prisons, leading to mass intoxication and overdose, as witnessed in historic incidents globally. The study underscores the challenges in determining whether such deaths are accidental, intentional (suicidal), or a consequence of uncontrollable drug consumption during a riot. The prison environment also amplifies pre-existing psychiatric disorders, and incidents like riots can trigger a cascade of uncontrollable psychological reactions. The three potential scenarios are drug dependence, accidental overdose in recreational drug use, and suicide attempts through substance ingestion.
监狱暴乱虽然经常被媒体大肆渲染,但其后果却十分严重,造成大量人员死亡。监狱服刑人员历来饱受精神疾病的困扰,他们的自杀率很高,尤其与暴乱等动荡事件有关。本研究探讨了意大利 SARS-CoV-2 大流行初期监狱暴乱导致的三起吸毒过量死亡事件。为了确定这些死亡事件的性质,我们进行了全面的毒理学分析。采用免疫化学筛选和气相色谱-质谱法检测了一系列药物,包括亚甲二氧基甲基苯丙胺、美沙酮、吗啡、大麻衍生物、苯二氮卓等。毒理学研究结果表明,已故囚犯的生物体液中含有高浓度的各种物质。曲马多和米氮平与一起案件有关,而美沙酮是造成两名囚犯死亡的共同因素,其中一人还摄入了地西泮。对药物的协同作用进行了探讨,在两起案件中,美沙酮被确定为主要死因。监狱暴乱加剧了监狱内的药物滥用问题,导致大规模中毒和用药过量,这在全球历史性事件中都有发生。这项研究强调了在确定此类死亡是意外、故意(自杀)还是骚乱期间无法控制的毒品消费造成的后果方面所面临的挑战。监狱环境也会放大原有的精神障碍,暴乱等事件会引发一连串无法控制的心理反应。三种可能的情况是药物依赖、娱乐性吸毒意外过量以及通过药物摄入企图自杀。
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Frontiers in Psychiatry
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