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Case Report: Ocular paroxysmal non-epileptic events as the presenting sign of celiac disease in children: a case series. 病例报告:以眼部阵发性非癫痫事件作为乳糜泻儿童的先兆:一个病例系列。
IF 2.1 3区 医学 Q2 PEDIATRICS Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI: 10.3389/fped.2024.1450563
Alice Monzani, Giulia Genoni, Amanda Papa, Noemi Paggi, Eleonora Capra, Francesca Brustia, Ivana Rabbone

Introduction: Neurologic manifestations may be presenting signs of celiac disease (CD). Pediatric-onset paroxysmal non-epileptic events (PNEEs) are not included among them.

Cases presentation: We report the case of two children who presented with ocular PNEEs in association with mild symptoms evocative for CD, who were subsequently diagnosed with CD and experienced regression of PNEEs on a gluten-free diet. Data from 12 patients undergoing neurological evaluation in 2019-2023 for ocular PNEEs were reviewed: 3 (25%) had a subsequent diagnosis of CD.

Conclusions: Ocular PNEEs could be a presenting manifestation of CD. In the diagnostic work-up of PNEEs, screening for CD could be included, both to avoid unnecessary tests and to promptly start a gluten-free diet, which might lead to a favorable clinical response.

导言:神经系统表现可能是乳糜泻(CD)的先兆。小儿发作性阵发性非癫痫事件(PNEEs)并不包括在其中:我们报告了两名儿童的病例,他们在出现眼部 PNEEs 的同时伴有可诱发 CD 的轻微症状,随后被诊断为 CD,并在无麸质饮食后 PNEEs 消失。我们回顾了2019-2023年因眼部PNEE接受神经学评估的12名患者的数据:3人(25%)随后被诊断为CD:结论:眼部 PNEE 可能是 CD 的一种表现形式。在 PNEE 的诊断工作中,可纳入 CD 筛查,以避免不必要的检查,并及时开始无麸质饮食,这可能会带来良好的临床反应。
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引用次数: 0
Management of pediatric ankle fractures: comparison of biodegradable PLGA implants with traditional metal screws. 小儿踝关节骨折的治疗:生物可降解聚乳酸(PLGA)植入物与传统金属螺钉的比较。
IF 2.1 3区 医学 Q2 PEDIATRICS Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI: 10.3389/fped.2024.1410750
Hermann Nudelman, Aba Lőrincz, Anna Gabriella Lamberti, Marcell Varga, Tamás Kassai, Gergő Józsa

Introduction: The relevance of biodegradable implants has gained more importance in modern clinical practice. The study aimed to evaluate the effects and outcomes of ankle fracture treatment with absorbable implants compared to metal screws. These implants are made from poly l-lactic-co-glycolic acid (PLGA), however, there are several other materials available on the market.

Methods: In a retrospective review, a total of 128 patients were under observation, with distal tibial fracture types ranging from Salter-Harris II-IV. In the absorbable group, patients were treated with the implants (n = 76). The metal group included patients treated with titanium or steel screws (n = 52). The extremities were placed in a cast for six weeks after surgery and were utilized for another 6-8 weeks. Patients were followed up for 12-30 months and were evaluated accordingly. The authors examined several aspects such as age, gender, open or closed repair, mechanism of injury, length of hospitalization, type of fracture, time of recovery, and complications.

Results: There were no statistically significant differences between the groups regarding demographic qualities, such as age, type of fracture, side of injury, and length of cast application (p > 0.05 in all cases). Out of 76 patients in the PLGA group, only two presented with complications, so reoperation took place. The rest healed without complications or refractures. Two of those treated with metal screws (n = 52) had minor, and four had major complications with reoperation.

Discussion: In pediatric cases, PLGA implants may present excellent results for treating ankle fractures. They do not disturb the growth plate and do not require reoperation. For this reason, they reduce the burden on the patient and the healthcare provider while simultaneously decreasing the risk of complications, such as infections or problems due to general anesthesia.

简介在现代临床实践中,生物可降解植入物的重要性日益凸显。本研究旨在评估与金属螺钉相比,使用可吸收植入物治疗踝关节骨折的效果和结果。这些植入物由聚 l-乳酸-聚乙二醇酸(PLGA)制成,但市场上也有其他几种材料可供选择:在一项回顾性研究中,共观察了 128 例胫骨远端骨折患者,其骨折类型从 Salter-Harris II 到 IV 不等。在可吸收组中,患者接受了植入物治疗(n = 76)。金属组包括使用钛或钢螺钉治疗的患者(n = 52)。术后肢体石膏固定 6 周,再使用 6-8 周。对患者进行了 12-30 个月的随访和相应的评估。作者从年龄、性别、开放或闭合修复、损伤机制、住院时间、骨折类型、恢复时间和并发症等几个方面进行了研究:结果:在年龄、骨折类型、受伤侧和石膏使用时间等人口统计学特征方面,各组之间没有明显差异(所有情况下,P>0.05)。在 PLGA 组的 76 名患者中,只有两人出现了并发症,因此进行了再次手术。其余患者均痊愈,未出现并发症或骨折。使用金属螺钉治疗的患者(52 人)中,2 人出现轻微并发症,4 人出现严重并发症,需要再次手术:讨论:在儿科病例中,PLGA植入物治疗踝关节骨折效果极佳。讨论:在小儿病例中,PLGA 植入物在治疗踝关节骨折方面效果极佳。因此,PLGA植入物可减轻患者和医护人员的负担,同时降低并发症的风险,如感染或全身麻醉引起的问题。
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引用次数: 0
Erratum: Creating a community advisory board for pediatric bladder health. 勘误:创建儿科膀胱健康社区咨询委员会。
IF 2.1 3区 医学 Q2 PEDIATRICS Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI: 10.3389/fped.2024.1514789

[This corrects the article DOI: 10.3389/fped.2024.1396003.].

[This corrects the article DOI: 10.3389/fped.2024.1396003.].
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引用次数: 0
Call the experts: identifying stakeholders in the long-term care of youth with hypospadias. 召集专家:确定尿道下裂青少年长期护理的利益相关者。
IF 2.1 3区 医学 Q2 PEDIATRICS Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI: 10.3389/fped.2024.1445205
Vinaya P Bhatia, Kristin Ebert, Shannon Cannon, Walid A Farhat, Heidi W Brown, Jane Mahoney, Marisa E Hilliard, Kristina L Penniston

Long-term follow-up for individuals with hypospadias remains a critical area of need, yet evidence-based guidelines for such follow-up are lacking, and the role of involvement of relevant experts is not yet established. Using our hypospadias-specific health-related quality of life conceptual framework and a subsequent qualitative study of prepubertal males and parents of males with hypospadias, we identified potential priorities for long-term follow-up of youth with hypospadias. Using thematic codes from our patient and parent interviews, we searched PubMed for relevant articles and identified the specialties represented by all the authors of these articles. Our search strategy revealed consistent expertise across HRQOL themes and subthemes, including pediatric and adult urology, health psychology, psychiatry, endocrinology, genetics, and social work. Communication experts, as well as patients and families, were also represented in our literature search. Using these findings, we compiled a comprehensive list of potential stakeholders to inform the development of holistic care guidelines for individuals with hypospadias. By engaging these stakeholders, we aim to develop consensus-based, long-term follow-up guidelines and tools to address the evolving physical and psychosocial needs of people with hypospadias over a lifetime. The use of qualitatively derived thematic codes to search for relevant literature is an accessible approach to identifying relevant stakeholders. These findings underscore the importance of involving diverse, multidisciplinary expertise to ensure comprehensive, patient-centered care in complex genitourinary conditions.

尿道下裂患者的长期随访仍是一个亟待解决的问题,但目前尚缺乏以证据为基础的随访指南,相关专家的参与作用也尚未确立。我们利用尿道下裂特有的健康相关生活质量概念框架以及随后对青春期前男性和尿道下裂男性家长进行的定性研究,确定了尿道下裂青少年长期随访的潜在优先事项。利用患者和家长访谈中的主题代码,我们在 PubMed 上搜索了相关文章,并确定了这些文章的所有作者所代表的专业。我们的搜索策略显示,在 HRQOL 主题和次主题方面,包括小儿和成人泌尿科、健康心理学、精神病学、内分泌学、遗传学和社会工作在内的专业知识是一致的。在我们的文献检索中,也有沟通专家以及患者和家属的身影。利用这些研究结果,我们编制了一份潜在利益相关者的综合名单,以便为尿道下裂患者制定整体护理指南提供信息。通过让这些利益相关者参与进来,我们旨在制定基于共识的长期随访指南和工具,以满足尿道下裂患者一生中不断变化的生理和心理需求。使用定性得出的主题代码搜索相关文献是识别相关利益方的一种简便方法。这些发现强调了让不同的多学科专业人员参与进来的重要性,以确保为复杂的泌尿生殖系统疾病患者提供全面的、以患者为中心的护理。
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引用次数: 0
Primary scrotal lipoma in a child: a rare case report and review of literature. 儿童原发性阴囊脂肪瘤:罕见病例报告和文献综述。
IF 2.1 3区 医学 Q2 PEDIATRICS Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI: 10.3389/fped.2024.1360943
Meng Kong, Yuexia Bai, Jinhua Jia, Chuanyang Liu, Shisong Zhang

Lipoma is a common benign tumor of the body surface, while scrotal lipoma is relatively rare. We report a case of scrotal lipoma in a 5-year-old boy, which presented as a progressively enlarging scrotal mass. Scrotal ultrasonography highly suggested a lipoma, and a scrotal mass resection was performed, leading to a final pathological diagnosis of benign scrotal lipoma.

脂肪瘤是一种常见的体表良性肿瘤,而阴囊脂肪瘤则相对罕见。我们报告了一例 5 岁男孩的阴囊脂肪瘤病例,患者表现为逐渐增大的阴囊肿块。阴囊超声波检查高度提示为脂肪瘤,并进行了阴囊肿块切除术,最终病理诊断为良性阴囊脂肪瘤。
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引用次数: 0
Acute pediatric appendicitis in black and white: clinical disparities, impact and future recommendations. 黑人和白人的急性小儿阑尾炎:临床差异、影响和未来建议。
IF 2.1 3区 医学 Q2 PEDIATRICS Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI: 10.3389/fped.2024.1453927
Aimen Waqar Khan, Marrium Sultan Dar, Rayyan Nabi, Ahmad Ali, Muhammad Abdullah Humayun, Eman Riaz

Racial and ethnic disparities have long been studied in the delivery of healthcare. One such avenue is acute pediatric appendicitis, which continues to be an area of significant and continual research. Because of its routine clinical presentation and standardized management, acute pediatric appendicitis serves as an appropriate proxy for studying discrepancies in healthcare. Our review therefore aims to comprehensively highlight the various dimensions of its clinical management subject to disparities, their collective clinical impact, and future recommendations to mitigate it.

长期以来,人们一直在研究医疗服务中的种族和民族差异。急性小儿阑尾炎就是其中之一,它仍然是一个重要的持续研究领域。由于其常规的临床表现和标准化的管理,急性小儿阑尾炎是研究医疗保健差异的一个合适的代表。因此,我们的综述旨在全面强调其临床管理中存在差异的各个层面、它们对临床的集体影响以及未来缩小差距的建议。
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引用次数: 0
A systematic review of surgical and interventional radiology procedures for pediatric idiopathic intracranial hypertension. 小儿特发性颅内高压手术和介入放射学程序的系统回顾。
IF 2.1 3区 医学 Q2 PEDIATRICS Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI: 10.3389/fped.2024.1466688
Sofia Friso, Vittoria Giacobbo, Luca Mattia Toscano, Beatrice Baldo, Chiara Guariento, Fabrizio Lacarra, Jacopo Norberto Pin, Claudio Ancona, Stefano Sartori, Francesco Causin, Irene Toldo

Background: Idiopathic intracranial hypertension (IIH) is defined as elevated intracranial pressure and consequent symptoms (mainly headache and visual deterioration) occurring in the absence of secondary causes. Surgical and interventional radiology procedures should be considered for refractory IIH and mainly include cerebrospinal fluid (CSF) diversion techniques, optic nerve sheath fenestration (ONSF), and venous sinus stenting (VSS). Our study aims to review the current literature on the application of these techniques in clinical practice.

Methods: A systematic literature review on the surgical and interventional radiology treatment of IIH was conducted, focusing on ONSF, VSS, and CSF diversion techniques. According to PRISMA guidelines, all reports published in PubMed in the last 30 years (1993-2023) were considered, and among 722 papers, 48 were included in the present study, resulting in a total study population of 454 children or adolescents (11 months-17 years old).

Results: Among 454 patients, 193 underwent an invasive approach, divided into CSF diversion (115/193), ONSF (65/193), VSS (11/193), cranial subtemporal decompression (8/193), and internal cranial expansion (9/193). Sixteen of the 193 patients (8%) required reintervention due to relapsing symptoms or surgical complications, particularly those who underwent CSF diversion. Furthermore, 9/115 required shunt revision due to shunt obstruction or malfunction. We extracted data on the outcome of each procedure: of the 193 patients, 71 experienced a positive outcome with symptom resolution or improvement, while 27 demonstrated a negative outcome.

Discussion and conclusions: Severe and refractory cases of IIH are eligible for invasive treatments. CSF diversion is the most frequently used technique, despite its high failure risk and need for reintervention. ONSF has shown good results in terms of outcome and safety, particularly in children with visual symptoms. VSS is the most recent approach, indicated in children with stenosis of the venous sinus. In our study population, VSS demonstrated good results in terms of symptom resolution and need for reintervention, but its use remains limited to a few centers.

Systematic review registration: https://www.crd.york.ac.uk/, PROSPERO (CRD42024504244).

背景:特发性颅内高压(IIH)是指在无继发性病因的情况下出现的颅内压升高及随之而来的症状(主要是头痛和视力下降)。难治性 IIH 应考虑手术和介入放射学治疗,主要包括脑脊液(CSF)引流技术、视神经鞘开孔术(ONSF)和静脉窦支架植入术(VSS)。我们的研究旨在回顾这些技术在临床实践中应用的现有文献:方法:我们对 IIH 的手术和介入放射学治疗进行了系统性文献综述,重点关注 ONSF、VSS 和 CSF 分流技术。根据PRISMA指南,考虑了过去30年(1993-2023年)发表在PubMed上的所有报告,在722篇论文中,有48篇被纳入本研究,研究对象为454名儿童或青少年(11个月-17岁):在454名患者中,有193名接受了侵入性方法治疗,分为脑脊液转移术(115/193)、脑脊液外流术(65/193)、VSS(11/193)、颅颞下减压术(8/193)和颅内扩张术(9/193)。193 名患者中有 16 人(8%)因症状复发或手术并发症而需要再次手术,尤其是那些接受脑脊液转流手术的患者。此外,9/115 的患者因分流管阻塞或故障而需要进行分流管翻修。我们提取了每次手术的结果数据:在193名患者中,有71人获得了症状缓解或改善的积极结果,有27人获得了消极结果:严重和难治性 IIH 病例可接受侵入性治疗。脑脊液引流术是最常用的技术,尽管其失败风险高且需要再次介入。ONSF在治疗效果和安全性方面都取得了良好的效果,尤其是对有视觉症状的儿童。VSS 是最新的方法,适用于静脉窦狭窄的儿童。在我们的研究人群中,VSS在症状缓解和再干预需求方面显示出良好的效果,但其使用仍仅限于少数几个中心。系统综述注册:https://www.crd.york.ac.uk/,PROSPERO (CRD42024504244)。
{"title":"A systematic review of surgical and interventional radiology procedures for pediatric idiopathic intracranial hypertension.","authors":"Sofia Friso, Vittoria Giacobbo, Luca Mattia Toscano, Beatrice Baldo, Chiara Guariento, Fabrizio Lacarra, Jacopo Norberto Pin, Claudio Ancona, Stefano Sartori, Francesco Causin, Irene Toldo","doi":"10.3389/fped.2024.1466688","DOIUrl":"10.3389/fped.2024.1466688","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic intracranial hypertension (IIH) is defined as elevated intracranial pressure and consequent symptoms (mainly headache and visual deterioration) occurring in the absence of secondary causes. Surgical and interventional radiology procedures should be considered for refractory IIH and mainly include cerebrospinal fluid (CSF) diversion techniques, optic nerve sheath fenestration (ONSF), and venous sinus stenting (VSS). Our study aims to review the current literature on the application of these techniques in clinical practice.</p><p><strong>Methods: </strong>A systematic literature review on the surgical and interventional radiology treatment of IIH was conducted, focusing on ONSF, VSS, and CSF diversion techniques. According to PRISMA guidelines, all reports published in PubMed in the last 30 years (1993-2023) were considered, and among 722 papers, 48 were included in the present study, resulting in a total study population of 454 children or adolescents (11 months-17 years old).</p><p><strong>Results: </strong>Among 454 patients, 193 underwent an invasive approach, divided into CSF diversion (115/193), ONSF (65/193), VSS (11/193), cranial subtemporal decompression (8/193), and internal cranial expansion (9/193). Sixteen of the 193 patients (8%) required reintervention due to relapsing symptoms or surgical complications, particularly those who underwent CSF diversion. Furthermore, 9/115 required shunt revision due to shunt obstruction or malfunction. We extracted data on the outcome of each procedure: of the 193 patients, 71 experienced a positive outcome with symptom resolution or improvement, while 27 demonstrated a negative outcome.</p><p><strong>Discussion and conclusions: </strong>Severe and refractory cases of IIH are eligible for invasive treatments. CSF diversion is the most frequently used technique, despite its high failure risk and need for reintervention. ONSF has shown good results in terms of outcome and safety, particularly in children with visual symptoms. VSS is the most recent approach, indicated in children with stenosis of the venous sinus. In our study population, VSS demonstrated good results in terms of symptom resolution and need for reintervention, but its use remains limited to a few centers.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/, PROSPERO (CRD42024504244).</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"12 ","pages":"1466688"},"PeriodicalIF":2.1,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A national survey of first line antibiotic use in neonatal units - and the potential scope for iatrogenic sensorineural hearing loss prevention. 新生儿病房一线抗生素使用情况全国调查--以及预防先天性感音神经性听力损失的潜在范围。
IF 2.1 3区 医学 Q2 PEDIATRICS Pub Date : 2024-10-29 eCollection Date: 2024-01-01 DOI: 10.3389/fped.2024.1471463
J Peterson, L Muddiman, F Groves, N Booth, W G Newman, J H McDermott, A Mahaveer

Objective: National Institute for Clinical Excellence (NICE) guidance for the management of neonatal sepsis recommends a first-line antibiotic regimen containing an aminoglycoside (gentamicin). Aminoglycoside exposure causes sensorineural hearing loss in individuals with a specific mitochondrial genetic variant (m.1555A>G). This variant can be detected promptly (in <30 min) by a point of care test. NICE does allow for variation in antibiotic regimes depending on local microbiology guidance. As practices can vary, this survey aimed to determine the current use of first-line antibiotic agents within neonatal units and postnatal wards across the UK.

Design and setting: A telephone survey was conducted across all neonatal units in the United Kingdom. Responses were requested from a member of the neonatal team experienced in neonatal septic screening processes. One response was recorded per unit.

Results: Of the 187 neonatal units, 186 (99%) responded to the survey. One unit declined to participate. The survey results show most neonatal units (93%) and postnatal wards (74%) across the United Kingdom use aminoglycosides as first-line antibiotic agents. Antibiotic regimes varied between different units and between different locations within the same hospital (NICU vs. postnatal wards). In cases where there was a contraindication to aminoglycosides, the most common alternative antibiotic was cefotaxime.

Conclusions: Most neonatal units in the UK use an aminoglycoside antibiotic as first-line agent for suspected sepsis. This places infants with the m.1555A>G genetic variant at risk of iatrogenic hearing loss. There needs to be integration of point-of-care genetic testing within the neonatal septic screening pathway.

目的:美国国家临床优化研究所(NICE)关于新生儿败血症治疗的指导建议采用含有氨基糖苷(庆大霉素)的一线抗生素治疗方案。接触氨基糖苷类药物会导致具有特定线粒体基因变异(m.1555A>G)的个体出现感音神经性听力损失。这种变异可被及时发现(在设计和环境中):对英国所有新生儿科室进行了电话调查。要求一名在新生儿败血症筛查过程中经验丰富的新生儿团队成员进行回复。每个单位记录一个回复:结果:在 187 个新生儿科室中,有 186 个(99%)对调查做出了回复。一个单位拒绝参与。调查结果显示,英国大部分新生儿科室(93%)和产后病房(74%)将氨基糖苷类药物作为一线抗生素。不同单位和同一医院不同地点(新生儿重症监护室与产后病房)的抗生素方案各不相同。在禁用氨基糖苷类药物的情况下,最常用的替代抗生素是头孢他啶:结论:英国大多数新生儿科室将氨基糖苷类抗生素作为治疗疑似败血症的一线药物。这使得m.1555A>G基因变异的婴儿面临先天性听力损失的风险。在新生儿败血症筛查过程中,需要整合护理点基因检测。
{"title":"A national survey of first line antibiotic use in neonatal units - and the potential scope for iatrogenic sensorineural hearing loss prevention.","authors":"J Peterson, L Muddiman, F Groves, N Booth, W G Newman, J H McDermott, A Mahaveer","doi":"10.3389/fped.2024.1471463","DOIUrl":"https://doi.org/10.3389/fped.2024.1471463","url":null,"abstract":"<p><strong>Objective: </strong>National Institute for Clinical Excellence (NICE) guidance for the management of neonatal sepsis recommends a first-line antibiotic regimen containing an aminoglycoside (gentamicin). Aminoglycoside exposure causes sensorineural hearing loss in individuals with a specific mitochondrial genetic variant (m.1555A>G). This variant can be detected promptly (in <30 min) by a point of care test. NICE does allow for variation in antibiotic regimes depending on local microbiology guidance. As practices can vary, this survey aimed to determine the current use of first-line antibiotic agents within neonatal units and postnatal wards across the UK.</p><p><strong>Design and setting: </strong>A telephone survey was conducted across all neonatal units in the United Kingdom. Responses were requested from a member of the neonatal team experienced in neonatal septic screening processes. One response was recorded per unit.</p><p><strong>Results: </strong>Of the 187 neonatal units, 186 (99%) responded to the survey. One unit declined to participate. The survey results show most neonatal units (93%) and postnatal wards (74%) across the United Kingdom use aminoglycosides as first-line antibiotic agents. Antibiotic regimes varied between different units and between different locations within the same hospital (NICU vs. postnatal wards). In cases where there was a contraindication to aminoglycosides, the most common alternative antibiotic was cefotaxime.</p><p><strong>Conclusions: </strong>Most neonatal units in the UK use an aminoglycoside antibiotic as first-line agent for suspected sepsis. This places infants with the m.1555A>G genetic variant at risk of iatrogenic hearing loss. There needs to be integration of point-of-care genetic testing within the neonatal septic screening pathway.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"12 ","pages":"1471463"},"PeriodicalIF":2.1,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive modeling of bronchopulmonary dysplasia in premature infants: the impact of new diagnostic standards. 早产儿支气管肺发育不良的预测模型:新诊断标准的影响。
IF 2.1 3区 医学 Q2 PEDIATRICS Pub Date : 2024-10-29 eCollection Date: 2024-01-01 DOI: 10.3389/fped.2024.1434823
Lijun Tang, Weibin Wu, Weimin Huang, Guangliang Bi

Aim: To provide a risk prediction for bronchopulmonary dysplasia (BPD) in premature infants under the new diagnostic criteria and establish a prediction model.

Methods: In this study, we retrospectively collected case data on preterm infants admitted to the NICU from August 2015 to August 2018. A lasso analysis was performed to identify the risk factors associated with the development of BPD. A nomogram predictive model was constructed in accordance with the new diagnostic criteria for BPD.

Result: A total of 276 preterm infants were included in the study.The incidence of BPD under the 2018 diagnostic criteria was 11.2%. Mortality was significantly higher in the BPD group than the non-BPD group under the 2018 diagnostic criteria (P < 0.05). Fourteen possible variables were selected by the Lasso method, with a penalty coefficient λ=0.0154. The factors that eventually entered the logistic regression model included birth weight [BW, OR = 0.9945, 95% CI: 0.9904-0.9979], resuscitation way (OR = 4.8249, 95% CI: 1.3990-19.4752), intrauterine distress (OR = 8.0586, 95% CI: 1.7810-39.5696), score for SNAPPE-II (OR = 1.0880, 95% CI: 1.0210-1.1639), hematocrit (OR = 1.1554, 95% CI: 1.0469-1.2751) and apnea (OR = 7.6916, 95% CI: 1.4180-52.1236). The C-index after adjusting for fitting deviation was 0.894.

Conclusion: This study made a preliminary exploration of the risk model for early prediction of BPD and indicated good discrimination and calibration in premature infants.

目的:根据新的诊断标准对早产儿支气管肺发育不良(BPD)进行风险预测,并建立预测模型:在这项研究中,我们回顾性地收集了2015年8月至2018年8月期间NICU收治的早产儿病例数据。我们进行了拉索分析,以确定与 BPD 发生相关的风险因素。根据BPD的新诊断标准,构建了一个提名图预测模型:根据2018年的诊断标准,BPD的发生率为11.2%。根据2018年诊断标准,BPD组死亡率明显高于非BPD组(Pλ=0.0154。最终进入逻辑回归模型的因素包括出生体重[BW,OR = 0.9945,95% CI:0.9904-0.9979]、复苏方式(OR = 4.8249,95% CI:1.3990-19.4752)、宫内窘迫(OR = 8.0586,95% CI:1.7810-39.5696)、SNAPPE-II 评分(OR = 1.0880,95% CI:1.0210-1.1639)、血细胞比容(OR = 1.1554,95% CI:1.0469-1.2751)和呼吸暂停(OR = 7.6916,95% CI:1.4180-52.1236)。调整拟合偏差后的 C 指数为 0.894:本研究对早期预测 BPD 的风险模型进行了初步探索,结果表明该模型在早产儿中具有良好的区分度和校准性。
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引用次数: 0
Relationship between thyroid function and lipid atherogenic profile in pediatric patients with multisystem inflammatory syndrome associated with COVID-19. 与COVID-19相关的多系统炎症综合征儿科患者的甲状腺功能与血脂动脉粥样硬化之间的关系。
IF 2.1 3区 医学 Q2 PEDIATRICS Pub Date : 2024-10-29 eCollection Date: 2024-01-01 DOI: 10.3389/fped.2024.1456545
Valeria Calcaterra, Raffaella De Santis, Davide Braghieri, Sara Zanelli, Gianvincenzo Zuccotti

Introduction: Concurrent alterations in the metabolic profile and thyroid dysfunction, including non-thyroidal illness syndrome (NTIS) has been reported in multisystem inflammatory syndrome in children (MIS-C). Considering the influence of thyroid hormones (TH) on lipid metabolism, we explored the relationship between thyroid function and the atherogenic lipid profile in children with MIS-C at admission and during a 12-month follow-up.

Patients and methods: we considered children admitted for MIS-C. Total and HDL cholesterol, triglycerides (TG), fasting plasma glucose, fasting plasma insulin as well as free T3 (FT3), free T4 (FT4), and TSH were assessed at diagnosis within 24 h of admission and during follow-up. TG/HDL ratio, no-HDL/HDL ratio and atherogenic index of plasma was also considered as atherogenic risk markers.

Results: we monitored 56 children. On admission, pathological levels of FT3, FT4, TSH, TG, TC, HDL, TG/HDL ratio, no-HDL/HDL ratio, and AIP were detected. Correlation analyses revealed associations between FT3, FT4, and lipid markers and TSH with TG. During monitoring, while complete restoration of TH balance was achieved at 12 months, some patients still exhibited an altered lipid profile, without correlation between thyroid function and lipid markers.

Conclusions: we supported a relationship between thyroid function and an atherogenic lipid profile in children with MIS-C. This may result from interactions between adaptive and innate metabolic responses and genetic predisposition. Elucidating the relationship between TH and metabolic pathways during infections could help identify new biomarkers to prevent acute and fatal outcomes, improving patient prognosis and protecting long-term health.

简介有报道称,儿童多系统炎症综合征(MIS-C)患者的代谢特征与甲状腺功能障碍(包括非甲状腺疾病综合征(NTIS))同时发生改变。考虑到甲状腺激素(TH)对脂质代谢的影响,我们探讨了儿童多系统炎症综合征(MIS-C)患者在入院时和 12 个月随访期间甲状腺功能与致动脉粥样硬化脂质谱之间的关系。总胆固醇和高密度脂蛋白胆固醇、甘油三酯(TG)、空腹血浆葡萄糖、空腹血浆胰岛素以及游离 T3(FT3)、游离 T4(FT4)和促甲状腺激素均在入院诊断时、入院后 24 小时内和随访期间进行了评估。TG/HDL比率、无HDL/HDL比率和血浆致动脉粥样硬化指数也被视为致动脉粥样硬化风险标志物。入院时,FT3、FT4、TSH、TG、TC、HDL、TG/HDL 比值、no-HDL/HDL 比值和 AIP 均达到病理水平。相关分析显示,FT3、FT4 和血脂指标之间存在关联,TSH 和 TG 之间存在关联。在监测过程中,虽然12个月时TH平衡已完全恢复,但一些患者仍表现出血脂改变,甲状腺功能和血脂指标之间没有相关性。结论:我们证实了甲状腺功能与MIS-C患儿的致动脉粥样硬化血脂谱之间的关系,这可能是适应性和先天性代谢反应以及遗传易感性之间相互作用的结果。阐明感染期间甲状腺激素与代谢途径之间的关系有助于确定新的生物标志物,从而预防急性和致命性后果,改善患者预后并保护长期健康。
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引用次数: 0
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