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Proceedings. 1998 IEEE International Conference on Information Technology Applications in Biomedicine, ITAB '98 (Cat. No.98EX188)最新文献

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Telemedicine: Information Can Help Cure 远程医疗:信息可以帮助治疗
M. Ackerman
Telemedicine is the use of telecommunications and computers for information to support medical decision making, signal processing, and the arrangements to practice medicine at a distance. The u m q t encompasses everythmg from the use of standard telephone service to high speed, wide bandwidth transrms * sion of digitized signals in conjunction with computers, fiber optics, satellites, and other sophisticated peripheral equipment and software. The growth of the National Informaton Infkastructure and the increasing access to highspeed computers and communications by co~~sumefs, health care providers, public health professionals, and basic, clinical, and health services researchers will have a i ” e n d effect on health and human seMces throughout the nation and the world. The major research and evaluation issues, of interest to NLM, arising tiom the current and future application of this technology include: the impact of telemedicine on the health care system as a whole and on cost, quality, and access to m e for specific populations; 0 the benefits of integrated access to practice guidelines, expert systems, bibliographic databases, electronic publications, and other knowledge-based informaiion from within computer-based patient record systems and other automated systems that suppoa research and practice; the maintenance of patient confidentiality as increasing amounts of electronic health data are transmitted via telecommunications during health care and aggregated for important public health and research purposes; and the development of data standards and d o r m practices for effective transmission, aggregation, and integration of health care, public health, and research data. The National Library of Medicine is sponsoring projects which evaluate the impact of the National I&ormation In fkas t~~cm on health care, research, and public heal^, test methods to preserve the privacy of individual health data while also providhg efficient access for legitjmate health care, research, and public health purposes; and assess the utility of emerging health data standards in health applications of advanced communications and computing technologies.
远程医疗是利用电信和计算机获取信息来支持医疗决策、信号处理和安排远距离行医。它包括从标准电话服务的使用到与计算机、光纤、卫星和其他复杂的外围设备和软件相结合的数字化信号的高速、宽带宽传输。国家信息基础设施的发展和高速计算机的日益普及,以及医疗服务提供者、公共卫生专业人员、基础、临床和卫生服务研究人员对高速计算机和通信的日益普及,将对全国乃至全世界的健康和人类活动产生深远的影响。NLM感兴趣的主要研究和评估问题包括:远程医疗对整个卫生保健系统的影响,以及对特定人群的成本、质量和获得医疗服务的影响;从基于计算机的患者记录系统和其他支持研究和实践的自动化系统中综合获取实践指南、专家系统、书目数据库、电子出版物和其他基于知识的信息的好处;在保健期间通过电信传输越来越多的电子健康数据,并将其汇总用于重要的公共卫生和研究目的,因此维护患者的机密性;制定数据标准和数据管理实践,以便有效地传输、汇总和整合医疗保健、公共卫生和研究数据。国家医学图书馆正在赞助一些项目,评估国家信息数据库对卫生保健、研究和公众健康的影响,测试保护个人健康数据隐私的方法,同时也为合法的卫生保健、研究和公共卫生目的提供有效的访问;并评估新兴卫生数据标准在先进通信和计算技术的卫生应用中的效用。
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引用次数: 0
Extraction and characterization of regions of interest in biomedical images 生物医学图像中感兴趣区域的提取和表征
Y. Keselman, E. Micheli-Tzanakou
A system that could serve as a first stage of a two stage automated biomedical image classification system is presented. The underlying image segmentation algorithm and several region representations are discussed. Examples are given of extracted (robustly and quickly) regions which show flexibility and potential of the approach.
提出了一种可作为两阶段生物医学图像自动分类系统第一阶段的系统。讨论了基本的图像分割算法和几种区域表示。给出了鲁棒性和快速提取区域的实例,显示了该方法的灵活性和潜力。
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引用次数: 6
Digital Libraries In Medicine 医学领域的数字图书馆
P. Dev, P. R. Hubbs, P.J. Godin, M. Tsai, W. Wood, P. Youngblood, T. Rindfleisch, K.L. Mehnon
The rapid rate of change of medical knowledge, as well as the need for maintained certification, make continuing medical education a requirement for all physicians. The changes in health care management place increased decision-making in the hands of primary care physicians, with correspondingly increased need for current medical information. With these information and learning needs in mind, we have designed and implemented SHINE, Stanford Health Information Network for Education, a digital library and learning resource for primary care physicians. The architecture of the system assumes a federation of knowledge bases, a single Web-based query interface, middleware to translate between the query and the knowledge bases, and auxiliary services such as a thesaurus, a log and a notebook. The system has been deployed for use by physicians and medical students. The system architecture, design choices and initial results of evaluation will be presented.
医学知识的快速变化,以及对持续认证的需求,使得继续医学教育成为所有医生的一项要求。卫生保健管理的变化增加了初级保健医生手中的决策权,相应地增加了对当前医疗信息的需求。考虑到这些信息和学习需求,我们设计并实施了SHINE,斯坦福健康教育信息网络,这是一个面向初级保健医生的数字图书馆和学习资源。该系统的体系结构假定了一个知识库联盟、一个基于web的查询接口、用于在查询和知识库之间进行转换的中间件,以及辅助服务,如同义词库、日志和笔记本。该系统已被部署供医生和医学生使用。将介绍系统架构、设计选择和初步评估结果。
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引用次数: 7
Ventricular tachycardia in a parallel processing environment 平行处理环境下的室性心动过速
J. Hsieh, W. Craelius
A one dimensional ring of cardiac tissue was modeled on parallel processors in order to investigate double wave reentry (DWR). The ring contained 1600 Beeler-Reuter cells, coupled by resistive gaps. The conditions required for DWR were studied using S1-S4 programmed stimulation. The results indicated the following: (1) A vulnerable window for DWR can be opened by S3, after wave collision is induced in the ring. Located between the points of collision and stimulation, the window is open for several milliseconds following S3. (2) Acceleration of tachycardia beyond DWR can be accomplished by adding a third reentrant wave in the same circuit, with the S3-S4 pacing protocol and sufficient substrate values. The number of reentrant waves and the degree of acceleration are limited only by the ratio of action potential duration to excitable gap.
为了研究心脏组织的双波再入(DWR)问题,在并行处理器上建立了一维心脏组织环的模型。该环包含1600个比勒-罗伊特细胞,由电阻隙连接。采用S1-S4程控增产技术研究了DWR所需条件。结果表明:(1)在环内诱导波碰撞后,S3可以打开DWR的脆弱窗口。该窗口位于碰撞点和刺激点之间,在S3之后打开几毫秒。(2)使用S3-S4起搏协议和足够的衬底值,可以通过在同一电路中添加第三个重入波来实现超过DWR的心动过速加速。重入波数和加速程度仅受动作电位持续时间与可激发间隙之比的限制。
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引用次数: 0
Fractals for hybrid orbitals in protein models 蛋白质模型中杂化轨道的分形
Francisco Torrens, J. Sánchez-Marín, I. Nebot-Gil
The concept of fractal has been applied to a number of properties of proteins. The structure and shape of the polypeptide chain of proteins are determined by the hybridized states of atomic orbitals in the molecular chain. The fractal dimension in the range of short distances (1-10 /spl Aring/) of the tertiary structures of some proteins covering various structural classes of protein molecules have been analyzed and compared with a Gaussian chain. The interpretation is given in terms of steric repulsion. The calculated s ratio in the sp/sup n/ hybrid orbitals is computed from the fractal dimension. A mean value of about 0.29 predicts sp/sup 2.46/ hybrid orbitals, half-way between planar sp/sup 2/ orbitals and tetrahedral sp/sup 3/ hydrids. The /spl beta/ proteins are distinguished quantitatively from other classes. They show a higher s ratio (about 0.32) which predicts about sp/sup 2.1/ hybrid orbitals, very similar to planar sp/sup 2/ orbitals.
分形的概念已被应用于蛋白质的许多性质。蛋白质多肽链的结构和形状是由分子链中原子轨道的杂化状态决定的。本文用高斯链分析了几种不同结构类别的蛋白质的三级结构在短距离范围内(1-10 /spl ing/)的分形维数。用空间排斥力给出了解释。根据分形维数计算sp/sup n/杂化轨道的s比。平均值约为0.29,预测sp/sup 2.46/杂化轨道,介于平面sp/sup 2/轨道和四面体sp/sup 3/氢化物之间。/spl β /蛋白在数量上区别于其他种类。它们显示出较高的s比(约0.32),这预示着sp/sup 2.1/杂化轨道,与平面sp/sup 2/轨道非常相似。
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引用次数: 14
VRML-based anatomical teaching (VAT): work in progress 基于vrml的解剖学教学(VAT):工作正在进行中
P. Warrick, W. Funnell
The VAT project is a continuation of the development of a VRML based anatomical visualization tool for medical education. Previous work created static VRML 1.0 models for various anatomical structures. The intent now is to extend the capabilities of the tool using the dynamic features of the new VRML 2.0 standard. The article describes ways that the new VRML 2.0 functionality can be used in teaching, and presents the strands of development that will be required for their implementation.
VAT项目是基于VRML的医学教育解剖可视化工具开发的延续。之前的工作为各种解剖结构创建了静态VRML 1.0模型。现在的目的是使用新的VRML 2.0标准的动态特性扩展该工具的功能。本文描述了在教学中使用新的VRML 2.0功能的方法,并介绍了实现这些功能所需的开发流程。
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引用次数: 2
High Performance Computing In Molecular Biology 分子生物学中的高性能计算
J. Maizel
Sequences of DNA and RNA make up the genomes of organisms. As sequences accumulate we see an increasing role for computation in utilizing this data for a deeper understanding of all living things. The genomic era started with the revelation that the arrangement of four chemical subunits of nucleic acids in long sequences gave the information for the sequential arrangement of the 20 chemical subunits of proteins. As complete genomes of many viruses, microbes and parts of higher organisms appear it is obvious that the even the human genome is likely to be determined in less than a decade. Computational challenges arise fkom our immediate need to understand not only the linear data of sequences but the 3dimensional constellations of atoms in the molecules that they represent. All biological bctions are expressed through a rich variety of molecular interactions. Enzymes perform catalytic roles by interacting with chemical bonds. Regulatory and structural functions are expressed through molecular associations generally involving non-covalent bonds. Consequently, knowledge of structures is vital to discerning functions. Increasingly powerful computers ' can simulate these properties, sometimes giving insight into details that are difficult to obtain experimentally. This paper addresses several immediate areas of opportunity for computation involving genomic data. Sequence data acquisition, storage, retrieval and analysis are areas of intense activity. These activities are oRen called bioinformatics. The employment sections of scientific journals reflect the need of industry and academia for computational people to be central players, along with experimentalists, in many projects. Another area involves the analysis of biophysical data fiom crystallography or spectroscopy to produce high resolution structural details. Coming fiom biophysical foundations scientists in this area embraced high performance computing before many others in the biological field. An area of even more intensive computational challenge is given by the availabjlity of high resolution structural data. Computation can add value through refinement and analysis. Even more tantalizing is the prospect. for the use of computers to explore and to discover the principles of macromolecular structure, which may then be used to derive rules for
DNA和RNA序列构成生物体的基因组。随着序列的积累,我们看到计算在利用这些数据更深入地了解所有生物方面的作用越来越大。基因组时代开始于这样的发现:核酸的4个化学亚基在长序列中的排列为蛋白质的20个化学亚基的顺序排列提供了信息。随着许多病毒、微生物和部分高等生物的完整基因组的出现,很明显,甚至人类基因组也可能在不到十年的时间内确定。我们不仅需要理解序列的线性数据,还需要理解它们所代表的分子中的原子的三维星群,这给计算带来了挑战。所有的生物行为都是通过丰富多样的分子相互作用来表达的。酶通过与化学键相互作用来发挥催化作用。调节和结构功能是通过通常涉及非共价键的分子结合来表达的。因此,结构知识对于辨别功能是至关重要的。越来越强大的计算机可以模拟这些特性,有时可以深入了解难以通过实验获得的细节。本文讨论了涉及基因组数据计算的几个直接领域的机会。序列数据的获取、存储、检索和分析是活跃的领域。这些活动被称为生物信息学。科学期刊的就业部分反映了工业界和学术界在许多项目中需要计算人员和实验人员一起成为核心参与者。另一个领域涉及从晶体学或光谱学中分析生物物理数据,以产生高分辨率的结构细节。来自生物物理基础的这一领域的科学家比其他生物领域的科学家更早地接受了高性能计算。高分辨率结构数据的可用性给计算带来了更大的挑战。计算可以通过细化和分析来增加价值。更诱人的是前景。使用计算机来探索和发现大分子结构的原理,然后可以用来推导出大分子结构的规则
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引用次数: 0
Distributed Object Technology Eor Health Care Information Management 分布式对象技术或医疗保健信息管理
Stephen T. C. Wong
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引用次数: 0
Concept based query of digital library objects 基于概念的数字图书馆对象查询
N. Adam, R. Holowczak
Research in digital libraries has many applications in the field of biomedical information. Our current research into the areas of concept extraction, indexing and searching in digital libraries has led to novel applications in information retrieval and indexing. We present an overview of our work and discuss future applications in biomedicine.
数字图书馆的研究在生物医学信息领域有着广泛的应用。我们目前对数字图书馆概念提取、索引和检索领域的研究已经在信息检索和索引方面带来了新的应用。我们介绍了我们的工作概况,并讨论了未来在生物医学上的应用。
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引用次数: 0
A high performance continuous data flow filter using sliding discrete Fourier transform (DFT) and one point inverse DFT 采用滑动离散傅立叶变换(DFT)和一点逆傅立叶变换的高性能连续数据流滤波器
Wen Zhuo, E. Micheli-Tzanakou
This paper presents a high performance frequency domain filter implementation for a moving window-type processing. The computational structure consists of three stages: a sliding discrete Fourier transform (SDFT) for a vectorized updating of the DFT; a frequency domain filter; and a one-point inverse discrete Fourier transform (IDFT). The total computation required for generating one filtered output point is 2/spl times/N multiplications (N is the frequency window length) and 3/spl times/N additions compared to 2/spl times/N/spl times/log/sub 2/N multiplications and additions if using FFT and IFFT. The proposed structure also has the advantage of being parallel in nature and can be used in various real-time frequency processing, continuous data flow, single or multiple channel applications.
本文提出了一种用于移动窗口型处理的高性能频域滤波器实现方法。计算结构包括三个阶段:滑动离散傅里叶变换(SDFT)对DFT进行矢量化更新;频域滤波器;和一点反离散傅里叶变换(IDFT)。生成一个滤波输出点所需的总计算量为2/spl次/N次乘法(N是频率窗长度)和3/spl次/N次加法,而如果使用FFT和IFFT,则为2/spl次/N/spl次/log/sub 2/N次乘法和加法。该结构还具有并行性的优点,可用于各种实时频率处理、连续数据流、单通道或多通道应用。
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引用次数: 3
期刊
Proceedings. 1998 IEEE International Conference on Information Technology Applications in Biomedicine, ITAB '98 (Cat. No.98EX188)
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