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MDM2 inhibitors in cancer immunotherapy: Current status and perspective 癌症免疫疗法中的 MDM2 抑制剂:现状与展望
IF 6.9 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-03-28 DOI: 10.1016/j.gendis.2024.101279

Murine double minute 2 (MDM2) plays an essential role in the cell cycle, apoptosis, DNA repair, and oncogene activation through p53-dependent and p53-independent signaling pathways. Several preclinical studies have shown that MDM2 is involved in tumor immune evasion. Therefore, MDM2-based regulation of tumor cell-intrinsic immunoregulation and the immune microenvironment has attracted increasing research attention. In recent years, immune checkpoint inhibitors targeting PD-1/PD-L1 have been widely used in the clinic. However, the effectiveness of a single agent is only approximately 20%–40%, which may be related to primary and secondary drug resistance caused by the dysregulation of oncoproteins. Here, we reviewed the role of MDM2 in regulating the immune microenvironment, tumor immune evasion, and hyperprogression during immunotherapy. In addition, we summarized preclinical and clinical findings on the use of MDM2 inhibitors in combination with immunotherapy in tumors with MDM2 overexpression or amplification. The results reveal that the inhibition of MDM2 could be a promising strategy for enhancing immunotherapy.

Murine double minute 2(MDM2)通过依赖 p53 和不依赖 p53 的信号通路,在细胞周期、细胞凋亡、DNA 修复和癌基因激活中发挥着重要作用。一些临床前研究表明,MDM2 参与了肿瘤免疫逃避。因此,基于MDM2对肿瘤细胞内在免疫调节和免疫微环境的调控引起了越来越多的研究关注。近年来,以PD-1/PD-L1为靶点的免疫检查点抑制剂已广泛应用于临床。然而,单药的有效率仅为20%-40%左右,这可能与肿瘤蛋白失调导致的原发性和继发性耐药有关。在此,我们回顾了 MDM2 在调节免疫微环境、肿瘤免疫逃避和免疫治疗过程中的过度进展中的作用。此外,我们还总结了在MDM2过表达或扩增的肿瘤中使用MDM2抑制剂联合免疫疗法的临床前和临床研究结果。研究结果表明,抑制MDM2可能是增强免疫疗法的一种有前途的策略。
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引用次数: 0
STIM1 promotes acquired resistance to sorafenib by attenuating ferroptosis in hepatocellular carcinoma STIM1 通过减弱肝细胞癌中的铁变态反应,促进对索拉非尼的获得性耐药性
IF 6.9 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-03-28 DOI: 10.1016/j.gendis.2024.101281

Dysregulated calcium (Ca2+) signaling pathways are associated with tumor cell death and drug resistance. In non-excitable cells, such as hepatocellular carcinoma (HCC) cells, the primary pathway for Ca2+ influx is through stromal interaction molecule 1 (STIM1)-mediated store-operated calcium entry (SOCE). Previous studies have demonstrated the involvement of STIM1-mediated SOCE in processes such as genesis, metastasis, and stem cell self-renewal of HCC. However, it remains unclear whether STIM1-mediated SOCE plays a role in developing acquired resistance to sorafenib in HCC patients. In this study, we established acquired sorafenib-resistant (SR) HCC cell lines by intermittently exposing them to increasing concentrations of sorafenib. Our results showed higher levels of STIM1 and stronger SOCE in SR cells compared with parental cells. Deleting STIM1 significantly enhanced sensitivity to sorafenib in SR cells, while overexpressing STIM1 promoted SR by activating SOCE. Mechanistically, STIM1 increased the transcription of SLC7A11 through the SOCE-CaN-NFAT pathway. Subsequently, up-regulated SLC7A11 increased glutathione synthesis, resulting in ferroptosis insensitivity and SR. Furthermore, combining the SOCE inhibitor SKF96365 with sorafenib significantly improved the sensitivity of SR cells to sorafenib both in vitro and in vivo. These findings suggest a potential strategy to overcome acquired resistance to sorafenib in HCC cells.

钙(Ca2+)信号通路失调与肿瘤细胞死亡和耐药性有关。在肝细胞癌(HCC)细胞等非可兴奋细胞中,Ca2+流入的主要途径是基质相互作用分子1(STIM1)介导的贮存操作钙离子通道(SOCE)。以往的研究表明,STIM1 介导的 SOCE 参与了 HCC 的发生、转移和干细胞自我更新等过程。然而,STIM1 介导的 SOCE 是否在 HCC 患者对索拉非尼产生获得性耐药性的过程中发挥作用,目前仍不清楚。在本研究中,我们将获得性索拉非尼耐药(SR)HCC细胞系间歇性地暴露于浓度不断增加的索拉非尼。结果显示,与亲代细胞相比,SR细胞中STIM1的水平更高,SOCE更强。删除 STIM1 能显著提高 SR 细胞对索拉非尼的敏感性,而过表达 STIM1 则能通过激活 SOCE 促进 SR。从机理上讲,STIM1通过SOCE-CaN-NFAT途径增加了SLC7A11的转录。随后,上调的 SLC7A11 增加了谷胱甘肽的合成,导致铁变态反应不敏感和 SR。此外,将 SOCE 抑制剂 SKF96365 与索拉非尼结合使用,可显著改善 SR 细胞在体外和体内对索拉非尼的敏感性。这些发现为克服HCC细胞对索拉非尼的获得性耐药性提供了一种潜在的策略。
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引用次数: 0
Expanding the spectrum of novel candidate genes using trio exome sequencing and identification of monogenic cause in 27.5% of 320 families with steroid-resistant nephrotic syndrome 利用三组外显子测序扩展新型候选基因谱,在 320 个类固醇耐受性肾病综合征家族中确定 27.5% 的单基因病因
IF 6.9 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-03-28 DOI: 10.1016/j.gendis.2024.101280
Ronen Schneider , Shirlee Shril , Florian Buerger , Konstantin Deutsch , Kirollos Yousef , Camille N. Frank , Ana C. Onuchic-Whitford , Thomas M. Kitzler , Youying Mao , Verena Klämbt , Muhammad Y. Zahoor , Katharina Lemberg , Amar J. Majmundar , Bshara Mansour , Ken Saida , Steve Seltzsam , Caroline M. Kolvenbach , Lea Maria Merz , Nils D. Mertens , Tobias Hermle , Friedhelm Hildebrandt
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引用次数: 0
Transcriptional programs associated with luminal play a vital role in invasive mucinous lung adenocarcinoma 与管腔相关的转录程序在浸润性黏液肺腺癌中发挥着重要作用
IF 6.9 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-03-26 DOI: 10.1016/j.gendis.2024.101278
Shufan Zhang , Rong Jiang , Changguo Wang , Manqiu Yang , Tao Wang , Jianzhou Cui , Guangbin Li , Shaomu Chen , Moli Huang
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引用次数: 0
CD147 facilitates cisplatin resistance in ovarian cancer through FOXM1 degradation inhibition CD147 通过抑制 FOXM1 降解促进卵巢癌的顺铂耐药性
IF 6.8 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-03-24 DOI: 10.1016/j.gendis.2024.101277
Miao Wang , Lin Chen , Yu Wang , Tian Fan , Chunyu Zhu , Zhixian Li , Lei Mou , Hong Yang , Airong Qian , Yu Li
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引用次数: 0
Reduction of Atp5b protects mice from diet-induced obesity 减少 Atp5b 可保护小鼠免于饮食诱发的肥胖症
IF 6.9 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-03-22 DOI: 10.1016/j.gendis.2024.101276
Xiaohua Huang , Binting Qin , Zhengfeng Fang , Lianqiang Che , Yan Lin , Shengyu Xu , Yong Zhuo , Lun Hua , Xuemei Jiang , Mengmeng Sun , Hairui Wang , De Wu , Qingqiang Long , Bin Feng
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引用次数: 0
Predicting anti-cancer drug sensitivity through WRE-XGBoost algorithm with weighted feature selection 通过带有加权特征选择的 WRE-XGBoost 算法预测抗癌药物敏感性
IF 6.9 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-03-22 DOI: 10.1016/j.gendis.2024.101275
Yiyao Jiang , Ming Chen , Zhongmin Xiong , Yufang Qin
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引用次数: 0
The important role and core marker gene of tumor-infiltrating plasma cells in the microenvironment of lung adenocarcinoma 肿瘤浸润浆细胞在肺腺癌微环境中的重要作用及核心标记基因
IF 6.9 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-03-22 DOI: 10.1016/j.gendis.2024.101274
Jianhong Zhang , Chengyang Song , Xiuqin Feng, Qian Yu, Xueying Yang
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引用次数: 0
Corrigendum to “SEMA4D acts as a novel oligogenic pathogenic gene of idiopathic hypogonadotropic hypogonadism through the PlexinB1/MET/RND1/RHOA/RAF1/MAPK signaling axis” [Genes & Diseases 10 (2023) 65–68] 对 "SEMA4D通过PlexinB1/MET/RND1/RHOA/RAF1/MAPK信号轴作为特发性性腺功能减退症的新型寡致病基因 "的更正 [Genes & Diseases 10 (2023) 65-68]
IF 6.8 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-03-22 DOI: 10.1016/j.gendis.2024.101273
Daoqi Wang , Yonghua Niu , Jiahong Tan , Jiaxin Wang , Le Ling , Yinwei Chen , Jianan Gong , Hao Xu , Qing Ling , Jianhe Liu , Jihong Liu
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引用次数: 0
The link between ten-eleven translocation-2 (Tet2) related clonal hematopoiesis and sequential onset of two hematologic malignancies 十-十一易位-2(Tet2)相关克隆造血与两种血液恶性肿瘤相继发病之间的联系
IF 6.9 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-03-22 DOI: 10.1016/j.gendis.2024.101270
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引用次数: 0
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